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The map label for this gene is acdA [H]

Identifier: 159897777

GI number: 159897777

Start: 1456462

End: 1457709

Strand: Direct

Name: acdA [H]

Synonym: Haur_1248

Alternate gene names: 159897777

Gene position: 1456462-1457709 (Clockwise)

Preceding gene: 159897776

Following gene: 159897778

Centisome position: 22.95

GC content: 50.72

Gene sequence:

>1248_bases
ATGATTGATTGGACCGAAAATTACGGGTTTTTGCTGAATGAACAGCACGATATGCTGCGTAAAACTGTGCGCGATTTTGC
TGAAAAAGAAGTCGCTCCCTACATCCAAGAATGGGATCGTAAGGGCGCTGGTGAGCATGCCGGAACTGCCGAGCATATGT
TGCCAATTATCAAACGCATGGGTGAACTCGGTTTTCTCGGGGTGTGTCTACCACAAAAATATGGCGGTGCAGGCTTCGAT
TATTTGGGGCTAGCAGTCGTTTGTGAAGAATTAGAGCGGGTTGATACATCGCTGCGGGTGATTCTCAGTGTGCATACTGG
CCTCAACTCGTTGGCCGTGTTCCAATGGGGCACTGAAGAACAAAAGCAAAAATATCTTGTACCCCAAGCGACTGGCGCAA
AAATTGCCGCCTATTGTCTGACTGAGCCAAATGCTGGCACCGACGTTGCTGGGATGCAATCGACCGCTGTGCTCGAAGGC
GATCACTATATTCTCAACGGCGAAAAAACCTGGATCAGCCTCTCGGATTTGGCCGACCATTTCTTGGTGGTAGCCTACAC
CGATAAGAGCAAAAAGCAACGTGGCATGACCGCGTTTATCGTCGAACGCAGCTTTGAGGGCGTTTCAACGATGCCAATTC
ATGGTAAGTTGGGCGTGCGGGCTGGTAACACTGGTAGCGTCGTATTCGAAAATGTACGCGTACCCGTTGCCAATCGCTTG
GGCGAAGAAGGCGAAGGCTTCAAAATTGCTATGACGGCGCTCGATAATGGCCGCTACACCGTGGCAACTGGGGCAACTGG
CTTGATCCAAGCTGCCTTGGAAGCATCGGTCAAGTATGCCAAAGAGCGTGAAACCTTTGGTGTGCCGATTGGTCAACACC
AATTGGTCAAGCGTATGATCAGCCATATGGTGCTGAAGTTGGAAACCGCTCGTTTGTTGTGCTATCGCGCTGGCTGGCTC
AAAAACCAAGGTATTCGCAACACCCGCGAAACTACCTTGGCCAAATGGCATGCTACTGTCGAAAGCTTCAACTGTGCCAA
CGATGCAATTCAAATTCACGGAGCCTATGGCTTTAGCGACGAGTATCCAGTCGAACGCTATTTGCGCAATAGCCGTGGCG
CGGTAATTTACGAAGGAACCCGCGAGTTGCAAGAACTGTTACAAGCGGATTTTGCGCTCTCAGAGCGAGAAAACAAGCCT
TTGCGCTGTGAGCTACCAGCCTACGATGAAGAGGCTTGGAACGCCTAA

Upstream 100 bases:

>100_bases
TTACCCGCAAATTGCCAAGATATGCTATGCTAGAAGCTACAATGTTGTTTGCAATGGGGCAAACAACGAGCTATACAGCA
CACACGAGGTAGAACAAGCC

Downstream 100 bases:

>100_bases
ACAGCCTTGGCTGTCGGAGCGAACACCACCGCGAGCAAGGTTTTTTGAGCTTGTTCGCGGTGGTCGTGTTTTTAAGGAGG
AAGTATGTCGCGTTGGATTA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MIDWTENYGFLLNEQHDMLRKTVRDFAEKEVAPYIQEWDRKGAGEHAGTAEHMLPIIKRMGELGFLGVCLPQKYGGAGFD
YLGLAVVCEELERVDTSLRVILSVHTGLNSLAVFQWGTEEQKQKYLVPQATGAKIAAYCLTEPNAGTDVAGMQSTAVLEG
DHYILNGEKTWISLSDLADHFLVVAYTDKSKKQRGMTAFIVERSFEGVSTMPIHGKLGVRAGNTGSVVFENVRVPVANRL
GEEGEGFKIAMTALDNGRYTVATGATGLIQAALEASVKYAKERETFGVPIGQHQLVKRMISHMVLKLETARLLCYRAGWL
KNQGIRNTRETTLAKWHATVESFNCANDAIQIHGAYGFSDEYPVERYLRNSRGAVIYEGTRELQELLQADFALSERENKP
LRCELPAYDEEAWNA

Sequences:

>Translated_415_residues
MIDWTENYGFLLNEQHDMLRKTVRDFAEKEVAPYIQEWDRKGAGEHAGTAEHMLPIIKRMGELGFLGVCLPQKYGGAGFD
YLGLAVVCEELERVDTSLRVILSVHTGLNSLAVFQWGTEEQKQKYLVPQATGAKIAAYCLTEPNAGTDVAGMQSTAVLEG
DHYILNGEKTWISLSDLADHFLVVAYTDKSKKQRGMTAFIVERSFEGVSTMPIHGKLGVRAGNTGSVVFENVRVPVANRL
GEEGEGFKIAMTALDNGRYTVATGATGLIQAALEASVKYAKERETFGVPIGQHQLVKRMISHMVLKLETARLLCYRAGWL
KNQGIRNTRETTLAKWHATVESFNCANDAIQIHGAYGFSDEYPVERYLRNSRGAVIYEGTRELQELLQADFALSERENKP
LRCELPAYDEEAWNA
>Mature_415_residues
MIDWTENYGFLLNEQHDMLRKTVRDFAEKEVAPYIQEWDRKGAGEHAGTAEHMLPIIKRMGELGFLGVCLPQKYGGAGFD
YLGLAVVCEELERVDTSLRVILSVHTGLNSLAVFQWGTEEQKQKYLVPQATGAKIAAYCLTEPNAGTDVAGMQSTAVLEG
DHYILNGEKTWISLSDLADHFLVVAYTDKSKKQRGMTAFIVERSFEGVSTMPIHGKLGVRAGNTGSVVFENVRVPVANRL
GEEGEGFKIAMTALDNGRYTVATGATGLIQAALEASVKYAKERETFGVPIGQHQLVKRMISHMVLKLETARLLCYRAGWL
KNQGIRNTRETTLAKWHATVESFNCANDAIQIHGAYGFSDEYPVERYLRNSRGAVIYEGTRELQELLQADFALSERENKP
LRCELPAYDEEAWNA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=39.7368421052632, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI187960098, Length=394, Percent_Identity=36.5482233502538, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4557231, Length=394, Percent_Identity=36.5482233502538, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=34.8525469168901, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI7656849, Length=387, Percent_Identity=34.1085271317829, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI226958412, Length=387, Percent_Identity=34.8837209302326, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI21361497, Length=336, Percent_Identity=38.3928571428571, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=36.0703812316716, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI76496475, Length=336, Percent_Identity=35.7142857142857, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4557235, Length=336, Percent_Identity=35.7142857142857, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4503943, Length=393, Percent_Identity=32.0610687022901, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4501857, Length=383, Percent_Identity=31.0704960835509, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI7669494, Length=384, Percent_Identity=32.03125, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI48976061, Length=339, Percent_Identity=28.3185840707965, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI211971008, Length=339, Percent_Identity=28.3185840707965, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI38505218, Length=346, Percent_Identity=24.8554913294798, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=26.3157894736842, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081958, Length=393, Percent_Identity=26.7175572519084, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081702, Length=317, Percent_Identity=25.2365930599369, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=35.9249329758713, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=37.5328083989501, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=35.2, Blast_Score=244, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=35.9580052493438, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17538396, Length=378, Percent_Identity=33.8624338624339, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=34.1145833333333, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI71985184, Length=342, Percent_Identity=36.5497076023392, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17533517, Length=364, Percent_Identity=32.4175824175824, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI71990804, Length=304, Percent_Identity=35.5263157894737, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17534353, Length=378, Percent_Identity=31.4814814814815, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI71985192, Length=278, Percent_Identity=37.0503597122302, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71982178, Length=276, Percent_Identity=35.1449275362319, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.6623376623377, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=27.5862068965517, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=27.0557029177719, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17531909, Length=249, Percent_Identity=32.5301204819277, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17562446, Length=378, Percent_Identity=26.7195767195767, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17531913, Length=169, Percent_Identity=27.810650887574, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646207, Length=389, Percent_Identity=41.6452442159383, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI21356377, Length=386, Percent_Identity=40.1554404145078, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=39.1076115485564, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=33.2446808510638, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=33.9473684210526, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI19920834, Length=380, Percent_Identity=33.1578947368421, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI281363737, Length=336, Percent_Identity=32.7380952380952, Blast_Score=195, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 46206; Mature: 46206

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDWTENYGFLLNEQHDMLRKTVRDFAEKEVAPYIQEWDRKGAGEHAGTAEHMLPIIKRM
CCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
GELGFLGVCLPQKYGGAGFDYLGLAVVCEELERVDTSLRVILSVHTGLNSLAVFQWGTEE
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEHHCCCCEEEEEECCCHH
QKQKYLVPQATGAKIAAYCLTEPNAGTDVAGMQSTAVLEGDHYILNGEKTWISLSDLADH
HHHEECCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCEEEECCCCEEEEHHHHCCC
FLVVAYTDKSKKQRGMTAFIVERSFEGVSTMPIHGKLGVRAGNTGSVVFENVRVPVANRL
EEEEEEECCCHHHCCCEEEEEEECCCCCEECCCCCCEEEECCCCCCEEEEECCCCHHHHC
GEEGEGFKIAMTALDNGRYTVATGATGLIQAALEASVKYAKERETFGVPIGQHQLVKRMI
CCCCCCEEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SHMVLKLETARLLCYRAGWLKNQGIRNTRETTLAKWHATVESFNCANDAIQIHGAYGFSD
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
EYPVERYLRNSRGAVIYEGTRELQELLQADFALSERENKPLRCELPAYDEEAWNA
CCCHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MIDWTENYGFLLNEQHDMLRKTVRDFAEKEVAPYIQEWDRKGAGEHAGTAEHMLPIIKRM
CCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
GELGFLGVCLPQKYGGAGFDYLGLAVVCEELERVDTSLRVILSVHTGLNSLAVFQWGTEE
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEHHCCCCEEEEEECCCHH
QKQKYLVPQATGAKIAAYCLTEPNAGTDVAGMQSTAVLEGDHYILNGEKTWISLSDLADH
HHHEECCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCEEEECCCCEEEEHHHHCCC
FLVVAYTDKSKKQRGMTAFIVERSFEGVSTMPIHGKLGVRAGNTGSVVFENVRVPVANRL
EEEEEEECCCHHHCCCEEEEEEECCCCCEECCCCCCEEEECCCCCCEEEEECCCCHHHHC
GEEGEGFKIAMTALDNGRYTVATGATGLIQAALEASVKYAKERETFGVPIGQHQLVKRMI
CCCCCCEEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SHMVLKLETARLLCYRAGWLKNQGIRNTRETTLAKWHATVESFNCANDAIQIHGAYGFSD
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
EYPVERYLRNSRGAVIYEGTRELQELLQADFALSERENKPLRCELPAYDEEAWNA
CCCHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]