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The map label for this gene is groL

Identifier: 159900196

GI number: 159900196

Start: 4621519

End: 4623162

Strand: Direct

Name: groL

Synonym: Haur_3679

Alternate gene names: 159900196

Gene position: 4621519-4623162 (Clockwise)

Preceding gene: 159900195

Following gene: 159900197

Centisome position: 72.82

GC content: 52.43

Gene sequence:

>1644_bases
ATGGCAAAGCAAGTTGCTTTTAATGAAGAAGCCCGCCGCGCACTCAAACGTGGCGTGGACGTGGTTGCAGATGCAGTTAA
GACGACCTTGGGCCCACGCGGTCGCAACGTCGCTATCGATAAAAAATTCGGCTCACCAACCGTAACCCACGACGGCGTTA
CCGTTGCTAAAGAAATCGAATTAAAAGACCCATTTGAAAACATGGGCGCTCGCTTGTTGGTTGAAGCCGCAACCAAAACC
AACGATGTTGCTGGTGACGGTACCACCACCGCCACCGTTTTGGCTCAAGCAATTGTCCACGAAGGCTTGCGCCAAGTGGC
TGCTGGCGCTAACTCGATGATGATCAAGCGTGGCTTGGACAAAGGCACTGCCGTTTTGTTGCAAGCAATCCGCGATTTGG
CCAAGCCAGTCAACGATCGCACCGACATCTCAAGCGTTGCCACCATCTCAGCTGCCGATTCGTCAATTGGCGATTTGATT
GCTGAAGTGATGGACAAAGTTGGCAAAGACGGCGTTATCACCGTTGAAGAAGGCAAAGGCTTGGGCTACGAAACCGAGTA
TACCGAAGGTATGCAATTCGATCGTGGCTACATCTCAGCCTACTTCGTCACCAACAGCGATCGCATGGAATCAGATTTGG
AAGACCCCTACATTTTGATCACCGACAAGAAGATCAGCTCGATCCAAGAAATCTTGCCAGTGCTCGAAAAAGTCTTGCAA
TTCACCAAGAACTTCGTCATTATCGCTGAAGATATCGACGGCGAAGCCTTGCCAACCCTCGTGTTGAACAAATTGCGCGG
CACGATCAACGTGTTGGCAATCAAAGCTCCTGGCTTCGGCGATCGCCGCAAAGCCATGTTGCAAGATATCGCCATCCTCA
CCGGTGGTACGGTTATCAGCGAAGAAATTGGCCGCAAGCTTGATAGCGCCACGGTCGAAGATTTGGGCCGCGCTCGCCGC
GTGATTGCCAACAAAGACGAAACCACGGTTATCGAAGGCCGCGGCGACGAAGATGCAATCAAAGCTCGGATCGAACAAAT
TCGTGCTCAAATTGAAACCACCACCAGCGATTTCGATCGCGAGAAACTGCAAGAACGCTTGGCCAAATTGGCTGGTGGCG
TAGCAGTGCTCAAAGTTGGTGCTGCAACCGAGCCAGAATTGAAAGAACGCAAGCACCGCGTCGAAGATGCCCTCTCAACC
GCTCGTGCAGCTGTTGAAGAAGGTATCGTGCCTGGTGGCGGGATTGCCTTGTTGAGCGTATTGCCAGCCTTGGATAGCGT
TGTGCCAGCCAACCAAGACGAAAAAGCTGCTGTCTTGATTCTGCGCCGCGCCTTGGAAGAACCAATTCGCCAATTGGCCC
GCAACGCTGGTGAAGATGGTGCTGTGATTATCGACACCGTGCGCCGCTTGCAAAAAGAAAAAGGCGATTCAACCCTTGGC
TACAACGTCATCACTGGCGAATATGGCTCAATGGTTGAAATGGGCATCATCGACCCAGCCAAGGTAACTCGCTCGGCCTT
GCAAAACGCCGTTTCGATTGCCTCGATGATCTTGACCACCGATGCTTTGGTCGCCGATATCCCAGAAAAAGAAGCTGCTC
CAGCTCCTGGTGGTATGGGTGGCATGGGCGGCATGGATTTCTAA

Upstream 100 bases:

>100_bases
TGGACGACGAAGATTATTTGATTTTGGCTGAAAAAGATATTTTGGCCGTCGTTCAAGGCTAAGGCTAATTCGCGACGCTT
CTTAGGAGGATTATTTACCA

Downstream 100 bases:

>100_bases
TCCAGCCCAATCGGCAACGCAAAACCCCTGTTGTTCAATTGAGCAACGGGGGTTTTCATTTAACTTGGATGATAAATCTA
GAGCTTTTTAATTAGGAGAT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAKQVAFNEEARRALKRGVDVVADAVKTTLGPRGRNVAIDKKFGSPTVTHDGVTVAKEIELKDPFENMGARLLVEAATKT
NDVAGDGTTTATVLAQAIVHEGLRQVAAGANSMMIKRGLDKGTAVLLQAIRDLAKPVNDRTDISSVATISAADSSIGDLI
AEVMDKVGKDGVITVEEGKGLGYETEYTEGMQFDRGYISAYFVTNSDRMESDLEDPYILITDKKISSIQEILPVLEKVLQ
FTKNFVIIAEDIDGEALPTLVLNKLRGTINVLAIKAPGFGDRRKAMLQDIAILTGGTVISEEIGRKLDSATVEDLGRARR
VIANKDETTVIEGRGDEDAIKARIEQIRAQIETTTSDFDREKLQERLAKLAGGVAVLKVGAATEPELKERKHRVEDALST
ARAAVEEGIVPGGGIALLSVLPALDSVVPANQDEKAAVLILRRALEEPIRQLARNAGEDGAVIIDTVRRLQKEKGDSTLG
YNVITGEYGSMVEMGIIDPAKVTRSALQNAVSIASMILTTDALVADIPEKEAAPAPGGMGGMGGMDF

Sequences:

>Translated_547_residues
MAKQVAFNEEARRALKRGVDVVADAVKTTLGPRGRNVAIDKKFGSPTVTHDGVTVAKEIELKDPFENMGARLLVEAATKT
NDVAGDGTTTATVLAQAIVHEGLRQVAAGANSMMIKRGLDKGTAVLLQAIRDLAKPVNDRTDISSVATISAADSSIGDLI
AEVMDKVGKDGVITVEEGKGLGYETEYTEGMQFDRGYISAYFVTNSDRMESDLEDPYILITDKKISSIQEILPVLEKVLQ
FTKNFVIIAEDIDGEALPTLVLNKLRGTINVLAIKAPGFGDRRKAMLQDIAILTGGTVISEEIGRKLDSATVEDLGRARR
VIANKDETTVIEGRGDEDAIKARIEQIRAQIETTTSDFDREKLQERLAKLAGGVAVLKVGAATEPELKERKHRVEDALST
ARAAVEEGIVPGGGIALLSVLPALDSVVPANQDEKAAVLILRRALEEPIRQLARNAGEDGAVIIDTVRRLQKEKGDSTLG
YNVITGEYGSMVEMGIIDPAKVTRSALQNAVSIASMILTTDALVADIPEKEAAPAPGGMGGMGGMDF
>Mature_546_residues
AKQVAFNEEARRALKRGVDVVADAVKTTLGPRGRNVAIDKKFGSPTVTHDGVTVAKEIELKDPFENMGARLLVEAATKTN
DVAGDGTTTATVLAQAIVHEGLRQVAAGANSMMIKRGLDKGTAVLLQAIRDLAKPVNDRTDISSVATISAADSSIGDLIA
EVMDKVGKDGVITVEEGKGLGYETEYTEGMQFDRGYISAYFVTNSDRMESDLEDPYILITDKKISSIQEILPVLEKVLQF
TKNFVIIAEDIDGEALPTLVLNKLRGTINVLAIKAPGFGDRRKAMLQDIAILTGGTVISEEIGRKLDSATVEDLGRARRV
IANKDETTVIEGRGDEDAIKARIEQIRAQIETTTSDFDREKLQERLAKLAGGVAVLKVGAATEPELKERKHRVEDALSTA
RAAVEEGIVPGGGIALLSVLPALDSVVPANQDEKAAVLILRRALEEPIRQLARNAGEDGAVIIDTVRRLQKEKGDSTLGY
NVITGEYGSMVEMGIIDPAKVTRSALQNAVSIASMILTTDALVADIPEKEAAPAPGGMGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=535, Percent_Identity=49.1588785046729, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI31542947, Length=535, Percent_Identity=49.1588785046729, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI38455427, Length=131, Percent_Identity=31.2977099236641, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=533, Percent_Identity=59.0994371482176, Blast_Score=626, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17555558, Length=533, Percent_Identity=48.5928705440901, Blast_Score=495, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI193210679, Length=215, Percent_Identity=48.3720930232558, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17564182, Length=557, Percent_Identity=22.9802513464991, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=50.853889943074, Blast_Score=504, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6322350, Length=541, Percent_Identity=22.735674676525, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322524, Length=152, Percent_Identity=29.6052631578947, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24641193, Length=532, Percent_Identity=50.3759398496241, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24641191, Length=532, Percent_Identity=50.3759398496241, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI45550936, Length=532, Percent_Identity=47.7443609022556, Blast_Score=487, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550132, Length=532, Percent_Identity=47.7443609022556, Blast_Score=487, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550935, Length=532, Percent_Identity=47.7443609022556, Blast_Score=487, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17864606, Length=548, Percent_Identity=41.4233576642336, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24584129, Length=540, Percent_Identity=36.1111111111111, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI19921262, Length=540, Percent_Identity=36.1111111111111, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24645179, Length=527, Percent_Identity=23.719165085389, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_HERA2 (A9B6A4)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001546443.1
- GeneID:   5735555
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_3679
- HOGENOM:   HBG625289
- OMA:   DKPAAGM
- ProtClustDB:   CLSK2516915
- BioCyc:   HAUR316274:HAUR_3679-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58380; Mature: 58249

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQVAFNEEARRALKRGVDVVADAVKTTLGPRGRNVAIDKKFGSPTVTHDGVTVAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEEECC
LKDPFENMGARLLVEAATKTNDVAGDGTTTATVLAQAIVHEGLRQVAAGANSMMIKRGLD
CCCCHHHCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
KGTAVLLQAIRDLAKPVNDRTDISSVATISAADSSIGDLIAEVMDKVGKDGVITVEEGKG
HHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCC
LGYETEYTEGMQFDRGYISAYFVTNSDRMESDLEDPYILITDKKISSIQEILPVLEKVLQ
CCCCCCCCCCCCCCCCEEEEEEEECCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
FTKNFVIIAEDIDGEALPTLVLNKLRGTINVLAIKAPGFGDRRKAMLQDIAILTGGTVIS
HHCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EEIGRKLDSATVEDLGRARRVIANKDETTVIEGRGDEDAIKARIEQIRAQIETTTSDFDR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVLKVGAATEPELKERKHRVEDALSTARAAVEEGIVPGGGIALLSV
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LPALDSVVPANQDEKAAVLILRRALEEPIRQLARNAGEDGAVIIDTVRRLQKEKGDSTLG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
YNVITGEYGSMVEMGIIDPAKVTRSALQNAVSIASMILTTDALVADIPEKEAAPAPGGMG
CEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GMGGMDF
CCCCCCC
>Mature Secondary Structure 
AKQVAFNEEARRALKRGVDVVADAVKTTLGPRGRNVAIDKKFGSPTVTHDGVTVAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEEECC
LKDPFENMGARLLVEAATKTNDVAGDGTTTATVLAQAIVHEGLRQVAAGANSMMIKRGLD
CCCCHHHCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
KGTAVLLQAIRDLAKPVNDRTDISSVATISAADSSIGDLIAEVMDKVGKDGVITVEEGKG
HHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCC
LGYETEYTEGMQFDRGYISAYFVTNSDRMESDLEDPYILITDKKISSIQEILPVLEKVLQ
CCCCCCCCCCCCCCCCEEEEEEEECCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
FTKNFVIIAEDIDGEALPTLVLNKLRGTINVLAIKAPGFGDRRKAMLQDIAILTGGTVIS
HHCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
EEIGRKLDSATVEDLGRARRVIANKDETTVIEGRGDEDAIKARIEQIRAQIETTTSDFDR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVLKVGAATEPELKERKHRVEDALSTARAAVEEGIVPGGGIALLSV
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LPALDSVVPANQDEKAAVLILRRALEEPIRQLARNAGEDGAVIIDTVRRLQKEKGDSTLG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
YNVITGEYGSMVEMGIIDPAKVTRSALQNAVSIASMILTTDALVADIPEKEAAPAPGGMG
CEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GMGGMDF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA