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The map label for this gene is mccB [H]

Identifier: 15920723

GI number: 15920723

Start: 505408

End: 506541

Strand: Direct

Name: mccB [H]

Synonym: ST0506

Alternate gene names: 15920723

Gene position: 505408-506541 (Clockwise)

Preceding gene: 15920722

Following gene: 15920726

Centisome position: 18.76

GC content: 33.95

Gene sequence:

>1134_bases
GTGCATGGGTTGAGAGAAGGGACTAAAGTTACAACGGAAGGATATGATGAAGAGACTGGTGCTATAACTACTCCAATATA
TCAGACTACTTCTTATATTTATCCTATAGGTGAGAAATATCGGTATAGCCGAGAAGTTAACCCTACTGTACTTAAACTTG
CCGAAAAGATATCTGAACTTGAAGAGGCAGAGATGGGAGTAGCTTTTTCATCTGGAATGGGGGCTATTTCGTCTACTTTG
CTTACATTAGCTAAGCCTGGGAGCAAAATACTAATACATAGAGATATGTTTGGAAGGACTTACAGATTCTTTACGGACTT
CATGCGTAATCTAGGAGTAGAAGTAGATGTTGCAAATCCAGGAGAAATTTTAGAAATGGTAAAAGTCAAAAAATACGATA
TTGTTTATGTTGAAACTATATCAAATCCATTATTAAGAGTTATAGATATTCCAGCTCTTTCAAAAATATGTAAAGAGAAT
GGAAGCTTACTAATTACTGACGCTACTTTTTCAACACCAATCAACCAGAAACCGTTAGTTCAAGGTGCAGATATAGTTTT
ACATAGTGCTTCAAAATTTATAGCAGGACATAATGATGTTATTGCTGGTTTAGGTGCTGGGTCTAAAGAATTAATGACTA
AAGTAGATTTAATGAGAAGAACTTTGGGCACATCTTTAGATCCTCATGCAGCATATCTTGTGATAAGAGGAATAAAAACT
CTTAAAATTAGAATGGATGTGATTAATTCAAATGCACAGAAAATAGCCGAATATTTACAAGAACATAATAAAATCAAATC
AGTATATTATCCTGGACTAAAGTCACATCCAGATTACGAAACTGCTAGACGAATACTAAAAGGATATGGTGGTGTAGTTA
CATTTGAAATTAAAGGTAGTATGAATGATGCACTTAATTTAATAACGAGATTCAAAGTTATTTTGCCTGCACAGACTTTA
GGTGGAGTGAATTCTACAATTTCACATCCTGCAACAATGACTCATAGAACTTTAACTCCCGAAGAAAGGAAAATCATTGG
TATTTCGGATTCCATGTTAAGACTCTCTGTTGGAATAGAGGATGTTAACGATTTAATAGAAGATTTAGATAAAGCACTAA
CTTCACTTAATTAA

Upstream 100 bases:

>100_bases
GATTCAAAGTCAGATAAAAATAAAATTCTTGGGGAATCACTTAATGTTTGTAAAGCTTATGGATATGAATGCACATATAA
AATAGCTAAAGTTTCAGGAG

Downstream 100 bases:

>100_bases
ATTATCGCCCTTATTTCGTTTTTGAGCTCTTCTTCTAACATAGTCTTTATTTCGTTTCTATGCAGTCTTATCAAATGTAA
ATATAATCCTCTTTTCGTAA

Product: hypothetical protein

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MHGLREGTKVTTEGYDEETGAITTPIYQTTSYIYPIGEKYRYSREVNPTVLKLAEKISELEEAEMGVAFSSGMGAISSTL
LTLAKPGSKILIHRDMFGRTYRFFTDFMRNLGVEVDVANPGEILEMVKVKKYDIVYVETISNPLLRVIDIPALSKICKEN
GSLLITDATFSTPINQKPLVQGADIVLHSASKFIAGHNDVIAGLGAGSKELMTKVDLMRRTLGTSLDPHAAYLVIRGIKT
LKIRMDVINSNAQKIAEYLQEHNKIKSVYYPGLKSHPDYETARRILKGYGGVVTFEIKGSMNDALNLITRFKVILPAQTL
GGVNSTISHPATMTHRTLTPEERKIIGISDSMLRLSVGIEDVNDLIEDLDKALTSLN

Sequences:

>Translated_377_residues
MHGLREGTKVTTEGYDEETGAITTPIYQTTSYIYPIGEKYRYSREVNPTVLKLAEKISELEEAEMGVAFSSGMGAISSTL
LTLAKPGSKILIHRDMFGRTYRFFTDFMRNLGVEVDVANPGEILEMVKVKKYDIVYVETISNPLLRVIDIPALSKICKEN
GSLLITDATFSTPINQKPLVQGADIVLHSASKFIAGHNDVIAGLGAGSKELMTKVDLMRRTLGTSLDPHAAYLVIRGIKT
LKIRMDVINSNAQKIAEYLQEHNKIKSVYYPGLKSHPDYETARRILKGYGGVVTFEIKGSMNDALNLITRFKVILPAQTL
GGVNSTISHPATMTHRTLTPEERKIIGISDSMLRLSVGIEDVNDLIEDLDKALTSLN
>Mature_377_residues
MHGLREGTKVTTEGYDEETGAITTPIYQTTSYIYPIGEKYRYSREVNPTVLKLAEKISELEEAEMGVAFSSGMGAISSTL
LTLAKPGSKILIHRDMFGRTYRFFTDFMRNLGVEVDVANPGEILEMVKVKKYDIVYVETISNPLLRVIDIPALSKICKEN
GSLLITDATFSTPINQKPLVQGADIVLHSASKFIAGHNDVIAGLGAGSKELMTKVDLMRRTLGTSLDPHAAYLVIRGIKT
LKIRMDVINSNAQKIAEYLQEHNKIKSVYYPGLKSHPDYETARRILKGYGGVVTFEIKGSMNDALNLITRFKVILPAQTL
GGVNSTISHPATMTHRTLTPEERKIIGISDSMLRLSVGIEDVNDLIEDLDKALTSLN

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=323, Percent_Identity=35.9133126934984, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI299473759, Length=263, Percent_Identity=36.1216730038023, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI25453487, Length=320, Percent_Identity=31.875, Blast_Score=171, Evalue=9e-43,
Organism=Escherichia coli, GI1790375, Length=368, Percent_Identity=35.8695652173913, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789383, Length=375, Percent_Identity=24.5333333333333, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=36.1185983827493, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17560056, Length=365, Percent_Identity=35.3424657534247, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17538055, Length=327, Percent_Identity=36.3914373088685, Blast_Score=213, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319307, Length=372, Percent_Identity=36.2903225806452, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6321254, Length=395, Percent_Identity=29.873417721519, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6323333, Length=412, Percent_Identity=29.126213592233, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6321904, Length=343, Percent_Identity=28.8629737609329, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6321170, Length=320, Percent_Identity=26.875, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI19922554, Length=365, Percent_Identity=35.0684931506849, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 41625; Mature: 41625

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGLREGTKVTTEGYDEETGAITTPIYQTTSYIYPIGEKYRYSREVNPTVLKLAEKISEL
CCCCCCCCEECCCCCCCCCCCEECCHHHCCCEEEECCHHHCCCCCCCHHHHHHHHHHHHH
EEAEMGVAFSSGMGAISSTLLTLAKPGSKILIHRDMFGRTYRFFTDFMRNLGVEVDVANP
HHHHCCEEECCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEECCC
GEILEMVKVKKYDIVYVETISNPLLRVIDIPALSKICKENGSLLITDATFSTPINQKPLV
HHHHHHHHHHHCEEEEEEECCCCHHHHHCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
QGADIVLHSASKFIAGHNDVIAGLGAGSKELMTKVDLMRRTLGTSLDPHAAYLVIRGIKT
CCCHHEEECCHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHEEECCEE
LKIRMDVINSNAQKIAEYLQEHNKIKSVYYPGLKSHPDYETARRILKGYGGVVTFEIKGS
EEEEEEHHCCCHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCC
MNDALNLITRFKVILPAQTLGGVNSTISHPATMTHRTLTPEERKIIGISDSMLRLSVGIE
HHHHHHHHHHHHHEECHHHHCCCCCCCCCCCHHCCCCCCCCCCEEEECCCCEEEEECCHH
DVNDLIEDLDKALTSLN
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHGLREGTKVTTEGYDEETGAITTPIYQTTSYIYPIGEKYRYSREVNPTVLKLAEKISEL
CCCCCCCCEECCCCCCCCCCCEECCHHHCCCEEEECCHHHCCCCCCCHHHHHHHHHHHHH
EEAEMGVAFSSGMGAISSTLLTLAKPGSKILIHRDMFGRTYRFFTDFMRNLGVEVDVANP
HHHHCCEEECCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEECCC
GEILEMVKVKKYDIVYVETISNPLLRVIDIPALSKICKENGSLLITDATFSTPINQKPLV
HHHHHHHHHHHCEEEEEEECCCCHHHHHCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
QGADIVLHSASKFIAGHNDVIAGLGAGSKELMTKVDLMRRTLGTSLDPHAAYLVIRGIKT
CCCHHEEECCHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHEEECCEE
LKIRMDVINSNAQKIAEYLQEHNKIKSVYYPGLKSHPDYETARRILKGYGGVVTFEIKGS
EEEEEEHHCCCHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCC
MNDALNLITRFKVILPAQTLGGVNSTISHPATMTHRTLTPEERKIIGISDSMLRLSVGIE
HHHHHHHHHHHHHEECHHHHCCCCCCCCCCCHHCCCCCCCCCCEEEECCCCEEEEECCHH
DVNDLIEDLDKALTSLN
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]