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The map label for this gene is yhcA [H]

Identifier: 159897940

GI number: 159897940

Start: 1631536

End: 1632963

Strand: Reverse

Name: yhcA [H]

Synonym: Haur_1415

Alternate gene names: 159897940

Gene position: 1632963-1631536 (Counterclockwise)

Preceding gene: 159897941

Following gene: 159897936

Centisome position: 25.73

GC content: 52.24

Gene sequence:

>1428_bases
ATGAAACGGATCGTGATCGATCAAAAAATTGCAGTTTGCGTCGTCTTTGTAGCGGCGTTGTTTATGAGCATTATGGATGG
CACAATTATCAACGTGGCACTAGCAACCATCCAACAAGATTTTGGCGCGAGTAGCAGCGCGATCAACGCAATCGTGGTGA
TCTATTTAATTTGTATTGCGGTGGTGATTCCGGCTTCGGGTTGGTTGGGCGACCGTTGGAACACCAAATGGGTCTTTTTA
ACCTCACTTGGTTTGTTTACGTTGGCCTCGCTGGCCTGTGGCTTAGCTCAAAATATTGAGCAATTGATGCTAACTCGGGC
GGCTCAAGGCATCGCAGCAGGCGCACTAATGCCAGTCGGCACAACCATGCTCTTTCGGACTTTCCCGCCGCACCAGCGCA
TCCAAGTTTCGCGGGTGCTGATTATTCCAACGGTGATAGCACCCGCAGTTGGGCCGGTGCTCGGCGGATTTTTAGTCGAT
CATCTGTCGTGGCACTGGGTCTTTTTCGTCAATGGCCCAATTGGCTTAGCCGCGCTGATCTTCGGGGTCATTTGGTTGCA
AGCGCCTGCCCAAGAAGAAGTTGGCGCATTCGATTGGCTGGGTTTTATTTTAGCGGGCGCTGGCTTTGCCGCCTTGCTCT
ACACCTTGACCGAAGGCGCGAGCAAAGGCTGGGGTTCGCCAATCATTTTGGTTAGTGCCGCGATTGGGGTTGGCGCACTT
GCCGCGCTGGTGGTCGTTGAATTAGCCAAAGCCAAGCCAATGCTTGATCTGCGGCTCTTCTCCATTCGCTTGTTTCGCGT
CAGCAATTTAGTAGCGATTTTTGGCTCAGCCGCCTTTACGGGCATTCTGTTTCTGATGCCCCAATTTTTGCAAAATGTCG
TTGGAGCCAGTGCGCTCGAATCGGGCTTGACCACCTCGCCCGAAGCGATTGGCGTGGTACTATCGAGCCAAATCGTAGCG
CGACTTTACCCCAAAGTTGGCCCACGCCGCTTGACTTTTGGCGGGGTTTTAGGGGTTGCCGTGATGATGGGCTTGATGAG
CACAATCGATGCTGAAACCAATTTGTGGTTGGTACGTGCCTTGATGTTTGGCACAGGCGTGGGGATGGCCTACCTCTTTT
TGCCAATTGAGGCCGCCGTTTTTGCCCAAATTCCGCATGCCTCAACTGGCCAAGCTTCAGCAATTTTCAGCATGCAACAA
CAACTTGGTTCGGCCTTGGGCGTAGCCATTTTGGGCAGCGTGTTGGCGCTCAATCATAGCGGCACAACAGTTAATCAAAA
TGCCCAAAGCTATCAGTATGCCTTCTTGGCAGCAGCAATTTTGGCATTTGTTTCAGCCTGTGTAGCGTTGTTTATTCGCG
ATCGCGATGCAGCGGCGACCATGGCCCAACATGGCGAGCACAGTGAATTGAGTCATTCAATCGCCTAA

Upstream 100 bases:

>100_bases
TCCATTTCTTCGATCTCCCATAATCGCTACAATAAAGCGATGGCTTGCATTCCAGCAGATACGAGCCAGCAACGAATTAG
CACAATCAAACGAGGGCTTC

Downstream 100 bases:

>100_bases
AAAAATTGCGGCGCATGCGTAATTTCATGCGCCGCTGATCTTTAACTAAATAACTTCTTGGTCACGCAAACGCGGCTGCG
GATCGTCGCCACGGCTGCTA

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKRIVIDQKIAVCVVFVAALFMSIMDGTIINVALATIQQDFGASSSAINAIVVIYLICIAVVIPASGWLGDRWNTKWVFL
TSLGLFTLASLACGLAQNIEQLMLTRAAQGIAAGALMPVGTTMLFRTFPPHQRIQVSRVLIIPTVIAPAVGPVLGGFLVD
HLSWHWVFFVNGPIGLAALIFGVIWLQAPAQEEVGAFDWLGFILAGAGFAALLYTLTEGASKGWGSPIILVSAAIGVGAL
AALVVVELAKAKPMLDLRLFSIRLFRVSNLVAIFGSAAFTGILFLMPQFLQNVVGASALESGLTTSPEAIGVVLSSQIVA
RLYPKVGPRRLTFGGVLGVAVMMGLMSTIDAETNLWLVRALMFGTGVGMAYLFLPIEAAVFAQIPHASTGQASAIFSMQQ
QLGSALGVAILGSVLALNHSGTTVNQNAQSYQYAFLAAAILAFVSACVALFIRDRDAAATMAQHGEHSELSHSIA

Sequences:

>Translated_475_residues
MKRIVIDQKIAVCVVFVAALFMSIMDGTIINVALATIQQDFGASSSAINAIVVIYLICIAVVIPASGWLGDRWNTKWVFL
TSLGLFTLASLACGLAQNIEQLMLTRAAQGIAAGALMPVGTTMLFRTFPPHQRIQVSRVLIIPTVIAPAVGPVLGGFLVD
HLSWHWVFFVNGPIGLAALIFGVIWLQAPAQEEVGAFDWLGFILAGAGFAALLYTLTEGASKGWGSPIILVSAAIGVGAL
AALVVVELAKAKPMLDLRLFSIRLFRVSNLVAIFGSAAFTGILFLMPQFLQNVVGASALESGLTTSPEAIGVVLSSQIVA
RLYPKVGPRRLTFGGVLGVAVMMGLMSTIDAETNLWLVRALMFGTGVGMAYLFLPIEAAVFAQIPHASTGQASAIFSMQQ
QLGSALGVAILGSVLALNHSGTTVNQNAQSYQYAFLAAAILAFVSACVALFIRDRDAAATMAQHGEHSELSHSIA
>Mature_475_residues
MKRIVIDQKIAVCVVFVAALFMSIMDGTIINVALATIQQDFGASSSAINAIVVIYLICIAVVIPASGWLGDRWNTKWVFL
TSLGLFTLASLACGLAQNIEQLMLTRAAQGIAAGALMPVGTTMLFRTFPPHQRIQVSRVLIIPTVIAPAVGPVLGGFLVD
HLSWHWVFFVNGPIGLAALIFGVIWLQAPAQEEVGAFDWLGFILAGAGFAALLYTLTEGASKGWGSPIILVSAAIGVGAL
AALVVVELAKAKPMLDLRLFSIRLFRVSNLVAIFGSAAFTGILFLMPQFLQNVVGASALESGLTTSPEAIGVVLSSQIVA
RLYPKVGPRRLTFGGVLGVAVMMGLMSTIDAETNLWLVRALMFGTGVGMAYLFLPIEAAVFAQIPHASTGQASAIFSMQQ
QLGSALGVAILGSVLALNHSGTTVNQNAQSYQYAFLAAAILAFVSACVALFIRDRDAAATMAQHGEHSELSHSIA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=446, Percent_Identity=28.6995515695067, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1789042, Length=459, Percent_Identity=28.7581699346405, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI1788710, Length=424, Percent_Identity=30.8962264150943, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1788392, Length=438, Percent_Identity=29.6803652968037, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI87081983, Length=431, Percent_Identity=26.6821345707657, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1790146, Length=167, Percent_Identity=28.7425149700599, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=235, Percent_Identity=28.5106382978723, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49999; Mature: 49999

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIVIDQKIAVCVVFVAALFMSIMDGTIINVALATIQQDFGASSSAINAIVVIYLICIA
CCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VVIPASGWLGDRWNTKWVFLTSLGLFTLASLACGLAQNIEQLMLTRAAQGIAAGALMPVG
HHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
TTMLFRTFPPHQRIQVSRVLIIPTVIAPAVGPVLGGFLVDHLSWHWVFFVNGPIGLAALI
HHHHHCCCCCCCCEEHHHHEEHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHH
FGVIWLQAPAQEEVGAFDWLGFILAGAGFAALLYTLTEGASKGWGSPIILVSAAIGVGAL
HHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHH
AALVVVELAKAKPMLDLRLFSIRLFRVSNLVAIFGSAAFTGILFLMPQFLQNVVGASALE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLTTSPEAIGVVLSSQIVARLYPKVGPRRLTFGGVLGVAVMMGLMSTIDAETNLWLVRA
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LMFGTGVGMAYLFLPIEAAVFAQIPHASTGQASAIFSMQQQLGSALGVAILGSVLALNHS
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTTVNQNAQSYQYAFLAAAILAFVSACVALFIRDRDAAATMAQHGEHSELSHSIA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MKRIVIDQKIAVCVVFVAALFMSIMDGTIINVALATIQQDFGASSSAINAIVVIYLICIA
CCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VVIPASGWLGDRWNTKWVFLTSLGLFTLASLACGLAQNIEQLMLTRAAQGIAAGALMPVG
HHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
TTMLFRTFPPHQRIQVSRVLIIPTVIAPAVGPVLGGFLVDHLSWHWVFFVNGPIGLAALI
HHHHHCCCCCCCCEEHHHHEEHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHH
FGVIWLQAPAQEEVGAFDWLGFILAGAGFAALLYTLTEGASKGWGSPIILVSAAIGVGAL
HHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHH
AALVVVELAKAKPMLDLRLFSIRLFRVSNLVAIFGSAAFTGILFLMPQFLQNVVGASALE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLTTSPEAIGVVLSSQIVARLYPKVGPRRLTFGGVLGVAVMMGLMSTIDAETNLWLVRA
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LMFGTGVGMAYLFLPIEAAVFAQIPHASTGQASAIFSMQQQLGSALGVAILGSVLALNHS
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTTVNQNAQSYQYAFLAAAILAFVSACVALFIRDRDAAATMAQHGEHSELSHSIA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]