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The map label for this gene is comEA

Identifier: 16079613

GI number: 16079613

Start: 2640513

End: 2641130

Strand: Reverse

Name: comEA

Synonym: BSU25590

Alternate gene names: 16079613

Gene position: 2641130-2640513 (Counterclockwise)

Preceding gene: 16079615

Following gene: 16079612

Centisome position: 62.65

GC content: 45.95

Gene sequence:

>618_bases
ATGAATTGGTTGAATCAGCATAAGAAAGCAATTATTTTAGCGGCTTCTGCGGCTGTTTTCACAGCGATTATGATCTTTCT
GGCCACAGGGAAAAATAAAGAGCCGGTGAAGCAAGCTGTACCAACAGAGACAGAAAATACAGTGGTAAAGCAGGAAGCAA
ACAACGACGAGTCAAACGAAACAATTGTGATAGACATCAAAGGTGCTGTTCAGCATCCTGGCGTTTATGAAATGCGAACA
GGGGACAGAGTATCTCAGGCAATTGAGAAAGCGGGCGGGACCAGTGAACAAGCAGACGAAGCGCAAGTAAATTTGGCGGA
GATTCTGCAGGACGGGACAGTGGTGTACATCCCGAAAAAGGGAGAGGAAACAGCAGTGCAGCAAGGTGGCGGAGGGTCTG
TCCAAAGCGATGGAGGGAAGGGAGCGCTGGTGAATATCAATACAGCAACCTTAGAGGAGTTACAAGGCATCTCAGGGGTG
GGGCCATCCAAAGCTGAAGCTATTATTGCATACCGGGAGGAAAACGGTCGTTTCCAAACAATTGAAGATATCACTAAGGT
TTCAGGAATAGGTGAAAAGTCATTTGAGAAAATAAAGTCTTCCATTACAGTAAAGTGA

Upstream 100 bases:

>100_bases
ATAAAGCCTATCTTCAATGGTTTCCCCTCCTTTGAGCTATTATCCTCTAAACCATATGTGTTATGAAAATAAAATATGAC
GAAAGCGGGGAACATGCACG

Downstream 100 bases:

>100_bases
TTTGACGGTCATGCATTATGATAGGTAAACTAAAGGTCAGGCAACACAACATTTGGAGGGAACAACGTGGAACGAATTTC
ATGGAATCAATACTTTATGG

Product: membrane bound high-affinity DNA-binding receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTETENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRT
GDRVSQAIEKAGGTSEQADEAQVNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV
GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK

Sequences:

>Translated_205_residues
MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTETENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRT
GDRVSQAIEKAGGTSEQADEAQVNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV
GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK
>Mature_205_residues
MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTETENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRT
GDRVSQAIEKAGGTSEQADEAQVNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV
GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains

Homologues:

Organism=Escherichia coli, GI1786646, Length=86, Percent_Identity=38.3720930232558, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COMEA_BACSU (P39694)

Other databases:

- EMBL:   L15202
- EMBL:   D84432
- EMBL:   AL009126
- PIR:   S39863
- RefSeq:   NP_390437.1
- ProteinModelPortal:   P39694
- SMR:   P39694
- EnsemblBacteria:   EBBACT00000003423
- GeneID:   937827
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU25590
- NMPDR:   fig|224308.1.peg.2562
- GenoList:   BSU25590
- GeneTree:   EBGT00050000002964
- HOGENOM:   HBG728721
- OMA:   KEGVYEM
- PhylomeDB:   P39694
- ProtClustDB:   CLSK887604
- BioCyc:   BSUB:BSU25590-MONOMER
- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554
- SMART:   SM00278
- TIGRFAMs:   TIGR01259
- TIGRFAMs:   TIGR00426

Pfam domain/function: PF00633 HHH; PF10531 SLBB; SSF47781 RuvA_2_like

EC number: NA

Molecular weight: Translated: 21770; Mature: 21770

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x105f25e0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTETENTVVKQEANNDESNE
CCCHHHHCEEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCC
TIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQVNLAEILQDGTVVYIPKK
EEEEEECCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECC
GEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGVGPSKAEAIIAYREENGRFQT
CCHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCH
IEDITKVSGIGEKSFEKIKSSITVK
HHHHHHHHCCCHHHHHHHHHHCCCH
>Mature Secondary Structure
MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTETENTVVKQEANNDESNE
CCCHHHHCEEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCC
TIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQVNLAEILQDGTVVYIPKK
EEEEEECCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECC
GEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGVGPSKAEAIIAYREENGRFQT
CCHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCH
IEDITKVSGIGEKSFEKIKSSITVK
HHHHHHHHCCCHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800