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The map label for this gene is kbl [C]

Identifier: 160877581

GI number: 160877581

Start: 5292170

End: 5293363

Strand: Direct

Name: kbl [C]

Synonym: Sbal195_4480

Alternate gene names: 160877581

Gene position: 5292170-5293363 (Clockwise)

Preceding gene: 160877580

Following gene: 160877582

Centisome position: 98.97

GC content: 48.91

Gene sequence:

>1194_bases
GTGGCCTCTACCTCATTCTACGCACAGATTAATCAACAGCTTGCAGACATCAAAGCCGAAGGCTTATATAAAAGCGAGCG
TGTTATTGCCTCACCGCAACAGACTGCCATTCAAGTTAATCAGCAAGAAGTTGTTAACTTTTGCGCGAATAATTACTTAG
GCTTAGCGAATCACCCTGAGCTAATCAAAGCCGCCCAACAGGGCTTAGACAGCCACGGCTTTGGTATGGCGTCGGTGCGC
TTTATTTGCGGCACCCAAGATATCCATAAAAAGCTAGAAGCTAGCCTGAGCGAATTCCTCGGCACTGAAGATACCATTCT
TTATTCTTCATGTTTTGATGCTAACGCCGGTTTATTCGAAACCTTGTTAGATGCAGAAGACGCGATTATTTCCGATGCGC
TAAACCATGCTTCTATCATCGACGGTGTACGTTTATGTAAAGCCAAGCGTTTCCGCTATGCCAACAACGACATGGCCGAT
TTAGAAACTCAGTTGATCGCCGCGAAAGAAGCAGGCGCCCGTAATATCTTGATCGCCACCGACGGTGTATTTTCGATGGA
CGGCGTGATTGCTAATCTGCAAGGCATATGTGATTTAGCCGATAAATACGGCGCACTGGTGATGGTCGATGACTCTCACG
CGGTAGGCTTTATCGGCGCAAACGGCCGTGGCACCCACGAATATTGCAATGTGATGGACAGAGTCGACATCATCACAGGC
ACCTTAGGCAAAGCCTTAGGCGGCGCATCGGGCGGTTTCACTTCGGGTAAAAAAGAAGTCATCGACTGGTTACGCCAGCG
TTCACGTCCTTACCTGTTCTCTAACTCATTAGCGCCGTCAATCGTGACTGCATCTATCCATGTGTTAGAAATGCTCAAAT
CAGGCCAAGCCCTGCGCGAAGCCGTATGGGAAAACAGCCGTTATTTCCGTGAGCAAATGTCAGCAGCAGGCTTTACTTTG
GGCGGCGCCGACCACGCGATTATCCCTGTGATGATTGGCGATGCGAAACTGGCGGGCGACTTTGCTAACCGCTTATTAGC
AGAACATATTTATGTTATTGGCTTCTCGTTCCCTGTGGTTCCTAAGGGACAAGCCCGTATCCGTACGCAAATGTCAGCGG
CACATACCCGTGAGCAACTCGACAAAGCGATCACCGCCTTTACACGTATTGCCAAAGAAATGGGCATTATTTAG

Upstream 100 bases:

>100_bases
TTGCGAACCTGCATGAAAAAAAGGCTGTAGGCCGATTAGGTTTAGAGTTAGAATGCCGCCACTCCCAAAATCAGAATAAA
GTTAACTAAGGAGATATCAG

Downstream 100 bases:

>100_bases
GACTCAAGACAATGAAAGCACTAAGCAAGTTAAAAGCCGAAAAAGGTATTTGGTTAGTCGATGCGCCTAAGCCAGTAATG
GGCCACAACGATCTGCTGAT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MASTSFYAQINQQLADIKAEGLYKSERVIASPQQTAIQVNQQEVVNFCANNYLGLANHPELIKAAQQGLDSHGFGMASVR
FICGTQDIHKKLEASLSEFLGTEDTILYSSCFDANAGLFETLLDAEDAIISDALNHASIIDGVRLCKAKRFRYANNDMAD
LETQLIAAKEAGARNILIATDGVFSMDGVIANLQGICDLADKYGALVMVDDSHAVGFIGANGRGTHEYCNVMDRVDIITG
TLGKALGGASGGFTSGKKEVIDWLRQRSRPYLFSNSLAPSIVTASIHVLEMLKSGQALREAVWENSRYFREQMSAAGFTL
GGADHAIIPVMIGDAKLAGDFANRLLAEHIYVIGFSFPVVPKGQARIRTQMSAAHTREQLDKAITAFTRIAKEMGII

Sequences:

>Translated_397_residues
MASTSFYAQINQQLADIKAEGLYKSERVIASPQQTAIQVNQQEVVNFCANNYLGLANHPELIKAAQQGLDSHGFGMASVR
FICGTQDIHKKLEASLSEFLGTEDTILYSSCFDANAGLFETLLDAEDAIISDALNHASIIDGVRLCKAKRFRYANNDMAD
LETQLIAAKEAGARNILIATDGVFSMDGVIANLQGICDLADKYGALVMVDDSHAVGFIGANGRGTHEYCNVMDRVDIITG
TLGKALGGASGGFTSGKKEVIDWLRQRSRPYLFSNSLAPSIVTASIHVLEMLKSGQALREAVWENSRYFREQMSAAGFTL
GGADHAIIPVMIGDAKLAGDFANRLLAEHIYVIGFSFPVVPKGQARIRTQMSAAHTREQLDKAITAFTRIAKEMGII
>Mature_396_residues
ASTSFYAQINQQLADIKAEGLYKSERVIASPQQTAIQVNQQEVVNFCANNYLGLANHPELIKAAQQGLDSHGFGMASVRF
ICGTQDIHKKLEASLSEFLGTEDTILYSSCFDANAGLFETLLDAEDAIISDALNHASIIDGVRLCKAKRFRYANNDMADL
ETQLIAAKEAGARNILIATDGVFSMDGVIANLQGICDLADKYGALVMVDDSHAVGFIGANGRGTHEYCNVMDRVDIITGT
LGKALGGASGGFTSGKKEVIDWLRQRSRPYLFSNSLAPSIVTASIHVLEMLKSGQALREAVWENSRYFREQMSAAGFTLG
GADHAIIPVMIGDAKLAGDFANRLLAEHIYVIGFSFPVVPKGQARIRTQMSAAHTREQLDKAITAFTRIAKEMGII

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=390, Percent_Identity=54.6153846153846, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI284448556, Length=416, Percent_Identity=51.2019230769231, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI83977442, Length=361, Percent_Identity=34.9030470914127, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI83977440, Length=361, Percent_Identity=34.9030470914127, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI83977444, Length=361, Percent_Identity=34.9030470914127, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4502025, Length=363, Percent_Identity=32.7823691460055, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI40316939, Length=363, Percent_Identity=32.7823691460055, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4758668, Length=357, Percent_Identity=36.1344537815126, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=33.5135135135135, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI5454084, Length=261, Percent_Identity=30.6513409961686, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1790046, Length=393, Percent_Identity=74.5547073791349, Blast_Score=618, Evalue=1e-178,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=33.1412103746398, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=55.25, Blast_Score=446, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI32566772, Length=373, Percent_Identity=31.9034852546917, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=34.2541436464088, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=34.2541436464088, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71982617, Length=303, Percent_Identity=25.4125412541254, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=303, Percent_Identity=25.4125412541254, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=382, Percent_Identity=33.2460732984293, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=30.7065217391304, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6323954, Length=291, Percent_Identity=29.8969072164948, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24662918, Length=390, Percent_Identity=58.2051282051282, Blast_Score=475, Evalue=1e-134,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=32.3943661971831, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17136286, Length=376, Percent_Identity=33.2446808510638, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24653280, Length=307, Percent_Identity=28.3387622149837, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653276, Length=307, Percent_Identity=28.3387622149837, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653278, Length=307, Percent_Identity=28.3387622149837, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42962; Mature: 42831

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTSFYAQINQQLADIKAEGLYKSERVIASPQQTAIQVNQQEVVNFCANNYLGLANHPE
CCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHCCCHHHHHHHHHHCCCCCCCCHH
LIKAAQQGLDSHGFGMASVRFICGTQDIHKKLEASLSEFLGTEDTILYSSCFDANAGLFE
HHHHHHHCCCCCCCCHHHHEEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHH
TLLDAEDAIISDALNHASIIDGVRLCKAKRFRYANNDMADLETQLIAAKEAGARNILIAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEE
DGVFSMDGVIANLQGICDLADKYGALVMVDDSHAVGFIGANGRGTHEYCNVMDRVDIITG
CCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHH
TLGKALGGASGGFTSGKKEVIDWLRQRSRPYLFSNSLAPSIVTASIHVLEMLKSGQALRE
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHH
AVWENSRYFREQMSAAGFTLGGADHAIIPVMIGDAKLAGDFANRLLAEHIYVIGFSFPVV
HHHCCHHHHHHHHHHCCCEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHEEEEEECCCC
PKGQARIRTQMSAAHTREQLDKAITAFTRIAKEMGII
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASTSFYAQINQQLADIKAEGLYKSERVIASPQQTAIQVNQQEVVNFCANNYLGLANHPE
CCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHCCCHHHHHHHHHHCCCCCCCCHH
LIKAAQQGLDSHGFGMASVRFICGTQDIHKKLEASLSEFLGTEDTILYSSCFDANAGLFE
HHHHHHHCCCCCCCCHHHHEEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHH
TLLDAEDAIISDALNHASIIDGVRLCKAKRFRYANNDMADLETQLIAAKEAGARNILIAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEE
DGVFSMDGVIANLQGICDLADKYGALVMVDDSHAVGFIGANGRGTHEYCNVMDRVDIITG
CCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHH
TLGKALGGASGGFTSGKKEVIDWLRQRSRPYLFSNSLAPSIVTASIHVLEMLKSGQALRE
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHH
AVWENSRYFREQMSAAGFTLGGADHAIIPVMIGDAKLAGDFANRLLAEHIYVIGFSFPVV
HHHCCHHHHHHHHHHCCCEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHEEEEEECCCC
PKGQARIRTQMSAAHTREQLDKAITAFTRIAKEMGII
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]