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The map label for this gene is epsD [H]

Identifier: 159900344

GI number: 159900344

Start: 4805299

End: 4806615

Strand: Direct

Name: epsD [H]

Synonym: Haur_3827

Alternate gene names: 159900344

Gene position: 4805299-4806615 (Clockwise)

Preceding gene: 159900343

Following gene: 159900345

Centisome position: 75.71

GC content: 50.95

Gene sequence:

>1317_bases
GTGAGTACCTTTGCAGATTTACGCAGCGCGATCGAAACACGACGTGCGCAAGTTGGGGTTATTGGCATGGGCTATGTTGG
CTTGCCAATGTTGGCTCGGGCTGGCAACGTTGGATTCAATGTGCTAGGCTTCGATATTAGTGCTGAACGAATTGCCAGCA
TCAACGAGGGCGTGAGCTATATCGGCGATGTGCCAAGCAGCGATTTGGCCGCGCTCCGCAATAATAAGTTGATCGAAGCA
ACCGCCCAATTTGAGCGATTGCGCGATTGCGACATTATTATTATTTGTATGCCGACCCCACTCAACGAAGCTCGCGACCC
CGATATGAGCTATATCGAATCGGCGACCAACGAGATTGCCGCGCGACTCCGCCCAGGCCAATTGATTATTCTTGAAAGCA
CCACCTACCCCGGCACCACGGTTGAAGTGCTCAAACCAGCCTTTGATGCTTGCAATCTCAGCGTGGGCGCAGATTATTTC
TTGGCCTTTTCGCCCGAGCGGATCGATCCTGGCTCGGTTAATTTCAAGGTGCACAATATTCCCAAGGTGGTTGGTGGAGT
TACGCCGCAGTGCAACGAGCTAACCTCGTTGTTCTACGGCCATATCGTAACTGCGGTAACCGAAGTTTCATCGCCAGCCG
CCGCCGAAATGACCAAATTGTTCGAGAATATTTTCCGCAACGTCAATATTGCCTTGGTCAACGAATTAACTCTAATCTGC
GATCGCATGGGCTTGAATGTTTGGGAAATTATCGATGCTGCCGCAACCAAGCCATTTGGGTTTATGCGCTTTACCCCAGG
CCCAGGTTTGGGCGGCCACTGTATCCCGCTTGATCCCTTCTATTTGGCTTGGAAGGCGCGGCATTACGATATTTCGGCGC
GTTTTATCGAGCTAGCAGGCGAGATCAATTTGACCATGCCGCGCTTTGTGCGCGATCGCATCAGCCATGCGCTGAATGAT
CAAGAACGTAGCATCAAAGGCTCAACGGTTGTACTGCTCGGGGTGGCCTACAAAAAAGACATCGACGACTACCGCGAATC
GCCAATTTTCAAAGTAATGGATTTGTTGGCGGCTGATGGGGCCAATGTGTACTGTTGCGATCCCCATGTAACCGTCTTTT
ATGATCACCATAATCATGAATACCAAACCGTGCCACTGACTGATGAACTACTACAGCAAGCCCATTGTACGGTAATTGTG
ACCGATCACAGTGCCTTCGATTATGCCAAGATCGTCGAGCAAAGTCGCGTGGTTGTGGATACCCGCAACGCCACCCGCGA
GGTCAAAAGCCACCGCGAAAAAATTCGTTTGTTGTAA

Upstream 100 bases:

>100_bases
TGAGGGGGCTTAACAACAATCGTTCTCGTGCCAAGCTTATTTGGCACATGGGTTTCAGTTTCGCATAGATGCCAATCTAT
GAAACAATAAAGGATTTAGT

Downstream 100 bases:

>100_bases
AGCGAGCGTAATCACGAAGCCATAAATCTTTTGAGCCACGAAGGACACGAAGCGCACGAAGGACGAGGGATGAGGGATCA
GCAGTCAGGGATCAGTTAAT

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSTFADLRSAIETRRAQVGVIGMGYVGLPMLARAGNVGFNVLGFDISAERIASINEGVSYIGDVPSSDLAALRNNKLIEA
TAQFERLRDCDIIIICMPTPLNEARDPDMSYIESATNEIAARLRPGQLIILESTTYPGTTVEVLKPAFDACNLSVGADYF
LAFSPERIDPGSVNFKVHNIPKVVGGVTPQCNELTSLFYGHIVTAVTEVSSPAAAEMTKLFENIFRNVNIALVNELTLIC
DRMGLNVWEIIDAAATKPFGFMRFTPGPGLGGHCIPLDPFYLAWKARHYDISARFIELAGEINLTMPRFVRDRISHALND
QERSIKGSTVVLLGVAYKKDIDDYRESPIFKVMDLLAADGANVYCCDPHVTVFYDHHNHEYQTVPLTDELLQQAHCTVIV
TDHSAFDYAKIVEQSRVVVDTRNATREVKSHREKIRLL

Sequences:

>Translated_438_residues
MSTFADLRSAIETRRAQVGVIGMGYVGLPMLARAGNVGFNVLGFDISAERIASINEGVSYIGDVPSSDLAALRNNKLIEA
TAQFERLRDCDIIIICMPTPLNEARDPDMSYIESATNEIAARLRPGQLIILESTTYPGTTVEVLKPAFDACNLSVGADYF
LAFSPERIDPGSVNFKVHNIPKVVGGVTPQCNELTSLFYGHIVTAVTEVSSPAAAEMTKLFENIFRNVNIALVNELTLIC
DRMGLNVWEIIDAAATKPFGFMRFTPGPGLGGHCIPLDPFYLAWKARHYDISARFIELAGEINLTMPRFVRDRISHALND
QERSIKGSTVVLLGVAYKKDIDDYRESPIFKVMDLLAADGANVYCCDPHVTVFYDHHNHEYQTVPLTDELLQQAHCTVIV
TDHSAFDYAKIVEQSRVVVDTRNATREVKSHREKIRLL
>Mature_437_residues
STFADLRSAIETRRAQVGVIGMGYVGLPMLARAGNVGFNVLGFDISAERIASINEGVSYIGDVPSSDLAALRNNKLIEAT
AQFERLRDCDIIIICMPTPLNEARDPDMSYIESATNEIAARLRPGQLIILESTTYPGTTVEVLKPAFDACNLSVGADYFL
AFSPERIDPGSVNFKVHNIPKVVGGVTPQCNELTSLFYGHIVTAVTEVSSPAAAEMTKLFENIFRNVNIALVNELTLICD
RMGLNVWEIIDAAATKPFGFMRFTPGPGLGGHCIPLDPFYLAWKARHYDISARFIELAGEINLTMPRFVRDRISHALNDQ
ERSIKGSTVVLLGVAYKKDIDDYRESPIFKVMDLLAADGANVYCCDPHVTVFYDHHNHEYQTVPLTDELLQQAHCTVIVT
DHSAFDYAKIVEQSRVVVDTRNATREVKSHREKIRLL

Specific function: Probably involved in the synthesis of sugar components of EPS I, by converting NDP-N-acetyl-D-galactosamine into NDP-N- acetyl-D-galactosaminuronic acid [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=371, Percent_Identity=23.4501347708895, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI296040438, Length=279, Percent_Identity=24.0143369175627, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI48994968, Length=429, Percent_Identity=33.7995337995338, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1788340, Length=363, Percent_Identity=26.7217630853994, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560350, Length=375, Percent_Identity=22.9333333333333, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136908, Length=374, Percent_Identity=26.2032085561497, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48529; Mature: 48398

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFADLRSAIETRRAQVGVIGMGYVGLPMLARAGNVGFNVLGFDISAERIASINEGVSY
CCCHHHHHHHHHHHHHEEEEEEECHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCHHH
IGDVPSSDLAALRNNKLIEATAQFERLRDCDIIIICMPTPLNEARDPDMSYIESATNEIA
HCCCCCHHHHHHHCCCEEEHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
ARLRPGQLIILESTTYPGTTVEVLKPAFDACNLSVGADYFLAFSPERIDPGSVNFKVHNI
HHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEEECC
PKVVGGVTPQCNELTSLFYGHIVTAVTEVSSPAAAEMTKLFENIFRNVNIALVNELTLIC
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHH
DRMGLNVWEIIDAAATKPFGFMRFTPGPGLGGHCIPLDPFYLAWKARHYDISARFIELAG
HHHCCCHHHHHHHHCCCCCCEEEECCCCCCCCCEEECCCCEEEEEEEEEEHHHEEEEECC
EINLTMPRFVRDRISHALNDQERSIKGSTVVLLGVAYKKDIDDYRESPIFKVMDLLAADG
CCCCCHHHHHHHHHHHHHCCHHHCCCCCEEEEEEEHHHHCHHHHHCCCHHHHHHHHHCCC
ANVYCCDPHVTVFYDHHNHEYQTVPLTDELLQQAHCTVIVTDHSAFDYAKIVEQSRVVVD
CEEEEECCCEEEEEECCCCCEEEECCHHHHHHHCCCEEEEECCCCHHHHHHHHCCEEEEE
TRNATREVKSHREKIRLL
CCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STFADLRSAIETRRAQVGVIGMGYVGLPMLARAGNVGFNVLGFDISAERIASINEGVSY
CCHHHHHHHHHHHHHEEEEEEECHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCHHH
IGDVPSSDLAALRNNKLIEATAQFERLRDCDIIIICMPTPLNEARDPDMSYIESATNEIA
HCCCCCHHHHHHHCCCEEEHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
ARLRPGQLIILESTTYPGTTVEVLKPAFDACNLSVGADYFLAFSPERIDPGSVNFKVHNI
HHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEEECC
PKVVGGVTPQCNELTSLFYGHIVTAVTEVSSPAAAEMTKLFENIFRNVNIALVNELTLIC
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHH
DRMGLNVWEIIDAAATKPFGFMRFTPGPGLGGHCIPLDPFYLAWKARHYDISARFIELAG
HHHCCCHHHHHHHHCCCCCCEEEECCCCCCCCCEEECCCCEEEEEEEEEEHHHEEEEECC
EINLTMPRFVRDRISHALNDQERSIKGSTVVLLGVAYKKDIDDYRESPIFKVMDLLAADG
CCCCCHHHHHHHHHHHHHCCHHHCCCCCEEEEEEEHHHHCHHHHHCCCHHHHHHHHHCCC
ANVYCCDPHVTVFYDHHNHEYQTVPLTDELLQQAHCTVIVTDHSAFDYAKIVEQSRVVVD
CEEEEECCCEEEEEECCCCCEEEECCHHHHHHHCCCEEEEECCCCHHHHHHHHCCEEEEE
TRNATREVKSHREKIRLL
CCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]