Click here to switch to the map view.

The map label for this gene is aarA [H]

Identifier: 159898531

GI number: 159898531

Start: 2486215

End: 2487498

Strand: Direct

Name: aarA [H]

Synonym: Haur_2007

Alternate gene names: 159898531

Gene position: 2486215-2487498 (Clockwise)

Preceding gene: 159898530

Following gene: 159898534

Centisome position: 39.17

GC content: 49.84

Gene sequence:

>1284_bases
GTGACTAACAGCTTGACGATCACCGATAATCGTACTGGGAAAACTTACGAATTGCCCATCGTCGATGGCACCATCCGCGC
CCTCGACTTACGTCAGATCAAAGCAGATGCCGAAGATTTTGGGCTGATGACCCACGACCCAGGCTTCAATAACACCTCAT
CATGCCGTAGCTCAATTACCTATATCGATGGCGACGCTGGGATTCTGCGCTATCGCGGCTACCCAATTGAGCAATTGGCT
GATAGCAGCAGCTACCTCGAAACCGCCTACTTGATTCTCAATGGAGAACTGCCAACCAAACCACAACTTGATGCATGGGT
TCATGAAATTACCCACCGCACAATGGTGCATGAAAATATCAAGAAGTTAATGGATGGCTTTCATTTTGATGCCCACCCCA
TGGGGATGTTGATTAGTACCTTGAGTGCAATGTCAACCTTCTATCCTCAAGCCAAAAACGTCAAAGATCCAGCAATGCGC
CGTTTGCAGATTGCTCGCTTGATCGCCAAAGTGCCAACGATCTCGGCCTATGCCTATCGCAAACGTATGGGCTTGCCCTA
CGTTTACCCCGATAACTCGTTGAGCTATACTGGCAACTTCTTGAAGATGATGTTCCAAAGAGCTGATCCATACATTCCAG
ACCCAATTATGGAAAAAGCCTTGGATGTTTTGTTCGTTTTGCATGCCGACCACGAGCAAAATTGTGGCACGAATGCGATG
CGCTCAGTGGGTAGCTCAAACGTCGATCCCTATTCAGCCATGGCTGGGGCGGCGGCAGCCTTGTATGGTCCGCTGCATGG
CGGCGCAAACGAGCAAGTGCTGCGCATGTTGCAAGAAATCGGTTCCGCCAGTAATGTTGCCGATTACATCCGCCGCGTCA
AAAATCGTGAAGTCTTGTTGATGGGCTTCGGCCATCGCGTCTACAAGAACTACGATCCTCGCGCTGCGATCGTCAAGCAG
CTGGCCTACGATGTGTTTGAAGTTGTTGGGCGTAACCCAATGATCGACATTGCCTTGGAACTTGAAAAGATTGCGCTCGA
AGATGATTATTTCGTCTCACGCAAGCTGTACCCCAATGTCGATTTCTACACGGGCATTATTTACCAAGCAATGAAATTCC
CTGTTGATATGTTCCCAGTGCTGTTTGCCATCCCTCGCACGGTCGGTTGGTTGGCCCAGTGGGATGAAATGCACAACGAC
AAGGAAACTTCAATTGCTCGCCCACGCCAGATCTACACTGGCTACGATGCTCGCGATTTCGTTCCAGTCGAAAAACGCGG
CTAA

Upstream 100 bases:

>100_bases
GCAACGAATAGGCTCAAGCTTATGTTACAATGACAAACCAATCAGGATTTTTGGGGCAATGTCGCCTCATTTTTTGTTCT
AAGCTTTTAGGAGGTCGCTG

Downstream 100 bases:

>100_bases
ATCAAATACCACGGTGATCGGAACGCCCGCTGGGAGTTTGCTCCCAACGGGCGTTTTTTAAGTTATAGGGTTGTAAAGTG
CTGGAGATCTGGCTGAAATC

Product: citrate synthase I

Products: NA

Alternate protein names: Acetic acid resistance protein [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTNSLTITDNRTGKTYELPIVDGTIRALDLRQIKADAEDFGLMTHDPGFNNTSSCRSSITYIDGDAGILRYRGYPIEQLA
DSSSYLETAYLILNGELPTKPQLDAWVHEITHRTMVHENIKKLMDGFHFDAHPMGMLISTLSAMSTFYPQAKNVKDPAMR
RLQIARLIAKVPTISAYAYRKRMGLPYVYPDNSLSYTGNFLKMMFQRADPYIPDPIMEKALDVLFVLHADHEQNCGTNAM
RSVGSSNVDPYSAMAGAAAALYGPLHGGANEQVLRMLQEIGSASNVADYIRRVKNREVLLMGFGHRVYKNYDPRAAIVKQ
LAYDVFEVVGRNPMIDIALELEKIALEDDYFVSRKLYPNVDFYTGIIYQAMKFPVDMFPVLFAIPRTVGWLAQWDEMHND
KETSIARPRQIYTGYDARDFVPVEKRG

Sequences:

>Translated_427_residues
MTNSLTITDNRTGKTYELPIVDGTIRALDLRQIKADAEDFGLMTHDPGFNNTSSCRSSITYIDGDAGILRYRGYPIEQLA
DSSSYLETAYLILNGELPTKPQLDAWVHEITHRTMVHENIKKLMDGFHFDAHPMGMLISTLSAMSTFYPQAKNVKDPAMR
RLQIARLIAKVPTISAYAYRKRMGLPYVYPDNSLSYTGNFLKMMFQRADPYIPDPIMEKALDVLFVLHADHEQNCGTNAM
RSVGSSNVDPYSAMAGAAAALYGPLHGGANEQVLRMLQEIGSASNVADYIRRVKNREVLLMGFGHRVYKNYDPRAAIVKQ
LAYDVFEVVGRNPMIDIALELEKIALEDDYFVSRKLYPNVDFYTGIIYQAMKFPVDMFPVLFAIPRTVGWLAQWDEMHND
KETSIARPRQIYTGYDARDFVPVEKRG
>Mature_426_residues
TNSLTITDNRTGKTYELPIVDGTIRALDLRQIKADAEDFGLMTHDPGFNNTSSCRSSITYIDGDAGILRYRGYPIEQLAD
SSSYLETAYLILNGELPTKPQLDAWVHEITHRTMVHENIKKLMDGFHFDAHPMGMLISTLSAMSTFYPQAKNVKDPAMRR
LQIARLIAKVPTISAYAYRKRMGLPYVYPDNSLSYTGNFLKMMFQRADPYIPDPIMEKALDVLFVLHADHEQNCGTNAMR
SVGSSNVDPYSAMAGAAAALYGPLHGGANEQVLRMLQEIGSASNVADYIRRVKNREVLLMGFGHRVYKNYDPRAAIVKQL
AYDVFEVVGRNPMIDIALELEKIALEDDYFVSRKLYPNVDFYTGIIYQAMKFPVDMFPVLFAIPRTVGWLAQWDEMHNDK
ETSIARPRQIYTGYDARDFVPVEKRG

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=365, Percent_Identity=28.4931506849315, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1786939, Length=416, Percent_Identity=48.5576923076923, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1786527, Length=379, Percent_Identity=32.4538258575198, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17555174, Length=379, Percent_Identity=26.1213720316623, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6319850, Length=386, Percent_Identity=26.4248704663212, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324328, Length=372, Percent_Identity=24.7311827956989, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=401, Percent_Identity=25.1870324189526, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24640124, Length=404, Percent_Identity=26.2376237623762, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24640126, Length=404, Percent_Identity=25.7425742574257, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21356863, Length=331, Percent_Identity=26.8882175226586, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48332; Mature: 48201

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSLTITDNRTGKTYELPIVDGTIRALDLRQIKADAEDFGLMTHDPGFNNTSSCRSSIT
CCCCEEEECCCCCCEEEEEEECCCHHHHHHHHHHCCHHHCCCEECCCCCCCHHHHHCCCE
YIDGDAGILRYRGYPIEQLADSSSYLETAYLILNGELPTKPQLDAWVHEITHRTMVHENI
EEECCCCEEEECCCCHHHHCCCCHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KKLMDGFHFDAHPMGMLISTLSAMSTFYPQAKNVKDPAMRRLQIARLIAKVPTISAYAYR
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
KRMGLPYVYPDNSLSYTGNFLKMMFQRADPYIPDPIMEKALDVLFVLHADHEQNCGTNAM
HHCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCCCCCCCHHH
RSVGSSNVDPYSAMAGAAAALYGPLHGGANEQVLRMLQEIGSASNVADYIRRVKNREVLL
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEE
MGFGHRVYKNYDPRAAIVKQLAYDVFEVVGRNPMIDIALELEKIALEDDYFVSRKLYPNV
EECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHEECCCCEECCCCCCCC
DFYTGIIYQAMKFPVDMFPVLFAIPRTVGWLAQWDEMHNDKETSIARPRQIYTGYDARDF
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCCCCCCC
VPVEKRG
CCCCCCC
>Mature Secondary Structure 
TNSLTITDNRTGKTYELPIVDGTIRALDLRQIKADAEDFGLMTHDPGFNNTSSCRSSIT
CCCEEEECCCCCCEEEEEEECCCHHHHHHHHHHCCHHHCCCEECCCCCCCHHHHHCCCE
YIDGDAGILRYRGYPIEQLADSSSYLETAYLILNGELPTKPQLDAWVHEITHRTMVHENI
EEECCCCEEEECCCCHHHHCCCCHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KKLMDGFHFDAHPMGMLISTLSAMSTFYPQAKNVKDPAMRRLQIARLIAKVPTISAYAYR
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
KRMGLPYVYPDNSLSYTGNFLKMMFQRADPYIPDPIMEKALDVLFVLHADHEQNCGTNAM
HHCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCCCCCCCHHH
RSVGSSNVDPYSAMAGAAAALYGPLHGGANEQVLRMLQEIGSASNVADYIRRVKNREVLL
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEE
MGFGHRVYKNYDPRAAIVKQLAYDVFEVVGRNPMIDIALELEKIALEDDYFVSRKLYPNV
EECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHEECCCCEECCCCCCCC
DFYTGIIYQAMKFPVDMFPVLFAIPRTVGWLAQWDEMHNDKETSIARPRQIYTGYDARDF
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCCCCCCC
VPVEKRG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2156811 [H]