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The map label for this gene is cimH

Identifier: 16080928

GI number: 16080928

Start: 3979753

End: 3981105

Strand: Direct

Name: cimH

Synonym: BSU38770

Alternate gene names: 16080928

Gene position: 3979753-3981105 (Clockwise)

Preceding gene: 16080922

Following gene: 16080929

Centisome position: 94.41

GC content: 47.6

Gene sequence:

>1353_bases
ATGGGAGAGCTTCAAACACACATGCAATTGCAAACGGATACAATTCACGAAGGGGTTCGAAAAGAGAATTGGTTTGCGAA
AGCCATGAATATAAAAGTAGGCATCATACCGCTTCCTGTGTATGCCTTGCTGTTTATATTAATCACTGTTTTTGTTATGC
ATCACGATGTAAAAAGTGACATTTTGACATCCATTGCCGTCATGGCGTTTTTCGGGTTTACCTTTGCCCAAATCGGCAAA
TCGATACCGATTGTTCGTTCTATCGGCGGCCCGGCCATCCTAGCTACTTTTATTCCGTCCGCTGTCGTGTACTATCACCT
GCTGCCTAATGATATCGTCAAATCCACCACAGAATTTACAGAAAACTCAAACTTTCTATATTTGTTTATCGCCGGTATTG
TCGTCGGAAGCATTCTCGGCATGAAAAGAGAAACACTCGTAAAAGCATTCATGAAAATCTTTATTCCGCTTATTGTCGGT
TCTGTCACAGCCGCTATTGTCGGACTGGCTGTCGGGACATTGCTCGGACTCGGATTTCAGCATACCCTGCTGTACATTGT
CATTCCGATCATGGCTGGAGGAGTCGGAGAAGGCGCTATCCCGCTGTCCATCGGATATTCTGACATCATGCCCATTTCTC
AAGGGGAAGCGTTTGCACTTGTTCTGCCATCGATTATGCTGGGCAGCTTGTGCGCGATTATTCTAGCGGGATTGCTGAAC
CGAATCGGAAAGAAAAAACCGGAATGGACAGGCAACGGCAAAGTGGACCGCTCCGAAGAAGAGTCCCCTGCGCTGGAGGA
ATCTCAAAGCGGACAGCAAATGTTCAACCTTTCTTTATTTGCGTCAGGCGGTATCCTTGCTGTTTCTTTATACTTAGTCG
GCATGCTCGCTCACGATTTTTTCGGTTTTCCGGCACCCGTTGCCATGCTGTTACTGGCTGTTCTAATCAAGCTGTTCAGA
TTGGTGCCTGCCTCAATTGAAAATGGCGCGTTTGGAGTGTCCCGCTTCTTTTCAACAGCTGTGACCTACCCGCTTCTCTT
TGCGATTGGGGTATCCATGACGCCGTGGGACAAGCTTGTCGCCGCTTTTAACCTCAGCAATATTATCACGATTCTGTCTG
TCGTTGTGACCATGATGGCCGTTGGCTTCTTCACTGGAAAATGGCTGAACATGTATCCGATTGAAACCGCCATTATTAAT
GCATGCCATTCTGGGCAAGGCGGCACGGGTGACGTTGCCATTTTAAGCGCCGCTGAAAGGCTTGAGCTAATGCCTTTCGC
CCAGGTGTCTACCCGCATCGGGGGCGCGATTACAGTATCCTTAACCTTATTGCTGCTGCACCAGTTTTATTGA

Upstream 100 bases:

>100_bases
AGTTGAATAGTAAATTTTTAATATATTAATAATTTCAATTTTTTAGTATACTTAACATAGTGAACAATTTCACTGCATCA
AGAATAGGGGAGGTTTTTCA

Downstream 100 bases:

>100_bases
TCCCCGCAAGCAAGTTCTTCGTCAAACGAAAGAGCTTGCTTTTTTGCATGTCCATGTTTTTGCAAGTTCCCATCCCATGC
TATAGTAATAGTTGGAAATA

Product: citrate/malate/H+ symporter

Products: NA

Alternate protein names: Citrate/malate-proton symporter

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALLFILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGK
SIPIVRSIGGPAILATFIPSAVVYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG
SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAFALVLPSIMLGSLCAIILAGLLN
RIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFNLSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFR
LVPASIENGAFGVSRFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMYPIETAIIN
ACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY

Sequences:

>Translated_450_residues
MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALLFILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGK
SIPIVRSIGGPAILATFIPSAVVYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG
SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAFALVLPSIMLGSLCAIILAGLLN
RIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFNLSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFR
LVPASIENGAFGVSRFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMYPIETAIIN
ACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY
>Mature_449_residues
GELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALLFILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKS
IPIVRSIGGPAILATFIPSAVVYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVGS
VTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAFALVLPSIMLGSLCAIILAGLLNR
IGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFNLSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRL
VPASIENGAFGVSRFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMYPIETAIINA
CHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY

Specific function: Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictl

COG id: COG3493

COG function: function code C; Na+/citrate symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:citrate (SCF) symporter family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CIMH_BACSU (P94363)

Other databases:

- EMBL:   D83026
- EMBL:   AL009126
- PIR:   C70081
- RefSeq:   NP_391756.1
- ProteinModelPortal:   P94363
- EnsemblBacteria:   EBBACT00000003362
- GeneID:   937407
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU38770
- NMPDR:   fig|224308.1.peg.3882
- GenoList:   BSU38770
- GeneTree:   EBGT00050000001855
- HOGENOM:   HBG304840
- OMA:   ICATFIP
- ProtClustDB:   CLSK888124
- BioCyc:   BSUB:BSU38770-MONOMER
- InterPro:   IPR004679
- InterPro:   IPR018025
- TIGRFAMs:   TIGR00783

Pfam domain/function: PF03390 2HCT

EC number: NA

Molecular weight: Translated: 48340; Mature: 48209

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x134379a0)-; HASH(0x13187224)-; HASH(0x13201958)-; HASH(0x12f05734)-; HASH(0x12caddfc)-; HASH(0x12d8c2f4)-; HASH(0x125585d4)-; HASH(0x130ccb54)-; HASH(0x120b6550)-; HASH(0x135566e0)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALLFILITVFVMHHDVKSD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHH
ILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAVVYYHLLPNDIVKSTTEFT
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
ENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVGSVTAAIVGLAVGTLLGLGFQ
CCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
HTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAFALVLPSIMLGSLCAIILAGLLN
HHHHHHHHHHHCCCCCCCCEEEEECHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFNLSLFASGGILAVSLYLVGMLAHDF
HHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHEEHEEECCCHHHHHHHHHHHHHHHH
FGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVSRFFSTAVTYPLLFAIGVSMTPWDKLV
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AAFNLSNIITILSVVVTMMAVGFFTGKWLNMYPIETAIINACHSGQGGTGDVAILSAAER
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHCCCCCCCCCHHHHHHHHH
LELMPFAQVSTRIGGAITVSLTLLLLHQFY
HHHCCHHHHHHHCCCHHHHHHHHHHHHHCH
>Mature Secondary Structure 
GELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALLFILITVFVMHHDVKSD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHH
ILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAVVYYHLLPNDIVKSTTEFT
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
ENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVGSVTAAIVGLAVGTLLGLGFQ
CCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
HTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAFALVLPSIMLGSLCAIILAGLLN
HHHHHHHHHHHCCCCCCCCEEEEECHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFNLSLFASGGILAVSLYLVGMLAHDF
HHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHEEHEEECCCHHHHHHHHHHHHHHHH
FGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVSRFFSTAVTYPLLFAIGVSMTPWDKLV
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AAFNLSNIITILSVVVTMMAVGFFTGKWLNMYPIETAIINACHSGQGGTGDVAILSAAER
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHCCCCCCCCCHHHHHHHHH
LELMPFAQVSTRIGGAITVSLTLLLLHQFY
HHHCCHHHHHHHCCCHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969509; 9384377; 11566984