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The map label for this gene is ybdL [H]

Identifier: 159900419

GI number: 159900419

Start: 4894787

End: 4895950

Strand: Reverse

Name: ybdL [H]

Synonym: Haur_3904

Alternate gene names: 159900419

Gene position: 4895950-4894787 (Counterclockwise)

Preceding gene: 159900420

Following gene: 159900418

Centisome position: 77.14

GC content: 49.23

Gene sequence:

>1164_bases
GTGCATCCCAAATCCGCCAATCGCTTAGCTGGCTTTGGTACATCAATTTTTAGTGAAATAAGTGCTTTGGCTGCGCGTTA
TCAAGCGATTAATCTCGGCCAAGGCTTTCCTGATTTTGCTGGCCCAGCATTTTTAAAAGATGCTGCTTGTAGCGCTATCA
ACGCTGATCTCAATCAATATGCGCCAAGCACTGGCTTGCCAACCTTGCGAGCGGCGATTGCGCGGACATGGGAACGTCAT
AGCAAGGCCTCAGTTGACCCCGACGCTGAAATTACCGTAACTAGCGGGGCAACTGAAGCTATGTTTGCCATAATTATGGC
GTTGATTAACCCTGGCGATGAGGTTTTGATTTTCGAGCCGTTCTATGATTCGTATCCGCCGAATGTGCTGATGGCGGGAG
GCATACCACGTTATATTCGCTTGCACGAGCCACGCTGGGATGTGGATTTTGCTCAAGTTCGTGCCGCAATTACTCCCCAA
ACCAAGGCGATTATTTTGAACACGCCGCATAATCCCACAGGCAAGGTTTGGTCGCGGGCCGAATTGAGCCAATTAGCAAC
GATTGCAATCGAGCATGATCTCTTGGTGATCAGCGATGAAGTTTATGATCGTTTGGTGTTTGAGGATTATCAGCATTGCT
CGATTGCCACCTTGCCCGGCATGTGGGATCGTACAATCACCATCAGTAGCACTGGCAAAACCTTTAGCGTCACAGGCTGG
AAAATTGGTTATGCAATTGCCCCCAATTCATTAACTGAGGCAATTCGGCGGGTGCATCAATTTGTGACCTTTGCCAGTGC
CACGCCCTTGCAAGCAGCAGCGGTGGTTGGTTTAAACGCTGGCGAACCCTATGAACGCCAACTATTGCAATTTTATAATG
CCCGCCGCGAGCAATTGGTGAAGGTCTTGCGCGATGCTGGATTGTATGTGTTGCCGCCGCAAGGCACCTATTTCGTAATG
GCTGATATTCGTGATTTGGGCTGGGAGAATGATGCAGAATTTTGCCGTTATCTGATTAGCGAAATTGGCGTGGCGGCAAT
TCCACCCTCAGCGTTTTACCACGATGGCTATCAATCAGGGATGGTACGCTTTTGCTTTGCCAAAAAGCCCGAAACAATTG
CTGCCGCCGCTGAAAAACTCAAGCAATTAGGGAGTCGAAGCTAA

Upstream 100 bases:

>100_bases
GTTGATACCACTGTCGCGCTTGATGATCTCGCCGGAATTGTGCGCGTGGCCACCGAAGGCGGCGCTGGTAAAGTTGTGAT
TACAGGCTAGGAGGCTCGTT

Downstream 100 bases:

>100_bases
TGCGTTTTCCCAAATCTCAAGCGTTACAACTGCATTCGTGCTTCGAAGAATTGATTCCAGGTCGCATGCATACGAGCGGC
CAGCGCTTCTTGCCTTTAAT

Product: class I and II aminotransferase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MHPKSANRLAGFGTSIFSEISALAARYQAINLGQGFPDFAGPAFLKDAACSAINADLNQYAPSTGLPTLRAAIARTWERH
SKASVDPDAEITVTSGATEAMFAIIMALINPGDEVLIFEPFYDSYPPNVLMAGGIPRYIRLHEPRWDVDFAQVRAAITPQ
TKAIILNTPHNPTGKVWSRAELSQLATIAIEHDLLVISDEVYDRLVFEDYQHCSIATLPGMWDRTITISSTGKTFSVTGW
KIGYAIAPNSLTEAIRRVHQFVTFASATPLQAAAVVGLNAGEPYERQLLQFYNARREQLVKVLRDAGLYVLPPQGTYFVM
ADIRDLGWENDAEFCRYLISEIGVAAIPPSAFYHDGYQSGMVRFCFAKKPETIAAAAEKLKQLGSRS

Sequences:

>Translated_387_residues
MHPKSANRLAGFGTSIFSEISALAARYQAINLGQGFPDFAGPAFLKDAACSAINADLNQYAPSTGLPTLRAAIARTWERH
SKASVDPDAEITVTSGATEAMFAIIMALINPGDEVLIFEPFYDSYPPNVLMAGGIPRYIRLHEPRWDVDFAQVRAAITPQ
TKAIILNTPHNPTGKVWSRAELSQLATIAIEHDLLVISDEVYDRLVFEDYQHCSIATLPGMWDRTITISSTGKTFSVTGW
KIGYAIAPNSLTEAIRRVHQFVTFASATPLQAAAVVGLNAGEPYERQLLQFYNARREQLVKVLRDAGLYVLPPQGTYFVM
ADIRDLGWENDAEFCRYLISEIGVAAIPPSAFYHDGYQSGMVRFCFAKKPETIAAAAEKLKQLGSRS
>Mature_387_residues
MHPKSANRLAGFGTSIFSEISALAARYQAINLGQGFPDFAGPAFLKDAACSAINADLNQYAPSTGLPTLRAAIARTWERH
SKASVDPDAEITVTSGATEAMFAIIMALINPGDEVLIFEPFYDSYPPNVLMAGGIPRYIRLHEPRWDVDFAQVRAAITPQ
TKAIILNTPHNPTGKVWSRAELSQLATIAIEHDLLVISDEVYDRLVFEDYQHCSIATLPGMWDRTITISSTGKTFSVTGW
KIGYAIAPNSLTEAIRRVHQFVTFASATPLQAAAVVGLNAGEPYERQLLQFYNARREQLVKVLRDAGLYVLPPQGTYFVM
ADIRDLGWENDAEFCRYLISEIGVAAIPPSAFYHDGYQSGMVRFCFAKKPETIAAAAEKLKQLGSRS

Specific function: Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=408, Percent_Identity=39.9509803921569, Blast_Score=295, Evalue=7e-80,
Organism=Homo sapiens, GI56713256, Length=408, Percent_Identity=39.9509803921569, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI95147551, Length=412, Percent_Identity=37.8640776699029, Blast_Score=285, Evalue=3e-77,
Organism=Homo sapiens, GI169881279, Length=412, Percent_Identity=37.8640776699029, Blast_Score=285, Evalue=3e-77,
Organism=Homo sapiens, GI169881281, Length=412, Percent_Identity=33.9805825242718, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI4507369, Length=317, Percent_Identity=26.813880126183, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI7705897, Length=358, Percent_Identity=25.1396648044693, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI33469970, Length=358, Percent_Identity=25.1396648044693, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4885351, Length=351, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786816, Length=377, Percent_Identity=44.2970822281167, Blast_Score=340, Evalue=6e-95,
Organism=Escherichia coli, GI1788722, Length=386, Percent_Identity=29.2746113989637, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1788627, Length=189, Percent_Identity=33.8624338624339, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1787909, Length=266, Percent_Identity=25.9398496240602, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=418, Percent_Identity=38.755980861244, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71994476, Length=418, Percent_Identity=38.755980861244, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17567369, Length=403, Percent_Identity=33.2506203473945, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17567663, Length=379, Percent_Identity=25.5936675461741, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322401, Length=388, Percent_Identity=35.8247422680412, Blast_Score=246, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6320317, Length=343, Percent_Identity=22.7405247813411, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28573069, Length=409, Percent_Identity=39.6088019559902, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24646114, Length=409, Percent_Identity=39.6088019559902, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI28573067, Length=409, Percent_Identity=39.6088019559902, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI28573065, Length=409, Percent_Identity=39.6088019559902, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI18859735, Length=347, Percent_Identity=26.5129682997118, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 42525; Mature: 42525

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPKSANRLAGFGTSIFSEISALAARYQAINLGQGFPDFAGPAFLKDAACSAINADLNQY
CCCCCCCHHHHCHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHCCHHHC
APSTGLPTLRAAIARTWERHSKASVDPDAEITVTSGATEAMFAIIMALINPGDEVLIFEP
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECC
FYDSYPPNVLMAGGIPRYIRLHEPRWDVDFAQVRAAITPQTKAIILNTPHNPTGKVWSRA
CCCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
ELSQLATIAIEHDLLVISDEVYDRLVFEDYQHCSIATLPGMWDRTITISSTGKTFSVTGW
HHHHHHHHEEECCEEEECHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCEEEECCE
KIGYAIAPNSLTEAIRRVHQFVTFASATPLQAAAVVGLNAGEPYERQLLQFYNARREQLV
EEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHHHHH
KVLRDAGLYVLPPQGTYFVMADIRDLGWENDAEFCRYLISEIGVAAIPPSAFYHDGYQSG
HHHHHCCEEEECCCCCEEEEEEHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCHHCC
MVRFCFAKKPETIAAAAEKLKQLGSRS
CEEEEECCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHPKSANRLAGFGTSIFSEISALAARYQAINLGQGFPDFAGPAFLKDAACSAINADLNQY
CCCCCCCHHHHCHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHCCHHHC
APSTGLPTLRAAIARTWERHSKASVDPDAEITVTSGATEAMFAIIMALINPGDEVLIFEP
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECC
FYDSYPPNVLMAGGIPRYIRLHEPRWDVDFAQVRAAITPQTKAIILNTPHNPTGKVWSRA
CCCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
ELSQLATIAIEHDLLVISDEVYDRLVFEDYQHCSIATLPGMWDRTITISSTGKTFSVTGW
HHHHHHHHEEECCEEEECHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCEEEECCE
KIGYAIAPNSLTEAIRRVHQFVTFASATPLQAAAVVGLNAGEPYERQLLQFYNARREQLV
EEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHHHHH
KVLRDAGLYVLPPQGTYFVMADIRDLGWENDAEFCRYLISEIGVAAIPPSAFYHDGYQSG
HHHHHCCEEEECCCCCEEEEEEHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCHHCC
MVRFCFAKKPETIAAAAEKLKQLGSRS
CEEEEECCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]