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The map label for this gene is pmrA [H]

Identifier: 16125553

GI number: 16125553

Start: 1451939

End: 1452604

Strand: Direct

Name: pmrA [H]

Synonym: CC_1304

Alternate gene names: 16125553

Gene position: 1451939-1452604 (Clockwise)

Preceding gene: 16125552

Following gene: 16125554

Centisome position: 36.15

GC content: 70.12

Gene sequence:

>666_bases
ATGCGCGCGCTCGTCGTCGAGGATGATCCGGTCGTGGGCCCAGACCTCGCCAAGGCGCTGAGCGCGTCGGGCTTCGTGGT
CGATATCGCCCGCGATGGCGAGGACGCGTCCTTCAAGGGCGAGGTCGAGGATTACGCGCTTGTCGTGCTGGATCTGGGCC
TGCCGCGTCTTGACGGTCTGTCGGTGCTTCGGCGCTGGCGGGCCAATGACCGCGCCTTCCCGGTGCTGATCCTGTCGGCG
CGGGGCGACTGGACCGAGAAGGTCGAAGGCATCGAGGCCGGCGCCGACGACTATCTGGCCAAGCCTTTCGAGATGGGCGA
ACTGCTGGCGCGCGCGCGTGGCCTCGTGCGCCGTGCGGCGGGCCGCACGTCACCCGTGATCGGCGCGGGGCGACTGGCCC
TGGATACGCGGCGCATGTCCGCCACCCTGGACGGCGCGCCGATCCGCTTGTCGCCGCTTGAGTTCCGGCTGCTGGACTGC
CTGGCGCACAACCCCGGACGGGCTGTTTCGGCCGGTGAGCTTGCCGAACAGCTCTACGGCGTCGCCGACACCGCCGACAC
CAACGCCATCGAGGCCCTGGTGGCGCGCCTTCGCCGCAAGATCGGCGCCGACGTTATCGAAACCCGCAGAGGCTTTGGCT
ACCTGCTGGCCGGCGGGACGGCGTGA

Upstream 100 bases:

>100_bases
GCCTGAAGTATGATCTCAAGATCCTGGCCAAGAACGGACGTGTCCGGGAGTTGGAACTCGACGCCAAGACCGGCGCGACC
CTGAAGCTTGAGGACGATTG

Downstream 100 bases:

>100_bases
GCGGCGGCTCGTTGCGATGGCGACTGATCGTCGGCGGCATGCTGGCGATCCTGGCGGCCCTGGCGGTCGCCTGGCTGGCC
ATGACCTGGCTTTTCGAGCG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRALVVEDDPVVGPDLAKALSASGFVVDIARDGEDASFKGEVEDYALVVLDLGLPRLDGLSVLRRWRANDRAFPVLILSA
RGDWTEKVEGIEAGADDYLAKPFEMGELLARARGLVRRAAGRTSPVIGAGRLALDTRRMSATLDGAPIRLSPLEFRLLDC
LAHNPGRAVSAGELAEQLYGVADTADTNAIEALVARLRRKIGADVIETRRGFGYLLAGGTA

Sequences:

>Translated_221_residues
MRALVVEDDPVVGPDLAKALSASGFVVDIARDGEDASFKGEVEDYALVVLDLGLPRLDGLSVLRRWRANDRAFPVLILSA
RGDWTEKVEGIEAGADDYLAKPFEMGELLARARGLVRRAAGRTSPVIGAGRLALDTRRMSATLDGAPIRLSPLEFRLLDC
LAHNPGRAVSAGELAEQLYGVADTADTNAIEALVARLRRKIGADVIETRRGFGYLLAGGTA
>Mature_221_residues
MRALVVEDDPVVGPDLAKALSASGFVVDIARDGEDASFKGEVEDYALVVLDLGLPRLDGLSVLRRWRANDRAFPVLILSA
RGDWTEKVEGIEAGADDYLAKPFEMGELLARARGLVRRAAGRTSPVIGAGRLALDTRRMSATLDGAPIRLSPLEFRLLDC
LAHNPGRAVSAGELAEQLYGVADTADTNAIEALVARLRRKIGADVIETRRGFGYLLAGGTA

Specific function: Member of the two-component regulatory system pmrB/pmrA involved in regulation of virulence. Unphosphorylated pmrA represses extracellular enzyme genes. Phosphorylation of pmrA by pmrB relieves such repression, which leads to activation of extracellular e

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=40.990990990991, Blast_Score=168, Evalue=3e-43,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=43.37899543379, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=38.9140271493213, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=38.8127853881278, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=34.8623853211009, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=35.8744394618834, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=32.4561403508772, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=33.6206896551724, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=31.981981981982, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=30.2222222222222, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788394, Length=204, Percent_Identity=30.8823529411765, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=30.9090909090909, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=28.695652173913, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=27.5423728813559, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 23623; Mature: 23623

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALVVEDDPVVGPDLAKALSASGFVVDIARDGEDASFKGEVEDYALVVLDLGLPRLDGL
CCEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCHHH
SVLRRWRANDRAFPVLILSARGDWTEKVEGIEAGADDYLAKPFEMGELLARARGLVRRAA
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHC
GRTSPVIGAGRLALDTRRMSATLDGAPIRLSPLEFRLLDCLAHNPGRAVSAGELAEQLYG
CCCCCCCCCCHHEEHHHHHHEECCCCCEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
VADTADTNAIEALVARLRRKIGADVIETRRGFGYLLAGGTA
CCCCCCHHHHHHHHHHHHHHHCHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure
MRALVVEDDPVVGPDLAKALSASGFVVDIARDGEDASFKGEVEDYALVVLDLGLPRLDGL
CCEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCHHH
SVLRRWRANDRAFPVLILSARGDWTEKVEGIEAGADDYLAKPFEMGELLARARGLVRRAA
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHC
GRTSPVIGAGRLALDTRRMSATLDGAPIRLSPLEFRLLDCLAHNPGRAVSAGELAEQLYG
CCCCCCCCCCHHEEHHHHHHEECCCCCEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
VADTADTNAIEALVARLRRKIGADVIETRRGFGYLLAGGTA
CCCCCCHHHHHHHHHHHHHHHCHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14617142 [H]