Click here to switch to the map view.

The map label for this gene is gnd [H]

Identifier: 159899144

GI number: 159899144

Start: 3367633

End: 3369084

Strand: Direct

Name: gnd [H]

Synonym: Haur_2625

Alternate gene names: 159899144

Gene position: 3367633-3369084 (Clockwise)

Preceding gene: 159899143

Following gene: 159899147

Centisome position: 53.06

GC content: 53.51

Gene sequence:

>1452_bases
ATGGACGCAACAGCCGATATTGGCTTAATCGGGTTGGCCGTAATGGGCCAAAACTTAGTTTTGAACATGAACGACCACGG
TTTTGTGGTCGCTGTCTATAATCGCACCACCAGCAAAGTCGATCAATTTTTGGCTAACGAGGCTCAAGGCACCAATGTTG
TCGGAGCGCATTCGTTGGAAGAATTGGTCGGCAAACTCAAGCGCCCACGCCGCGTGATGTTGATGATTCAGGCTGGCAGT
GCGGTCGATGCCACAATCGATCAATTAGTGCCCTTGCTGGAACCTGGCGATATTATCATTGATGGTGGTAATTCACTGTT
TACCGATAGCAATCGCCGAACTGCTGATCTCGAAGCCAAAGGCTTGTTGTTCATCGGCACAGGGGTTTCGGGCGGCGAGG
AAGGTGCACGCCATGGCCCTTCGATTATGCCTGGTGGTTCGCCCGCCGCATGGCCGCATGTGCAGCCAATTTTCCAAGCC
ATCGCGGCCAAAGTTGATGATGGTTCGCCATGTTGCGATTGGGTTGGCGAGGGCGGCGCTGGCCACTTCGTCAAGATGGT
GCATAACGGCATCGAATATGGCGACATGCAATTGATCGGCGAAACCTACGATGTCATGCGCTCGTTGGGCTTGAGCGCCG
ACGAGATGAGCAGCGTGTTTGGCGAATGGAACGCGGGCAAACTCGATTCATATCTGATCGAAATTACCCGCGATATTCTG
GCCTTCCGAGATAGCGATGGAGCACCGTTGGTCGATAAGATTTTGGATAGCGCTGGCCAAAAAGGTACAGGCAAATGGAC
GGTCGTTTCCGCTTTGGATAATGGCATTCCGCTGACATTAATCGGCGAAGCCGTGTTTAGCCGCTTTTTGTCGGCACTCA
AAGATGAACGGGTGCACGCCGCCAGCGCGATCAGCGGGCCAGCCGATCAGCCAAACGTTGATCGGGCCGCCTTGGTCAAC
GATCTCCGTGATGCCTTGTATGCTGCCAAAATCGTTTCATATACGCAAGGCTATATGCTGATGCGAGCCGCTGCCAAGGA
ACAAGGCTGGAATCTCAATTATGGTGGGATTGCCTTGATGTGGCGCGGTGGCTGTATCATTCGCTCGGCCTTCTTGGGCA
AAATTGAGGAAGCCTATCGCAATAATCCCGAATTGGTGAACTTGTTGCTCGACCCCTATTTCAGCAACGAAGTACAGCAA
TCGCAAGCCGCTTGGCGACGAGTGATTGCCCACGCCGTCCTCGCAGGCATTCCAGTGCCAGCCTTATCGAGCGCTTTGGC
CTTCTTTGATGGTTACCGCACCGGCAATTTGCCAGCCAATCTGTTACAAGCTCAACGCGATTACTTCGGTGCTCATACCT
ACGAGCGCATTGATGCTGAGCGTGGCAAGTTCTTCCATACCAACTGGACAGGCAAAGGCGGCACGACAACTGCCGGAACG
TACCAAGCGTAG

Upstream 100 bases:

>100_bases
ATATAGAATAGCATTAAACTGTTACTCCGCCCCAATGCTGTGGCTGGTATACTTAAGCGAGAGAGTCGAAGGCCATTCTT
TGTGCGGAGGCTTAGAACCC

Downstream 100 bases:

>100_bases
TTCAAGGCAGAAAGCACAAGTCAAAAGTCAAAATAGTTCATTCTTGGTTTAATCTAAGAAACCATTTTGATTTTTGACTT
GTGCCTTTTGAATTAATTTG

Product: 6-phosphogluconate dehydrogenase, decarboxylating

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MDATADIGLIGLAVMGQNLVLNMNDHGFVVAVYNRTTSKVDQFLANEAQGTNVVGAHSLEELVGKLKRPRRVMLMIQAGS
AVDATIDQLVPLLEPGDIIIDGGNSLFTDSNRRTADLEAKGLLFIGTGVSGGEEGARHGPSIMPGGSPAAWPHVQPIFQA
IAAKVDDGSPCCDWVGEGGAGHFVKMVHNGIEYGDMQLIGETYDVMRSLGLSADEMSSVFGEWNAGKLDSYLIEITRDIL
AFRDSDGAPLVDKILDSAGQKGTGKWTVVSALDNGIPLTLIGEAVFSRFLSALKDERVHAASAISGPADQPNVDRAALVN
DLRDALYAAKIVSYTQGYMLMRAAAKEQGWNLNYGGIALMWRGGCIIRSAFLGKIEEAYRNNPELVNLLLDPYFSNEVQQ
SQAAWRRVIAHAVLAGIPVPALSSALAFFDGYRTGNLPANLLQAQRDYFGAHTYERIDAERGKFFHTNWTGKGGTTTAGT
YQA

Sequences:

>Translated_483_residues
MDATADIGLIGLAVMGQNLVLNMNDHGFVVAVYNRTTSKVDQFLANEAQGTNVVGAHSLEELVGKLKRPRRVMLMIQAGS
AVDATIDQLVPLLEPGDIIIDGGNSLFTDSNRRTADLEAKGLLFIGTGVSGGEEGARHGPSIMPGGSPAAWPHVQPIFQA
IAAKVDDGSPCCDWVGEGGAGHFVKMVHNGIEYGDMQLIGETYDVMRSLGLSADEMSSVFGEWNAGKLDSYLIEITRDIL
AFRDSDGAPLVDKILDSAGQKGTGKWTVVSALDNGIPLTLIGEAVFSRFLSALKDERVHAASAISGPADQPNVDRAALVN
DLRDALYAAKIVSYTQGYMLMRAAAKEQGWNLNYGGIALMWRGGCIIRSAFLGKIEEAYRNNPELVNLLLDPYFSNEVQQ
SQAAWRRVIAHAVLAGIPVPALSSALAFFDGYRTGNLPANLLQAQRDYFGAHTYERIDAERGKFFHTNWTGKGGTTTAGT
YQA
>Mature_483_residues
MDATADIGLIGLAVMGQNLVLNMNDHGFVVAVYNRTTSKVDQFLANEAQGTNVVGAHSLEELVGKLKRPRRVMLMIQAGS
AVDATIDQLVPLLEPGDIIIDGGNSLFTDSNRRTADLEAKGLLFIGTGVSGGEEGARHGPSIMPGGSPAAWPHVQPIFQA
IAAKVDDGSPCCDWVGEGGAGHFVKMVHNGIEYGDMQLIGETYDVMRSLGLSADEMSSVFGEWNAGKLDSYLIEITRDIL
AFRDSDGAPLVDKILDSAGQKGTGKWTVVSALDNGIPLTLIGEAVFSRFLSALKDERVHAASAISGPADQPNVDRAALVN
DLRDALYAAKIVSYTQGYMLMRAAAKEQGWNLNYGGIALMWRGGCIIRSAFLGKIEEAYRNNPELVNLLLDPYFSNEVQQ
SQAAWRRVIAHAVLAGIPVPALSSALAFFDGYRTGNLPANLLQAQRDYFGAHTYERIDAERGKFFHTNWTGKGGTTTAGT
YQA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=483, Percent_Identity=65.0103519668737, Blast_Score=650, Evalue=0.0,
Organism=Escherichia coli, GI1788341, Length=464, Percent_Identity=54.9568965517241, Blast_Score=533, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17542558, Length=485, Percent_Identity=62.4742268041237, Blast_Score=640, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321695, Length=491, Percent_Identity=61.9144602851324, Blast_Score=633, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321977, Length=490, Percent_Identity=62.8571428571429, Blast_Score=622, Evalue=1e-179,
Organism=Drosophila melanogaster, GI24639279, Length=484, Percent_Identity=66.5289256198347, Blast_Score=655, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51850; Mature: 51850

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATADIGLIGLAVMGQNLVLNMNDHGFVVAVYNRTTSKVDQFLANEAQGTNVVGAHSLE
CCCCCCHHHHHHHHCCCCEEEEECCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHH
ELVGKLKRPRRVMLMIQAGSAVDATIDQLVPLLEPGDIIIDGGNSLFTDSNRRTADLEAK
HHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCEECCCCC
GLLFIGTGVSGGEEGARHGPSIMPGGSPAAWPHVQPIFQAIAAKVDDGSPCCDWVGEGGA
CEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCC
GHFVKMVHNGIEYGDMQLIGETYDVMRSLGLSADEMSSVFGEWNAGKLDSYLIEITRDIL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AFRDSDGAPLVDKILDSAGQKGTGKWTVVSALDNGIPLTLIGEAVFSRFLSALKDERVHA
HHCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASAISGPADQPNVDRAALVNDLRDALYAAKIVSYTQGYMLMRAAAKEQGWNLNYGGIALM
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
WRGGCIIRSAFLGKIEEAYRNNPELVNLLLDPYFSNEVQQSQAAWRRVIAHAVLAGIPVP
EECCHHHHHHHHHHHHHHHCCCHHEEHHHHCCHHCHHHHHHHHHHHHHHHHHHHHCCCHH
ALSSALAFFDGYRTGNLPANLLQAQRDYFGAHTYERIDAERGKFFHTNWTGKGGTTTAGT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCCCCCCCCC
YQA
CCC
>Mature Secondary Structure
MDATADIGLIGLAVMGQNLVLNMNDHGFVVAVYNRTTSKVDQFLANEAQGTNVVGAHSLE
CCCCCCHHHHHHHHCCCCEEEEECCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHH
ELVGKLKRPRRVMLMIQAGSAVDATIDQLVPLLEPGDIIIDGGNSLFTDSNRRTADLEAK
HHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCEECCCCC
GLLFIGTGVSGGEEGARHGPSIMPGGSPAAWPHVQPIFQAIAAKVDDGSPCCDWVGEGGA
CEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCC
GHFVKMVHNGIEYGDMQLIGETYDVMRSLGLSADEMSSVFGEWNAGKLDSYLIEITRDIL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AFRDSDGAPLVDKILDSAGQKGTGKWTVVSALDNGIPLTLIGEAVFSRFLSALKDERVHA
HHCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASAISGPADQPNVDRAALVNDLRDALYAAKIVSYTQGYMLMRAAAKEQGWNLNYGGIALM
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
WRGGCIIRSAFLGKIEEAYRNNPELVNLLLDPYFSNEVQQSQAAWRRVIAHAVLAGIPVP
EECCHHHHHHHHHHHHHHHCCCHHEEHHHHCCHHCHHHHHHHHHHHHHHHHHHHHCCCHH
ALSSALAFFDGYRTGNLPANLLQAQRDYFGAHTYERIDAERGKFFHTNWTGKGGTTTAGT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCCCCCCCCC
YQA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA