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Identifier: 16120214

GI number: 16120214

Start: 234195

End: 235574

Strand: Direct

Name: Not Available

Synonym: VNG6302C

Alternate gene names: 16120214

Gene position: 234195-235574 (Clockwise)

Preceding gene: 16120211

Following gene: 16120219

Centisome position: 64.09

GC content: 66.96

Gene sequence:

>1380_bases
ATGCGGTGGCGTCACCCCAGCGCCCTTCGGAAGGCAGATGAGCGGGGCCGGCGAACGCCGTGCGTAGTGTCAGCTACGTC
ACTTGCGGTTGGTCGGATCGCGCTCGCCCTCCTCCTCGTCGTCCTGAACGGCTTTTTCGTCGCCGCAGAGTTCGCGTTCG
TGCGGCTGCGGTCGGCGTCCGTCGAGACGCTCGTTCAGGACGGACGGCGTGGCGCAACGGCGGTCAAGGAAGCCACGGAC
AACCTCGATGATTACCTCGCGGTCTCCCAACTCGGGATCACGATCGCGTCGCTCGGGCTCGGGTGGGTCGGTGAACCCGC
GGTCGCGGTTCTGGTCGACCCACTACTGGAGCCGGTGCTCCCGGCTCCCGTTCGCCACACCGTGACTGTGGCCCTCGGGT
TCGGGATCGTGACCCTGTTGCACGTCGTGTACGGCGAACTCGCGCCGAAGACGATCGCGATCCAGCGCGCCGAGCGCGTC
GCGCTCGTGGTTGCGCCCGTGATGAAACTGTTCTACTACGTGTTCCTGCCGGGCACGATCCTGTTCAACGGCATCGCGAC
ACGGTCGGTCCAACTCATCGGCGTCTCCCCGGAGACAGAGGGCCACGACACCCACACCGAGCCGGAGATCCTGAGCGTGC
TCTCGGAAGCCAGCGCCGCCGGCCGGATCAGCCCGGCGGAGGTGTCGATGATCGAGCACGTCTTCAGCCTCGACGACACG
ACTGTTCGTGAGATCATGCGGCCACGCCCCGACGTGACCAGCGTGTCCGCAGACACTCCGCTCCCCGAACTCCGAACGAT
GGCCGCCAGCGGCGAATACACCCGCTACCCGGTCACCGAAGGCCCGGACGACGACGTGATCGGGTTCGTCGACGTGAAAG
ACATCTTGCGCGCCAGCGACGCCATCGACGAGTCGGGCGATGTCACGGCCCGGGAGCTGAGCCGGCCGGTCGTCGTGGTT
CCCGAGACGCTGCGCGTCGACGAGCTGCTCGCGGAGTTCCAGGCCGAGCACCGCCAGATGGCGGTCGTCATCGACGAATG
GGGTGCCTTCGAGGGGTTGGCAACCATCGAAGACGCCCTCGAAGTGATCGTCGGCGACATCCGCGACCAGTTCGATCTGG
CGACCCACGCGCAGTCCATCGAGCCCCGCGACGATGGCGGCTACGAGGTTCCTGGCGCGGTGTCGATCACCGAACTCAAC
GACCACCTCGGCACGGATTTCGAGAACGAGGCGGTCGAAACCGTCGCCGGGCTCGTGGTCAGCCGACTCGGGCACGCCCC
CACGGTCGGTGATCGTGCCGTGATCGACACGCACACGTTCCGCGTGACTGGCGTCGACGGCGCACGGATCACGTCGCTGA
CGGTGACTCCCGACTCCTGA

Upstream 100 bases:

>100_bases
GGTGACTCTGTGGTGTGCGGTGTTGGCATCTGATCGCTCTACACGGCTGTACCACCACTGCGCTCAAAGCCACTTATAAT
AGTCGTCCGGACGCCTATAT

Downstream 100 bases:

>100_bases
CCGGAGCGGTCACCGGCGCTCGCCGTTTCCACCGGGGCGCGCGAACGGCCGCCATTACGTGTACGACGGGCGCTCGGCGT
ATTCGATCGGGTCGCGTTCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MRWRHPSALRKADERGRRTPCVVSATSLAVGRIALALLLVVLNGFFVAAEFAFVRLRSASVETLVQDGRRGATAVKEATD
NLDDYLAVSQLGITIASLGLGWVGEPAVAVLVDPLLEPVLPAPVRHTVTVALGFGIVTLLHVVYGELAPKTIAIQRAERV
ALVVAPVMKLFYYVFLPGTILFNGIATRSVQLIGVSPETEGHDTHTEPEILSVLSEASAAGRISPAEVSMIEHVFSLDDT
TVREIMRPRPDVTSVSADTPLPELRTMAASGEYTRYPVTEGPDDDVIGFVDVKDILRASDAIDESGDVTARELSRPVVVV
PETLRVDELLAEFQAEHRQMAVVIDEWGAFEGLATIEDALEVIVGDIRDQFDLATHAQSIEPRDDGGYEVPGAVSITELN
DHLGTDFENEAVETVAGLVVSRLGHAPTVGDRAVIDTHTFRVTGVDGARITSLTVTPDS

Sequences:

>Translated_459_residues
MRWRHPSALRKADERGRRTPCVVSATSLAVGRIALALLLVVLNGFFVAAEFAFVRLRSASVETLVQDGRRGATAVKEATD
NLDDYLAVSQLGITIASLGLGWVGEPAVAVLVDPLLEPVLPAPVRHTVTVALGFGIVTLLHVVYGELAPKTIAIQRAERV
ALVVAPVMKLFYYVFLPGTILFNGIATRSVQLIGVSPETEGHDTHTEPEILSVLSEASAAGRISPAEVSMIEHVFSLDDT
TVREIMRPRPDVTSVSADTPLPELRTMAASGEYTRYPVTEGPDDDVIGFVDVKDILRASDAIDESGDVTARELSRPVVVV
PETLRVDELLAEFQAEHRQMAVVIDEWGAFEGLATIEDALEVIVGDIRDQFDLATHAQSIEPRDDGGYEVPGAVSITELN
DHLGTDFENEAVETVAGLVVSRLGHAPTVGDRAVIDTHTFRVTGVDGARITSLTVTPDS
>Mature_459_residues
MRWRHPSALRKADERGRRTPCVVSATSLAVGRIALALLLVVLNGFFVAAEFAFVRLRSASVETLVQDGRRGATAVKEATD
NLDDYLAVSQLGITIASLGLGWVGEPAVAVLVDPLLEPVLPAPVRHTVTVALGFGIVTLLHVVYGELAPKTIAIQRAERV
ALVVAPVMKLFYYVFLPGTILFNGIATRSVQLIGVSPETEGHDTHTEPEILSVLSEASAAGRISPAEVSMIEHVFSLDDT
TVREIMRPRPDVTSVSADTPLPELRTMAASGEYTRYPVTEGPDDDVIGFVDVKDILRASDAIDESGDVTARELSRPVVVV
PETLRVDELLAEFQAEHRQMAVVIDEWGAFEGLATIEDALEVIVGDIRDQFDLATHAQSIEPRDDGGYEVPGAVSITELN
DHLGTDFENEAVETVAGLVVSRLGHAPTVGDRAVIDTHTFRVTGVDGARITSLTVTPDS

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=407, Percent_Identity=34.6437346437346, Blast_Score=240, Evalue=2e-63,
Organism=Escherichia coli, GI1790664, Length=429, Percent_Identity=26.1072261072261, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786879, Length=261, Percent_Identity=33.7164750957854, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI145693175, Length=414, Percent_Identity=21.7391304347826, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI87082033, Length=260, Percent_Identity=27.3076923076923, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1788119, Length=226, Percent_Identity=33.1858407079646, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 49331; Mature: 49331

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWRHPSALRKADERGRRTPCVVSATSLAVGRIALALLLVVLNGFFVAAEFAFVRLRSAS
CCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VETLVQDGRRGATAVKEATDNLDDYLAVSQLGITIASLGLGWVGEPAVAVLVDPLLEPVL
HHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PAPVRHTVTVALGFGIVTLLHVVYGELAPKTIAIQRAERVALVVAPVMKLFYYVFLPGTI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFNGIATRSVQLIGVSPETEGHDTHTEPEILSVLSEASAAGRISPAEVSMIEHVFSLDDT
HHCCHHHCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHH
TVREIMRPRPDVTSVSADTPLPELRTMAASGEYTRYPVTEGPDDDVIGFVDVKDILRASD
HHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCEECCCCCCCCCCEEEEECHHHHHHHHH
AIDESGDVTARELSRPVVVVPETLRVDELLAEFQAEHRQMAVVIDEWGAFEGLATIEDAL
CCCCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHH
EVIVGDIRDQFDLATHAQSIEPRDDGGYEVPGAVSITELNDHLGTDFENEAVETVAGLVV
HHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEEECHHHHCCCCCHHHHHHHHHHHH
SRLGHAPTVGDRAVIDTHTFRVTGVDGARITSLTVTPDS
HHHCCCCCCCCCEEEECEEEEEECCCCCEEEEEEECCCC
>Mature Secondary Structure
MRWRHPSALRKADERGRRTPCVVSATSLAVGRIALALLLVVLNGFFVAAEFAFVRLRSAS
CCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VETLVQDGRRGATAVKEATDNLDDYLAVSQLGITIASLGLGWVGEPAVAVLVDPLLEPVL
HHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PAPVRHTVTVALGFGIVTLLHVVYGELAPKTIAIQRAERVALVVAPVMKLFYYVFLPGTI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFNGIATRSVQLIGVSPETEGHDTHTEPEILSVLSEASAAGRISPAEVSMIEHVFSLDDT
HHCCHHHCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHH
TVREIMRPRPDVTSVSADTPLPELRTMAASGEYTRYPVTEGPDDDVIGFVDVKDILRASD
HHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCEECCCCCCCCCCEEEEECHHHHHHHHH
AIDESGDVTARELSRPVVVVPETLRVDELLAEFQAEHRQMAVVIDEWGAFEGLATIEDAL
CCCCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHH
EVIVGDIRDQFDLATHAQSIEPRDDGGYEVPGAVSITELNDHLGTDFENEAVETVAGLVV
HHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEEECHHHHCCCCCHHHHHHHHHHHH
SRLGHAPTVGDRAVIDTHTFRVTGVDGARITSLTVTPDS
HHHCCCCCCCCCEEEECEEEEEECCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]