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The map label for this gene is argG

Identifier: 15921795

GI number: 15921795

Start: 1497284

End: 1498456

Strand: Direct

Name: argG

Synonym: ST1501

Alternate gene names: 15921795

Gene position: 1497284-1498456 (Clockwise)

Preceding gene: 15921794

Following gene: 15921796

Centisome position: 55.56

GC content: 33.25

Gene sequence:

>1173_bases
ATGAAAATAGTTCTTGCATACTCTGGTGGGTTAGATACTACAGTAGCGATAAGATGGCTAAAGGAAACCTTTAATGCTGA
CGTTATCACAGTCACAGTAGATGTAGGGCAAAAAGATAACTTTGAAGACATAGAAAAAAGAGCATATATAGCAGGAGCAA
CAAAACATTATACTATAGATGCAAAAAAGGAATTTGCTGATAATTTCATTTCTTACGCAATCAAAATGAACGCATTATAT
GAGGATGTTTATCCATTATCAACAGCCTTAGCAAGACCATTAATAGCACAAAAAGTTGTTGAAATAGCAAAAAAAGAAAA
AGTAGACTATATTGCTCACGGTTCAACATCTAAAGGAAATGATCAAGTAAGATTCGACTTAGCAGTTAAAGCATTATATC
CAGAGGCTAAAATCATAGCTCCAGCTAGAATATGGAATATGACAAGAGAGAAAGAGATAGAGTTTGCAAAAGCCAGAGGG
ATTCCTATCAAAACTGAAAGCAGTAAATATAGTATTGACGAGAACTTATGGGGTAGAAGTATTGAAGGTGATGATATTTC
TGATCCGTCAAAAGAAGTCCCAGAAGATGCTTTTGAATGGACCAAAAAGAAAAATAATGGTAAAATTACTCTCTCCATTG
AATTTGAAAAAGGTATTCCAGTTGCTATAAATAATGAAAAAATGGATTTAGTTAAAATTATTCAAGTGTTAAATGAGGTA
GTAGGTTCTTATGGTTTTGGAAGAGTAGAACATTTAGAAAATAGAGTTGTAGGTTTTAAATCTAGAGAAGTTTATGAAGT
TCCTGCAGCGTTAGTTTTGATAAATTCACATAAAGACTTAGAAAAGACTGTTTATTCTCCGTTAGAGTTTAGATTTAAGA
AATATATAGACTCACAATGGGCTGATTTAGTTTATCAAGGGCTTTGGTTTGAACCTTTAAGAGAGACTATACAATTGGCC
GGTGATAATTTAAATAAATGGGTTACTGGTGAGGTAAAAATAGAAATAGAAGGTAATGGAATGAGAACATTAGGTAGGGC
TTCAAAGTACTCTCCATTTTCTGAAAAAGTTGCCAGTTATAATAAAGGATGGTACCCAACTGATGAGATGGCAAGAGGGT
TTATTGAAATATATGGTATGCATTCATTACTAACCAGACAGGTGAGAGAATAG

Upstream 100 bases:

>100_bases
AAGAGCTAAAGGACTCCTTTACCATTCTATTTCTTGAGAAATGCCTTTTTTTACTTAACCTCATACTTTTTAAGTAATTT
CTTATATCAACAAAGCCGAT

Downstream 100 bases:

>100_bases
TGGTATTGTACAGAAGATGGGGCACAGAAAAAGATTTTGTGTCTACTTATACTTCTTCCATAGATAGTGATAAGGAAATA
GTAGAAGAAGTAAAAGTTGT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKIVLAYSGGLDTTVAIRWLKETFNADVITVTVDVGQKDNFEDIEKRAYIAGATKHYTIDAKKEFADNFISYAIKMNALY
EDVYPLSTALARPLIAQKVVEIAKKEKVDYIAHGSTSKGNDQVRFDLAVKALYPEAKIIAPARIWNMTREKEIEFAKARG
IPIKTESSKYSIDENLWGRSIEGDDISDPSKEVPEDAFEWTKKKNNGKITLSIEFEKGIPVAINNEKMDLVKIIQVLNEV
VGSYGFGRVEHLENRVVGFKSREVYEVPAALVLINSHKDLEKTVYSPLEFRFKKYIDSQWADLVYQGLWFEPLRETIQLA
GDNLNKWVTGEVKIEIEGNGMRTLGRASKYSPFSEKVASYNKGWYPTDEMARGFIEIYGMHSLLTRQVRE

Sequences:

>Translated_390_residues
MKIVLAYSGGLDTTVAIRWLKETFNADVITVTVDVGQKDNFEDIEKRAYIAGATKHYTIDAKKEFADNFISYAIKMNALY
EDVYPLSTALARPLIAQKVVEIAKKEKVDYIAHGSTSKGNDQVRFDLAVKALYPEAKIIAPARIWNMTREKEIEFAKARG
IPIKTESSKYSIDENLWGRSIEGDDISDPSKEVPEDAFEWTKKKNNGKITLSIEFEKGIPVAINNEKMDLVKIIQVLNEV
VGSYGFGRVEHLENRVVGFKSREVYEVPAALVLINSHKDLEKTVYSPLEFRFKKYIDSQWADLVYQGLWFEPLRETIQLA
GDNLNKWVTGEVKIEIEGNGMRTLGRASKYSPFSEKVASYNKGWYPTDEMARGFIEIYGMHSLLTRQVRE
>Mature_390_residues
MKIVLAYSGGLDTTVAIRWLKETFNADVITVTVDVGQKDNFEDIEKRAYIAGATKHYTIDAKKEFADNFISYAIKMNALY
EDVYPLSTALARPLIAQKVVEIAKKEKVDYIAHGSTSKGNDQVRFDLAVKALYPEAKIIAPARIWNMTREKEIEFAKARG
IPIKTESSKYSIDENLWGRSIEGDDISDPSKEVPEDAFEWTKKKNNGKITLSIEFEKGIPVAINNEKMDLVKIIQVLNEV
VGSYGFGRVEHLENRVVGFKSREVYEVPAALVLINSHKDLEKTVYSPLEFRFKKYIDSQWADLVYQGLWFEPLRETIQLA
GDNLNKWVTGEVKIEIEGNGMRTLGRASKYSPFSEKVASYNKGWYPTDEMARGFIEIYGMHSLLTRQVRE

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=391, Percent_Identity=40.4092071611253, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI16950633, Length=391, Percent_Identity=40.4092071611253, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1789563, Length=400, Percent_Identity=28.25, Blast_Score=121, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6324514, Length=410, Percent_Identity=31.7073170731707, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21358151, Length=399, Percent_Identity=36.0902255639098, Blast_Score=237, Evalue=8e-63,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_SULTO (Q970V0)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377464.1
- ProteinModelPortal:   Q970V0
- SMR:   Q970V0
- GeneID:   1459537
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1501
- NMPDR:   fig|273063.1.peg.1632
- HOGENOM:   HBG335267
- OMA:   VAVDVGQ
- ProtClustDB:   PRK00509
- BioCyc:   STOK273063:ST1501-MONOMER
- BRENDA:   6.3.4.5
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 44392; Mature: 44392

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 84-84 BINDING 114-114 BINDING 116-116 BINDING 120-120 BINDING 120-120 BINDING 121-121 BINDING 124-124 BINDING 171-171 BINDING 180-180 BINDING 253-253 BINDING 265-265

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVLAYSGGLDTTVAIRWLKETFNADVITVTVDVGQKDNFEDIEKRAYIAGATKHYTID
CEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHEEECCCEEEEEC
AKKEFADNFISYAIKMNALYEDVYPLSTALARPLIAQKVVEIAKKEKVDYIAHGSTSKGN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
DQVRFDLAVKALYPEAKIIAPARIWNMTREKEIEFAKARGIPIKTESSKYSIDENLWGRS
CEEEEEEEEEEECCCCCEECHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCC
IEGDDISDPSKEVPEDAFEWTKKKNNGKITLSIEFEKGIPVAINNEKMDLVKIIQVLNEV
CCCCCCCCCHHHCCHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCHHHHHHHHHHHHH
VGSYGFGRVEHLENRVVGFKSREVYEVPAALVLINSHKDLEKTVYSPLEFRFKKYIDSQW
HCCCCCCHHHHHHHHHCCCCCCEEEECCEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHH
ADLVYQGLWFEPLRETIQLAGDNLNKWVTGEVKIEIEGNGMRTLGRASKYSPFSEKVASY
HHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCHHHHHHHC
NKGWYPTDEMARGFIEIYGMHSLLTRQVRE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIVLAYSGGLDTTVAIRWLKETFNADVITVTVDVGQKDNFEDIEKRAYIAGATKHYTID
CEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHEEECCCEEEEEC
AKKEFADNFISYAIKMNALYEDVYPLSTALARPLIAQKVVEIAKKEKVDYIAHGSTSKGN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
DQVRFDLAVKALYPEAKIIAPARIWNMTREKEIEFAKARGIPIKTESSKYSIDENLWGRS
CEEEEEEEEEEECCCCCEECHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCC
IEGDDISDPSKEVPEDAFEWTKKKNNGKITLSIEFEKGIPVAINNEKMDLVKIIQVLNEV
CCCCCCCCCHHHCCHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCHHHHHHHHHHHHH
VGSYGFGRVEHLENRVVGFKSREVYEVPAALVLINSHKDLEKTVYSPLEFRFKKYIDSQW
HCCCCCCHHHHHHHHHCCCCCCEEEECCEEEEEEECCCHHHHHHCCHHHHHHHHHHHHHH
ADLVYQGLWFEPLRETIQLAGDNLNKWVTGEVKIEIEGNGMRTLGRASKYSPFSEKVASY
HHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCHHHHHHHC
NKGWYPTDEMARGFIEIYGMHSLLTRQVRE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479