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The map label for this gene is neuC [H]

Identifier: 160876228

GI number: 160876228

Start: 3684999

End: 3686168

Strand: Direct

Name: neuC [H]

Synonym: Sbal195_3122

Alternate gene names: 160876228

Gene position: 3684999-3686168 (Clockwise)

Preceding gene: 160876227

Following gene: 160876229

Centisome position: 68.91

GC content: 42.22

Gene sequence:

>1170_bases
ATGAGTCGTAAAATATGTGTCGTGTCAGCGACTAGAGCCGAATATGGACTGTTAAAACCCCTGCTAACGGCTATACACTA
TGATGTTGATTTGATATTGCAACTTGTTGTTACAGGGACACATCTTTCACCTGAATTTGGGTATACCCTCAAAGAAATCC
AAAAAGATCCCTATCCAATTGCAAAAAAAATTGAAATTTTACTCTCATCCGACTCAGCCGTTGGCGTTAGCAAAAGCATG
GGATTGGCCCAAATATCCTTTGCAGAAGCCTTCGATGACCTACGTCCAGACCTCGTCCTAGTGTTAGGGGACAGGTATGA
ATTATTACCAATTGTATTAGCTGCGAATATTGCACACATCCCCGTAGCACACCTTAGTGGTGGCGAGCTAACAGAAGGCG
TTATGGACGAATTGTTTCGCCATGCCATAACGAAATTGGCTCACCTGCACTTTGCCGCCATAGAAGACTACCGCCAAAGG
ATCATTCAGATGGGGGAGCATCCCAGCAGAGTGTTCACAGTTGGAGAAGCTGGCTTAGATAATATTCGCGAAATGACCTT
GATGAATAAAGCGGAAATTGAAGAGAGCTTGCAATGCCCGTTAAAGTCCAAAAACTTAATCATCACCTATCATCCCGATA
GTCACGATAATCTAGAGGCCATTAAACAATCATTCCGTACGATACTGGCAGCACTTGATACGCTTGAGGATACACTACTC
ATCTTTACGAAAGCCAATAGTGATATTGGTGGCCGGCTCATCAATGAGCTTATTGATGAGTATGTTTCGTTAAATCCACG
CAAATCTCTTGGATTTACCTCTCTGGGGCAAAGAAGATATCTGTCTTTACTTCAATATGTCGATGCTGTGGTCGGTAACT
CATCCAGTGGTATTGTCGAAACACCGTCATTTAAGTTACCGAGCATCAATATTGGTCCTCGACAGCAAGGTCGGATCCGT
GCGAACAGTACTATCGATGTGGAATGTGAAACACAAGCGTTAACCACTGCTCTTTCTACAATTTACAATGAGGCATTTTT
AGCAACGATCAAACAGACTCAAAATCCTTACGATCAAGGTGGAAGTTCTCTCAAGATTAAAGAGATAATCAAGCAGTTTG
ATCTCAGTAATCTAGAAATGAAACGCTTTTATGACTTACCCAAACATTAA

Upstream 100 bases:

>100_bases
TAACTATTATGCGTCCAGGCACAGGGTTACCTCCGAGTCGCTGGAATGAAGTGATTGGTTCAGCAGCTAAAGTTGATTAT
GCGGAGGGGGATCTTATCCA

Downstream 100 bases:

>100_bases
ACCCATCGGTGGAGAGGCTGAATATGAGGCGACTCACTTTGAGGCGATCACCCAAACAGGGCGTTCATCGCTACGATTGA
TCATTGAAAGTGCCAAGTTA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSRKICVVSATRAEYGLLKPLLTAIHYDVDLILQLVVTGTHLSPEFGYTLKEIQKDPYPIAKKIEILLSSDSAVGVSKSM
GLAQISFAEAFDDLRPDLVLVLGDRYELLPIVLAANIAHIPVAHLSGGELTEGVMDELFRHAITKLAHLHFAAIEDYRQR
IIQMGEHPSRVFTVGEAGLDNIREMTLMNKAEIEESLQCPLKSKNLIITYHPDSHDNLEAIKQSFRTILAALDTLEDTLL
IFTKANSDIGGRLINELIDEYVSLNPRKSLGFTSLGQRRYLSLLQYVDAVVGNSSSGIVETPSFKLPSINIGPRQQGRIR
ANSTIDVECETQALTTALSTIYNEAFLATIKQTQNPYDQGGSSLKIKEIIKQFDLSNLEMKRFYDLPKH

Sequences:

>Translated_389_residues
MSRKICVVSATRAEYGLLKPLLTAIHYDVDLILQLVVTGTHLSPEFGYTLKEIQKDPYPIAKKIEILLSSDSAVGVSKSM
GLAQISFAEAFDDLRPDLVLVLGDRYELLPIVLAANIAHIPVAHLSGGELTEGVMDELFRHAITKLAHLHFAAIEDYRQR
IIQMGEHPSRVFTVGEAGLDNIREMTLMNKAEIEESLQCPLKSKNLIITYHPDSHDNLEAIKQSFRTILAALDTLEDTLL
IFTKANSDIGGRLINELIDEYVSLNPRKSLGFTSLGQRRYLSLLQYVDAVVGNSSSGIVETPSFKLPSINIGPRQQGRIR
ANSTIDVECETQALTTALSTIYNEAFLATIKQTQNPYDQGGSSLKIKEIIKQFDLSNLEMKRFYDLPKH
>Mature_388_residues
SRKICVVSATRAEYGLLKPLLTAIHYDVDLILQLVVTGTHLSPEFGYTLKEIQKDPYPIAKKIEILLSSDSAVGVSKSMG
LAQISFAEAFDDLRPDLVLVLGDRYELLPIVLAANIAHIPVAHLSGGELTEGVMDELFRHAITKLAHLHFAAIEDYRQRI
IQMGEHPSRVFTVGEAGLDNIREMTLMNKAEIEESLQCPLKSKNLIITYHPDSHDNLEAIKQSFRTILAALDTLEDTLLI
FTKANSDIGGRLINELIDEYVSLNPRKSLGFTSLGQRRYLSLLQYVDAVVGNSSSGIVETPSFKLPSINIGPRQQGRIRA
NSTIDVECETQALTTALSTIYNEAFLATIKQTQNPYDQGGSSLKIKEIIKQFDLSNLEMKRFYDLPKH

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI190014632, Length=392, Percent_Identity=27.8061224489796, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI298566312, Length=392, Percent_Identity=27.8061224489796, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4885285, Length=392, Percent_Identity=27.8061224489796, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI298566325, Length=360, Percent_Identity=26.6666666666667, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI298566315, Length=334, Percent_Identity=23.6526946107784, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 43280; Mature: 43149

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKICVVSATRAEYGLLKPLLTAIHYDVDLILQLVVTGTHLSPEFGYTLKEIQKDPYPI
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHCCCCCCH
AKKIEILLSSDSAVGVSKSMGLAQISFAEAFDDLRPDLVLVLGDRYELLPIVLAANIAHI
HHHEEEEEECCCCCCCHHCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCHHHC
PVAHLSGGELTEGVMDELFRHAITKLAHLHFAAIEDYRQRIIQMGEHPSRVFTVGEAGLD
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHCHH
NIREMTLMNKAEIEESLQCPLKSKNLIITYHPDSHDNLEAIKQSFRTILAALDTLEDTLL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCEEE
IFTKANSDIGGRLINELIDEYVSLNPRKSLGFTSLGQRRYLSLLQYVDAVVGNSSSGIVE
EEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCCEE
TPSFKLPSINIGPRQQGRIRANSTIDVECETQALTTALSTIYNEAFLATIKQTQNPYDQG
CCCCCCCCCCCCCCCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCC
GSSLKIKEIIKQFDLSNLEMKRFYDLPKH
CCCEEHHHHHHHHCCCCCCHHHHHCCCCC
>Mature Secondary Structure 
SRKICVVSATRAEYGLLKPLLTAIHYDVDLILQLVVTGTHLSPEFGYTLKEIQKDPYPI
CCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHCCCCCCH
AKKIEILLSSDSAVGVSKSMGLAQISFAEAFDDLRPDLVLVLGDRYELLPIVLAANIAHI
HHHEEEEEECCCCCCCHHCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCHHHC
PVAHLSGGELTEGVMDELFRHAITKLAHLHFAAIEDYRQRIIQMGEHPSRVFTVGEAGLD
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHCHH
NIREMTLMNKAEIEESLQCPLKSKNLIITYHPDSHDNLEAIKQSFRTILAALDTLEDTLL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCEEE
IFTKANSDIGGRLINELIDEYVSLNPRKSLGFTSLGQRRYLSLLQYVDAVVGNSSSGIVE
EEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCCEE
TPSFKLPSINIGPRQQGRIRANSTIDVECETQALTTALSTIYNEAFLATIKQTQNPYDQG
CCCCCCCCCCCCCCCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCC
GSSLKIKEIIKQFDLSNLEMKRFYDLPKH
CCCEEHHHHHHHHCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]