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The map label for this gene is argH

Identifier: 15921796

GI number: 15921796

Start: 1498456

End: 1499796

Strand: Direct

Name: argH

Synonym: ST1502

Alternate gene names: 15921796

Gene position: 1498456-1499796 (Clockwise)

Preceding gene: 15921795

Following gene: 15921797

Centisome position: 55.61

GC content: 31.32

Gene sequence:

>1341_bases
GTGGTATTGTACAGAAGATGGGGCACAGAAAAAGATTTTGTGTCTACTTATACTTCTTCCATAGATAGTGATAAGGAAAT
AGTAGAAGAAGTAAAAGTTGTGATGAAAGCTCATGTTATAGAACTTTATCTATCTGGTTATATAACAAAAGATACTGCTA
AGAGAATTTTGTTAGCAATAAACTCTTTTCATGAATTGAAAGAAGGATATGAAGATATTCATGAGGCTTTAGAAGATCAT
ATAATAAAGACAGTTGGTGAAGAAGGCGGATGGGTAGGATTTGGAAGGAGTAGAAATGATCACGTTGCTACAGCACTAAG
ACTTAAGATGAGAAAATATCTTATTGAAATTTTATACGATATTATATCTTTAAGAAAAACCCTCATTGAAAAGAGTAAGA
CATCTACAGAAATTTTATTTCCTACTTATACTCACTTTCAACCAGCTCAACCATCAACGTTAGCTCATTATTTCTTATAT
ATTGAAGACGAATTGGATACAATCTGGAATTATATTTATTCCTCTTTACTTTTAGTAAATAGATCTCCATTAGGAAGCGG
GGCTATTGTAGGGACTAACGTTAAATTAGATAGAAAAAGAGAAGCTGAATTGCTAGGATTCGATGACATTATATATAACA
CAATATCTGCTACTTCATCAAGATTAGATCTGATTAATGCAGTATCAAATTTGTCATTACTAATGTTATTTTTTAGCAGA
ATAGCAGAAGATTTGATTCTTCTTTCCTCCATGTTTATTAATATAGTAAAATTACCTGACTCTCACGTAAGTACCAGTAG
TCTAATGCCACAAAAAAGAAATGCAGTCACGTTAGAGATTCTAAGAAGTAAGGCTGGAGAATGCTTTGGCGATCTATCTT
CTCTTTTTAACATTTACAAAGGTTTACCCTCTGGTTATAATTTGGATTTACAAGAAATGAATAAGCATTATTGGGATTGC
GTTAAAATTGTTAATTCTTCAATAGAAGTAATAAATTCAATACTAGAAGGTATCGAAGTTCTAAACTTTCAATTAGATGA
CAAGACTACAGCTACTGATGTTGCAGAAGACTTAGCTATTACCGGAATACCGTACAGAAAAGCTTATATGGAGGTAGCTA
ACAAAATTAGAGCGGGCACTTTTATATCCGAAATTTCTCCAAAAACTTCTATATATAAGAAGGCTGTTATAGGCTCTCCT
AATCCCGAGTTAATAAATGAAGAGATAAAAATTAAAGAAAATAGAATAGCAGAAGAAGAGAGTAAATTGAAAAAATATGA
AGAAAAAATAATCGGAAAAATGAATGAATTAAAGGTGATCGAAGATGACCTTATATTGTAA

Upstream 100 bases:

>100_bases
CCAGTTATAATAAAGGATGGTACCCAACTGATGAGATGGCAAGAGGGTTTATTGAAATATATGGTATGCATTCATTACTA
ACCAGACAGGTGAGAGAATA

Downstream 100 bases:

>100_bases
GAGAGGATATAAAGGGTATTTATACCTAGAAGATGGTACATTAATTGAAGGTTGCGGTTTTGGAGCTAAAGGAATTAGAG
CTGGAGAAGTAGTTTTCACT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MVLYRRWGTEKDFVSTYTSSIDSDKEIVEEVKVVMKAHVIELYLSGYITKDTAKRILLAINSFHELKEGYEDIHEALEDH
IIKTVGEEGGWVGFGRSRNDHVATALRLKMRKYLIEILYDIISLRKTLIEKSKTSTEILFPTYTHFQPAQPSTLAHYFLY
IEDELDTIWNYIYSSLLLVNRSPLGSGAIVGTNVKLDRKREAELLGFDDIIYNTISATSSRLDLINAVSNLSLLMLFFSR
IAEDLILLSSMFINIVKLPDSHVSTSSLMPQKRNAVTLEILRSKAGECFGDLSSLFNIYKGLPSGYNLDLQEMNKHYWDC
VKIVNSSIEVINSILEGIEVLNFQLDDKTTATDVAEDLAITGIPYRKAYMEVANKIRAGTFISEISPKTSIYKKAVIGSP
NPELINEEIKIKENRIAEEESKLKKYEEKIIGKMNELKVIEDDLIL

Sequences:

>Translated_446_residues
MVLYRRWGTEKDFVSTYTSSIDSDKEIVEEVKVVMKAHVIELYLSGYITKDTAKRILLAINSFHELKEGYEDIHEALEDH
IIKTVGEEGGWVGFGRSRNDHVATALRLKMRKYLIEILYDIISLRKTLIEKSKTSTEILFPTYTHFQPAQPSTLAHYFLY
IEDELDTIWNYIYSSLLLVNRSPLGSGAIVGTNVKLDRKREAELLGFDDIIYNTISATSSRLDLINAVSNLSLLMLFFSR
IAEDLILLSSMFINIVKLPDSHVSTSSLMPQKRNAVTLEILRSKAGECFGDLSSLFNIYKGLPSGYNLDLQEMNKHYWDC
VKIVNSSIEVINSILEGIEVLNFQLDDKTTATDVAEDLAITGIPYRKAYMEVANKIRAGTFISEISPKTSIYKKAVIGSP
NPELINEEIKIKENRIAEEESKLKKYEEKIIGKMNELKVIEDDLIL
>Mature_446_residues
MVLYRRWGTEKDFVSTYTSSIDSDKEIVEEVKVVMKAHVIELYLSGYITKDTAKRILLAINSFHELKEGYEDIHEALEDH
IIKTVGEEGGWVGFGRSRNDHVATALRLKMRKYLIEILYDIISLRKTLIEKSKTSTEILFPTYTHFQPAQPSTLAHYFLY
IEDELDTIWNYIYSSLLLVNRSPLGSGAIVGTNVKLDRKREAELLGFDDIIYNTISATSSRLDLINAVSNLSLLMLFFSR
IAEDLILLSSMFINIVKLPDSHVSTSSLMPQKRNAVTLEILRSKAGECFGDLSSLFNIYKGLPSGYNLDLQEMNKHYWDC
VKIVNSSIEVINSILEGIEVLNFQLDDKTTATDVAEDLAITGIPYRKAYMEVANKIRAGTFISEISPKTSIYKKAVIGSP
NPELINEEIKIKENRIAEEESKLKKYEEKIIGKMNELKVIEDDLIL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=368, Percent_Identity=33.9673913043478, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI68303542, Length=368, Percent_Identity=33.9673913043478, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI68303549, Length=368, Percent_Identity=32.6086956521739, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI68303547, Length=366, Percent_Identity=31.9672131147541, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1790398, Length=439, Percent_Identity=29.3849658314351, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321806, Length=305, Percent_Identity=35.0819672131148, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI221473854, Length=383, Percent_Identity=30.5483028720627, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI78706858, Length=383, Percent_Identity=30.5483028720627, Blast_Score=168, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_SULTO (Q970U9)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377465.1
- ProteinModelPortal:   Q970U9
- SMR:   Q970U9
- GeneID:   1459538
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1502
- NMPDR:   fig|273063.1.peg.1633
- HOGENOM:   HBG539632
- OMA:   IMEEVKL
- ProtClustDB:   PRK00855
- BioCyc:   STOK273063:ST1502-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50704; Mature: 50704

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLYRRWGTEKDFVSTYTSSIDSDKEIVEEVKVVMKAHVIELYLSGYITKDTAKRILLAI
CEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
NSFHELKEGYEDIHEALEDHIIKTVGEEGGWVGFGRSRNDHVATALRLKMRKYLIEILYD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
IISLRKTLIEKSKTSTEILFPTYTHFQPAQPSTLAHYFLYIEDELDTIWNYIYSSLLLVN
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHEEEEEEEEHHHHHHHHHHHHHHHHHC
RSPLGSGAIVGTNVKLDRKREAELLGFDDIIYNTISATSSRLDLINAVSNLSLLMLFFSR
CCCCCCCCEEECCCEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAEDLILLSSMFINIVKLPDSHVSTSSLMPQKRNAVTLEILRSKAGECFGDLSSLFNIYK
HHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLPSGYNLDLQEMNKHYWDCVKIVNSSIEVINSILEGIEVLNFQLDDKTTATDVAEDLAI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHH
TGIPYRKAYMEVANKIRAGTFISEISPKTSIYKKAVIGSPNPELINEEIKIKENRIAEEE
CCCCHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHH
SKLKKYEEKIIGKMNELKVIEDDLIL
HHHHHHHHHHHCCHHHHEEHHHHCCC
>Mature Secondary Structure
MVLYRRWGTEKDFVSTYTSSIDSDKEIVEEVKVVMKAHVIELYLSGYITKDTAKRILLAI
CEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
NSFHELKEGYEDIHEALEDHIIKTVGEEGGWVGFGRSRNDHVATALRLKMRKYLIEILYD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
IISLRKTLIEKSKTSTEILFPTYTHFQPAQPSTLAHYFLYIEDELDTIWNYIYSSLLLVN
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHEEEEEEEEHHHHHHHHHHHHHHHHHC
RSPLGSGAIVGTNVKLDRKREAELLGFDDIIYNTISATSSRLDLINAVSNLSLLMLFFSR
CCCCCCCCEEECCCEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAEDLILLSSMFINIVKLPDSHVSTSSLMPQKRNAVTLEILRSKAGECFGDLSSLFNIYK
HHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLPSGYNLDLQEMNKHYWDCVKIVNSSIEVINSILEGIEVLNFQLDDKTTATDVAEDLAI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHH
TGIPYRKAYMEVANKIRAGTFISEISPKTSIYKKAVIGSPNPELINEEIKIKENRIAEEE
CCCCHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHH
SKLKKYEEKIIGKMNELKVIEDDLIL
HHHHHHHHHHHCCHHHHEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479