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The map label for this gene is tdh [H]

Identifier: 160877582

GI number: 160877582

Start: 5293375

End: 5294400

Strand: Direct

Name: tdh [H]

Synonym: Sbal195_4481

Alternate gene names: 160877582

Gene position: 5293375-5294400 (Clockwise)

Preceding gene: 160877581

Following gene: 160877583

Centisome position: 98.99

GC content: 49.03

Gene sequence:

>1026_bases
ATGAAAGCACTAAGCAAGTTAAAAGCCGAAAAAGGTATTTGGTTAGTCGATGCGCCTAAGCCAGTAATGGGCCACAACGA
TCTGCTGATCAAAATTAAAAAAACGGCGATTTGTGGCACCGACATGCACATCTACAACTGGGACGAGTGGTCACAAAAAA
CCATTCCCGTTCCTATGGTTGTTGGCCATGAATATGTAGGCGAAGTGGTTGATATCGGCCAAGAAGTGCGTGGTTTTAAG
ATTGGCGACCGCGTATCTGGCGAAGGTCATATTACCTGCGGCCACTGCCGTAACTGTCGCGCTGGCCGCACCCATTTATG
CCGCAACACCTCTGGTGTCGGTGTGAACCGTGAAGGTTCATTCGCGGAATACTTAGTGATTCCCGCCTTTAACGCCTTTA
AAATCCCTGATGACATCAGCGATGATTTAGCGTCAATCTTCGACCCGTTTGGTAACGCTGTGCACACAGCATTATCCTTC
GATTTAGTCGGTGAAGACGTCTTGATCACAGGCGCAGGTCCCATCGGCATAATGGCTGCGGCAGTATGTCGTCACGTAGG
TGCGCGCCATGTAGTGATCACAGACGTTAACGAATACCGCTTAGAGCTGGCCCGTAAAATGGGTGCCACTCGCGCAGTCA
ATGTGTCTAAGGAAAGCCTGAAAGACGTGATGAAAGAACTGGGCATGACCGAAGGTTTCGACGTCGGTTTGGAAATGTCT
GGCGTACCATCAGCCTTCCACGCCATGTTAGATACCATGAACCACGGCGGCAAAGTCGCTATGCTGGGTATTCCTGGTGG
CGAAATGGCGATTGATTGGAGCAAAGTGATCTTCAAAGGTTTGGTCATTAAAGGCATCTACGGCCGCGAAATGTTCGAAA
CTTGGTACAAGATGGCGAGCCTTATCCAATCTGGCTTAGATATTTCGCCTATCATCACTCACCACTTCAAGATTGATGAT
TTCCAACAAGGTTTCGACGCTATGGGCTCGGGCCAATCAGGTAAAGTAATCCTCAGCTGGGATTAA

Upstream 100 bases:

>100_bases
CGCAAATGTCAGCGGCACATACCCGTGAGCAACTCGACAAAGCGATCACCGCCTTTACACGTATTGCCAAAGAAATGGGC
ATTATTTAGGACTCAAGACA

Downstream 100 bases:

>100_bases
TCCTGCAGAGCATTACTTAGATAGGGGCTGTACACTCGCAGCCCCTTGTTGCACACTTATCCCATCTTGATTTCCATCTC
TTAGCTTTGTCAGGTTTTAT

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKALSKLKAEKGIWLVDAPKPVMGHNDLLIKIKKTAICGTDMHIYNWDEWSQKTIPVPMVVGHEYVGEVVDIGQEVRGFK
IGDRVSGEGHITCGHCRNCRAGRTHLCRNTSGVGVNREGSFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSF
DLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELARKMGATRAVNVSKESLKDVMKELGMTEGFDVGLEMS
GVPSAFHAMLDTMNHGGKVAMLGIPGGEMAIDWSKVIFKGLVIKGIYGREMFETWYKMASLIQSGLDISPIITHHFKIDD
FQQGFDAMGSGQSGKVILSWD

Sequences:

>Translated_341_residues
MKALSKLKAEKGIWLVDAPKPVMGHNDLLIKIKKTAICGTDMHIYNWDEWSQKTIPVPMVVGHEYVGEVVDIGQEVRGFK
IGDRVSGEGHITCGHCRNCRAGRTHLCRNTSGVGVNREGSFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSF
DLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELARKMGATRAVNVSKESLKDVMKELGMTEGFDVGLEMS
GVPSAFHAMLDTMNHGGKVAMLGIPGGEMAIDWSKVIFKGLVIKGIYGREMFETWYKMASLIQSGLDISPIITHHFKIDD
FQQGFDAMGSGQSGKVILSWD
>Mature_341_residues
MKALSKLKAEKGIWLVDAPKPVMGHNDLLIKIKKTAICGTDMHIYNWDEWSQKTIPVPMVVGHEYVGEVVDIGQEVRGFK
IGDRVSGEGHITCGHCRNCRAGRTHLCRNTSGVGVNREGSFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSF
DLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELARKMGATRAVNVSKESLKDVMKELGMTEGFDVGLEMS
GVPSAFHAMLDTMNHGGKVAMLGIPGGEMAIDWSKVIFKGLVIKGIYGREMFETWYKMASLIQSGLDISPIITHHFKIDD
FQQGFDAMGSGQSGKVILSWD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=335, Percent_Identity=26.865671641791, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4501929, Length=351, Percent_Identity=24.5014245014245, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI34577061, Length=352, Percent_Identity=24.4318181818182, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI71743840, Length=351, Percent_Identity=25.9259259259259, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262073058, Length=351, Percent_Identity=25.9259259259259, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156523966, Length=350, Percent_Identity=25.4285714285714, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4501933, Length=358, Percent_Identity=23.463687150838, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501939, Length=344, Percent_Identity=25.2906976744186, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI71565152, Length=359, Percent_Identity=23.6768802228412, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI71565154, Length=353, Percent_Identity=26.0623229461756, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=86.8035190615836, Blast_Score=622, Evalue=1e-180,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=30.1104972375691, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788073, Length=326, Percent_Identity=29.7546012269939, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1787863, Length=319, Percent_Identity=30.4075235109718, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI226510992, Length=312, Percent_Identity=30.1282051282051, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082125, Length=336, Percent_Identity=30.0595238095238, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790718, Length=323, Percent_Identity=26.0061919504644, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=26.2390670553936, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87081918, Length=269, Percent_Identity=30.4832713754647, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1786825, Length=384, Percent_Identity=27.0833333333333, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786552, Length=359, Percent_Identity=26.4623955431755, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=30.4477611940298, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17562878, Length=335, Percent_Identity=31.044776119403, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17562584, Length=126, Percent_Identity=36.5079365079365, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=231, Percent_Identity=31.6017316017316, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=25.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=271, Percent_Identity=26.5682656826568, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=373, Percent_Identity=24.9329758713137, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=379, Percent_Identity=24.5382585751979, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=306, Percent_Identity=29.4117647058824, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323099, Length=318, Percent_Identity=30.8176100628931, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319955, Length=306, Percent_Identity=29.0849673202614, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319258, Length=363, Percent_Identity=25.8953168044077, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6319257, Length=276, Percent_Identity=28.2608695652174, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=27.1739130434783, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=304, Percent_Identity=30.5921052631579, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=325, Percent_Identity=29.8461538461538, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=28.4403669724771, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=256, Percent_Identity=28.90625, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=267, Percent_Identity=27.7153558052434, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=258, Percent_Identity=29.8449612403101, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737897, Length=330, Percent_Identity=26.3636363636364, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17137530, Length=330, Percent_Identity=25.4545454545455, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=25.9946949602122, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI221457811, Length=209, Percent_Identity=25.8373205741627, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550770, Length=209, Percent_Identity=25.8373205741627, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45551930, Length=209, Percent_Identity=25.8373205741627, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37179; Mature: 37179

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALSKLKAEKGIWLVDAPKPVMGHNDLLIKIKKTAICGTDMHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEEEECCCCEEEECCCCCCCCCCCEEE
VGHEYVGEVVDIGQEVRGFKIGDRVSGEGHITCGHCRNCRAGRTHLCRNTSGVGVNREGS
ECHHHHHHHHHHHHHHCCEECCCCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCCCCCC
FAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAA
CEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHHHHHH
AVCRHVGARHVVITDVNEYRLELARKMGATRAVNVSKESLKDVMKELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCCCCCCCEECC
GVPSAFHAMLDTMNHGGKVAMLGIPGGEMAIDWSKVIFKGLVIKGIYGREMFETWYKMAS
CCCHHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LIQSGLDISPIITHHFKIDDFQQGFDAMGSGQSGKVILSWD
HHHCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MKALSKLKAEKGIWLVDAPKPVMGHNDLLIKIKKTAICGTDMHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEEEECCCCEEEECCCCCCCCCCCEEE
VGHEYVGEVVDIGQEVRGFKIGDRVSGEGHITCGHCRNCRAGRTHLCRNTSGVGVNREGS
ECHHHHHHHHHHHHHHCCEECCCCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCCCCCC
FAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAA
CEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHHHHHH
AVCRHVGARHVVITDVNEYRLELARKMGATRAVNVSKESLKDVMKELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCCCCCCCEECC
GVPSAFHAMLDTMNHGGKVAMLGIPGGEMAIDWSKVIFKGLVIKGIYGREMFETWYKMAS
CCCHHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LIQSGLDISPIITHHFKIDDFQQGFDAMGSGQSGKVILSWD
HHHCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA