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The map label for this gene is aroB

Identifier: 15922603

GI number: 15922603

Start: 2280907

End: 2281965

Strand: Direct

Name: aroB

Synonym: ST2272

Alternate gene names: 15922603

Gene position: 2280907-2281965 (Clockwise)

Preceding gene: 15922602

Following gene: 15922604

Centisome position: 84.64

GC content: 33.99

Gene sequence:

>1059_bases
ATGAGGATAGTAAATGAGAATTTATGTAATAATGAGATTTCTATAGTAATTGGAAAAGGAGCCTTATCTGCATTAGAGGA
ATTAAAAGATAAGAAGGTTGCCCTTTTTTATTCACAAAAAATTGATCCCTCTAGAGTGAAGAGTCATCTGAAGAGTTTTA
TCGAAATACCAATTATTGACGGTGAAGGTGCTAAAGACATTCAATATGCATTAAAGCTTGTGAAACTTCTTTTTGAAAAT
GGCTTTGATAGAGGAGATTATGTTATTGCTTTAGGTGGTGGTACAGTAACAGATGTGGTAGGTTTTGTTGCGTCTATCTA
TATGAGAGGGATAAATCTAATCAATATTCCAACTACTCTTCTAGGTATGGTAGATGCGGCTATTGGTGGAAAGACCGGTG
TAAATTTTGAAAATGTGAAAAATGTTTTAGGTACATTTTATCAGCCAACTATGATAATATCAGATTTAAATTTTTTAGAA
ACTCTTCCATTAGAAGAGATAAAGAAGGGCTTAGCTGAAGTTATTAAATATGGTTTAGTTCTAGATAAAGATCTATATGA
TTATCTGGCTATGAATAAAGAGAAGATTTTTGCTAAAGATGAAAGTGCATTAGAGGAAATTATATATAAATCAAGTGTAG
ATAAGTTTTCTGTAGTAAAGGCTGATGAAAGGGAGACAAAGGGTATTAGAATTGTATTAAATTTTGGTCACACAATAGGT
CATGCTATAGAAGCAGGAAGCAACTTTACTGTACCGCATGGTTATGCTATATCTGTTGGCATGGTTTGCGAAGCTAAGAT
GGCCGAAGAAGTAGGGTATGCCGAAGAAGGAGTTGTAGAGGACGTTACATGGATATTGTCTCAATATGAATTACCTCTTA
CCGTGGACTCTCTTAATGCTAAGATTGATGTTAAGAAAGCTATTGATGCAATTACAAAGGATAAAAAAGTAAGAGGTGGA
TATGTAATGATGCCTTTTCCAACTAGGATAGGTGATTGGAAAAGAGTAGATGTACCGATAGAAACTTTAAAGGGGTTTGC
AGAGCAATGCTTGAGATAA

Upstream 100 bases:

>100_bases
AAAAAGCATTAAGTGATTCAGAACAACAATTAACCCCAGAGTCCTTTGAAGTATTAATGAATAGGATTAGGGCATTAGCT
AATGCACTAGGTAGAACTGC

Downstream 100 bases:

>100_bases
ATTATGATACGAAACTTTTAGGTGTAGTTGGCGAAAATATATCATATACATTATCACCAGCGATACACAATTATTCTTTT
CAAGAATTAGGTATTAATGC

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MRIVNENLCNNEISIVIGKGALSALEELKDKKVALFYSQKIDPSRVKSHLKSFIEIPIIDGEGAKDIQYALKLVKLLFEN
GFDRGDYVIALGGGTVTDVVGFVASIYMRGINLINIPTTLLGMVDAAIGGKTGVNFENVKNVLGTFYQPTMIISDLNFLE
TLPLEEIKKGLAEVIKYGLVLDKDLYDYLAMNKEKIFAKDESALEEIIYKSSVDKFSVVKADERETKGIRIVLNFGHTIG
HAIEAGSNFTVPHGYAISVGMVCEAKMAEEVGYAEEGVVEDVTWILSQYELPLTVDSLNAKIDVKKAIDAITKDKKVRGG
YVMMPFPTRIGDWKRVDVPIETLKGFAEQCLR

Sequences:

>Translated_352_residues
MRIVNENLCNNEISIVIGKGALSALEELKDKKVALFYSQKIDPSRVKSHLKSFIEIPIIDGEGAKDIQYALKLVKLLFEN
GFDRGDYVIALGGGTVTDVVGFVASIYMRGINLINIPTTLLGMVDAAIGGKTGVNFENVKNVLGTFYQPTMIISDLNFLE
TLPLEEIKKGLAEVIKYGLVLDKDLYDYLAMNKEKIFAKDESALEEIIYKSSVDKFSVVKADERETKGIRIVLNFGHTIG
HAIEAGSNFTVPHGYAISVGMVCEAKMAEEVGYAEEGVVEDVTWILSQYELPLTVDSLNAKIDVKKAIDAITKDKKVRGG
YVMMPFPTRIGDWKRVDVPIETLKGFAEQCLR
>Mature_352_residues
MRIVNENLCNNEISIVIGKGALSALEELKDKKVALFYSQKIDPSRVKSHLKSFIEIPIIDGEGAKDIQYALKLVKLLFEN
GFDRGDYVIALGGGTVTDVVGFVASIYMRGINLINIPTTLLGMVDAAIGGKTGVNFENVKNVLGTFYQPTMIISDLNFLE
TLPLEEIKKGLAEVIKYGLVLDKDLYDYLAMNKEKIFAKDESALEEIIYKSSVDKFSVVKADERETKGIRIVLNFGHTIG
HAIEAGSNFTVPHGYAISVGMVCEAKMAEEVGYAEEGVVEDVTWILSQYELPLTVDSLNAKIDVKKAIDAITKDKKVRGG
YVMMPFPTRIGDWKRVDVPIETLKGFAEQCLR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=273, Percent_Identity=38.4615384615385, Blast_Score=176, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320332, Length=306, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_SULTO (Q96Y96)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_378272.1
- ProteinModelPortal:   Q96Y96
- SMR:   Q96Y96
- GeneID:   1460354
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST2272
- NMPDR:   fig|273063.1.peg.2440
- HOGENOM:   HBG632303
- OMA:   TERMISD
- ProtClustDB:   PRK00002
- BioCyc:   STOK273063:ST2272-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 38914; Mature: 38914

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVNENLCNNEISIVIGKGALSALEELKDKKVALFYSQKIDPSRVKSHLKSFIEIPIID
CCCCCCCCCCCCEEEEECCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHEEEEEC
GEGAKDIQYALKLVKLLFENGFDRGDYVIALGGGTVTDVVGFVASIYMRGINLINIPTTL
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEHHHHH
LGMVDAAIGGKTGVNFENVKNVLGTFYQPTMIISDLNFLETLPLEEIKKGLAEVIKYGLV
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCC
LDKDLYDYLAMNKEKIFAKDESALEEIIYKSSVDKFSVVKADERETKGIRIVLNFGHTIG
CCHHHHHHHHCCCHHHEECCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHH
HAIEAGSNFTVPHGYAISVGMVCEAKMAEEVGYAEEGVVEDVTWILSQYELPLTVDSLNA
HHHHCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEECCCC
KIDVKKAIDAITKDKKVRGGYVMMPFPTRIGDWKRVDVPIETLKGFAEQCLR
EEEHHHHHHHHHCCCCCCCCEEEECCCCCCCCCEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRIVNENLCNNEISIVIGKGALSALEELKDKKVALFYSQKIDPSRVKSHLKSFIEIPIID
CCCCCCCCCCCCEEEEECCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHEEEEEC
GEGAKDIQYALKLVKLLFENGFDRGDYVIALGGGTVTDVVGFVASIYMRGINLINIPTTL
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEHHHHH
LGMVDAAIGGKTGVNFENVKNVLGTFYQPTMIISDLNFLETLPLEEIKKGLAEVIKYGLV
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCC
LDKDLYDYLAMNKEKIFAKDESALEEIIYKSSVDKFSVVKADERETKGIRIVLNFGHTIG
CCHHHHHHHHCCCHHHEECCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHH
HAIEAGSNFTVPHGYAISVGMVCEAKMAEEVGYAEEGVVEDVTWILSQYELPLTVDSLNA
HHHHCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEECCCC
KIDVKKAIDAITKDKKVRGGYVMMPFPTRIGDWKRVDVPIETLKGFAEQCLR
EEEHHHHHHHHHCCCCCCCCEEEECCCCCCCCCEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479