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The map label for this gene is nrdA [H]

Identifier: 160875519

GI number: 160875519

Start: 2841782

End: 2844070

Strand: Direct

Name: nrdA [H]

Synonym: Sbal195_2407

Alternate gene names: 160875519

Gene position: 2841782-2844070 (Clockwise)

Preceding gene: 160875518

Following gene: 160875520

Centisome position: 53.14

GC content: 46.57

Gene sequence:

>2289_bases
ATGAATAGCACTATGACAGTCACAAAACGCTGTGGCGATCGTGAAAATATCGATCTCGAAAAAATACACCGCGTAATTAC
TTGGGCAGCCAAGGGATTAAAAAACGTTTCTGTTTCTGAAGTTGAACTTCGCTCGCACCTACAGTTTTTCGATGGCATCC
CAACCGAAGCTATCCATGAAACCATTATCAAAGCGGCTGCGGATTTAATTTCTCCAGAATCACCGGACTATCAATTCCTC
GCCGCCCGTTTAGCGGTGTTTCATTTGCGTAAGAAGGCCTTTGGTCAGTTCGAGCCGCCAGCACTGTATACCCACGTGAC
TAAGTTAGTTGAGCTTGGCAAGTATGACATGCACATTCTGCAGGATTACAGCCGCGAAGAACTCGACGTGATGGATACCT
ATATCGACCATTGGCGCGATATGGACTTCTCTTACGCTGCGGTAAAACAGCTTGAAGGCAAATATTTAGTTCAAAACCGT
GTGACGCACGAAATCTACGAGAGCGCCCAGTTCCTCTACATTTTGGTCGCGGCCTGTTTGTTTGCCCGTTATCCAAAAGA
AACGCGCCTGAAATACGTTAAAGATTTCTATGACGCGGTATCGACCTTTAAGATTTCGCTACCGACGCCAATCATGGCCG
GTGTGCGCACGCCAACGCGTCAGTTCAGCTCTTGCGTACTGATCGAATGTGGTGACAGCTTAGATTCCATCAACGCGACA
GCTTCGTCTATCGTGAAATACGTTAGCCAACGTGCGGGTATCGGTATTAACGCCGGTCGTATTCGCGCCTTAGGTAGCCC
AATCCGTGGTGGTGAAGCCTTCCACACCGGTTGTTTACCTTTCTATAAGTATTTCCAAACCGCAGTGAAATCTTGTTCTC
AAGGCGGCGTGCGTGGCGGTGCTGCGACCCTGTTCTACCCTATTTGGCACTTAGAAGTCGAATCTCTGCTGGTATTGAAA
AATAACCGCGGCGTAGAAGACAACCGTATCCGTCATTTAGACTACGGTGTGCAGTTGAACAAAGTCATGTATCAACGTCT
GATCAAAGGCGAAAACATCAGCCTGTTTAGCCCATCTGACGTACCTGGCTTGTACGATGCTTTCTTTGAAGATCAAAATG
AATTCGAACGTTTATATGTGCAATATGAGCAAGACAGCAGCATTCGTAAGAAAACCATAAAGGCTGTTGAGCTGTTTTCA
CTGATGATGCAAGAGCGCGCCTCAACTGGCCGTATCTACATTCAAAACGTGGATCACTGCAACACTCACAGCCCGTTCGA
TTCAAAAGTCGCACCGATCAGACAGTCTAACCTGTGTCTTGAAATCGCCCTGCCGACTAAACCATTGAACAACATCGATG
ATCCAGAAGGTGAAATCGCGCTTTGTACGCTGTCAGCACTTAACTTAGGTTCTATCAAAGAATTATCTGATATTGAGCCA
TTAGCCGACCTCGCCGTACGTGCACTGGATAACCTGTTGGATTATCAAGATTACCCCATCAAGGCCGCGCAAATTGCCTC
GATGAATCGCCGTACTTTAGGCATAGGCGTGATTAACTTTGCTAACTACTTAGCAAAAAATGGCATGAAGTATTCTGATG
GCAGCGCGAACGAGCTTACCCACAGAACCTTCGAAGCGATTCAGTTCTATTTACTGAAAGCCTCAATGAACTTGGCCAAA
GAGCAAGGTGCGTGTCCGTTATTCCACGAGACCACTTACTCTCAAGGTATTTTGCCAATCGATACCTACAAACGTGACCT
AGATAAAATTTGTGCTGAACCATTGCACTTAGACTGGGAATCACTGCGTAGCGATATCAAGCAATATGGCCTACGTAACT
CAACGCTGTCGGCATTAATGCCTTCAGAAACCTCGTCGCAAATCTCCAATGCGACCAATGGTATTGAGCCACCACGTGGT
CTTATCAGCGTGAAATCGAGCAAAGACGGTCAGTTGAAGCAAGTCGTGCCAGATTTCGATACGCTGAAAGATAGCTATGA
ATTACTGTGGAAAATGCCAAGCAACGACGGTTACTTACAGCTAGTGGGTATCATGCAGAAGTTCGTTGACCAAGCGATTT
CAGCCAACACTAACTACGATCCTTCACGTTTTGAAGGCCGTAAAGTACCGATGCAAACCCTGCTGAAAGATTTGCTCAAT
GCTTACAAGTTAGGTGTGAAAACGCTTTACTACCATAACACTCGCGATGGTGCGTCGGATTCACACGATGACATCACCAA
TTTAGAGAAAGAAGACGATGGTTGCGCCGGCGGCGCGTGTAAAATCTAG

Upstream 100 bases:

>100_bases
AGTCAGCAGTATTTAAGGGACGGTTATTGATTGTTTTACAAGGATACGTACGGTGAACTTGCTCACCTAAATAGATATAA
GAACCAAGGCCTATCTCCAA

Downstream 100 bases:

>100_bases
TCTTTAACGTTAACGCGGCTCTTACAAATAAAAAGTATAGGGATCCCGATTGAGTGGATCCCTATCCATTGGAAAATAGC
ACCATGGCCTACTCTACCTT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Protein B1; Ribonucleoside-diphosphate reductase 1 R1 subunit; Ribonucleotide reductase 1 [H]

Number of amino acids: Translated: 762; Mature: 762

Protein sequence:

>762_residues
MNSTMTVTKRCGDRENIDLEKIHRVITWAAKGLKNVSVSEVELRSHLQFFDGIPTEAIHETIIKAAADLISPESPDYQFL
AARLAVFHLRKKAFGQFEPPALYTHVTKLVELGKYDMHILQDYSREELDVMDTYIDHWRDMDFSYAAVKQLEGKYLVQNR
VTHEIYESAQFLYILVAACLFARYPKETRLKYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
ASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLK
NNRGVEDNRIRHLDYGVQLNKVMYQRLIKGENISLFSPSDVPGLYDAFFEDQNEFERLYVQYEQDSSIRKKTIKAVELFS
LMMQERASTGRIYIQNVDHCNTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPEGEIALCTLSALNLGSIKELSDIEP
LADLAVRALDNLLDYQDYPIKAAQIASMNRRTLGIGVINFANYLAKNGMKYSDGSANELTHRTFEAIQFYLLKASMNLAK
EQGACPLFHETTYSQGILPIDTYKRDLDKICAEPLHLDWESLRSDIKQYGLRNSTLSALMPSETSSQISNATNGIEPPRG
LISVKSSKDGQLKQVVPDFDTLKDSYELLWKMPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGRKVPMQTLLKDLLN
AYKLGVKTLYYHNTRDGASDSHDDITNLEKEDDGCAGGACKI

Sequences:

>Translated_762_residues
MNSTMTVTKRCGDRENIDLEKIHRVITWAAKGLKNVSVSEVELRSHLQFFDGIPTEAIHETIIKAAADLISPESPDYQFL
AARLAVFHLRKKAFGQFEPPALYTHVTKLVELGKYDMHILQDYSREELDVMDTYIDHWRDMDFSYAAVKQLEGKYLVQNR
VTHEIYESAQFLYILVAACLFARYPKETRLKYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
ASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLK
NNRGVEDNRIRHLDYGVQLNKVMYQRLIKGENISLFSPSDVPGLYDAFFEDQNEFERLYVQYEQDSSIRKKTIKAVELFS
LMMQERASTGRIYIQNVDHCNTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPEGEIALCTLSALNLGSIKELSDIEP
LADLAVRALDNLLDYQDYPIKAAQIASMNRRTLGIGVINFANYLAKNGMKYSDGSANELTHRTFEAIQFYLLKASMNLAK
EQGACPLFHETTYSQGILPIDTYKRDLDKICAEPLHLDWESLRSDIKQYGLRNSTLSALMPSETSSQISNATNGIEPPRG
LISVKSSKDGQLKQVVPDFDTLKDSYELLWKMPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGRKVPMQTLLKDLLN
AYKLGVKTLYYHNTRDGASDSHDDITNLEKEDDGCAGGACKI
>Mature_762_residues
MNSTMTVTKRCGDRENIDLEKIHRVITWAAKGLKNVSVSEVELRSHLQFFDGIPTEAIHETIIKAAADLISPESPDYQFL
AARLAVFHLRKKAFGQFEPPALYTHVTKLVELGKYDMHILQDYSREELDVMDTYIDHWRDMDFSYAAVKQLEGKYLVQNR
VTHEIYESAQFLYILVAACLFARYPKETRLKYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
ASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLK
NNRGVEDNRIRHLDYGVQLNKVMYQRLIKGENISLFSPSDVPGLYDAFFEDQNEFERLYVQYEQDSSIRKKTIKAVELFS
LMMQERASTGRIYIQNVDHCNTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPEGEIALCTLSALNLGSIKELSDIEP
LADLAVRALDNLLDYQDYPIKAAQIASMNRRTLGIGVINFANYLAKNGMKYSDGSANELTHRTFEAIQFYLLKASMNLAK
EQGACPLFHETTYSQGILPIDTYKRDLDKICAEPLHLDWESLRSDIKQYGLRNSTLSALMPSETSSQISNATNGIEPPRG
LISVKSSKDGQLKQVVPDFDTLKDSYELLWKMPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGRKVPMQTLLKDLLN
AYKLGVKTLYYHNTRDGASDSHDDITNLEKEDDGCAGGACKI

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=786, Percent_Identity=27.4809160305344, Blast_Score=237, Evalue=3e-62,
Organism=Escherichia coli, GI2367133, Length=762, Percent_Identity=79.7900262467192, Blast_Score=1291, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=684, Percent_Identity=24.8538011695906, Blast_Score=166, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17555242, Length=699, Percent_Identity=28.3261802575107, Blast_Score=230, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322123, Length=672, Percent_Identity=28.2738095238095, Blast_Score=240, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6320914, Length=815, Percent_Identity=26.6257668711656, Blast_Score=238, Evalue=3e-63,
Organism=Drosophila melanogaster, GI17352481, Length=692, Percent_Identity=29.4797687861272, Blast_Score=238, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85759; Mature: 85759

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTMTVTKRCGDRENIDLEKIHRVITWAAKGLKNVSVSEVELRSHLQFFDGIPTEAIHE
CCCCEEHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHH
TIIKAAADLISPESPDYQFLAARLAVFHLRKKAFGQFEPPALYTHVTKLVELGKYDMHIL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHH
QDYSREELDVMDTYIDHWRDMDFSYAAVKQLEGKYLVQNRVTHEIYESAQFLYILVAACL
HHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FARYPKETRLKYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
HHHCCHHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCHHHHCCEEEEEECCCHHHHHHH
ASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
AATLFYPIWHLEVESLLVLKNNRGVEDNRIRHLDYGVQLNKVMYQRLIKGENISLFSPSD
CHHEEHHHHHEEEEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCC
VPGLYDAFFEDQNEFERLYVQYEQDSSIRKKTIKAVELFSLMMQERASTGRIYIQNVDHC
CCHHHHHHHCCHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPEGEIALCTLSALNLGSIKELSDIEP
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCH
LADLAVRALDNLLDYQDYPIKAAQIASMNRRTLGIGVINFANYLAKNGMKYSDGSANELT
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCCHHHH
HRTFEAIQFYLLKASMNLAKEQGACPLFHETTYSQGILPIDTYKRDLDKICAEPLHLDWE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEHHHHHHHHHHHHCCCCCCCHH
SLRSDIKQYGLRNSTLSALMPSETSSQISNATNGIEPPRGLISVKSSKDGQLKQVVPDFD
HHHHHHHHHCCCCCHHHHHCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHCCCHH
TLKDSYELLWKMPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGRKVPMQTLLKDLLN
HHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHH
AYKLGVKTLYYHNTRDGASDSHDDITNLEKEDDGCAGGACKI
HHHHHHHHEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNSTMTVTKRCGDRENIDLEKIHRVITWAAKGLKNVSVSEVELRSHLQFFDGIPTEAIHE
CCCCEEHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHH
TIIKAAADLISPESPDYQFLAARLAVFHLRKKAFGQFEPPALYTHVTKLVELGKYDMHIL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHH
QDYSREELDVMDTYIDHWRDMDFSYAAVKQLEGKYLVQNRVTHEIYESAQFLYILVAACL
HHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FARYPKETRLKYVKDFYDAVSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
HHHCCHHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCHHHHCCEEEEEECCCHHHHHHH
ASSIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
AATLFYPIWHLEVESLLVLKNNRGVEDNRIRHLDYGVQLNKVMYQRLIKGENISLFSPSD
CHHEEHHHHHEEEEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCC
VPGLYDAFFEDQNEFERLYVQYEQDSSIRKKTIKAVELFSLMMQERASTGRIYIQNVDHC
CCHHHHHHHCCHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSPFDSKVAPIRQSNLCLEIALPTKPLNNIDDPEGEIALCTLSALNLGSIKELSDIEP
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCH
LADLAVRALDNLLDYQDYPIKAAQIASMNRRTLGIGVINFANYLAKNGMKYSDGSANELT
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCCCHHHH
HRTFEAIQFYLLKASMNLAKEQGACPLFHETTYSQGILPIDTYKRDLDKICAEPLHLDWE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEHHHHHHHHHHHHCCCCCCCHH
SLRSDIKQYGLRNSTLSALMPSETSSQISNATNGIEPPRGLISVKSSKDGQLKQVVPDFD
HHHHHHHHHCCCCCHHHHHCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHCCCHH
TLKDSYELLWKMPSNDGYLQLVGIMQKFVDQAISANTNYDPSRFEGRKVPMQTLLKDLLN
HHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHH
AYKLGVKTLYYHNTRDGASDSHDDITNLEKEDDGCAGGACKI
HHHHHHHHEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6087316; 3287341; 9205837; 9278503; 3894026; 2663852; 8702814; 8052308; 9309223; 10493864 [H]