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The map label for this gene is bfmBAB [H]

Identifier: 159899111

GI number: 159899111

Start: 3326488

End: 3327471

Strand: Direct

Name: bfmBAB [H]

Synonym: Haur_2592

Alternate gene names: 159899111

Gene position: 3326488-3327471 (Clockwise)

Preceding gene: 159899110

Following gene: 159899112

Centisome position: 52.41

GC content: 49.49

Gene sequence:

>984_bases
GTGGCAGAATTAAATCTCTTAGAAGCGATCAATCAAGCGCTCGACCAAGCTATGGCCAACGATGAGCGGGTCTATATTAT
TGGTGAAGATGTTGGCCAACGCGGCGGGGTATTTCGGGTTACTGATGGTTTGCACGCTAAATATGGCAGCAAGCGGGTAA
TTGATGCGCCACTCGCTGAGTCAATTATTATTGGCTCGTCAATTGGCGCAGCAATGTATGGCATGCGCCCAATCGCCGAA
ATTCAATTTGCCGATTTTATCTTCCCAGCCTTCAATCAAATTATCAGCGAAGCCGCCCGCATGCGCTATCGCTCAAATAA
TACCTGGGAAGTACCCTTAGTGATTCGCGCTCCCTATGGCGGTGGTATCCACGGGGCACTCTATCACTCGCAAAGCATCG
AAGCCTTTTTCGCCCATATTCCAGGTCTCAAGGTGGTTGCGCCGTCAACGCCGTATGATGCCAAGGCCATGCTGCTGGCA
GCGATTGATGATCCCGATCCAGTGTTGTTTTTAGAGCACAAAAAATGCTATCGCTTGATCAAAGGCTATGTGCCCGATGA
GCACTATACTGTGCCAATTGGCAAGGCCGATATCGCCCGTGAAGGCAGTGATGTTTCGGTGATCACCTATGGCATGATGC
GTCATTACGCCGTTGAGGCCGCCGAAATGCTGGCCAAGGAAGATATTAGCGTCGAAGTCGTCGATTTGCGCTCGTTAGTG
CCACTCGATCGCGAAACAATTCTCAATTCGGTTAAGAAAACCAGTAAAGTGTTGGTGCTCTACGAAGATAATTTGTTTGG
TGGTTATGGCGCAGAAATTGCCGCAATCATCGCCCAAGATGGCTTTGAACATCTCGATGCGCCAGTGCAACGCTTGGCAG
GCTTGGATATTCCAGCGATGCCCTATAGTGCACCGCTCGAAAACGAATTCTTGCCAACACCAAGCAAAATTGCCGATACG
CTGCGCGATTTAGTCAATTATTAG

Upstream 100 bases:

>100_bases
GCACCCTTGCCCGACCCCAGCACCGTGCGCAAATATGTGTTTGCCGAATAACCGTGCTCGCAGGCAGTTTCGCTATTTAT
CATGTGCATAGAGGTATCAG

Downstream 100 bases:

>100_bases
TGGCGATTGGCTGTAGGCGATTGGCTATTGGATAGTGAAGATCCAACTTGGCTTTAGCTTATAGCCCATCAGTATCGATA
CCATAGAAAGGACTGGGATG

Product: transketolase central region

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MAELNLLEAINQALDQAMANDERVYIIGEDVGQRGGVFRVTDGLHAKYGSKRVIDAPLAESIIIGSSIGAAMYGMRPIAE
IQFADFIFPAFNQIISEAARMRYRSNNTWEVPLVIRAPYGGGIHGALYHSQSIEAFFAHIPGLKVVAPSTPYDAKAMLLA
AIDDPDPVLFLEHKKCYRLIKGYVPDEHYTVPIGKADIAREGSDVSVITYGMMRHYAVEAAEMLAKEDISVEVVDLRSLV
PLDRETILNSVKKTSKVLVLYEDNLFGGYGAEIAAIIAQDGFEHLDAPVQRLAGLDIPAMPYSAPLENEFLPTPSKIADT
LRDLVNY

Sequences:

>Translated_327_residues
MAELNLLEAINQALDQAMANDERVYIIGEDVGQRGGVFRVTDGLHAKYGSKRVIDAPLAESIIIGSSIGAAMYGMRPIAE
IQFADFIFPAFNQIISEAARMRYRSNNTWEVPLVIRAPYGGGIHGALYHSQSIEAFFAHIPGLKVVAPSTPYDAKAMLLA
AIDDPDPVLFLEHKKCYRLIKGYVPDEHYTVPIGKADIAREGSDVSVITYGMMRHYAVEAAEMLAKEDISVEVVDLRSLV
PLDRETILNSVKKTSKVLVLYEDNLFGGYGAEIAAIIAQDGFEHLDAPVQRLAGLDIPAMPYSAPLENEFLPTPSKIADT
LRDLVNY
>Mature_326_residues
AELNLLEAINQALDQAMANDERVYIIGEDVGQRGGVFRVTDGLHAKYGSKRVIDAPLAESIIIGSSIGAAMYGMRPIAEI
QFADFIFPAFNQIISEAARMRYRSNNTWEVPLVIRAPYGGGIHGALYHSQSIEAFFAHIPGLKVVAPSTPYDAKAMLLAA
IDDPDPVLFLEHKKCYRLIKGYVPDEHYTVPIGKADIAREGSDVSVITYGMMRHYAVEAAEMLAKEDISVEVVDLRSLVP
LDRETILNSVKKTSKVLVLYEDNLFGGYGAEIAAIIAQDGFEHLDAPVQRLAGLDIPAMPYSAPLENEFLPTPSKIADTL
RDLVNY

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=328, Percent_Identity=46.0365853658537, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI34101272, Length=328, Percent_Identity=46.0365853658537, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI156564403, Length=328, Percent_Identity=38.109756097561, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI291084858, Length=328, Percent_Identity=36.5853658536585, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI225637459, Length=237, Percent_Identity=27.8481012658228, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI225637461, Length=237, Percent_Identity=27.8481012658228, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI225637463, Length=237, Percent_Identity=27.8481012658228, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI133778974, Length=180, Percent_Identity=31.1111111111111, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17506935, Length=329, Percent_Identity=43.161094224924, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17538422, Length=329, Percent_Identity=40.1215805471125, Blast_Score=246, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6319698, Length=328, Percent_Identity=36.5853658536585, Blast_Score=228, Evalue=9e-61,
Organism=Drosophila melanogaster, GI160714828, Length=327, Percent_Identity=45.565749235474, Blast_Score=284, Evalue=5e-77,
Organism=Drosophila melanogaster, GI160714832, Length=327, Percent_Identity=45.565749235474, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI21358145, Length=314, Percent_Identity=42.9936305732484, Blast_Score=248, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24650940, Length=314, Percent_Identity=42.9936305732484, Blast_Score=248, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=43.3333333333333, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=43.3333333333333, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35913; Mature: 35781

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELNLLEAINQALDQAMANDERVYIIGEDVGQRGGVFRVTDGLHAKYGSKRVIDAPLAE
CCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCHHCCCCCEEECCCCHH
SIIIGSSIGAAMYGMRPIAEIQFADFIFPAFNQIISEAARMRYRSNNTWEVPLVIRAPYG
HEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
GGIHGALYHSQSIEAFFAHIPGLKVVAPSTPYDAKAMLLAAIDDPDPVLFLEHKKCYRLI
CCCCHHHCCCHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCEEEECCHHHHHHH
KGYVPDEHYTVPIGKADIAREGSDVSVITYGMMRHYAVEAAEMLAKEDISVEVVDLRSLV
HCCCCCCCEEEECCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHC
PLDRETILNSVKKTSKVLVLYEDNLFGGYGAEIAAIIAQDGFEHLDAPVQRLAGLDIPAM
CCCHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
PYSAPLENEFLPTPSKIADTLRDLVNY
CCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AELNLLEAINQALDQAMANDERVYIIGEDVGQRGGVFRVTDGLHAKYGSKRVIDAPLAE
CCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCHHCCCCCEEECCCCHH
SIIIGSSIGAAMYGMRPIAEIQFADFIFPAFNQIISEAARMRYRSNNTWEVPLVIRAPYG
HEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
GGIHGALYHSQSIEAFFAHIPGLKVVAPSTPYDAKAMLLAAIDDPDPVLFLEHKKCYRLI
CCCCHHHCCCHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCEEEECCHHHHHHH
KGYVPDEHYTVPIGKADIAREGSDVSVITYGMMRHYAVEAAEMLAKEDISVEVVDLRSLV
HCCCCCCCEEEECCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHC
PLDRETILNSVKKTSKVLVLYEDNLFGGYGAEIAAIIAQDGFEHLDAPVQRLAGLDIPAM
CCCHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
PYSAPLENEFLPTPSKIADTLRDLVNY
CCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]