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The map label for this gene is ndhA [H]

Identifier: 15922547

GI number: 15922547

Start: 2226133

End: 2227194

Strand: Direct

Name: ndhA [H]

Synonym: ST2219

Alternate gene names: 15922547

Gene position: 2226133-2227194 (Clockwise)

Preceding gene: 15922546

Following gene: 15922548

Centisome position: 82.61

GC content: 35.22

Gene sequence:

>1062_bases
ATGGTGGATGTACTTTCAGCTATCAGATATTATTTCTTTTATCCATCTTTTTTTGCAGTAATTATATTTCCAGGATTAAT
ATTTACTACAATAATATTATTACTTACAATATGGTTTGAAAGAAAAGCTGCTGCTCGAGTTCAAATGCGAATTGGTCCTC
TATATGTATCAAAAAGGACTGGTGGTATTACACAGTTGATAGCTGATGCTATAAGGTTGGTGTTCTCAGAAATAATTATC
CCAACTGGAGTAAATCCTACGCTTTATGTTTTAGCCCCAATATTTCCTATAATATTCAGTTTTATACCAATGGTTCTTAT
ACCATTTTCAGTAATACCCAAAAGTGGTTCAGTATTATCACCATACTTCCATTTCTTCTATGACCCTAACATAAATAGTG
GAATCTTTGTAGGTTACTTCTTGCCGTATAATATGATTTTAGTTTTAGGACTATCTTCTGTTGTTCCAGTATTTATATTG
CTTCAAGCGTGGGCTACTAATAACAGATTCGCTATTGTAGGTGCAGTTAGGGAAGCCTTATTGTCAGTGTCATATGATGT
TCTTTTAGTAATGTCAGTTGTTGCAATTGCAATAGAATATCATACGTTAGATATTGCTAAGGTTGTAGAATCTGGAATAC
CTGGCATCGTTGCTAATCCTCTAGCTGCTATCGTTTTTCTAGTCGGTATGCTAATGGGAACTGGAAGATTTCCGTTTGAA
ATTGTTGAGGCTGAGAGTGAATTAGTTGTAGGCCCTTCAACAGAGTATAGTGGCTTTTTATTCGTTTTAGCGATGGGAGG
AAGCTATATTTCGACTTTTGCATTATCATTTGTTTTCTCTGATCTCTTCTTGGGCGGATGGCTTCCGTTAAATGGTTTAC
CAGGGGCTTTAATAAATACAATAAAGGCTATAATTGTTTTATGGTTTACTGTGTTTTTAAGAGGTGTTTATGGCAGATAT
AGGATTGATCAAGCCTTAAGGGGTTCTTGGAAATATTTACTTCCCGTAGCTTTTGCCTCTTTAGTTTTAGGTTTGGTGGT
GGGATGGTTATGGATAAAGTAA

Upstream 100 bases:

>100_bases
TAATATATGTTTTTAAAGAATTAGCTAAGGGGGCACGTTACGCCGATTTAGTTGCGATATATGGTAGTTTAGATTATTTT
CCTCCGGAGGCTGATAGATA

Downstream 100 bases:

>100_bases
AAGAATATAAAAAAGAAAAAAATCCGTTTAGATTATTTGTAGATCATTTAAATGCAGTAGGAACTGGAATAAAGTATATG
ATACAACCTCAAAGAATAAC

Product: NADH dehydrogenase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I subunit 1; NDH-1 subunit 1; NDH-A [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MVDVLSAIRYYFFYPSFFAVIIFPGLIFTTIILLLTIWFERKAAARVQMRIGPLYVSKRTGGITQLIADAIRLVFSEIII
PTGVNPTLYVLAPIFPIIFSFIPMVLIPFSVIPKSGSVLSPYFHFFYDPNINSGIFVGYFLPYNMILVLGLSSVVPVFIL
LQAWATNNRFAIVGAVREALLSVSYDVLLVMSVVAIAIEYHTLDIAKVVESGIPGIVANPLAAIVFLVGMLMGTGRFPFE
IVEAESELVVGPSTEYSGFLFVLAMGGSYISTFALSFVFSDLFLGGWLPLNGLPGALINTIKAIIVLWFTVFLRGVYGRY
RIDQALRGSWKYLLPVAFASLVLGLVVGWLWIK

Sequences:

>Translated_353_residues
MVDVLSAIRYYFFYPSFFAVIIFPGLIFTTIILLLTIWFERKAAARVQMRIGPLYVSKRTGGITQLIADAIRLVFSEIII
PTGVNPTLYVLAPIFPIIFSFIPMVLIPFSVIPKSGSVLSPYFHFFYDPNINSGIFVGYFLPYNMILVLGLSSVVPVFIL
LQAWATNNRFAIVGAVREALLSVSYDVLLVMSVVAIAIEYHTLDIAKVVESGIPGIVANPLAAIVFLVGMLMGTGRFPFE
IVEAESELVVGPSTEYSGFLFVLAMGGSYISTFALSFVFSDLFLGGWLPLNGLPGALINTIKAIIVLWFTVFLRGVYGRY
RIDQALRGSWKYLLPVAFASLVLGLVVGWLWIK
>Mature_353_residues
MVDVLSAIRYYFFYPSFFAVIIFPGLIFTTIILLLTIWFERKAAARVQMRIGPLYVSKRTGGITQLIADAIRLVFSEIII
PTGVNPTLYVLAPIFPIIFSFIPMVLIPFSVIPKSGSVLSPYFHFFYDPNINSGIFVGYFLPYNMILVLGLSSVVPVFIL
LQAWATNNRFAIVGAVREALLSVSYDVLLVMSVVAIAIEYHTLDIAKVVESGIPGIVANPLAAIVFLVGMLMGTGRFPFE
IVEAESELVVGPSTEYSGFLFVLAMGGSYISTFALSFVFSDLFLGGWLPLNGLPGALINTIKAIIVLWFTVFLRGVYGRY
RIDQALRGSWKYLLPVAFASLVLGLVVGWLWIK

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=310, Percent_Identity=25.4838709677419, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788618, Length=308, Percent_Identity=29.5454545454545, Blast_Score=108, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: 1.6.5.3

Molecular weight: Translated: 39002; Mature: 39002

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDVLSAIRYYFFYPSFFAVIIFPGLIFTTIILLLTIWFERKAAARVQMRIGPLYVSKRT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEECCC
GGITQLIADAIRLVFSEIIIPTGVNPTLYVLAPIFPIIFSFIPMVLIPFSVIPKSGSVLS
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PYFHFFYDPNINSGIFVGYFLPYNMILVLGLSSVVPVFILLQAWATNNRFAIVGAVREAL
CHHHEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHH
LSVSYDVLLVMSVVAIAIEYHTLDIAKVVESGIPGIVANPLAAIVFLVGMLMGTGRFPFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
IVEAESELVVGPSTEYSGFLFVLAMGGSYISTFALSFVFSDLFLGGWLPLNGLPGALINT
EEECCCCEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
IKAIIVLWFTVFLRGVYGRYRIDQALRGSWKYLLPVAFASLVLGLVVGWLWIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDVLSAIRYYFFYPSFFAVIIFPGLIFTTIILLLTIWFERKAAARVQMRIGPLYVSKRT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEECCC
GGITQLIADAIRLVFSEIIIPTGVNPTLYVLAPIFPIIFSFIPMVLIPFSVIPKSGSVLS
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PYFHFFYDPNINSGIFVGYFLPYNMILVLGLSSVVPVFILLQAWATNNRFAIVGAVREAL
CHHHEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHH
LSVSYDVLLVMSVVAIAIEYHTLDIAKVVESGIPGIVANPLAAIVFLVGMLMGTGRFPFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
IVEAESELVVGPSTEYSGFLFVLAMGGSYISTFALSFVFSDLFLGGWLPLNGLPGALINT
EEECCCCEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
IKAIIVLWFTVFLRGVYGRYRIDQALRGSWKYLLPVAFASLVLGLVVGWLWIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA