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The map label for this gene is arsB [C]

Identifier: 160902989

GI number: 160902989

Start: 1678499

End: 1679788

Strand: Direct

Name: arsB [C]

Synonym: Pmob_1546

Alternate gene names: 160902989

Gene position: 1678499-1679788 (Clockwise)

Preceding gene: 160902988

Following gene: 160902990

Centisome position: 77.37

GC content: 32.4

Gene sequence:

>1290_bases
ATGTCACAAACTGAACTAATAACCCTTATAGTATTCGCTGTAGTATTGTTTTTTATCATCACTCACAAAATTAACAGAAC
CATTATTGCCATGCTTGGAGCTTCGGTGCTTATTATATTCGGAGTTTTTCCTGACGAAATTGAAGCTATAAGAAATTATA
TTGATTTCAACACCCTTCTTTTACTGCTCGGGATGATGTTATTTGTAAGCGTTATTCGTAGAACTGGCCTTTTTTCATAT
GTAGGTATTAAGACTTTGAAAATATTTGGACATAACGGATACATGTTGTTTATTTCCTTAACTTTTTTGGTTGCATTAAT
TTCAGGTTTCATTGATAATGTTACTACGATACTTGTTTTTATACCTATTACCTTTGCTATAACGGATTCTTTAAAAGTCA
ATTATTTCCCTTATGTTTTAGGTGAAATTTTTGCATCGAATATTGGAGGAATGGCAACCATCATTGGCGATCCACCCAAT
ATTATGATAGCTTCAGCTGCAGGATTTTCCTTTTCAGAATTTGCTTTAGTTATGTACCCAATTGCAATAATGAATCTCTT
GTTCATGGATATGCTTTTTATATTCATTTTTAAAAAAGATCTTCAAATCAAATTTGATAAAGAGAGTATAAAAAGTTTTG
ATACGTCCCATTTGATCGAAGATAAAAGAAGATTTTTCCTGTCCATAATTCTTTTTGTAAGTGTAATAATCGCTTTTTCT
ACTCAACACTTTTTAGGTTTGGAGAGTTCTACAATTGCAATAGTAGCAGGATTCTTCTCTTTACTACTATTAGCGCCAAA
TCAGGTGAGGGATACTTTGAATGAAGTTGAGTGGGAAAGTCTTTTATTCTTTTTTGGTTTATTTCTCATTACAGGGGCGA
TGGAAGAAACAGGACTGATAGCTAATTTATCCGATGTCATGGTAAAAGTTGCTGGAGATTCGGTAAAATCTTTCACTTTG
TTTATTTTACCTGTTGCTAGCTTAATTTCGGGATTCATTGATAATATTCCTTTTACAGCTACTATGATTCCCGTTGTTCA
ACATTTACAAGTGGTACAACCCGGTATTTTCAGTAATTTAGATCCAGTATGGTATTCTCTTGCGATGGGTGCATGTTTAG
GTGGAAATGCAACTTCCATCGGTGCATCCGCTAATATAATTGGACTCGCTATGTTAACCCAGTTTAAGAATAAAACTATC
TTGTTCAAAGATTTTGCTAAATACGGATTTTTACTTGTATTAGGAAATATAGTTATCTCAGAAATTTATTTATTATTATT
GTTTTTTTAG

Upstream 100 bases:

>100_bases
CCTTAGAAGGGTGGGAAGCGGGGCTAAGGGGGGTTATTTATAAAGTTCTTAAAGTTTCTAATGACAGTAAAAATATTAGA
TCAGGAGGAACCTTTAATTT

Downstream 100 bases:

>100_bases
AAACTTTTGGTGGATTATAGGGTGGGGAGCGGGGCAAGGGGCGCTAACAAAGACTAAACACGACTTACAAGAAAACTAAG
CAAACAATTAATCCAAAAAA

Product: citrate transporter

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSQTELITLIVFAVVLFFIITHKINRTIIAMLGASVLIIFGVFPDEIEAIRNYIDFNTLLLLLGMMLFVSVIRRTGLFSY
VGIKTLKIFGHNGYMLFISLTFLVALISGFIDNVTTILVFIPITFAITDSLKVNYFPYVLGEIFASNIGGMATIIGDPPN
IMIASAAGFSFSEFALVMYPIAIMNLLFMDMLFIFIFKKDLQIKFDKESIKSFDTSHLIEDKRRFFLSIILFVSVIIAFS
TQHFLGLESSTIAIVAGFFSLLLLAPNQVRDTLNEVEWESLLFFFGLFLITGAMEETGLIANLSDVMVKVAGDSVKSFTL
FILPVASLISGFIDNIPFTATMIPVVQHLQVVQPGIFSNLDPVWYSLAMGACLGGNATSIGASANIIGLAMLTQFKNKTI
LFKDFAKYGFLLVLGNIVISEIYLLLLFF

Sequences:

>Translated_429_residues
MSQTELITLIVFAVVLFFIITHKINRTIIAMLGASVLIIFGVFPDEIEAIRNYIDFNTLLLLLGMMLFVSVIRRTGLFSY
VGIKTLKIFGHNGYMLFISLTFLVALISGFIDNVTTILVFIPITFAITDSLKVNYFPYVLGEIFASNIGGMATIIGDPPN
IMIASAAGFSFSEFALVMYPIAIMNLLFMDMLFIFIFKKDLQIKFDKESIKSFDTSHLIEDKRRFFLSIILFVSVIIAFS
TQHFLGLESSTIAIVAGFFSLLLLAPNQVRDTLNEVEWESLLFFFGLFLITGAMEETGLIANLSDVMVKVAGDSVKSFTL
FILPVASLISGFIDNIPFTATMIPVVQHLQVVQPGIFSNLDPVWYSLAMGACLGGNATSIGASANIIGLAMLTQFKNKTI
LFKDFAKYGFLLVLGNIVISEIYLLLLFF
>Mature_428_residues
SQTELITLIVFAVVLFFIITHKINRTIIAMLGASVLIIFGVFPDEIEAIRNYIDFNTLLLLLGMMLFVSVIRRTGLFSYV
GIKTLKIFGHNGYMLFISLTFLVALISGFIDNVTTILVFIPITFAITDSLKVNYFPYVLGEIFASNIGGMATIIGDPPNI
MIASAAGFSFSEFALVMYPIAIMNLLFMDMLFIFIFKKDLQIKFDKESIKSFDTSHLIEDKRRFFLSIILFVSVIIAFST
QHFLGLESSTIAIVAGFFSLLLLAPNQVRDTLNEVEWESLLFFFGLFLITGAMEETGLIANLSDVMVKVAGDSVKSFTLF
ILPVASLISGFIDNIPFTATMIPVVQHLQVVQPGIFSNLDPVWYSLAMGACLGGNATSIGASANIIGLAMLTQFKNKTIL
FKDFAKYGFLLVLGNIVISEIYLLLLFF

Specific function: Involved In Arsenical Resistance. Thought To Form The Channel Of An Arsenite Pump (By Similarity). [C]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI157266326, Length=219, Percent_Identity=30.1369863013699, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI87082277, Length=392, Percent_Identity=22.7040816326531, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1787039, Length=374, Percent_Identity=23.7967914438503, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550608, Length=480, Percent_Identity=28.75, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221472711, Length=495, Percent_Identity=26.0606060606061, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24656008, Length=471, Percent_Identity=25.4777070063694, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24581759, Length=201, Percent_Identity=34.3283582089552, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19920704, Length=201, Percent_Identity=34.3283582089552, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574683, Length=201, Percent_Identity=34.3283582089552, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574681, Length=201, Percent_Identity=34.3283582089552, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574685, Length=201, Percent_Identity=34.3283582089552, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574678, Length=201, Percent_Identity=34.3283582089552, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI85724998, Length=485, Percent_Identity=26.3917525773196, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI62484377, Length=485, Percent_Identity=26.3917525773196, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581764, Length=160, Percent_Identity=30, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802
- InterPro:   IPR004680 [H]

Pfam domain/function: PF03600 CitMHS [H]

EC number: NA

Molecular weight: Translated: 47562; Mature: 47430

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTELITLIVFAVVLFFIITHKINRTIIAMLGASVLIIFGVFPDEIEAIRNYIDFNTLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LLLGMMLFVSVIRRTGLFSYVGIKTLKIFGHNGYMLFISLTFLVALISGFIDNVTTILVF
HHHHHHHHHHHHHHCCCHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IPITFAITDSLKVNYFPYVLGEIFASNIGGMATIIGDPPNIMIASAAGFSFSEFALVMYP
HHHHHHEECCCEECHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHH
IAIMNLLFMDMLFIFIFKKDLQIKFDKESIKSFDTSHLIEDKRRFFLSIILFVSVIIAFS
HHHHHHHHHHHHHHHHHHHCCEEEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TQHFLGLESSTIAIVAGFFSLLLLAPNQVRDTLNEVEWESLLFFFGLFLITGAMEETGLI
HHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
ANLSDVMVKVAGDSVKSFTLFILPVASLISGFIDNIPFTATMIPVVQHLQVVQPGIFSNL
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
DPVWYSLAMGACLGGNATSIGASANIIGLAMLTQFKNKTILFKDFAKYGFLLVLGNIVIS
CHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHH
EIYLLLLFF
HHHHHHHCC
>Mature Secondary Structure 
SQTELITLIVFAVVLFFIITHKINRTIIAMLGASVLIIFGVFPDEIEAIRNYIDFNTLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LLLGMMLFVSVIRRTGLFSYVGIKTLKIFGHNGYMLFISLTFLVALISGFIDNVTTILVF
HHHHHHHHHHHHHHCCCHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IPITFAITDSLKVNYFPYVLGEIFASNIGGMATIIGDPPNIMIASAAGFSFSEFALVMYP
HHHHHHEECCCEECHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHH
IAIMNLLFMDMLFIFIFKKDLQIKFDKESIKSFDTSHLIEDKRRFFLSIILFVSVIIAFS
HHHHHHHHHHHHHHHHHHHCCEEEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TQHFLGLESSTIAIVAGFFSLLLLAPNQVRDTLNEVEWESLLFFFGLFLITGAMEETGLI
HHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
ANLSDVMVKVAGDSVKSFTLFILPVASLISGFIDNIPFTATMIPVVQHLQVVQPGIFSNL
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
DPVWYSLAMGACLGGNATSIGASANIIGLAMLTQFKNKTILFKDFAKYGFLLVLGNIVIS
CHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHH
EIYLLLLFF
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]