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The map label for this gene is cobC [C]

Identifier: 159900188

GI number: 159900188

Start: 4615411

End: 4616034

Strand: Direct

Name: cobC [C]

Synonym: Haur_3671

Alternate gene names: 159900188

Gene position: 4615411-4616034 (Clockwise)

Preceding gene: 159900187

Following gene: 159900189

Centisome position: 72.72

GC content: 57.53

Gene sequence:

>624_bases
ATGCCAGATCCACGTGGCCTGCGTTTGCTGCTAGCCCGCCATGGTGCGACCGCCTGGAACGAAGCGGGACGCTACCAAGG
TCGTGCTGATGAAGGGCTAAGCCAGCGCGGTCAAGCTCAGGCTACCCAGCTTGGGCAGTGGCTCAGCGACGAAACACCAG
AAATTGTGCTTCACAGTGGCGCACGTCGTACAGCCGAAACGCTGGCGCGTGCGCTACCGCAGCATCAAGCGATCAGCGAC
CCGCGCTGGCGCGAAATTGACCATGGCGAATGGGAAGGTCTGACCTATCGCCAAGTTTTGGATCAAGCTCCTGAGCAAGC
CCGCGCTCATTGGAATGATCCGCTGCATATTCCCGCACCTCAAGGCGAAACCCTGATTACCGTCGCCGAGCGCGTCCAAG
CCGCCACCAACGATCTGATTACCAATTACGCTGGACGCAGTGTCCTGTTAGTTGCCCATGCCACAAGCCTGCAAGTGTTA
TGCTGCCAATTATTTCAAACTCCCCTCAAGCTTTATTGGCAGTGGAAATTCGACCTTGGCAGCCTTTCGTGCCTCGAACT
CTACCAAAGCGGTACGATCATCAATTGGCTCAATCGCGGCTACACCCGCCCCGCAAGCTGCTAG

Upstream 100 bases:

>100_bases
AAACCGGCTGGATGCGGCTCTCGGTTGGCGCGGTTTCAATCGCCGACGTTGAGCAATGCATCCCACGTATGCGAGCAATT
TTGGAGCGCGTCAAGTAACG

Downstream 100 bases:

>100_bases
CATTCAATAGACTCGCAGCATCCGCTATGGTATGATCGCTACGCTATACTGCCAAAACGAGGGTGTCACGATGGCCGAAC
TTCAGCTTAATTCATTAATC

Product: phosphoglycerate mutase

Products: 3-phospho-D-glycerate

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MPDPRGLRLLLARHGATAWNEAGRYQGRADEGLSQRGQAQATQLGQWLSDETPEIVLHSGARRTAETLARALPQHQAISD
PRWREIDHGEWEGLTYRQVLDQAPEQARAHWNDPLHIPAPQGETLITVAERVQAATNDLITNYAGRSVLLVAHATSLQVL
CCQLFQTPLKLYWQWKFDLGSLSCLELYQSGTIINWLNRGYTRPASC

Sequences:

>Translated_207_residues
MPDPRGLRLLLARHGATAWNEAGRYQGRADEGLSQRGQAQATQLGQWLSDETPEIVLHSGARRTAETLARALPQHQAISD
PRWREIDHGEWEGLTYRQVLDQAPEQARAHWNDPLHIPAPQGETLITVAERVQAATNDLITNYAGRSVLLVAHATSLQVL
CCQLFQTPLKLYWQWKFDLGSLSCLELYQSGTIINWLNRGYTRPASC
>Mature_206_residues
PDPRGLRLLLARHGATAWNEAGRYQGRADEGLSQRGQAQATQLGQWLSDETPEIVLHSGARRTAETLARALPQHQAISDP
RWREIDHGEWEGLTYRQVLDQAPEQARAHWNDPLHIPAPQGETLITVAERVQAATNDLITNYAGRSVLLVAHATSLQVLC
CQLFQTPLKLYWQWKFDLGSLSCLELYQSGTIINWLNRGYTRPASC

Specific function: Converts N1-(5-Phospho-Alpha-D-Ribosyl)-5,6- Dimethylbenzimidazole Into N1-Alpha-D-Ribosyl-5,6- Dimethylbenzimidazole; Involved In The Assembly Of The Nucleotide Loop Of Cobalamin. [C]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=194, Percent_Identity=28.8659793814433, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790856, Length=165, Percent_Identity=29.6969696969697, Blast_Score=64, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25145314, Length=163, Percent_Identity=30.0613496932515, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR012337
- InterPro:   IPR014636
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00300 PGAM; PF00075 RnaseH [H]

EC number: 5.4.2.1

Molecular weight: Translated: 23272; Mature: 23141

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPRGLRLLLARHGATAWNEAGRYQGRADEGLSQRGQAQATQLGQWLSDETPEIVLHSG
CCCCCHHEEHEECCCCCHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCEEEEECC
ARRTAETLARALPQHQAISDPRWREIDHGEWEGLTYRQVLDQAPEQARAHWNDPLHIPAP
CHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHCCCCCCCCCC
QGETLITVAERVQAATNDLITNYAGRSVLLVAHATSLQVLCCQLFQTPLKLYWQWKFDLG
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHEEEEEECCCC
SLSCLELYQSGTIINWLNRGYTRPASC
CHHHHHHHHCCCCHHHHHCCCCCCCCC
>Mature Secondary Structure 
PDPRGLRLLLARHGATAWNEAGRYQGRADEGLSQRGQAQATQLGQWLSDETPEIVLHSG
CCCCHHEEHEECCCCCHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCEEEEECC
ARRTAETLARALPQHQAISDPRWREIDHGEWEGLTYRQVLDQAPEQARAHWNDPLHIPAP
CHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHCCCCCCCCCC
QGETLITVAERVQAATNDLITNYAGRSVLLVAHATSLQVLCCQLFQTPLKLYWQWKFDLG
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHEEEEEECCCC
SLSCLELYQSGTIINWLNRGYTRPASC
CHHHHHHHHCCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-phospho-D-glycerate

Specific reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]