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The map label for this gene is ezrA

Identifier: 16080013

GI number: 16080013

Start: 3029729

End: 3031417

Strand: Reverse

Name: ezrA

Synonym: BSU29610

Alternate gene names: 16080013

Gene position: 3031417-3029729 (Counterclockwise)

Preceding gene: 16080015

Following gene: 16080011

Centisome position: 71.91

GC content: 43.99

Gene sequence:

>1689_bases
ATGGAGTTTGTCATTGGATTATTAATTGTACTGCTTGCGCTGTTTGCGGCAGGCTACTTTTTCAGGAAAAAAATCTACGC
CGAAATCGACCGGCTGGAATCGTGGAAGATTGAAATTCTGAATCGGTCGATCGTGGAAGAAATGTCTAAAATAAAACATT
TAAAAATGACGGGTCAGACAGAAGAGTTCTTTGAGAAGTGGCGTGAAGAATGGGATGAGATTGTCACAGCCCACATGCCG
AAAGTTGAAGAGCTCCTTTATGATGCCGAGGAAAATGCAGACAAATACCGGTTTAAAAAGGCCAATCAAGTGCTCGTTCA
TATCGACGACCTGCTGACAGCGGCTGAATCAAGCATTGAAAAGATTCTTCGGGAAATCAGCGATCTTGTCACAAGTGAGG
AAAAGAGCCGTGAAGAGATTGAACAGGTGAGGGAGCGCTATTCGAAATCTCGAAAAAACCTGCTGGCTTACAGCCACCTT
TACGGGGAGCTTTATGACAGCCTTGAAAAGGATCTGGACGAAATTTGGAGCGGCATCAAACAATTTGAAGAAGAAACAGA
AGGCGGAAACTATATTACTGCACGAAAAGTACTGCTTGAGCAGGACCGCAATCTTGAACGGCTTCAGTCATACATAGATG
ATGTGCCGAAGCTGTTAGCTGACTGTAAACAGACGGTGCCCGGACAGATTGCAAAGCTCAAGGATGGCTATGGCGAAATG
AAAGAAAAAGGGTACAAGCTTGAGCATATCCAGCTTGATAAGGAATTAGAAAATCTGTCAAACCAGCTGAAACGAGCGGA
ACATGTCCTGATGACTGAACTGGATATTGATGAAGCGTCCGCAATCCTGCAGCTCATTGACGAAAATATTCAATCTGTTT
ATCAGCAGCTGGAGGGCGAAGTTGAAGCCGGTCAATCCGTACTAAGCAAAATGCCTGAATTGATTATTGCTTACGACAAG
CTTAAAGAAGAGAAAGAGCATACGAAAGCGGAAACTGAGCTGGTGAAGGAAAGCTACAGGCTGACAGCCGGTGAGCTCGG
CAAACAGCAGGCTTTTGAAAAGCGCCTTGATGAAATTGGAAAGCTGCTATCATCCGTTAAAGATAAGCTTGATGCAGAGC
ATGTCGCCTACTCACTTTTAGTAGAAGAAGTTGCTTCAATAGAGAAGCAAATTGAAGAAGTGAAAAAAGAGCATGCCGAG
TATCGTGAAAATCTGCAAGCGCTGAGAAAAGAAGAGCTTCAGGCGAGGGAGACGCTCAGCAATTTGAAAAAAACAATTTC
TGAGACAGCAAGACTGCTGAAGACTAGCAACATTCCAGGCATTCCGAGCCATATTCAAGAGATGCTGGAGAACGCGCATC
ATCATATTCAAGAAACGGTCAATCAACTAAACGAACTTCCATTAAATATGGAAGAAGCCGGAGCCCATTTGAAACAAGCA
GAAGATATCGTCAACAGGGCAAGCCGGGAATCAGAGGAACTTGTCGAGCAGGTCATCCTCATTGAAAAAATCATTCAGTT
CGGAAACCGGTTCAGAAGCCAGAATCATATTTTATCTGAACAGCTGAAAGAAGCGGAAAGACGTTTTTATGCTTTTGATT
ATGACGACTCTTATGAAATTGCCGCTGCCGCTGTAGAAAAGGCTGCGCCAGGTGCAGTTGAAAAAATCAAAGCTGACATA
TCCGCTTAG

Upstream 100 bases:

>100_bases
TAACAATGAAAACGACAGTTTTTCTCAATACATATCCTGAAATCTTTCTGAATAAATAAAACACCCTGACAGATTAAGGT
AAACAGCAAGGGGGCTCATT

Downstream 100 bases:

>100_bases
ATAATCACGACCATGAAAAAGAGCCCGCAGTGTAATGAGCAGGCTCTTTTTTTATTACAAAACGCCTGCGCAATAACGCA
GGCGTTCTGTGACATTAACT

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSIVEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMP
KVEELLYDAEENADKYRFKKANQVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL
YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKLLADCKQTVPGQIAKLKDGYGEM
KEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDIDEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDK
LKEEKEHTKAETELVKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIEEVKKEHAE
YRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLENAHHHIQETVNQLNELPLNMEEAGAHLKQA
EDIVNRASRESEELVEQVILIEKIIQFGNRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADI
SA

Sequences:

>Translated_562_residues
MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSIVEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMP
KVEELLYDAEENADKYRFKKANQVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL
YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKLLADCKQTVPGQIAKLKDGYGEM
KEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDIDEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDK
LKEEKEHTKAETELVKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIEEVKKEHAE
YRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLENAHHHIQETVNQLNELPLNMEEAGAHLKQA
EDIVNRASRESEELVEQVILIEKIIQFGNRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADI
SA
>Mature_562_residues
MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSIVEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMP
KVEELLYDAEENADKYRFKKANQVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL
YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKLLADCKQTVPGQIAKLKDGYGEM
KEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDIDEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDK
LKEEKEHTKAETELVKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIEEVKKEHAE
YRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLENAHHHIQETVNQLNELPLNMEEAGAHLKQA
EDIVNRASRESEELVEQVILIEKIIQFGNRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADI
SA

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EZRA_BACSU (O34894)

Other databases:

- EMBL:   AF008220
- EMBL:   AL009126
- PIR:   G70002
- RefSeq:   NP_390839.1
- ProteinModelPortal:   O34894
- IntAct:   O34894
- EnsemblBacteria:   EBBACT00000000413
- GeneID:   937337
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU29610
- NMPDR:   fig|224308.1.peg.2964
- GenoList:   BSU29610
- GeneTree:   EBGT00050000000289
- HOGENOM:   HBG345654
- OMA:   MDIQELH
- ProtClustDB:   PRK04778
- BioCyc:   BSUB:BSU29610-MONOMER
- HAMAP:   MF_00728
- InterPro:   IPR010379

Pfam domain/function: PF06160 EzrA

EC number: NA

Molecular weight: Translated: 64996; Mature: 64996

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00591 GLYCOSYL_HYDROL_F10

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x11139d24)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSIVEEMSKIKHLKMTGQT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKANQVLVHIDDLLTAAESSIE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHLYGELYDSLEKDLDEIWSGIK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKLLADCKQTVPGQIAKLKDGYGEM
HHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHH
KEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDIDEASAILQLIDENIQSVYQQLEGE
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCH
VEAGQSVLSKMPELIIAYDKLKEEKEHTKAETELVKESYRLTAGELGKQQAFEKRLDEIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLSSVKDKLDAEHVAYSLLVEEVASIEKQIEEVKKEHAEYRENLQALRKEELQARETLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKKTISETARLLKTSNIPGIPSHIQEMLENAHHHIQETVNQLNELPLNMEEAGAHLKQA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EDIVNRASRESEELVEQVILIEKIIQFGNRFRSQNHILSEQLKEAERRFYAFDYDDSYEI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
AAAAVEKAAPGAVEKIKADISA
HHHHHHHHCCCHHHHHHHHCCH
>Mature Secondary Structure
MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSIVEEMSKIKHLKMTGQT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKANQVLVHIDDLLTAAESSIE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHLYGELYDSLEKDLDEIWSGIK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKLLADCKQTVPGQIAKLKDGYGEM
HHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHH
KEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDIDEASAILQLIDENIQSVYQQLEGE
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCH
VEAGQSVLSKMPELIIAYDKLKEEKEHTKAETELVKESYRLTAGELGKQQAFEKRLDEIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLSSVKDKLDAEHVAYSLLVEEVASIEKQIEEVKKEHAEYRENLQALRKEELQARETLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKKTISETARLLKTSNIPGIPSHIQEMLENAHHHIQETVNQLNELPLNMEEAGAHLKQA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EDIVNRASRESEELVEQVILIEKIIQFGNRFRSQNHILSEQLKEAERRFYAFDYDDSYEI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
AAAAVEKAAPGAVEKIKADISA
HHHHHHHHCCCHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10449747