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The map label for this gene is panC

Identifier: 16079299

GI number: 16079299

Start: 2352977

End: 2353837

Strand: Reverse

Name: panC

Synonym: BSU22420

Alternate gene names: 16079299

Gene position: 2353837-2352977 (Counterclockwise)

Preceding gene: 16079300

Following gene: 16079298

Centisome position: 55.84

GC content: 43.67

Gene sequence:

>861_bases
ATGAGACAGATTACTGATATTTCACAGCTGAAAGAAGCCATAAAACAATACCATTCAGAGGGCAAGTCAATCGGATTTGT
TCCGACGATGGGGTTTCTGCATGAGGGGCATTTAACCTTAGCAGACAAAGCAAGACAAGAAAACGACGCCGTTATTATGA
GTATTTTTGTGAATCCTGCACAATTCGGCCCTAATGAAGATTTTGAAGCATATCCGCGCGATATTGAGCGGGATGCAGCT
CTTGCAGAAAACGCCGGAGTCGATATTCTTTTTACGCCAGATGCTCATGATATGTATCCCGGTGAAAAGAATGTCACGAT
TCATGTAGAAAGACGCACAGACGTGTTATGCGGGCGCTCAAGAGAAGGACATTTTGACGGGGTCGCGATCGTACTGACGA
AGCTTTTCAATCTAGTCAAGCCGACTCGTGCCTATTTCGGTTTAAAAGATGCGCAGCAGGTAGCTGTTGTTGATGGGTTA
ATCAGCGACTTCTTCATGGATATTGAATTGGTTCCTGTCGATACGGTCAGAGAGGAAGACGGCTTAGCCAAAAGCTCTCG
CAATGTATACTTAACAGCTGAGGAAAGAAAAGAAGCGCCTAAGCTGTATCGGGCCCTTCAAACAAGTGCGGAACTTGTCC
AAGCCGGTGAAAGAGATCCTGAAGCGGTGATAAAAGCTGCAAAAGATATCATTGAAACGACTAGCGGAACCATAGACTAT
GTAGAGCTTTATTCCTATCCGGAACTCGAGCCTGTGAATGAAATTGCTGGAAAGATGATTCTCGCTGTTGCAGTTGCTTT
TTCAAAAGCGCGTTTAATAGATAATATCATTATTGATATTCGAGAAATGGAGAGAATATAA

Upstream 100 bases:

>100_bases
GGATATGTTCAGGATGTAAGACATCGTGCTTTCCCTGAACAAAAGCATTCCTTTCAAATGAACCAGACAGTGCTTGACGG
CTTGTACGGGGGAAAATAAG

Downstream 100 bases:

>100_bases
TATGTATCGAACAATGATGAGCGGCAAACTTCACAGGGCAACTGTTACGGAAGCAAACCTGAACTATGTGGGAAGCATTA
CAATTGATGAAGATCTCATT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKARQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAA
LAENAGVDILFTPDAHDMYPGEKNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL
ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGERDPEAVIKAAKDIIETTSGTIDY
VELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNIIIDIREMERI

Sequences:

>Translated_286_residues
MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKARQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAA
LAENAGVDILFTPDAHDMYPGEKNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL
ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGERDPEAVIKAAKDIIETTSGTIDY
VELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNIIIDIREMERI
>Mature_286_residues
MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKARQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAA
LAENAGVDILFTPDAHDMYPGEKNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL
ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGERDPEAVIKAAKDIIETTSGTIDY
VELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNIIIDIREMERI

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=282, Percent_Identity=40.7801418439716, Blast_Score=216, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322046, Length=285, Percent_Identity=36.8421052631579, Blast_Score=178, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_BACSU (P52998)

Other databases:

- EMBL:   L47709
- EMBL:   AL009126
- PIR:   H69671
- RefSeq:   NP_390123.1
- ProteinModelPortal:   P52998
- SMR:   P52998
- EnsemblBacteria:   EBBACT00000003278
- GeneID:   939030
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU22420
- NMPDR:   fig|224308.1.peg.2246
- GenoList:   BSU22420
- GeneTree:   EBGT00050000001451
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   P52998
- ProtClustDB:   PRK00380
- BioCyc:   BSUB:BSU22420-MONOMER
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31959; Mature: 31959

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKARQENDAVIMSIFVNPA
CCCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHCCCCEEEHHHHCCCCCEEEEEEEECHH
QFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGEKNVTIHVERRTDVLCGRS
HCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCC
REGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGLISDFFMDIELVPVDTVREED
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEECCHHCCCC
GLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGERDPEAVIKAAKDIIETTSGTIDY
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEE
VELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNIIIDIREMERI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKARQENDAVIMSIFVNPA
CCCCCCHHHHHHHHHHHHHCCCCEECCCCHHHHCCCCEEEHHHHCCCCCEEEEEEEECHH
QFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGEKNVTIHVERRTDVLCGRS
HCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCC
REGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGLISDFFMDIELVPVDTVREED
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEECCHHCCCC
GLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGERDPEAVIKAAKDIIETTSGTIDY
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEE
VELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNIIIDIREMERI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377