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The map label for this gene is nuoD [H]

Identifier: 15922546

GI number: 15922546

Start: 2224955

End: 2226133

Strand: Direct

Name: nuoD [H]

Synonym: ST2218

Alternate gene names: 15922546

Gene position: 2224955-2226133 (Clockwise)

Preceding gene: 15922545

Following gene: 15922547

Centisome position: 82.57

GC content: 35.54

Gene sequence:

>1179_bases
ATGGAAGTTGATATTGTTCCAGTAGAGGGAGAACTTAATGTAGGTCCTCAGCATCCTGGATCTGGACATATGAGAATTTA
TGTTAAACTTAATGGTGATATTATTGTTGATGCTGACTTAGATGTTGGCTATGTACATAGAGCTGTTGAAAAACTAAGTG
AAGTAAGAAATTATATGCATTTAATACCTTTAGTAGAAAGACCTGCGATCTTAGATTCTATACATATGAACTTAGGATAT
ATTATGGCTGTTGAAAAAATTTTAGGAGTTGACGTGCCAGAGAGAGCTCAATACTTACGCACATTAGCGGCTGAAGTTAA
TAGGATCGCAAGCCACTTATATGGTATTGGTATATTAGCAATATTTTTAGGTCACTCAACTGGTTTTATGTGGGGTTTTG
GAGATAGAGAAGTATGGGTAGAGATACTTCAAGCACTAACTGGTGCAAGGGTCACAAATTCTTACATTATTCCAGGAGGA
GTTAGAAGGGATCTTATACCAACTATTAAAGAAATGATAGAAAAGGCAATTGTTTATCAAAGGAAAAAAGTACAAGATTG
GTATAAAATTTTTGTGAAGAATCCCAATATAAGGGATAGATTAGAAAATGTTGGTGTTATGACTAGAGAGAATGCGATTA
AATGGGGTGCCGTAGGACCTAATTTAAGAGCTTCTGGAGTATATTATGATGTTAGGAAGATAGAGCCTTATGCAGCCTAT
GATAAGGTGGATTTTGAGATACCAGTATATAAAGAAGGAGATGCTTATGCTAGGTTATTGGTTAGATTTGAAGAAATAGA
ACAAAGTATGAGAATTTTAGAACAAGTAATAAAGAATATTCCAGAGGGGAATATATTAAGCGACAGATTCTTTAAACAAA
TTCCTCCGACTAGATTAAAGAAATGGTGGGAGGGGCAAAGAAGAGTTGTATTTCCAGGTTATTATGCTTCCTTCAGACCT
CCAAGGGGAGAAGCAATTTCTAGGGTTGAGGCTGCTAGAGGAGAACTAGTTTATTATGTAGTTAGTGATGGTTCTCCTCA
TCCATATAGGTTAAGAATGATTACTCCTTCATATCGTTTAATATATGTTTTTAAAGAATTAGCTAAGGGGGCACGTTACG
CCGATTTAGTTGCGATATATGGTAGTTTAGATTATTTTCCTCCGGAGGCTGATAGATAA

Upstream 100 bases:

>100_bases
GAAGATTTTGAAGGTGTTTACCCCATGAGAAAGAGCTATAAGATTAAAACGGAGGGGTTATTTGTTGACAAACCAAGCTG
ATGCATTATATTCATCTGGA

Downstream 100 bases:

>100_bases
TGGTGGATGTACTTTCAGCTATCAGATATTATTTCTTTTATCCATCTTTTTTTGCAGTAATTATATTTCCAGGATTAATA
TTTACTACAATAATATTATT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MEVDIVPVEGELNVGPQHPGSGHMRIYVKLNGDIIVDADLDVGYVHRAVEKLSEVRNYMHLIPLVERPAILDSIHMNLGY
IMAVEKILGVDVPERAQYLRTLAAEVNRIASHLYGIGILAIFLGHSTGFMWGFGDREVWVEILQALTGARVTNSYIIPGG
VRRDLIPTIKEMIEKAIVYQRKKVQDWYKIFVKNPNIRDRLENVGVMTRENAIKWGAVGPNLRASGVYYDVRKIEPYAAY
DKVDFEIPVYKEGDAYARLLVRFEEIEQSMRILEQVIKNIPEGNILSDRFFKQIPPTRLKKWWEGQRRVVFPGYYASFRP
PRGEAISRVEAARGELVYYVVSDGSPHPYRLRMITPSYRLIYVFKELAKGARYADLVAIYGSLDYFPPEADR

Sequences:

>Translated_392_residues
MEVDIVPVEGELNVGPQHPGSGHMRIYVKLNGDIIVDADLDVGYVHRAVEKLSEVRNYMHLIPLVERPAILDSIHMNLGY
IMAVEKILGVDVPERAQYLRTLAAEVNRIASHLYGIGILAIFLGHSTGFMWGFGDREVWVEILQALTGARVTNSYIIPGG
VRRDLIPTIKEMIEKAIVYQRKKVQDWYKIFVKNPNIRDRLENVGVMTRENAIKWGAVGPNLRASGVYYDVRKIEPYAAY
DKVDFEIPVYKEGDAYARLLVRFEEIEQSMRILEQVIKNIPEGNILSDRFFKQIPPTRLKKWWEGQRRVVFPGYYASFRP
PRGEAISRVEAARGELVYYVVSDGSPHPYRLRMITPSYRLIYVFKELAKGARYADLVAIYGSLDYFPPEADR
>Mature_392_residues
MEVDIVPVEGELNVGPQHPGSGHMRIYVKLNGDIIVDADLDVGYVHRAVEKLSEVRNYMHLIPLVERPAILDSIHMNLGY
IMAVEKILGVDVPERAQYLRTLAAEVNRIASHLYGIGILAIFLGHSTGFMWGFGDREVWVEILQALTGARVTNSYIIPGG
VRRDLIPTIKEMIEKAIVYQRKKVQDWYKIFVKNPNIRDRLENVGVMTRENAIKWGAVGPNLRASGVYYDVRKIEPYAAY
DKVDFEIPVYKEGDAYARLLVRFEEIEQSMRILEQVIKNIPEGNILSDRFFKQIPPTRLKKWWEGQRRVVFPGYYASFRP
PRGEAISRVEAARGELVYYVVSDGSPHPYRLRMITPSYRLIYVFKELAKGARYADLVAIYGSLDYFPPEADR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=383, Percent_Identity=35.2480417754569, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI260898743, Length=373, Percent_Identity=35.1206434316354, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI145693162, Length=385, Percent_Identity=33.5064935064935, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1789076, Length=392, Percent_Identity=30.3571428571429, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1788832, Length=383, Percent_Identity=29.5039164490862, Blast_Score=162, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17568379, Length=385, Percent_Identity=34.8051948051948, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17555284, Length=384, Percent_Identity=34.6354166666667, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24638644, Length=395, Percent_Identity=35.1898734177215, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=35.6770833333333, Blast_Score=241, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44935; Mature: 44935

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVDIVPVEGELNVGPQHPGSGHMRIYVKLNGDIIVDADLDVGYVHRAVEKLSEVRNYMH
CCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHH
LIPLVERPAILDSIHMNLGYIMAVEKILGVDVPERAQYLRTLAAEVNRIASHLYGIGILA
HHHHHCCCHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFLGHSTGFMWGFGDREVWVEILQALTGARVTNSYIIPGGVRRDLIPTIKEMIEKAIVYQ
HHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHH
RKKVQDWYKIFVKNPNIRDRLENVGVMTRENAIKWGAVGPNLRASGVYYDVRKIEPYAAY
HHHHHHHHHEEECCCCHHHHHHHCCCEECCCCEEECCCCCCCCCCCEEEEEEECCCCCCC
DKVDFEIPVYKEGDAYARLLVRFEEIEQSMRILEQVIKNIPEGNILSDRFFKQIPPTRLK
CCCCEEECEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHH
KWWEGQRRVVFPGYYASFRPPRGEAISRVEAARGELVYYVVSDGSPHPYRLRMITPSYRL
HHHCCCCEEECCCHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCHHH
IYVFKELAKGARYADLVAIYGSLDYFPPEADR
HHHHHHHHCCCCHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure
MEVDIVPVEGELNVGPQHPGSGHMRIYVKLNGDIIVDADLDVGYVHRAVEKLSEVRNYMH
CCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHH
LIPLVERPAILDSIHMNLGYIMAVEKILGVDVPERAQYLRTLAAEVNRIASHLYGIGILA
HHHHHCCCHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFLGHSTGFMWGFGDREVWVEILQALTGARVTNSYIIPGGVRRDLIPTIKEMIEKAIVYQ
HHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHH
RKKVQDWYKIFVKNPNIRDRLENVGVMTRENAIKWGAVGPNLRASGVYYDVRKIEPYAAY
HHHHHHHHHEEECCCCHHHHHHHCCCEECCCCEEECCCCCCCCCCCEEEEEEECCCCCCC
DKVDFEIPVYKEGDAYARLLVRFEEIEQSMRILEQVIKNIPEGNILSDRFFKQIPPTRLK
CCCCEEECEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHH
KWWEGQRRVVFPGYYASFRPPRGEAISRVEAARGELVYYVVSDGSPHPYRLRMITPSYRL
HHHCCCCEEECCCHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCHHH
IYVFKELAKGARYADLVAIYGSLDYFPPEADR
HHHHHHHHCCCCHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA