Definition Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome.
Accession NC_000964
Length 4,215,606

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The map label for this gene is mmuM

Identifier: 16077310

GI number: 16077310

Start: 261656

End: 262603

Strand: Reverse

Name: mmuM

Synonym: BSU02410

Alternate gene names: 16077310

Gene position: 262603-261656 (Counterclockwise)

Preceding gene: 255767059

Following gene: 16077309

Centisome position: 6.23

GC content: 50.53

Gene sequence:

>948_bases
ATGAATCCTATCCAACACATATTAGATACATACCCGCTTATTGTGCTAGACGGCGCCATGGCGACCGAGCTTGAACGCAA
GGGCTGTAATTTGAATGACAGTCTGTGGTCGGCAAAAATCCTGATGGAAGAGCCGGAGCTGATTAAACAAGTTCATACTG
ATTATTTTGCGGCAGGCGCCGATTGTGCAATCACCGCCAGCTATCAGTCTACATTTGAAGGCTTTGCCGCACGCGGGCTG
AGCGAAGCGGAAGCACGCCGGCTCATCGAGTTGTCCGTCAGCATCGCAGCTGAAGCACGTGATGAATTTTGGTCGCTTGA
AGAGAACCGTTTGAATCGGCCAAAACCGATCATTGCGGCTTCTATAGGCCCTTATGGCGCTTATCTTGCAGACGGGTCTG
AGTATCGCGGCAACTACGCAATATCAGAAGATGAACTGATTGAATTTCATCGCCCCCGGATGAAGGCGCTGATTGAAGCC
GGAGCTGATGTATTGGCATGCGAAACGATTCCGTGTCTGACTGAAGCCAAAGCGATTGTTCGGCTGTTGAAGGAATTTCC
TGAAACGTATGCATGGATCAGCTTCAGTGCTAAAGACGGCTTGCATATCAGTGACGGAACACCTGCAGCTGACTGCGCAT
CGTGGCTTGATGAACACCGCCAAATTGCAGCACTCGGCATCAACTGCACGCCGCTTCAGCATATCCCTTCCTTGATAGAG
GAGTTAAAAAAGAACACGTCAAAACCGATCATTGTCTACCCGAATTCAGGTGAGCAATATGATCCGGAAACAAAAACGTG
GAACGGCGCAGCATGCGCAGAATCTTACGGGGCGAGCGCCCGCACCTGGCATGAAAAAGGAGCGAGGCTGATTGGCGGCT
GCTGCCGGACAAAACCCGAAAATATTCAAGAAATTGCGGCTTGGGCCCGCTCTTTAAAAACAACTTGA

Upstream 100 bases:

>100_bases
ACACCTTTCTCTTTTTGCGTTTATTGACAAACACGTAAGCCTCCATTACGATTTTCATATCTTTTTCAAAAAAATCTGAA
AGAAGGCATCGGTACATTCT

Downstream 100 bases:

>100_bases
CTTATCGGAATAGTTTGTATATTCTAACTTAAAGCCGGTTCGCCGGAGTCTCGTGTCACTTTCTGACATGAGATTTTTTA
TTAGGAAGGAAATAAATCGC

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEEPELIKQVHTDYFAAGADCAITASYQSTFEGFAARGL
SEAEARRLIELSVSIAAEARDEFWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA
GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDEHRQIAALGINCTPLQHIPSLIE
ELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESYGASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT

Sequences:

>Translated_315_residues
MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEEPELIKQVHTDYFAAGADCAITASYQSTFEGFAARGL
SEAEARRLIELSVSIAAEARDEFWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA
GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDEHRQIAALGINCTPLQHIPSLIE
ELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESYGASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT
>Mature_315_residues
MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEEPELIKQVHTDYFAAGADCAITASYQSTFEGFAARGL
SEAEARRLIELSVSIAAEARDEFWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA
GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDEHRQIAALGINCTPLQHIPSLIE
ELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESYGASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT

Specific function: Catalyzes Methyl Transfer From S-Methylmethionine Or S- Adenosylmethionine (Less Efficient) To Homocysteine, Selenohomocysteine And Less Efficiently Selenocysteine. [C]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain

Homologues:

Organism=Homo sapiens, GI169790923, Length=330, Percent_Identity=29.0909090909091, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786456, Length=308, Percent_Identity=52.2727272727273, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1790450, Length=330, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322966, Length=328, Percent_Identity=27.4390243902439, Blast_Score=138, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6324982, Length=334, Percent_Identity=28.4431137724551, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323983, Length=89, Percent_Identity=40.4494382022472, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24585077, Length=320, Percent_Identity=34.6875, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI20129603, Length=319, Percent_Identity=33.8557993730408, Blast_Score=175, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMT_BACSU (O31463)

Other databases:

- EMBL:   AB006424
- EMBL:   AL009126
- PIR:   B69751
- RefSeq:   NP_388123.1
- ProteinModelPortal:   O31463
- SMR:   O31463
- EnsemblBacteria:   EBBACT00000004040
- GeneID:   938412
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU02410
- NMPDR:   fig|224308.1.peg.242
- GenoList:   BSU02410
- GeneTree:   EBGT00050000001526
- HOGENOM:   HBG395798
- OMA:   QPKEATA
- PhylomeDB:   O31463
- ProtClustDB:   PRK09485
- BioCyc:   BSUB:BSU02410-MONOMER
- InterPro:   IPR003726
- Gene3D:   G3DSA:3.20.20.330

Pfam domain/function: PF02574 S-methyl_trans; SSF82282 S_methyl_trans

EC number: =2.1.1.10

Molecular weight: Translated: 34737; Mature: 34737

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEEPELIKQVHTDYFAAGA
CCHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
DCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDEFWSLEENRLNRPKPIIAA
CEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEE
SIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEAGADVLACETIPCLTEAKAIV
CCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
RLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDEHRQIAALGINCTPLQHIPSLIE
HHHHHCCHHEEEEEEECCCCEEECCCCCHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHH
ELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESYGASARTWHEKGARLIGGCCRTKPE
HHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
NIQEIAAWARSLKTT
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEEPELIKQVHTDYFAAGA
CCHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
DCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDEFWSLEENRLNRPKPIIAA
CEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEE
SIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEAGADVLACETIPCLTEAKAIV
CCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
RLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDEHRQIAALGINCTPLQHIPSLIE
HHHHHCCHHEEEEEEECCCCEEECCCCCHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHH
ELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESYGASARTWHEKGARLIGGCCRTKPE
HHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
NIQEIAAWARSLKTT
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377