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The map label for this gene is phoQ [H]

Identifier: 16125554

GI number: 16125554

Start: 1452643

End: 1453959

Strand: Direct

Name: phoQ [H]

Synonym: CC_1305

Alternate gene names: 16125554

Gene position: 1452643-1453959 (Clockwise)

Preceding gene: 16125553

Following gene: 16125555

Centisome position: 36.16

GC content: 70.31

Gene sequence:

>1317_bases
ATGCTGGCGATCCTGGCGGCCCTGGCGGTCGCCTGGCTGGCCATGACCTGGCTTTTCGAGCGTCATATCGTGCGTCGGGA
AACGGCCGACCTGACACGCGCGGGTCAGGTGCTGGTCGCGGGTCTCCGGCTGGAGCCGAACGGCGCGCCGGTCATCGACG
CGACCTTGTCTGATCCGCGGCTGTCGAAAGCCGCAGGCGGCTTCTACTGGCAGGTTTCGACAACCTCTGGCAGCGAGCGG
TCGGTCTCCCTGTGGGATCAGGCGCTAAAGCCGCCGCAAACCGCGCCGGCTGAGGGCTGGTCCTCGCGCATCGCCGCCGG
GCCGTTTGATGATCGCGTCCTCCTGGTCGAGCGGAGCGTGCGACCGGACCGCGACGGTCCGGCCGTGCTGATCCAGGTCG
CCAGTGACGAAAAGGTGTTGCGCGCCGCCCGGCGCGAGTTCGGTCGCGAACTCGCCATTTTTCTGGGCGGGCTCTGGGCG
ATCCTCTCGGGCGCCGCAGCCTTGCAGGTGGTGCTGGGCCTGTCGCCCCTGACCCGCGTGCGCGCGGATCTTGCTCGCCT
ACGCAAAAGCCCTTCTGCCCGGATGTCGCTCGATCATCCGCGCGAGATCGCGCCGCTGGCCGAGGCGATCAACGCCTTGG
CCGAAGCGCGGGAGGCTGATCTGGCCCGTGCGCGCCGACGAGCCGGCGACCTGGCCCACAGTCTCAAAACGCCGCTCGCC
GCTCTGTCGGCCCAGAGCCGCCGCGCGCGCGAAGACGGCGCGGTCGCAGCCGCTGATGGTCTGGACGCCGCCATCGCCTC
GGTCGCCGCGGCGCTGGAGGCTGAGCTGGCCAGAGCTCGCGCCGCCGCCGCCCGAGAGGCCGTCTTCGCCGCCGAGACCG
CGCCTCTGGCCGTCGCAGAACGCCTCGTGGCCGTTCTGGAACGCACCGCCGATGGTGAGCGCTTGATCTTCGATATTGAT
GTTCCGGCCGATCTGAAGGCGCCGGCCTCTGAAGACGTGGTCACCGAAATGCTGGGCGCGCTCATCGAGAACGCCGCCCG
TCATGCTCGCCGCCAAGTCAGGATTTCGGGCGCTGTGGTGGGGCAGGGGGCAGTCCTGATCGTCGAGGATGATGGACCAG
GGCTGGACAAGGGCCGCGCGGAGGCGGCCCTCGCGCGCGGCGCCCGGTTGGACGAGGCCGGGCCAGGCCACGGTCTGGGC
CTGGCTATCGTTCGCGATCTTGCAGAGGCTTCGGGCGCGGTGTTGAGCATGGACCGCGGGGATCTGGGCGGCCTTCGCGC
GATGGTGTCGTGGACGGCGCCCGGAGCAGGGCCATGA

Upstream 100 bases:

>100_bases
GCGCCGACGTTATCGAAACCCGCAGAGGCTTTGGCTACCTGCTGGCCGGCGGGACGGCGTGAGCGGCGGCTCGTTGCGAT
GGCGACTGATCGTCGGCGGC

Downstream 100 bases:

>100_bases
GCGTCTGAGCTCAAAACCCGCCCATTGGTCGCATCGGCCCTTTGCGTCCTTGCGAAGGCCGAACGTCCCCCTTCTGCGAC
ACAGCGGCTCGCGGCAATTT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLAILAALAVAWLAMTWLFERHIVRRETADLTRAGQVLVAGLRLEPNGAPVIDATLSDPRLSKAAGGFYWQVSTTSGSER
SVSLWDQALKPPQTAPAEGWSSRIAAGPFDDRVLLVERSVRPDRDGPAVLIQVASDEKVLRAARREFGRELAIFLGGLWA
ILSGAAALQVVLGLSPLTRVRADLARLRKSPSARMSLDHPREIAPLAEAINALAEAREADLARARRRAGDLAHSLKTPLA
ALSAQSRRAREDGAVAAADGLDAAIASVAAALEAELARARAAAAREAVFAAETAPLAVAERLVAVLERTADGERLIFDID
VPADLKAPASEDVVTEMLGALIENAARHARRQVRISGAVVGQGAVLIVEDDGPGLDKGRAEAALARGARLDEAGPGHGLG
LAIVRDLAEASGAVLSMDRGDLGGLRAMVSWTAPGAGP

Sequences:

>Translated_438_residues
MLAILAALAVAWLAMTWLFERHIVRRETADLTRAGQVLVAGLRLEPNGAPVIDATLSDPRLSKAAGGFYWQVSTTSGSER
SVSLWDQALKPPQTAPAEGWSSRIAAGPFDDRVLLVERSVRPDRDGPAVLIQVASDEKVLRAARREFGRELAIFLGGLWA
ILSGAAALQVVLGLSPLTRVRADLARLRKSPSARMSLDHPREIAPLAEAINALAEAREADLARARRRAGDLAHSLKTPLA
ALSAQSRRAREDGAVAAADGLDAAIASVAAALEAELARARAAAAREAVFAAETAPLAVAERLVAVLERTADGERLIFDID
VPADLKAPASEDVVTEMLGALIENAARHARRQVRISGAVVGQGAVLIVEDDGPGLDKGRAEAALARGARLDEAGPGHGLG
LAIVRDLAEASGAVLSMDRGDLGGLRAMVSWTAPGAGP
>Mature_438_residues
MLAILAALAVAWLAMTWLFERHIVRRETADLTRAGQVLVAGLRLEPNGAPVIDATLSDPRLSKAAGGFYWQVSTTSGSER
SVSLWDQALKPPQTAPAEGWSSRIAAGPFDDRVLLVERSVRPDRDGPAVLIQVASDEKVLRAARREFGRELAIFLGGLWA
ILSGAAALQVVLGLSPLTRVRADLARLRKSPSARMSLDHPREIAPLAEAINALAEAREADLARARRRAGDLAHSLKTPLA
ALSAQSRRAREDGAVAAADGLDAAIASVAAALEAELARARAAAAREAVFAAETAPLAVAERLVAVLERTADGERLIFDID
VPADLKAPASEDVVTEMLGALIENAARHARRQVRISGAVVGQGAVLIVEDDGPGLDKGRAEAALARGARLDEAGPGHGLG
LAIVRDLAEASGAVLSMDRGDLGGLRAMVSWTAPGAGP

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=241, Percent_Identity=26.9709543568465, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787894, Length=249, Percent_Identity=28.5140562248996, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=314, Percent_Identity=25.1592356687898, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789403, Length=287, Percent_Identity=28.2229965156794, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790551, Length=336, Percent_Identity=25, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45833; Mature: 45833

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAILAALAVAWLAMTWLFERHIVRRETADLTRAGQVLVAGLRLEPNGAPVIDATLSDPR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCCCC
LSKAAGGFYWQVSTTSGSERSVSLWDQALKPPQTAPAEGWSSRIAAGPFDDRVLLVERSV
HHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCC
RPDRDGPAVLIQVASDEKVLRAARREFGRELAIFLGGLWAILSGAAALQVVLGLSPLTRV
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RADLARLRKSPSARMSLDHPREIAPLAEAINALAEAREADLARARRRAGDLAHSLKTPLA
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALSAQSRRAREDGAVAAADGLDAAIASVAAALEAELARARAAAAREAVFAAETAPLAVAE
HHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RLVAVLERTADGERLIFDIDVPADLKAPASEDVVTEMLGALIENAARHARRQVRISGAVV
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEE
GQGAVLIVEDDGPGLDKGRAEAALARGARLDEAGPGHGLGLAIVRDLAEASGAVLSMDRG
CCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCC
DLGGLRAMVSWTAPGAGP
CCCHHHHEEEECCCCCCC
>Mature Secondary Structure
MLAILAALAVAWLAMTWLFERHIVRRETADLTRAGQVLVAGLRLEPNGAPVIDATLSDPR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCCCC
LSKAAGGFYWQVSTTSGSERSVSLWDQALKPPQTAPAEGWSSRIAAGPFDDRVLLVERSV
HHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCC
RPDRDGPAVLIQVASDEKVLRAARREFGRELAIFLGGLWAILSGAAALQVVLGLSPLTRV
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RADLARLRKSPSARMSLDHPREIAPLAEAINALAEAREADLARARRRAGDLAHSLKTPLA
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALSAQSRRAREDGAVAAADGLDAAIASVAAALEAELARARAAAAREAVFAAETAPLAVAE
HHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RLVAVLERTADGERLIFDIDVPADLKAPASEDVVTEMLGALIENAARHARRQVRISGAVV
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEE
GQGAVLIVEDDGPGLDKGRAEAALARGARLDEAGPGHGLGLAIVRDLAEASGAVLSMDRG
CCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCC
DLGGLRAMVSWTAPGAGP
CCCHHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]