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The map label for this gene is arsB [C]

Identifier: 160902988

GI number: 160902988

Start: 1677058

End: 1678347

Strand: Direct

Name: arsB [C]

Synonym: Pmob_1545

Alternate gene names: 160902988

Gene position: 1677058-1678347 (Clockwise)

Preceding gene: 160902982

Following gene: 160902989

Centisome position: 77.3

GC content: 32.33

Gene sequence:

>1290_bases
ATGTCAATTTATGCCTTAACATCTTTGATAGTCTTCATAATTGTCGTTGTAGGAATGGTTTTTCAGAAAATAGATAGAAC
GCTTATTGCAATGTTGGGGGCTATTTTTCTATTAGGAACAGGGATTTTCCCTGACCAAATTGGTGCAATAAAAGAGTACG
TGGATTATAACACTCTGTTATTGCTGCTTGGAATGATGGTATTTGTTGAGACTTTAAGAAAGACAGGTATATTTACCTTC
TTAGGTCTCTCCATGTTAAGATTGTTTGGGAATAACACCTATACCTTATTCATCTCTCTAATTTTTTTGGTTGCTTTATT
TTCTGGCTTTATTGATAACGTTACTACTGTTTTAGTTTTTATTCCAATGACTTTTGCCATTACGGATTCATTAAATATTA
ATTATCTCCCTTTTGTTTTAGGAGAAATTTTCGCATCAAATATTGGAGGTATGGCAACTATAATTGGTGATCCTCCTAAT
ATTATGATTGCTTCTGCGGCAGGTTATTCTTTCTCAGAGTTCGCTCTTATTATGTATCCGGTTACATTGATCAATTTAGT
ATTCGCCATTCTCTTATTGATATATTTCTTCAAGGAAGATTTATCCGTTAAAATAGACAAAGAAGTGATTAAAAACTTTG
ATGTATCTCATATTGTAGAAAACAAAAAGGAATTTATCTTGTCTATACTTTTGTTTGGTGCAGTTATCGTGGCTTTTGCT
TTACAACATGAGCTTAATTTAGAAAGCTCAACCGTTGCCTTAGCGGGTGGTTTTTTTTCATTATTTATTCTTAGGCCAAA
GGATTTGAAAGATACATTATCTAAAGTTGAATGGGAAAATATTTTATTTTTCTTTGCTTTATTTTTAATTGCCGGTGCAC
TTGAAGAAACGGGTATCATTAACGCTTTTTCTAATATGCTTGTCAATTTTGCTGGTGGCTCTTTACTGTTATTTAGTTTT
TCCATTCTAACAATTTCTTCTTTCTTTACTGGTTTCCTAAATAATGTTCCTTTAGTGGCTGCAATGATACCTGTCATTGA
AAAATTATCTATTTCTGAATCTTCCATATTTAGTAATCTTGACCCCATTTGGTATTCATTATCATTGGGGGCTTGCTTGG
GAGGGAACTTAACTCCAATAGCCGCTTCAGCGAACGTTATAGCGTTAGGTCTCTTAACCCAATTTAAAGGGAAAACAATT
TCTTTTTGGGAGTTTTCTAAATACGGTTTGATAATATTATTAGGGAATATAGTAATTTCTGGAATATATGTAAATTTCAT
TTTTTTCTGA

Upstream 100 bases:

>100_bases
TTATTTGACTTTGTCTTTTTTTTAAACTATAATTAGTTTGGGATATTAAATCCTTTAAAAACATTAGTAAAAAAGAATGG
TTCCGTTTCGGAGGAATTAT

Downstream 100 bases:

>100_bases
TTTCTTACCCTTATAAGCTGGGATCAGGGATGAATTGGTCCAGATTTTTTTCCTTAGAAGGGTGGGAAGCGGGGCTAAGG
GGGGTTATTTATAAAGTTCT

Product: citrate transporter

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSIYALTSLIVFIIVVVGMVFQKIDRTLIAMLGAIFLLGTGIFPDQIGAIKEYVDYNTLLLLLGMMVFVETLRKTGIFTF
LGLSMLRLFGNNTYTLFISLIFLVALFSGFIDNVTTVLVFIPMTFAITDSLNINYLPFVLGEIFASNIGGMATIIGDPPN
IMIASAAGYSFSEFALIMYPVTLINLVFAILLLIYFFKEDLSVKIDKEVIKNFDVSHIVENKKEFILSILLFGAVIVAFA
LQHELNLESSTVALAGGFFSLFILRPKDLKDTLSKVEWENILFFFALFLIAGALEETGIINAFSNMLVNFAGGSLLLFSF
SILTISSFFTGFLNNVPLVAAMIPVIEKLSISESSIFSNLDPIWYSLSLGACLGGNLTPIAASANVIALGLLTQFKGKTI
SFWEFSKYGLIILLGNIVISGIYVNFIFF

Sequences:

>Translated_429_residues
MSIYALTSLIVFIIVVVGMVFQKIDRTLIAMLGAIFLLGTGIFPDQIGAIKEYVDYNTLLLLLGMMVFVETLRKTGIFTF
LGLSMLRLFGNNTYTLFISLIFLVALFSGFIDNVTTVLVFIPMTFAITDSLNINYLPFVLGEIFASNIGGMATIIGDPPN
IMIASAAGYSFSEFALIMYPVTLINLVFAILLLIYFFKEDLSVKIDKEVIKNFDVSHIVENKKEFILSILLFGAVIVAFA
LQHELNLESSTVALAGGFFSLFILRPKDLKDTLSKVEWENILFFFALFLIAGALEETGIINAFSNMLVNFAGGSLLLFSF
SILTISSFFTGFLNNVPLVAAMIPVIEKLSISESSIFSNLDPIWYSLSLGACLGGNLTPIAASANVIALGLLTQFKGKTI
SFWEFSKYGLIILLGNIVISGIYVNFIFF
>Mature_428_residues
SIYALTSLIVFIIVVVGMVFQKIDRTLIAMLGAIFLLGTGIFPDQIGAIKEYVDYNTLLLLLGMMVFVETLRKTGIFTFL
GLSMLRLFGNNTYTLFISLIFLVALFSGFIDNVTTVLVFIPMTFAITDSLNINYLPFVLGEIFASNIGGMATIIGDPPNI
MIASAAGYSFSEFALIMYPVTLINLVFAILLLIYFFKEDLSVKIDKEVIKNFDVSHIVENKKEFILSILLFGAVIVAFAL
QHELNLESSTVALAGGFFSLFILRPKDLKDTLSKVEWENILFFFALFLIAGALEETGIINAFSNMLVNFAGGSLLLFSFS
ILTISSFFTGFLNNVPLVAAMIPVIEKLSISESSIFSNLDPIWYSLSLGACLGGNLTPIAASANVIALGLLTQFKGKTIS
FWEFSKYGLIILLGNIVISGIYVNFIFF

Specific function: Involved In Arsenical Resistance. Thought To Form The Channel Of An Arsenite Pump (By Similarity). [C]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI157266326, Length=207, Percent_Identity=32.3671497584541, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87082277, Length=415, Percent_Identity=22.8915662650602, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1787039, Length=129, Percent_Identity=29.4573643410853, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28574683, Length=506, Percent_Identity=28.4584980237154, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI28574681, Length=506, Percent_Identity=28.4584980237154, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI28574685, Length=506, Percent_Identity=28.4584980237154, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI28574678, Length=506, Percent_Identity=28.4584980237154, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24581759, Length=506, Percent_Identity=28.4584980237154, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI19920704, Length=506, Percent_Identity=28.4584980237154, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI45550608, Length=482, Percent_Identity=26.7634854771784, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24656008, Length=438, Percent_Identity=25.3424657534247, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221472711, Length=150, Percent_Identity=32, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24581764, Length=188, Percent_Identity=28.1914893617021, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI62484377, Length=172, Percent_Identity=30.2325581395349, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI85724998, Length=172, Percent_Identity=30.2325581395349, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802
- InterPro:   IPR004680 [H]

Pfam domain/function: PF03600 CitMHS [H]

EC number: NA

Molecular weight: Translated: 47178; Mature: 47047

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYALTSLIVFIIVVVGMVFQKIDRTLIAMLGAIFLLGTGIFPDQIGAIKEYVDYNTLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LLLGMMVFVETLRKTGIFTFLGLSMLRLFGNNTYTLFISLIFLVALFSGFIDNVTTVLVF
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPMTFAITDSLNINYLPFVLGEIFASNIGGMATIIGDPPNIMIASAAGYSFSEFALIMYP
HHHHHHEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHH
VTLINLVFAILLLIYFFKEDLSVKIDKEVIKNFDVSHIVENKKEFILSILLFGAVIVAFA
HHHHHHHHHHHHHHHHHHHCCCEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LQHELNLESSTVALAGGFFSLFILRPKDLKDTLSKVEWENILFFFALFLIAGALEETGII
HHHHCCCCCCHHEEECHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
NAFSNMLVNFAGGSLLLFSFSILTISSFFTGFLNNVPLVAAMIPVIEKLSISESSIFSNL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCC
DPIWYSLSLGACLGGNLTPIAASANVIALGLLTQFKGKTISFWEFSKYGLIILLGNIVIS
CCHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHCCCCEEEEEEECCCCHHEEHHHHHHH
GIYVNFIFF
HHHHHHEEC
>Mature Secondary Structure 
SIYALTSLIVFIIVVVGMVFQKIDRTLIAMLGAIFLLGTGIFPDQIGAIKEYVDYNTLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LLLGMMVFVETLRKTGIFTFLGLSMLRLFGNNTYTLFISLIFLVALFSGFIDNVTTVLVF
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPMTFAITDSLNINYLPFVLGEIFASNIGGMATIIGDPPNIMIASAAGYSFSEFALIMYP
HHHHHHEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHH
VTLINLVFAILLLIYFFKEDLSVKIDKEVIKNFDVSHIVENKKEFILSILLFGAVIVAFA
HHHHHHHHHHHHHHHHHHHCCCEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LQHELNLESSTVALAGGFFSLFILRPKDLKDTLSKVEWENILFFFALFLIAGALEETGII
HHHHCCCCCCHHEEECHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
NAFSNMLVNFAGGSLLLFSFSILTISSFFTGFLNNVPLVAAMIPVIEKLSISESSIFSNL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCC
DPIWYSLSLGACLGGNLTPIAASANVIALGLLTQFKGKTISFWEFSKYGLIILLGNIVIS
CCHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHCCCCEEEEEEECCCCHHEEHHHHHHH
GIYVNFIFF
HHHHHHEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]