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The map label for this gene is tbpF

Identifier: 16120311

GI number: 16120311

Start: 329788

End: 330348

Strand: Direct

Name: tbpF

Synonym: VNG6438G

Alternate gene names: 16120311

Gene position: 329788-330348 (Clockwise)

Preceding gene: 16120310

Following gene: 16120313

Centisome position: 90.25

GC content: 58.11

Gene sequence:

>561_bases
ATGAGCAGTCTGGCGGACACGATCCACATCGAGAACGTTGTTGCATCCAGTGATCTCGGCCAGGAACTCGCCCTCGACCA
GCTCGCAACGGATCTCGATGGCGCTGAGTACAACCCAGAGGACTTCCCGGGGGTTGTCTACCGGCTTCAGGAGCCGAAGT
CAGCCACGCTGATCTTCCGGTCGGGGAAAGTTGTCTGCACCGGCGCGAAGAGCGTCGATGCTGTTCACGATGCTCTCGAG
ATCGTTTTCGATGACCTCCGCGAGTTAGGCATCGACGTCGACAGTACTCCACCGGTCAAGGTACAGAACATCGTCTCTAG
TGCCAGCCTTGAGCAGTCGCTGAATTTGAACGCAATCGCAATCGGGCTGGGCTTAGAGCAGATCGAATACGAACCCGAAC
AGTTCCCCGGGCTCGTCTATCGTCTCGACGACCCCGATGTCGTCGTTTTGCTGTTCGGGAGTGGGAAACTCGTGATTACT
GGCGCAGCGGAATCTGCGGATGCCCAGCACGCGTTGGCACACGTCAACGATCGGCTCACGGAACTCGGCCTGCTTGAGTG
A

Upstream 100 bases:

>100_bases
TACGTAGTGGGATATACTTGAGTAGAGTCTCCGATACGGGTCTGACCAGCGCCAGACAGGTCCACCCGCTATTTACGTGG
GGTGGCCGACGAATACCCGT

Downstream 100 bases:

>100_bases
GTCCACGGAGCTCTCGAGTAACTCCTACGCGACGGGAGCAGTGTTGCTGGAGTGGGTAATCTCCTTGAACGCTGGGCCGC
TTCGACTGGGTTGGATGAGT

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein F; BAP F; TATA sequence-binding protein F; TBP F; TATA-box factor F

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MSSLADTIHIENVVASSDLGQELALDQLATDLDGAEYNPEDFPGVVYRLQEPKSATLIFRSGKVVCTGAKSVDAVHDALE
IVFDDLRELGIDVDSTPPVKVQNIVSSASLEQSLNLNAIAIGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVIT
GAAESADAQHALAHVNDRLTELGLLE

Sequences:

>Translated_186_residues
MSSLADTIHIENVVASSDLGQELALDQLATDLDGAEYNPEDFPGVVYRLQEPKSATLIFRSGKVVCTGAKSVDAVHDALE
IVFDDLRELGIDVDSTPPVKVQNIVSSASLEQSLNLNAIAIGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVIT
GAAESADAQHALAHVNDRLTELGLLE
>Mature_185_residues
SSLADTIHIENVVASSDLGQELALDQLATDLDGAEYNPEDFPGVVYRLQEPKSATLIFRSGKVVCTGAKSVDAVHDALEI
VFDDLRELGIDVDSTPPVKVQNIVSSASLEQSLNLNAIAIGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVITG
AAESADAQHALAHVNDRLTELGLLE

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation

COG id: COG2101

COG function: function code K; TATA-box binding protein (TBP), component of TFIID and TFIIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family

Homologues:

Organism=Homo sapiens, GI285026520, Length=168, Percent_Identity=38.0952380952381, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4507379, Length=168, Percent_Identity=38.0952380952381, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI39930602, Length=168, Percent_Identity=37.5, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17555358, Length=166, Percent_Identity=40.3614457831325, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320996, Length=173, Percent_Identity=39.3063583815029, Blast_Score=121, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17647997, Length=157, Percent_Identity=40.1273885350318, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17136834, Length=165, Percent_Identity=36.3636363636364, Blast_Score=111, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TBPF_HALSA (Q9HHE9)

Other databases:

- EMBL:   AE004438
- RefSeq:   NP_395899.1
- ProteinModelPortal:   Q9HHE9
- SMR:   Q9HHE9
- GeneID:   1449409
- GenomeReviews:   AE004438_GR
- KEGG:   hal:VNG6438G
- NMPDR:   fig|64091.1.peg.2583
- HOGENOM:   HBG499930
- OMA:   FARIVHK
- ProtClustDB:   PRK00394
- BioCyc:   HSP64091:VNG6438G-MONOMER
- HAMAP:   MF_00408
- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294
- Gene3D:   G3DSA:3.30.310.10
- PANTHER:   PTHR10126
- PRINTS:   PR00686

Pfam domain/function: PF00352 TBP; SSF55945 TFIID_C/glycos_N

EC number: NA

Molecular weight: Translated: 19897; Mature: 19765

Theoretical pI: Translated: 3.90; Mature: 3.90

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLADTIHIENVVASSDLGQELALDQLATDLDGAEYNPEDFPGVVYRLQEPKSATLIFR
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEEE
SGKVVCTGAKSVDAVHDALEIVFDDLRELGIDVDSTPPVKVQNIVSSASLEQSLNLNAIA
CCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
IGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVITGAAESADAQHALAHVNDRLT
EECCHHHHCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHH
ELGLLE
HCCCCC
>Mature Secondary Structure 
SSLADTIHIENVVASSDLGQELALDQLATDLDGAEYNPEDFPGVVYRLQEPKSATLIFR
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEEE
SGKVVCTGAKSVDAVHDALEIVFDDLRELGIDVDSTPPVKVQNIVSSASLEQSLNLNAIA
CCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
IGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVITGAAESADAQHALAHVNDRLT
EECCHHHHCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHH
ELGLLE
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11016950