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The map label for this gene is hisD

Identifier: 15921756

GI number: 15921756

Start: 1467018

End: 1468202

Strand: Direct

Name: hisD

Synonym: ST1464

Alternate gene names: 15921756

Gene position: 1467018-1468202 (Clockwise)

Preceding gene: 15921755

Following gene: 15921757

Centisome position: 54.44

GC content: 34.01

Gene sequence:

>1185_bases
ATGATATTAAAGGAGTTACCTAAGCAAAGACCTAATGATTTTACCAAAGTACTTCAAGATGTAGAGAAGATTATTAGTTA
TGTTAAGCAAAAAGGTGACGAGGCTTTAATAGAACTCGAAGAAAAATTCGATAAAGTAAAACTTACATCCATAAAGTTTC
CTGAGGTAGATAAGCTAGCTTCTCAGATTTCACAAGATTTAAAAATGGCAATAGATGTAATCTTTACACAGATATACGAA
TTTAACAATTCAATAAAACCACCAAATATTATAGGAGGTAGTGCTAACGGTATAGATTACGGAATAATGTGGAAAAGTAT
CGAGAGAGTAGGAATTTATGTGCCAGGTGGTGAGAAAGCATACCCGTCAACACTATTAATGGCTGGTGTTCCTGCTTTAG
TTGCTGGTGTTAAGGAAATTTATGTTTCTTCTCCTCCAACTAAAATAAATTCAGCTATAGCATATATTTCTCTTAAGCTT
GGAGTTAAAGAAATCTATGCAATTGGTGGTGCACAGGCAATTGCTGCGATGGCATATGGAACTCAAACTGTTAAGAAAGT
GGATAAGATTGTTGGCCCTGGTAATATTTATGTTCAAGCGGCAAAATATTTAGTCAGTAGTGATGTTGGTATAGATGGTA
TCGAAGGTCCTACTGAATTAGTTATTATAGCTGATGAAACCGCTAATCCCTCTAACATAATATTAGATTTGAAAGCTCAA
GCTGAGCATGGGAGGTCAACTTTTCTAGTTTTGCTTTCCAATTCAGATAAGATTATTAACTTTGTATCTAAAGAACTTGA
TGTAGATTCCAATATCTATTATGTCATCAAAGTAAATTCTATAGATGAAGCAATAGATATTGCTAATGAGATAGCACCAG
AGCATTTATCTTTACAAATTTCTAGTGCTAGAGAATATCTACCAAAAGTGAAAAACGCTGGAGCTGTAACTTTGGGAAAT
ACCCCTCCAGCAATAATTGACTATTCTGCTGGTCCAAATCATATTTTACCTACAAATGGTTGGGCAAAAATTAGAGGTGG
AATATCAGTTTATGATTATCTAAAGATGATAATGTATGCTTCTACGTCGAATCCAGAGAAAAAACTTGTTGAAGCTTCTA
AAATTTTAGCAAAATATGAAGGTTTCGTATTTCATGCTGACAGTATTGGTGTTAGGTATGAGTAG

Upstream 100 bases:

>100_bases
TTGCGGATGCCGCGTTGGCTGCAGGTGTTTTTCATGATGGCGTTATTAAGATCCCTGAACTTAAAAGGTTTTTGTTAGAG
AAGGGTATAGAGGTGAGAGT

Downstream 100 bases:

>100_bases
TAATGTATTAGATACGCTATATTCCATTATTTTAGATAGGATAAGCAATAAGAAGGAAGGTAGTTATACTGTAAAATTGC
TAGAAAAAGGTAAACCTTAT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MILKELPKQRPNDFTKVLQDVEKIISYVKQKGDEALIELEEKFDKVKLTSIKFPEVDKLASQISQDLKMAIDVIFTQIYE
FNNSIKPPNIIGGSANGIDYGIMWKSIERVGIYVPGGEKAYPSTLLMAGVPALVAGVKEIYVSSPPTKINSAIAYISLKL
GVKEIYAIGGAQAIAAMAYGTQTVKKVDKIVGPGNIYVQAAKYLVSSDVGIDGIEGPTELVIIADETANPSNIILDLKAQ
AEHGRSTFLVLLSNSDKIINFVSKELDVDSNIYYVIKVNSIDEAIDIANEIAPEHLSLQISSAREYLPKVKNAGAVTLGN
TPPAIIDYSAGPNHILPTNGWAKIRGGISVYDYLKMIMYASTSNPEKKLVEASKILAKYEGFVFHADSIGVRYE

Sequences:

>Translated_394_residues
MILKELPKQRPNDFTKVLQDVEKIISYVKQKGDEALIELEEKFDKVKLTSIKFPEVDKLASQISQDLKMAIDVIFTQIYE
FNNSIKPPNIIGGSANGIDYGIMWKSIERVGIYVPGGEKAYPSTLLMAGVPALVAGVKEIYVSSPPTKINSAIAYISLKL
GVKEIYAIGGAQAIAAMAYGTQTVKKVDKIVGPGNIYVQAAKYLVSSDVGIDGIEGPTELVIIADETANPSNIILDLKAQ
AEHGRSTFLVLLSNSDKIINFVSKELDVDSNIYYVIKVNSIDEAIDIANEIAPEHLSLQISSAREYLPKVKNAGAVTLGN
TPPAIIDYSAGPNHILPTNGWAKIRGGISVYDYLKMIMYASTSNPEKKLVEASKILAKYEGFVFHADSIGVRYE
>Mature_394_residues
MILKELPKQRPNDFTKVLQDVEKIISYVKQKGDEALIELEEKFDKVKLTSIKFPEVDKLASQISQDLKMAIDVIFTQIYE
FNNSIKPPNIIGGSANGIDYGIMWKSIERVGIYVPGGEKAYPSTLLMAGVPALVAGVKEIYVSSPPTKINSAIAYISLKL
GVKEIYAIGGAQAIAAMAYGTQTVKKVDKIVGPGNIYVQAAKYLVSSDVGIDGIEGPTELVIIADETANPSNIILDLKAQ
AEHGRSTFLVLLSNSDKIINFVSKELDVDSNIYYVIKVNSIDEAIDIANEIAPEHLSLQISSAREYLPKVKNAGAVTLGN
TPPAIIDYSAGPNHILPTNGWAKIRGGISVYDYLKMIMYASTSNPEKKLVEASKILAKYEGFVFHADSIGVRYE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=396, Percent_Identity=33.3333333333333, Blast_Score=221, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6319819, Length=416, Percent_Identity=37.0192307692308, Blast_Score=232, Evalue=6e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_SULTO (Q970Y9)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377425.1
- ProteinModelPortal:   Q970Y9
- SMR:   Q970Y9
- GeneID:   1459498
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1464
- NMPDR:   fig|273063.1.peg.1593
- HOGENOM:   HBG329596
- OMA:   TEWEVEK
- ProtClustDB:   PRK00877
- BioCyc:   STOK273063:ST1464-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 42933; Mature: 42933

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 294-294 ACT_SITE 295-295 BINDING 113-113 BINDING 172-172 BINDING 195-195 BINDING 218-218 BINDING 240-240 BINDING 243-243 BINDING 295-295 BINDING 327-327 BINDING 380-380 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKELPKQRPNDFTKVLQDVEKIISYVKQKGDEALIELEEKFDKVKLTSIKFPEVDKLA
CCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCHHHHH
SQISQDLKMAIDVIFTQIYEFNNSIKPPNIIGGSANGIDYGIMWKSIERVGIYVPGGEKA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHCCCEEEEEECCCCCC
YPSTLLMAGVPALVAGVKEIYVSSPPTKINSAIAYISLKLGVKEIYAIGGAQAIAAMAYG
CCHHHHHHCHHHHHHHHHHHHCCCCCCHHHHEEEEEEEECCHHHHHHCCCHHHHHHHHHH
TQTVKKVDKIVGPGNIYVQAAKYLVSSDVGIDGIEGPTELVIIADETANPSNIILDLKAQ
HHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEEC
AEHGRSTFLVLLSNSDKIINFVSKELDVDSNIYYVIKVNSIDEAIDIANEIAPEHLSLQI
CCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHCCCCCEEEEE
SSAREYLPKVKNAGAVTLGNTPPAIIDYSAGPNHILPTNGWAKIRGGISVYDYLKMIMYA
HHHHHHHHHHCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHH
STSNPEKKLVEASKILAKYEGFVFHADSIGVRYE
CCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCC
>Mature Secondary Structure
MILKELPKQRPNDFTKVLQDVEKIISYVKQKGDEALIELEEKFDKVKLTSIKFPEVDKLA
CCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEECCCCHHHHH
SQISQDLKMAIDVIFTQIYEFNNSIKPPNIIGGSANGIDYGIMWKSIERVGIYVPGGEKA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHCCCEEEEEECCCCCC
YPSTLLMAGVPALVAGVKEIYVSSPPTKINSAIAYISLKLGVKEIYAIGGAQAIAAMAYG
CCHHHHHHCHHHHHHHHHHHHCCCCCCHHHHEEEEEEEECCHHHHHHCCCHHHHHHHHHH
TQTVKKVDKIVGPGNIYVQAAKYLVSSDVGIDGIEGPTELVIIADETANPSNIILDLKAQ
HHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEEC
AEHGRSTFLVLLSNSDKIINFVSKELDVDSNIYYVIKVNSIDEAIDIANEIAPEHLSLQI
CCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHCCCCCEEEEE
SSAREYLPKVKNAGAVTLGNTPPAIIDYSAGPNHILPTNGWAKIRGGISVYDYLKMIMYA
HHHHHHHHHHCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHH
STSNPEKKLVEASKILAKYEGFVFHADSIGVRYE
CCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479