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The map label for this gene is serS

Identifier: 15921761

GI number: 15921761

Start: 1469902

End: 1471263

Strand: Direct

Name: serS

Synonym: ST1469

Alternate gene names: 15921761

Gene position: 1469902-1471263 (Clockwise)

Preceding gene: 15921760

Following gene: 15921763

Centisome position: 54.55

GC content: 33.55

Gene sequence:

>1362_bases
GTGTCTTGGAGTATATTAGAGTTAGTTAGAAACAATCCGGATAAACTTAAGGAATATATAAAAAGAAGATTTATAGATGT
CTCTTTGGTTGATAGAGCTGTAGAATTAGATAAGAAATGGAGACAAACACTACAAGAAGTAGAAAAGCTAAGGCATGAGC
ACAATGTTATAAGCTCCTCTATTCCTAAGGCCAAACCAGAAGAGAGACAAGAGTTGATAAAGAAAGCAAAAGAATTATTA
AAGGCATTGGAAGAAAAGGAAAAAGAGCTAGATAATATAGAGAATGAAAGAGATAATATATTAATGCAATTGCCTAATAT
AGTAGATGATTCTGCTCCTATAGGGCCTGATGAAACATATAGCGTTCCTATAAGATTTTGGGGGAAATTTAAAGTATACG
AAAAAGATGAAGCTGAGTTTCTTAGTCAATTAAAAGGAAATAGGGTTGATTATGAAATTATACATTGGAAGCCAGTTGGA
CATGCAGATATGTTAGAAAATGTTCTAAAACTAGGAGATACCAAGAAAGCAGCAGAAGTATCTGGTGCCAGATTCTACTA
TTTATTTGATGACATAGTTTGGTTAGATATTGCATTACTTAATTATGCAATAGACACGATGACAAGTAAAGGATATACTT
TAGTACTTCCTCCATATATGTTAAGAGGGGAGGTCATAAAGAGCGTTATTGATTTAGATACATTTAAGGACGCAATTTAT
AAGATAGAAAATGAAGATCTTTATCTTATTGCTACCGCAGAACATCCAATAGCGGCCCTATACTTTAAGGAGGAAATACC
TAAAGAGAAACTTCCATTAAAATATGTTGGTATAAGTCCTGCATTTAGGAAAGAAGCTGGAGCTGCAAATAAGGATTTGA
AAGGTATATTTAGGGTTCATCAGTTTCATAAAGTGGAGCAATTTATCTTTTCATCTCCAGAAGATAGTTGGAAATTACAT
GAAGAATTAATAAGGAATGCAGAAGAGATATTTCAAGGATTAGGATTACCATATAGGGTCATAAATATCGCAACTGGTGA
CTTAGGTGCATGTGCAGCTAAAAAGTATGATTTAGAAGTATGGATGCCCGCACAAGCTAAGTTTAGAGAGATGGTAAGTT
GTAGTAATTGTCTTGATTGGCAAGCATATAGAATGAGGATAAGATATGTAGAAAAGGGAGGTAAGAAAGGTTATGTACAT
ACGCTAAATAGTACTGCTATAGCTAGTACTAGGACTATAACAGCAATCCTTGAAAATTACCAGAGAGAAGATGGTGTAGT
TGAAATACCTAAAGTGCTCAAAAAATACTTAGAACCATTTAGTAGGGCTCCTAAAGATTACATATATCCTAGAAAAGAAT
AA

Upstream 100 bases:

>100_bases
CTATGATATTGTTGAGATGTGGATTCAAACATATGGATTACCAGAAGGACAAGATCAACAAGATCAGAAGGCATAAATTC
TTTTGTGTTTTTTGTTAATT

Downstream 100 bases:

>100_bases
ATAAAGATATTTAATAAAAATTATTTCTTTAAATAATATTCTAGGTTTGATTCTATCTTTTTCATCATTCTTTTAGCTAC
TCTGAGGAATAATTTTAATG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSWSILELVRNNPDKLKEYIKRRFIDVSLVDRAVELDKKWRQTLQEVEKLRHEHNVISSSIPKAKPEERQELIKKAKELL
KALEEKEKELDNIENERDNILMQLPNIVDDSAPIGPDETYSVPIRFWGKFKVYEKDEAEFLSQLKGNRVDYEIIHWKPVG
HADMLENVLKLGDTKKAAEVSGARFYYLFDDIVWLDIALLNYAIDTMTSKGYTLVLPPYMLRGEVIKSVIDLDTFKDAIY
KIENEDLYLIATAEHPIAALYFKEEIPKEKLPLKYVGISPAFRKEAGAANKDLKGIFRVHQFHKVEQFIFSSPEDSWKLH
EELIRNAEEIFQGLGLPYRVINIATGDLGACAAKKYDLEVWMPAQAKFREMVSCSNCLDWQAYRMRIRYVEKGGKKGYVH
TLNSTAIASTRTITAILENYQREDGVVEIPKVLKKYLEPFSRAPKDYIYPRKE

Sequences:

>Translated_453_residues
MSWSILELVRNNPDKLKEYIKRRFIDVSLVDRAVELDKKWRQTLQEVEKLRHEHNVISSSIPKAKPEERQELIKKAKELL
KALEEKEKELDNIENERDNILMQLPNIVDDSAPIGPDETYSVPIRFWGKFKVYEKDEAEFLSQLKGNRVDYEIIHWKPVG
HADMLENVLKLGDTKKAAEVSGARFYYLFDDIVWLDIALLNYAIDTMTSKGYTLVLPPYMLRGEVIKSVIDLDTFKDAIY
KIENEDLYLIATAEHPIAALYFKEEIPKEKLPLKYVGISPAFRKEAGAANKDLKGIFRVHQFHKVEQFIFSSPEDSWKLH
EELIRNAEEIFQGLGLPYRVINIATGDLGACAAKKYDLEVWMPAQAKFREMVSCSNCLDWQAYRMRIRYVEKGGKKGYVH
TLNSTAIASTRTITAILENYQREDGVVEIPKVLKKYLEPFSRAPKDYIYPRKE
>Mature_452_residues
SWSILELVRNNPDKLKEYIKRRFIDVSLVDRAVELDKKWRQTLQEVEKLRHEHNVISSSIPKAKPEERQELIKKAKELLK
ALEEKEKELDNIENERDNILMQLPNIVDDSAPIGPDETYSVPIRFWGKFKVYEKDEAEFLSQLKGNRVDYEIIHWKPVGH
ADMLENVLKLGDTKKAAEVSGARFYYLFDDIVWLDIALLNYAIDTMTSKGYTLVLPPYMLRGEVIKSVIDLDTFKDAIYK
IENEDLYLIATAEHPIAALYFKEEIPKEKLPLKYVGISPAFRKEAGAANKDLKGIFRVHQFHKVEQFIFSSPEDSWKLHE
ELIRNAEEIFQGLGLPYRVINIATGDLGACAAKKYDLEVWMPAQAKFREMVSCSNCLDWQAYRMRIRYVEKGGKKGYVHT
LNSTAIASTRTITAILENYQREDGVVEIPKVLKKYLEPFSRAPKDYIYPRKE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=474, Percent_Identity=36.9198312236287, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI8923421, Length=362, Percent_Identity=31.2154696132597, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI225579074, Length=362, Percent_Identity=31.2154696132597, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1787120, Length=444, Percent_Identity=34.9099099099099, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17539260, Length=485, Percent_Identity=34.2268041237113, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17542084, Length=336, Percent_Identity=31.25, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320226, Length=443, Percent_Identity=37.4717832957111, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6321799, Length=431, Percent_Identity=32.0185614849188, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24581334, Length=473, Percent_Identity=35.7293868921776, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI17737985, Length=276, Percent_Identity=35.8695652173913, Blast_Score=172, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_SULTO (Q970Y4)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377430.1
- ProteinModelPortal:   Q970Y4
- SMR:   Q970Y4
- GeneID:   1459503
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1469
- NMPDR:   fig|273063.1.peg.1598
- HOGENOM:   HBG629391
- OMA:   VPIRFWG
- ProtClustDB:   PRK05431
- BioCyc:   STOK273063:ST1469-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 52614; Mature: 52483

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 299-299 BINDING 306-306 BINDING 405-405

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWSILELVRNNPDKLKEYIKRRFIDVSLVDRAVELDKKWRQTLQEVEKLRHEHNVISSS
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IPKAKPEERQELIKKAKELLKALEEKEKELDNIENERDNILMQLPNIVDDSAPIGPDETY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCE
SVPIRFWGKFKVYEKDEAEFLSQLKGNRVDYEIIHWKPVGHADMLENVLKLGDTKKAAEV
EEEEEEEEEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHC
SGARFYYLFDDIVWLDIALLNYAIDTMTSKGYTLVLPPYMLRGEVIKSVIDLDTFKDAIY
CCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
KIENEDLYLIATAEHPIAALYFKEEIPKEKLPLKYVGISPAFRKEAGAANKDLKGIFRVH
EECCCCEEEEEECCCCEEEEHHHHHCCHHHCCEEEECCCHHHHHHCCCCCHHHHHHHHHH
QFHKVEQFIFSSPEDSWKLHEELIRNAEEIFQGLGLPYRVINIATGDLGACAAKKYDLEV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCEEE
WMPAQAKFREMVSCSNCLDWQAYRMRIRYVEKGGKKGYVHTLNSTAIASTRTITAILENY
ECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHH
QREDGVVEIPKVLKKYLEPFSRAPKDYIYPRKE
HHCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
SWSILELVRNNPDKLKEYIKRRFIDVSLVDRAVELDKKWRQTLQEVEKLRHEHNVISSS
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IPKAKPEERQELIKKAKELLKALEEKEKELDNIENERDNILMQLPNIVDDSAPIGPDETY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCE
SVPIRFWGKFKVYEKDEAEFLSQLKGNRVDYEIIHWKPVGHADMLENVLKLGDTKKAAEV
EEEEEEEEEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHC
SGARFYYLFDDIVWLDIALLNYAIDTMTSKGYTLVLPPYMLRGEVIKSVIDLDTFKDAIY
CCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
KIENEDLYLIATAEHPIAALYFKEEIPKEKLPLKYVGISPAFRKEAGAANKDLKGIFRVH
EECCCCEEEEEECCCCEEEEHHHHHCCHHHCCEEEECCCHHHHHHCCCCCHHHHHHHHHH
QFHKVEQFIFSSPEDSWKLHEELIRNAEEIFQGLGLPYRVINIATGDLGACAAKKYDLEV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHCCCCCEEE
WMPAQAKFREMVSCSNCLDWQAYRMRIRYVEKGGKKGYVHTLNSTAIASTRTITAILENY
ECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHH
QREDGVVEIPKVLKKYLEPFSRAPKDYIYPRKE
HHCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479