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The map label for this gene is manB [H]

Identifier: 159901206

GI number: 159901206

Start: 5997026

End: 5998366

Strand: Direct

Name: manB [H]

Synonym: Haur_4694

Alternate gene names: 159901206

Gene position: 5997026-5998366 (Clockwise)

Preceding gene: 159901205

Following gene: 159901207

Centisome position: 94.49

GC content: 50.19

Gene sequence:

>1341_bases
ATGCAGGTCAATCCAGGGATTTTCAAAGCCTATGATATTCGCGGGATTTACCCCAGCGAACTCAACGAAGATGTAGCTTT
TTTGATTGGACGCGCTTTCGCCTCATTTTTGCAAGCTGAAACGGTGGTCGTTGGCCGCGATATGCGCACCTCAGGCCCAT
CGATTTTCGATGCGGTGACGCGGGGCTTGATGCACCAAGGCGCTGATGTGATCAACATCGGGATGGTTAGCACCGATCAA
TATTATTTTGCTTGTACCAAATTGGGCTTGCCGGGCATGATGGTGACGGCCTCGCACAACCCCAAACAATACAATGGCTT
CAAAATGGTCAAAAAAATGCCCCAATTGCTCTCAGGCGATGCCGGCATTCAAGATTTGCGCAAATTGGTCGAGAGCGAAG
CATTTGATGAACCAACTCGCCAAGGCAGCATGAGCGAGCTTGACCTGAGCGAAGAATTTATCGAATCGGTCTTGCAATTG
ATCGATGTAGCCAGCCTCAAATCACTCAAAGTAATCGCCGACACGGGCAATGGCATGGTCGGGCCAATTCTCCAACGGGT
CTACGAACGCTTGCCTGTCGAATTAATTGGCCTGTATCTTGACCCCGATGGCACCTTGCCTAACCACGGGCTTGACCCAT
TGCAACCAGAAAATCGCGCCGAATTGGAGGCTCGCGTGGTCAGCGAAAACGCTGATGTGGGCTTTGCCTTCGATGGCGAC
GGCGATCGCTTCTTTGCAATCGACAATCGCGGCCAATTTATCTCTGGCGATTTTATGACCGCGCTGATGGGTCAATACTT
CCTCGAAAAACACCCAGGAGCCAAAATTTTATATGATGTACGGGCTTCGTGGGCCGTGCCCGAACTAATTGGGGCTGCTG
GTGGTGTGCCGCTGATGGAGCGGGTTGGTCATGCCTTTATCAAAGCTCGCATGTCCAACGAAGGGGCAATTTTCGCGGGC
GAAGTGACAGGCCACTACTATTTTGGCGATTTCAATTATGCCGATTCAGGCGTGATTCCATCGCTGATTATTTTGGAGAT
GCTTTCGAAGAAGGGCAAAACTCTGAGCGAATTGCTGGCTCCGCTCGAAGCAACCTACTTTATCTCAGGCGAAATCAACA
CCAAAGTTGCCGATGTTAAAGCTGTATTGGCAACTTTAGCCGAAAAATATAGCGATGCTGAGCAACACACCATGGATGGT
CTATCGGTCAATTATCTCGATTGGCACTTCAATGTGCGCGGCTCCAACACTGAGCCATTGTTGCGGCTCAACCTCGAAGC
CCGCAGCAAAGAATTGATGGAAGCTAAGCGCGATGAAGTTTTAGCCATTATTCAAGGGTAA

Upstream 100 bases:

>100_bases
TGATTATATAAGCAATCAAAGATAAAAATCCTGCTATTCGCGATTTAACAATTTTGGCGTATGATAGCCTGTGATCGCTC
TGCACAGAAAGGATACGACG

Downstream 100 bases:

>100_bases
ACGAAGACTCAAGGGCTAGGTTTAATGGTTCATTGGTTTGGCAATGAATTGCATACCCTCACCCCCTGTCCCGCCCGCGA
GACCATGGGGAACCGCTCCA

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MQVNPGIFKAYDIRGIYPSELNEDVAFLIGRAFASFLQAETVVVGRDMRTSGPSIFDAVTRGLMHQGADVINIGMVSTDQ
YYFACTKLGLPGMMVTASHNPKQYNGFKMVKKMPQLLSGDAGIQDLRKLVESEAFDEPTRQGSMSELDLSEEFIESVLQL
IDVASLKSLKVIADTGNGMVGPILQRVYERLPVELIGLYLDPDGTLPNHGLDPLQPENRAELEARVVSENADVGFAFDGD
GDRFFAIDNRGQFISGDFMTALMGQYFLEKHPGAKILYDVRASWAVPELIGAAGGVPLMERVGHAFIKARMSNEGAIFAG
EVTGHYYFGDFNYADSGVIPSLIILEMLSKKGKTLSELLAPLEATYFISGEINTKVADVKAVLATLAEKYSDAEQHTMDG
LSVNYLDWHFNVRGSNTEPLLRLNLEARSKELMEAKRDEVLAIIQG

Sequences:

>Translated_446_residues
MQVNPGIFKAYDIRGIYPSELNEDVAFLIGRAFASFLQAETVVVGRDMRTSGPSIFDAVTRGLMHQGADVINIGMVSTDQ
YYFACTKLGLPGMMVTASHNPKQYNGFKMVKKMPQLLSGDAGIQDLRKLVESEAFDEPTRQGSMSELDLSEEFIESVLQL
IDVASLKSLKVIADTGNGMVGPILQRVYERLPVELIGLYLDPDGTLPNHGLDPLQPENRAELEARVVSENADVGFAFDGD
GDRFFAIDNRGQFISGDFMTALMGQYFLEKHPGAKILYDVRASWAVPELIGAAGGVPLMERVGHAFIKARMSNEGAIFAG
EVTGHYYFGDFNYADSGVIPSLIILEMLSKKGKTLSELLAPLEATYFISGEINTKVADVKAVLATLAEKYSDAEQHTMDG
LSVNYLDWHFNVRGSNTEPLLRLNLEARSKELMEAKRDEVLAIIQG
>Mature_446_residues
MQVNPGIFKAYDIRGIYPSELNEDVAFLIGRAFASFLQAETVVVGRDMRTSGPSIFDAVTRGLMHQGADVINIGMVSTDQ
YYFACTKLGLPGMMVTASHNPKQYNGFKMVKKMPQLLSGDAGIQDLRKLVESEAFDEPTRQGSMSELDLSEEFIESVLQL
IDVASLKSLKVIADTGNGMVGPILQRVYERLPVELIGLYLDPDGTLPNHGLDPLQPENRAELEARVVSENADVGFAFDGD
GDRFFAIDNRGQFISGDFMTALMGQYFLEKHPGAKILYDVRASWAVPELIGAAGGVPLMERVGHAFIKARMSNEGAIFAG
EVTGHYYFGDFNYADSGVIPSLIILEMLSKKGKTLSELLAPLEATYFISGEINTKVADVKAVLATLAEKYSDAEQHTMDG
LSVNYLDWHFNVRGSNTEPLLRLNLEARSKELMEAKRDEVLAIIQG

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=457, Percent_Identity=42.8884026258206, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1789566, Length=447, Percent_Identity=25.7270693512304, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 48985; Mature: 48985

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVNPGIFKAYDIRGIYPSELNEDVAFLIGRAFASFLQAETVVVGRDMRTSGPSIFDAVT
CCCCCCCEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCHHHHHHH
RGLMHQGADVINIGMVSTDQYYFACTKLGLPGMMVTASHNPKQYNGFKMVKKMPQLLSGD
HHHHHCCCCEEEEEEEECCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCC
AGIQDLRKLVESEAFDEPTRQGSMSELDLSEEFIESVLQLIDVASLKSLKVIADTGNGMV
CCHHHHHHHHHHHCCCCCHHCCCCHHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCH
GPILQRVYERLPVELIGLYLDPDGTLPNHGLDPLQPENRAELEARVVSENADVGFAFDGD
HHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHEEEECCCCEEEEEECC
GDRFFAIDNRGQFISGDFMTALMGQYFLEKHPGAKILYDVRASWAVPELIGAAGGVPLME
CCEEEEECCCCCEECHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCHHHH
RVGHAFIKARMSNEGAIFAGEVTGHYYFGDFNYADSGVIPSLIILEMLSKKGKTLSELLA
HHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHC
PLEATYFISGEINTKVADVKAVLATLAEKYSDAEQHTMDGLSVNYLDWHFNVRGSNTEPL
CHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEEEEEEECCCCCCCE
LRLNLEARSKELMEAKRDEVLAIIQG
EEEECHHHHHHHHHHHHCCEEEEECC
>Mature Secondary Structure
MQVNPGIFKAYDIRGIYPSELNEDVAFLIGRAFASFLQAETVVVGRDMRTSGPSIFDAVT
CCCCCCCEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCHHHHHHH
RGLMHQGADVINIGMVSTDQYYFACTKLGLPGMMVTASHNPKQYNGFKMVKKMPQLLSGD
HHHHHCCCCEEEEEEEECCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCC
AGIQDLRKLVESEAFDEPTRQGSMSELDLSEEFIESVLQLIDVASLKSLKVIADTGNGMV
CCHHHHHHHHHHHCCCCCHHCCCCHHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCH
GPILQRVYERLPVELIGLYLDPDGTLPNHGLDPLQPENRAELEARVVSENADVGFAFDGD
HHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHEEEECCCCEEEEEECC
GDRFFAIDNRGQFISGDFMTALMGQYFLEKHPGAKILYDVRASWAVPELIGAAGGVPLME
CCEEEEECCCCCEECHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCHHHH
RVGHAFIKARMSNEGAIFAGEVTGHYYFGDFNYADSGVIPSLIILEMLSKKGKTLSELLA
HHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHC
PLEATYFISGEINTKVADVKAVLATLAEKYSDAEQHTMDGLSVNYLDWHFNVRGSNTEPL
CHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEEEEEEECCCCCCCE
LRLNLEARSKELMEAKRDEVLAIIQG
EEEECHHHHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]