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The map label for this gene is folE [H]

Identifier: 160873508

GI number: 160873508

Start: 435911

End: 436561

Strand: Reverse

Name: folE [H]

Synonym: Sbal195_0383

Alternate gene names: 160873508

Gene position: 436561-435911 (Counterclockwise)

Preceding gene: 160873509

Following gene: 160873505

Centisome position: 8.16

GC content: 46.39

Gene sequence:

>651_bases
ATGGCATTAAGTGAAGCAGCAGTAAAAGTACAAGCCGCGTTATTAGAACGTGGACTTGAAACCCCAATGCTCCCAAGCGT
TTACAGCAGTGAAGAACGTAAAGACAAGATTGAACATCATATGAAAGAAATCCTGACATTAATGTCATTGGATCTGTCAG
ACGATAGCCTTGCCGATACGCCGCGCCGCATTGCTAAAATGTATGTCGATGAAATCTTCTCCGGCTTAGATTATGCGAAC
TTCCCTAAGATCACGGTTATCGACAATAAGATGGGCTTCGATGAAATGGTGCGAGTGCAAGACATTAGCCTCACCAGCAC
CTGCGAACACCATTTAGTGACGATCGATGGTACTGCGACCATAGCTTATCTACCACGCAAAAAAATCATCGGTTTATCAA
AGATTAATCGCATCGTGCGTTTCTTTGCCCAACGTCCACAAGTGCAAGAGCGTTTGACTCAGCAAGTGTTAGTCGCGCTG
CAGACCTTGCTCGAAACCAAAGACGTTGCGGTTAAAATGGATGCTGTGCATTACTGCGTCAAATCCCGTGGCGTGATGGA
CTCAACCAGTTCGACCACTACCACAGCGCTGGGCGGTATTTTCAAATCTAACCCTGCGACCCGCGCCGAGTTTTTGCATC
AGTCTAAATAA

Upstream 100 bases:

>100_bases
GAATAACAATAATTTGTATCTGATGCTGAACAACCCAAGTACCACTCGATGCTCAGCATAGATTTTCTGTTATAGCCGCT
ACGACGTAGTGGAGGATAAG

Downstream 100 bases:

>100_bases
GTGTATTGAAGCGTAATGTGATTTAAAGCGTGCCTAAATCAATAGCAATCAATACAAATCAACAAAAAAACGCTGCGATT
CCTTCTATAGAATCGCAGCG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MALSEAAVKVQAALLERGLETPMLPSVYSSEERKDKIEHHMKEILTLMSLDLSDDSLADTPRRIAKMYVDEIFSGLDYAN
FPKITVIDNKMGFDEMVRVQDISLTSTCEHHLVTIDGTATIAYLPRKKIIGLSKINRIVRFFAQRPQVQERLTQQVLVAL
QTLLETKDVAVKMDAVHYCVKSRGVMDSTSSTTTTALGGIFKSNPATRAEFLHQSK

Sequences:

>Translated_216_residues
MALSEAAVKVQAALLERGLETPMLPSVYSSEERKDKIEHHMKEILTLMSLDLSDDSLADTPRRIAKMYVDEIFSGLDYAN
FPKITVIDNKMGFDEMVRVQDISLTSTCEHHLVTIDGTATIAYLPRKKIIGLSKINRIVRFFAQRPQVQERLTQQVLVAL
QTLLETKDVAVKMDAVHYCVKSRGVMDSTSSTTTTALGGIFKSNPATRAEFLHQSK
>Mature_215_residues
ALSEAAVKVQAALLERGLETPMLPSVYSSEERKDKIEHHMKEILTLMSLDLSDDSLADTPRRIAKMYVDEIFSGLDYANF
PKITVIDNKMGFDEMVRVQDISLTSTCEHHLVTIDGTATIAYLPRKKIIGLSKINRIVRFFAQRPQVQERLTQQVLVALQ
TLLETKDVAVKMDAVHYCVKSRGVMDSTSSTTTTALGGIFKSNPATRAEFLHQSK

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=201, Percent_Identity=38.3084577114428, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI4503949, Length=201, Percent_Identity=38.3084577114428, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI66932970, Length=98, Percent_Identity=45.9183673469388, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI66932972, Length=164, Percent_Identity=37.1951219512195, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1788476, Length=213, Percent_Identity=69.4835680751174, Blast_Score=296, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17560486, Length=179, Percent_Identity=40.2234636871508, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=42.3076923076923, Blast_Score=132, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24656782, Length=120, Percent_Identity=50, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24656796, Length=120, Percent_Identity=50, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24656791, Length=120, Percent_Identity=50, Blast_Score=114, Evalue=4e-26,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 24174; Mature: 24043

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSEAAVKVQAALLERGLETPMLPSVYSSEERKDKIEHHMKEILTLMSLDLSDDSLADT
CCCHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
PRRIAKMYVDEIFSGLDYANFPKITVIDNKMGFDEMVRVQDISLTSTCEHHLVTIDGTAT
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHCCCCEEEEECCCEE
IAYLPRKKIIGLSKINRIVRFFAQRPQVQERLTQQVLVALQTLLETKDVAVKMDAVHYCV
EEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSRGVMDSTSSTTTTALGGIFKSNPATRAEFLHQSK
HHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure 
ALSEAAVKVQAALLERGLETPMLPSVYSSEERKDKIEHHMKEILTLMSLDLSDDSLADT
CCHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
PRRIAKMYVDEIFSGLDYANFPKITVIDNKMGFDEMVRVQDISLTSTCEHHLVTIDGTAT
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHCCCCEEEEECCCEE
IAYLPRKKIIGLSKINRIVRFFAQRPQVQERLTQQVLVALQTLLETKDVAVKMDAVHYCV
EEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSRGVMDSTSSTTTTALGGIFKSNPATRAEFLHQSK
HHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA