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The map label for this gene is serS

Identifier: 159900855

GI number: 159900855

Start: 5550589

End: 5551857

Strand: Reverse

Name: serS

Synonym: Haur_4342

Alternate gene names: 159900855

Gene position: 5551857-5550589 (Counterclockwise)

Preceding gene: 159900856

Following gene: 159900853

Centisome position: 87.48

GC content: 49.88

Gene sequence:

>1269_bases
ATGCTTGATATTCGTTTATTTCGTGAACAACCCGAGTTGGTACGCGAAGGCTTTGCCAAAGTTGGTCGTGATCCAGGTTT
AGTCGATCAGGTGATTGGCTTGGATCTTAAACGGCGCGAGGCGATTACCGAAGTTGAGCGGCTCAAGGCCGAGCGCAATG
CTGGCTCGAAAGATGTGGCCCGCACTAAAGATAAGGCTGAACGCGACGTGAAAATTGCCGCCATGAAGCTGGTTGGCGAT
CAAATTACTGAACTCGATGCACAGGCAAATGCAATCGATTTGGAATTGCACAATCTTCTGCTCGATTTACCTAACTTGCC
GTTGCCCGAAGTGCCTGTTGGCAAGGATGAACACGATAATGTTGTGGTGCGGGTCGAAGGTACAATCCAAGAGCCTGATT
TTGCGGTTAAGCCACACTGGGAGCTAGGCGAAGCCCTCGGGATTCTCGATTTTGAGCGAGGCGTGCGCATGAGTGGTACA
CGCTTTTTCGTGATGAAAGGCTTGGGCGTGCGCTTGCAACGGGCCTTGATTAGCTGGATGATCGATATGCATGTTGATCA
GCATGGTTACACCGAATTGGCCGTGCCCTACTTGGTTAAGGCCGATGCCATGGTTGGCACTGGCAACTTGCCCAAATTTG
CCGACACGATTTTTCATATCGAAGATACCGATTTATGGCTGATTCCGACCGCTGAAGTGCCAGTTACCAACTTGCATCGC
GAAGAAATTTTAGATAAAGCTCAATTGCCATTACGCTATGTGGCGCATACCCCATGTTTCCGCAACGAGCAAATGAGCGC
TGGACGTGATGTCCGTGGCATCAAGCGGCTGTATCAATTCGATAAAGTCGAGATGGTCAAAATGGTTGAGCCAGCTACCA
GCTACGATGAATTATTCTCGCTGATTAGCAATGCTGAGGATGTTTGCAAAGGCTTGAAAATTCCTTATCGCTTGTTGCAA
TTGTGCACCGCCGATTTGGGCATTGCCACGGTCAAGTACGATTTGGAAATGTGGGCACCTGGCATGAACGAATGGCTGGA
AGTTTCGTCGTGTGGCTTGTTTGGTGATTATCAAGCTCGTCGTGCCAATATTCGCTATCGCCCCGAAGCTGGGGCAAAAC
CTGAGTTTGTGCATACATTGAATGGTTCGGGCTTGGCTTTGCCACGGGTGATCATCGCGATTCTCGAAAATTATCAAAAT
GCTGATGGCAGCGTGACGGTTCCCGAAGTGCTGCGACCGTACATGGGCGGCATCGAACGGATTGGGTAA

Upstream 100 bases:

>100_bases
ATGTGGCATTTGGGGTGATTCGCCCAGGAATTGTTGTCGCAATCGAGGAATTAGATCATCTTGCTGCGTCAGCCGACGCA
TAATGTGAAGGAGTATTGCA

Downstream 100 bases:

>100_bases
TATTAGGGGGCAGGGGTTGGGGGTCAGGGGTCAGGAAACGCTGTGGTGAAACAGAAAGCAGCAGAATAATCAAAATAATC
TGTGCTCATCTGTGGCTAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLDIRLFREQPELVREGFAKVGRDPGLVDQVIGLDLKRREAITEVERLKAERNAGSKDVARTKDKAERDVKIAAMKLVGD
QITELDAQANAIDLELHNLLLDLPNLPLPEVPVGKDEHDNVVVRVEGTIQEPDFAVKPHWELGEALGILDFERGVRMSGT
RFFVMKGLGVRLQRALISWMIDMHVDQHGYTELAVPYLVKADAMVGTGNLPKFADTIFHIEDTDLWLIPTAEVPVTNLHR
EEILDKAQLPLRYVAHTPCFRNEQMSAGRDVRGIKRLYQFDKVEMVKMVEPATSYDELFSLISNAEDVCKGLKIPYRLLQ
LCTADLGIATVKYDLEMWAPGMNEWLEVSSCGLFGDYQARRANIRYRPEAGAKPEFVHTLNGSGLALPRVIIAILENYQN
ADGSVTVPEVLRPYMGGIERIG

Sequences:

>Translated_422_residues
MLDIRLFREQPELVREGFAKVGRDPGLVDQVIGLDLKRREAITEVERLKAERNAGSKDVARTKDKAERDVKIAAMKLVGD
QITELDAQANAIDLELHNLLLDLPNLPLPEVPVGKDEHDNVVVRVEGTIQEPDFAVKPHWELGEALGILDFERGVRMSGT
RFFVMKGLGVRLQRALISWMIDMHVDQHGYTELAVPYLVKADAMVGTGNLPKFADTIFHIEDTDLWLIPTAEVPVTNLHR
EEILDKAQLPLRYVAHTPCFRNEQMSAGRDVRGIKRLYQFDKVEMVKMVEPATSYDELFSLISNAEDVCKGLKIPYRLLQ
LCTADLGIATVKYDLEMWAPGMNEWLEVSSCGLFGDYQARRANIRYRPEAGAKPEFVHTLNGSGLALPRVIIAILENYQN
ADGSVTVPEVLRPYMGGIERIG
>Mature_422_residues
MLDIRLFREQPELVREGFAKVGRDPGLVDQVIGLDLKRREAITEVERLKAERNAGSKDVARTKDKAERDVKIAAMKLVGD
QITELDAQANAIDLELHNLLLDLPNLPLPEVPVGKDEHDNVVVRVEGTIQEPDFAVKPHWELGEALGILDFERGVRMSGT
RFFVMKGLGVRLQRALISWMIDMHVDQHGYTELAVPYLVKADAMVGTGNLPKFADTIFHIEDTDLWLIPTAEVPVTNLHR
EEILDKAQLPLRYVAHTPCFRNEQMSAGRDVRGIKRLYQFDKVEMVKMVEPATSYDELFSLISNAEDVCKGLKIPYRLLQ
LCTADLGIATVKYDLEMWAPGMNEWLEVSSCGLFGDYQARRANIRYRPEAGAKPEFVHTLNGSGLALPRVIIAILENYQN
ADGSVTVPEVLRPYMGGIERIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=466, Percent_Identity=32.4034334763949, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI8923421, Length=393, Percent_Identity=31.8066157760814, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI225579074, Length=400, Percent_Identity=32, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1787120, Length=432, Percent_Identity=47.2222222222222, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17539260, Length=470, Percent_Identity=31.9148936170213, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=327, Percent_Identity=28.4403669724771, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=32.579185520362, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321799, Length=399, Percent_Identity=28.3208020050125, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24581334, Length=464, Percent_Identity=31.6810344827586, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17737985, Length=363, Percent_Identity=32.5068870523416, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_HERA2 (A9AY92)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001547102.1
- ProteinModelPortal:   A9AY92
- SMR:   A9AY92
- GeneID:   5736202
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4342
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- BioCyc:   HAUR316274:HAUR_4342-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47436; Mature: 47436

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIRLFREQPELVREGFAKVGRDPGLVDQVIGLDLKRREAITEVERLKAERNAGSKDVA
CCCCEEHHCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHH
RTKDKAERDVKIAAMKLVGDQITELDAQANAIDLELHNLLLDLPNLPLPEVPVGKDEHDN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCC
VVVRVEGTIQEPDFAVKPHWELGEALGILDFERGVRMSGTRFFVMKGLGVRLQRALISWM
EEEEEECCCCCCCCCCCCCHHHHHHHCCEECCCCCCCCCCEEEEECCCCHHHHHHHHHHH
IDMHVDQHGYTELAVPYLVKADAMVGTGNLPKFADTIFHIEDTDLWLIPTAEVPVTNLHR
HHHHCCCCCCCHHHHHHHEECCCEECCCCCCHHHHHEEEEECCCEEEEECCCCCCCCCCH
EEILDKAQLPLRYVAHTPCFRNEQMSAGRDVRGIKRLYQFDKVEMVKMVEPATSYDELFS
HHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LISNAEDVCKGLKIPYRLLQLCTADLGIATVKYDLEMWAPGMNEWLEVSSCGLFGDYQAR
HHHCHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEHHHCCCCHHHHHHHHCCCCCCCCHHH
RANIRYRPEAGAKPEFVHTLNGSGLALPRVIIAILENYQNADGSVTVPEVLRPYMGGIER
HCCEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHH
IG
CC
>Mature Secondary Structure
MLDIRLFREQPELVREGFAKVGRDPGLVDQVIGLDLKRREAITEVERLKAERNAGSKDVA
CCCCEEHHCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHH
RTKDKAERDVKIAAMKLVGDQITELDAQANAIDLELHNLLLDLPNLPLPEVPVGKDEHDN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCC
VVVRVEGTIQEPDFAVKPHWELGEALGILDFERGVRMSGTRFFVMKGLGVRLQRALISWM
EEEEEECCCCCCCCCCCCCHHHHHHHCCEECCCCCCCCCCEEEEECCCCHHHHHHHHHHH
IDMHVDQHGYTELAVPYLVKADAMVGTGNLPKFADTIFHIEDTDLWLIPTAEVPVTNLHR
HHHHCCCCCCCHHHHHHHEECCCEECCCCCCHHHHHEEEEECCCEEEEECCCCCCCCCCH
EEILDKAQLPLRYVAHTPCFRNEQMSAGRDVRGIKRLYQFDKVEMVKMVEPATSYDELFS
HHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LISNAEDVCKGLKIPYRLLQLCTADLGIATVKYDLEMWAPGMNEWLEVSSCGLFGDYQAR
HHHCHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEHHHCCCCHHHHHHHHCCCCCCCCHHH
RANIRYRPEAGAKPEFVHTLNGSGLALPRVIIAILENYQNADGSVTVPEVLRPYMGGIER
HCCEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHH
IG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA