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The map label for this gene is hisE [H]

Identifier: 15921757

GI number: 15921757

Start: 1468153

End: 1468479

Strand: Direct

Name: hisE [H]

Synonym: ST1465

Alternate gene names: 15921757

Gene position: 1468153-1468479 (Clockwise)

Preceding gene: 15921756

Following gene: 15921758

Centisome position: 54.48

GC content: 34.25

Gene sequence:

>327_bases
ATGAAGGTTTCGTATTTCATGCTGACAGTATTGGTGTTAGGTATGAGTAGTAATGTATTAGATACGCTATATTCCATTAT
TTTAGATAGGATAAGCAATAAGAAGGAAGGTAGTTATACTGTAAAATTGCTAGAAAAAGGTAAACCTTATATAGCTAGAA
AAGTGGGTGAGGAAGCTACGGAAGTAATTGTGGCTTCATTAAGTGAAGGAAGAGAGAGATTTATTAGTGAAGTAGCAGAC
TTAATATATCATCTTTTCGTATTAATGGCTGTAGAAGGAGTTAAGCCAGAAGATGTTTATGAGGAGCTAAAAAGGAGGAT
GAAGTGA

Upstream 100 bases:

>100_bases
GGTGGAATATCAGTTTATGATTATCTAAAGATGATAATGTATGCTTCTACGTCGAATCCAGAGAAAAAACTTGTTGAAGC
TTCTAAAATTTTAGCAAAAT

Downstream 100 bases:

>100_bases
TGAAAGCTACTCTAATAAACTATGGTGTAGGAAACCTGTTCAGCATTAAGGCTGGTCTAGAAAGGGTTGGGTTTAATGTT
AAGATTTCTTTCTTACCAGA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-PH [H]

Number of amino acids: Translated: 108; Mature: 108

Protein sequence:

>108_residues
MKVSYFMLTVLVLGMSSNVLDTLYSIILDRISNKKEGSYTVKLLEKGKPYIARKVGEEATEVIVASLSEGRERFISEVAD
LIYHLFVLMAVEGVKPEDVYEELKRRMK

Sequences:

>Translated_108_residues
MKVSYFMLTVLVLGMSSNVLDTLYSIILDRISNKKEGSYTVKLLEKGKPYIARKVGEEATEVIVASLSEGRERFISEVAD
LIYHLFVLMAVEGVKPEDVYEELKRRMK
>Mature_108_residues
MKVSYFMLTVLVLGMSSNVLDTLYSIILDRISNKKEGSYTVKLLEKGKPYIARKVGEEATEVIVASLSEGRERFISEVAD
LIYHLFVLMAVEGVKPEDVYEELKRRMK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=86, Percent_Identity=38.3720930232558, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008179
- InterPro:   IPR021130 [H]

Pfam domain/function: PF01503 PRA-PH [H]

EC number: =3.6.1.31 [H]

Molecular weight: Translated: 12321; Mature: 12321

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSYFMLTVLVLGMSSNVLDTLYSIILDRISNKKEGSYTVKLLEKGKPYIARKVGEEAT
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
EVIVASLSEGRERFISEVADLIYHLFVLMAVEGVKPEDVYEELKRRMK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKVSYFMLTVLVLGMSSNVLDTLYSIILDRISNKKEGSYTVKLLEKGKPYIARKVGEEAT
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
EVIVASLSEGRERFISEVADLIYHLFVLMAVEGVKPEDVYEELKRRMK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]