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The map label for this gene is msrA [H]

Identifier: 160901977

GI number: 160901977

Start: 544981

End: 545502

Strand: Direct

Name: msrA [H]

Synonym: Pmob_0501

Alternate gene names: 160901977

Gene position: 544981-545502 (Clockwise)

Preceding gene: 160901976

Following gene: 160901996

Centisome position: 25.12

GC content: 34.87

Gene sequence:

>522_bases
ATGAGCGAAATACCAACAGATAAAGCGATCTTTGCAGCAGGTTGTTTTTGGGGAGTAGAATACATGTTTAAAAAAGTCGC
AGGTGTCCTCGACGTAGTCAGTGGTTATACAGGTGGTTTTGTTGAAAATCCATCTTATGAACAGGTTTGTAGTGGAAAAA
CAGGTCATGCAGAATCTGTTTTAATTGTCTTCGATCCAAACATAGTAAGCTACGAATCGTTAGTTAGATATTTTTTTGAA
ATTCATGACTTTAGTCAAGAAAACGGTCAGGGGCCCGATATTGGAGAGCAATATAGAAGCGAAATATTTTACATAAATGA
GGAACAAAAAGCAATCGCAGAAAAAGTAAAAGACGAGTTAATCCATAGAGGTTTGAAAGTCGCTACCAAGATAACTAAAG
CTTCAGAATTTTACAAAGCAGAGGATTATCACCAAAATTATTATGAAAAAACAGGAAAAGCCCCTTATTGCCACTTTAGA
AGAAGAGTTTTTAAAAATGATTATATCAAATTCTTAGTGTAG

Upstream 100 bases:

>100_bases
AGAAAGGTCAAAATAAGCAGCGACAATTATCGTGTGATTTTTGAAGCTCTTTTAGCGATAACTTATATATGTGGAGCATA
GAAAATAAGAGGTGATTAAA

Downstream 100 bases:

>100_bases
AATAAGGGGAATAATCTCAAAATTTAATTGTTTTAATCGTTATTAAAAAAGGCTTCTACTAGTAGACAGAATTCTTCAAA
TTTTTCAAAAAACAGCGCAT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSEIPTDKAIFAAGCFWGVEYMFKKVAGVLDVVSGYTGGFVENPSYEQVCSGKTGHAESVLIVFDPNIVSYESLVRYFFE
IHDFSQENGQGPDIGEQYRSEIFYINEEQKAIAEKVKDELIHRGLKVATKITKASEFYKAEDYHQNYYEKTGKAPYCHFR
RRVFKNDYIKFLV

Sequences:

>Translated_173_residues
MSEIPTDKAIFAAGCFWGVEYMFKKVAGVLDVVSGYTGGFVENPSYEQVCSGKTGHAESVLIVFDPNIVSYESLVRYFFE
IHDFSQENGQGPDIGEQYRSEIFYINEEQKAIAEKVKDELIHRGLKVATKITKASEFYKAEDYHQNYYEKTGKAPYCHFR
RRVFKNDYIKFLV
>Mature_172_residues
SEIPTDKAIFAAGCFWGVEYMFKKVAGVLDVVSGYTGGFVENPSYEQVCSGKTGHAESVLIVFDPNIVSYESLVRYFFEI
HDFSQENGQGPDIGEQYRSEIFYINEEQKAIAEKVKDELIHRGLKVATKITKASEFYKAEDYHQNYYEKTGKAPYCHFRR
RVFKNDYIKFLV

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=42.0382165605096, Blast_Score=121, Evalue=3e-28,
Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=42.0382165605096, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=40.9090909090909, Blast_Score=74, Evalue=7e-14,
Organism=Escherichia coli, GI1790665, Length=158, Percent_Identity=46.2025316455696, Blast_Score=146, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=33.8028169014084, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=169, Percent_Identity=37.2781065088757, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=32.7272727272727, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=32.1212121212121, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=36.0294117647059, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19936; Mature: 19804

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIPTDKAIFAAGCFWGVEYMFKKVAGVLDVVSGYTGGFVENPSYEQVCSGKTGHAESV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCEE
LIVFDPNIVSYESLVRYFFEIHDFSQENGQGPDIGEQYRSEIFYINEEQKAIAEKVKDEL
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEECCHHHHHHHHHHHHH
IHRGLKVATKITKASEFYKAEDYHQNYYEKTGKAPYCHFRRRVFKNDYIKFLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEIPTDKAIFAAGCFWGVEYMFKKVAGVLDVVSGYTGGFVENPSYEQVCSGKTGHAESV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCEE
LIVFDPNIVSYESLVRYFFEIHDFSQENGQGPDIGEQYRSEIFYINEEQKAIAEKVKDEL
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEECCHHHHHHHHHHHHH
IHRGLKVATKITKASEFYKAEDYHQNYYEKTGKAPYCHFRRRVFKNDYIKFLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]