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The map label for this gene is bfmBAA [H]

Identifier: 159899110

GI number: 159899110

Start: 3325464

End: 3326438

Strand: Direct

Name: bfmBAA [H]

Synonym: Haur_2591

Alternate gene names: 159899110

Gene position: 3325464-3326438 (Clockwise)

Preceding gene: 159899109

Following gene: 159899111

Centisome position: 52.4

GC content: 54.05

Gene sequence:

>975_bases
ATGGAGCAAGAACGCGATCAAACGCGGTTGTTAGCGATGTATCACACGATGGTTTTGGCTCGTTCGCTTGATGAGCGAAT
GTGGCAATTGAATCGTCAAGGCAAAGCCCCTTTTGTTATTTCCTGCCAAGGTCATGAGGCTGCTCAAGTAGGCGCAGCCT
TTGCAATGCGCCCCAAACACGATTGGATTGTGCCCTACTATCGTGATTTAGCAATGATGTTGGCAATGGGAATGACCCCG
CGCGAGGTGATGCTCGGCTTGTTGGCGAAAGCCGAAGATCCTAGCAGTGGTGGCCGCCAGATGCCCGCTCACTATAGCCA
TCGTGCTTTGAATATTGTTTCGCACTCGTCGCCAACGGGCACCCAAGTGCCGCATGCCGTCGGTGTCGCTATGGGCGCAC
AAATGCGCGGCGATGATATTGTGGTTTGGACGGCGTTTGGCGAAGGTACATCATCACAGGGCGATGTCCACGAGGCCATG
AACTTGGCTGGGGTGATGAAATTACCAGTAATTTTCTTCTGCGAAAATAATGGCTACGCCATCTCCGTGCCGCAGCACAA
GCAAATGGGCGTAGAAAACGTCTCGGATCGCGGCCCAGGCTACGGGTTTCCTGGGATCACGGTTGATGGCACCAATGTGC
TTGAGGTTTACGAAGCTATGACCGCTGCGGTCGAACGCGCCCGCCGTGGCGACGGCCCAACCTTGATCGAGGCCAAATGT
GTGCGTTTGACCGCCCACTCCTCTGATGATAATGACCGAACGTATCGCTCACCTGAAGATATCAAGGCCATGCGCACCCG
CGACCCAATCGCGAGCTTCGAGCATTTCTTGCGCGATGAAGGCATGCTCGATGATGCCAAAGTTGCCGCAATTCGCGCCG
AAATTAAAGAAATTGTCAATGATGCAACAGCCTATGCTGAAGCAGCACCCTTGCCCGACCCCAGCACCGTGCGCAAATAT
GTGTTTGCCGAATAA

Upstream 100 bases:

>100_bases
TTTCCTTGCTTGCCCTTGCCTCGGTCGCCATACCGGGGTTTTTAACTTAACAGGGTTCGACGGACGAACAAAGTAATCCT
TCATATGAGGAGTTGCCTTC

Downstream 100 bases:

>100_bases
CCGTGCTCGCAGGCAGTTTCGCTATTTATCATGTGCATAGAGGTATCAGGTGGCAGAATTAAATCTCTTAGAAGCGATCA
ATCAAGCGCTCGACCAAGCT

Product: 3-methyl-2-oxobutanoate dehydrogenase

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MEQERDQTRLLAMYHTMVLARSLDERMWQLNRQGKAPFVISCQGHEAAQVGAAFAMRPKHDWIVPYYRDLAMMLAMGMTP
REVMLGLLAKAEDPSSGGRQMPAHYSHRALNIVSHSSPTGTQVPHAVGVAMGAQMRGDDIVVWTAFGEGTSSQGDVHEAM
NLAGVMKLPVIFFCENNGYAISVPQHKQMGVENVSDRGPGYGFPGITVDGTNVLEVYEAMTAAVERARRGDGPTLIEAKC
VRLTAHSSDDNDRTYRSPEDIKAMRTRDPIASFEHFLRDEGMLDDAKVAAIRAEIKEIVNDATAYAEAAPLPDPSTVRKY
VFAE

Sequences:

>Translated_324_residues
MEQERDQTRLLAMYHTMVLARSLDERMWQLNRQGKAPFVISCQGHEAAQVGAAFAMRPKHDWIVPYYRDLAMMLAMGMTP
REVMLGLLAKAEDPSSGGRQMPAHYSHRALNIVSHSSPTGTQVPHAVGVAMGAQMRGDDIVVWTAFGEGTSSQGDVHEAM
NLAGVMKLPVIFFCENNGYAISVPQHKQMGVENVSDRGPGYGFPGITVDGTNVLEVYEAMTAAVERARRGDGPTLIEAKC
VRLTAHSSDDNDRTYRSPEDIKAMRTRDPIASFEHFLRDEGMLDDAKVAAIRAEIKEIVNDATAYAEAAPLPDPSTVRKY
VFAE
>Mature_324_residues
MEQERDQTRLLAMYHTMVLARSLDERMWQLNRQGKAPFVISCQGHEAAQVGAAFAMRPKHDWIVPYYRDLAMMLAMGMTP
REVMLGLLAKAEDPSSGGRQMPAHYSHRALNIVSHSSPTGTQVPHAVGVAMGAQMRGDDIVVWTAFGEGTSSQGDVHEAM
NLAGVMKLPVIFFCENNGYAISVPQHKQMGVENVSDRGPGYGFPGITVDGTNVLEVYEAMTAAVERARRGDGPTLIEAKC
VRLTAHSSDDNDRTYRSPEDIKAMRTRDPIASFEHFLRDEGMLDDAKVAAIRAEIKEIVNDATAYAEAAPLPDPSTVRKY
VFAE

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=319, Percent_Identity=35.1097178683386, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI258645172, Length=319, Percent_Identity=35.1097178683386, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4885543, Length=315, Percent_Identity=28.2539682539683, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI291084742, Length=304, Percent_Identity=30.2631578947368, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4505685, Length=304, Percent_Identity=30.2631578947368, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI291084744, Length=311, Percent_Identity=29.5819935691318, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI291084757, Length=304, Percent_Identity=26.6447368421053, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=304, Percent_Identity=36.8421052631579, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI86563357, Length=304, Percent_Identity=36.8421052631579, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI32564172, Length=314, Percent_Identity=28.9808917197452, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17536047, Length=314, Percent_Identity=28.9808917197452, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=320, Percent_Identity=30.9375, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21355903, Length=315, Percent_Identity=34.9206349206349, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24639740, Length=266, Percent_Identity=33.4586466165414, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24639746, Length=266, Percent_Identity=33.4586466165414, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24639744, Length=266, Percent_Identity=33.4586466165414, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI28571106, Length=266, Percent_Identity=33.4586466165414, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24639748, Length=309, Percent_Identity=29.126213592233, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35654; Mature: 35654

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQERDQTRLLAMYHTMVLARSLDERMWQLNRQGKAPFVISCQGHEAAQVGAAFAMRPKH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHEECCCC
DWIVPYYRDLAMMLAMGMTPREVMLGLLAKAEDPSSGGRQMPAHYSHRALNIVSHSSPTG
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHCCCEEEEEECCCCCC
TQVPHAVGVAMGAQMRGDDIVVWTAFGEGTSSQGDVHEAMNLAGVMKLPVIFFCENNGYA
CCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHEECCEEEEECCCCEE
ISVPQHKQMGVENVSDRGPGYGFPGITVDGTNVLEVYEAMTAAVERARRGDGPTLIEAKC
EECCCHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
VRLTAHSSDDNDRTYRSPEDIKAMRTRDPIASFEHFLRDEGMLDDAKVAAIRAEIKEIVN
EEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DATAYAEAAPLPDPSTVRKYVFAE
HHHHHHHCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MEQERDQTRLLAMYHTMVLARSLDERMWQLNRQGKAPFVISCQGHEAAQVGAAFAMRPKH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHEECCCC
DWIVPYYRDLAMMLAMGMTPREVMLGLLAKAEDPSSGGRQMPAHYSHRALNIVSHSSPTG
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHCCCEEEEEECCCCCC
TQVPHAVGVAMGAQMRGDDIVVWTAFGEGTSSQGDVHEAMNLAGVMKLPVIFFCENNGYA
CCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHEECCEEEEECCCCEE
ISVPQHKQMGVENVSDRGPGYGFPGITVDGTNVLEVYEAMTAAVERARRGDGPTLIEAKC
EECCCHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
VRLTAHSSDDNDRTYRSPEDIKAMRTRDPIASFEHFLRDEGMLDDAKVAAIRAEIKEIVN
EEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DATAYAEAAPLPDPSTVRKYVFAE
HHHHHHHCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]