Click here to switch to the map view.

The map label for this gene is fkpA [H]

Identifier: 160876341

GI number: 160876341

Start: 3803285

End: 3803755

Strand: Direct

Name: fkpA [H]

Synonym: Sbal195_3235

Alternate gene names: 160876341

Gene position: 3803285-3803755 (Clockwise)

Preceding gene: 160876339

Following gene: 160876344

Centisome position: 71.13

GC content: 45.44

Gene sequence:

>471_bases
ATGAAAATGTTACTTGCCGTTGCTGTGATTGCTGGGGTGATTTTTTACTTCTTTACCTCGATGAACGGCCAAAAAGCCGC
CCAAGAGAATATCCGTTTAGGCAATGAATTTTTAACGCAAAACAAAACCAAAGAAGGTGTCATCACCACAGCTTCGGGTT
TGCAATATCAAGTGTTAACTAAGGGCGATGGCACTGTTCATCCTAAAGCCAGCGATACAGTGACAGTGCATTACCATGGC
ACTTTGATCGACGGTACTGTGTTTGATAGTTCAGTTGATCGCGGTGAGCCTATCGCATTTCCGCTTAATCGGGTGATTAA
AGGCTGGACCGAGGGCGTACAACTTATGGTCGTTGGCGATAAAGTGCGTTTCTTTATCCCGAGTGTACTCGCCTACGGCA
ACAGCAGCACGGGCAAGATTGGCGGTGGTTCAGTGCTCATTTTTGATGTAGAACTGCTTAAGATTGATTAA

Upstream 100 bases:

>100_bases
GGTAGCACCAGATAGCAAGCCCAAAACACGGGCGAGTGCCGATAGCACCTCAAGCTAAAAAACTGATAATATGGCGAAAA
TTAACTAAGGTGCTCTTTAT

Downstream 100 bases:

>100_bases
ATCTGTCTTCAATGAGCCTAATAACGTAATAAAAAGCCCTGCATTATCGCAGGGCTTTTTGTCTCTATAACTCAAATAAT
ATTAGTATGTTGGATGATTA

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MKMLLAVAVIAGVIFYFFTSMNGQKAAQENIRLGNEFLTQNKTKEGVITTASGLQYQVLTKGDGTVHPKASDTVTVHYHG
TLIDGTVFDSSVDRGEPIAFPLNRVIKGWTEGVQLMVVGDKVRFFIPSVLAYGNSSTGKIGGGSVLIFDVELLKID

Sequences:

>Translated_156_residues
MKMLLAVAVIAGVIFYFFTSMNGQKAAQENIRLGNEFLTQNKTKEGVITTASGLQYQVLTKGDGTVHPKASDTVTVHYHG
TLIDGTVFDSSVDRGEPIAFPLNRVIKGWTEGVQLMVVGDKVRFFIPSVLAYGNSSTGKIGGGSVLIFDVELLKID
>Mature_156_residues
MKMLLAVAVIAGVIFYFFTSMNGQKAAQENIRLGNEFLTQNKTKEGVITTASGLQYQVLTKGDGTVHPKASDTVTVHYHG
TLIDGTVFDSSVDRGEPIAFPLNRVIKGWTEGVQLMVVGDKVRFFIPSVLAYGNSSTGKIGGGSVLIFDVELLKID

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=44.8598130841121, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=44.8598130841121, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI206725530, Length=94, Percent_Identity=44.6808510638298, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI17149844, Length=94, Percent_Identity=44.6808510638298, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI17149842, Length=94, Percent_Identity=44.6808510638298, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI4503727, Length=139, Percent_Identity=34.5323741007194, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=39.2523364485981, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI8923659, Length=92, Percent_Identity=42.3913043478261, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI4503729, Length=117, Percent_Identity=37.6068376068376, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI224809329, Length=95, Percent_Identity=42.1052631578947, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI224809327, Length=95, Percent_Identity=42.1052631578947, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4758384, Length=95, Percent_Identity=42.1052631578947, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI224809331, Length=95, Percent_Identity=42.1052631578947, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI33469985, Length=87, Percent_Identity=37.9310344827586, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI192448443, Length=87, Percent_Identity=41.3793103448276, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI87082390, Length=123, Percent_Identity=53.6585365853659, Blast_Score=126, Evalue=6e-31,
Organism=Escherichia coli, GI1789745, Length=132, Percent_Identity=46.969696969697, Blast_Score=111, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=49, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540882, Length=107, Percent_Identity=45.7943925233645, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=42.0560747663551, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=48.5148514851485, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320727, Length=97, Percent_Identity=50.5154639175258, Blast_Score=84, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323566, Length=118, Percent_Identity=38.9830508474576, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=45.7943925233645, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=47.2527472527472, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=47.2527472527472, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356629, Length=98, Percent_Identity=43.8775510204082, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=39.4230769230769, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16827; Mature: 16827

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMLLAVAVIAGVIFYFFTSMNGQKAAQENIRLGNEFLTQNKTKEGVITTASGLQYQVLT
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHCCCCCCCEEEECCCCEEEEEE
KGDGTVHPKASDTVTVHYHGTLIDGTVFDSSVDRGEPIAFPLNRVIKGWTEGVQLMVVGD
CCCCEECCCCCCEEEEEEECEEEECEEECCCCCCCCCCEECHHHHHHHHCCCEEEEEECC
KVRFFIPSVLAYGNSSTGKIGGGSVLIFDVELLKID
CHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEEC
>Mature Secondary Structure
MKMLLAVAVIAGVIFYFFTSMNGQKAAQENIRLGNEFLTQNKTKEGVITTASGLQYQVLT
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHCCCCCCCEEEECCCCEEEEEE
KGDGTVHPKASDTVTVHYHGTLIDGTVFDSSVDRGEPIAFPLNRVIKGWTEGVQLMVVGD
CCCCEECCCCCCEEEEEEECEEEECEEECCCCCCCCCCEECHHHHHHHHCCCEEEEEECC
KVRFFIPSVLAYGNSSTGKIGGGSVLIFDVELLKID
CHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]