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The map label for this gene is psmB1

Identifier: 15920523

GI number: 15920523

Start: 345748

End: 346341

Strand: Direct

Name: psmB1

Synonym: ST0324

Alternate gene names: 15920523

Gene position: 345748-346341 (Clockwise)

Preceding gene: 15920522

Following gene: 15920525

Centisome position: 12.83

GC content: 33.33

Gene sequence:

>594_bases
ATGGAAGAACTTCCTGCAACAGCGTTAGGTATTAAACTTAATGACGGTATAATTCTTGCTGCTGAAAGGAGACTTAGTTA
TGGCGGTTTCGTACTTAGTAGATCAGCTAAAAAAGTTTTTAAAATAGGAAGATTCGGCATAGCTGGAGCTGGTATAATGG
GTGATATTCAAACATTAACACGTTTAATGAATGTTGAGATAAAGTATTACGAAATGTATAATAATAAGCCTATATCAGTA
AAGGCAGCAGCTAAGTTATTATCAGTTATACTATACCAGTATAAGTGGACCCCCTTTATTTCGGAATTGTTATTTGGTGG
TGTAGACGATGAAGGTCCCAAATTGTTTGTTTTAGATCCTATAGGTTCATTAATTGAAGATAATTACGCTGCTGTTGGTT
CTGGTGCCAGAGTAGCAATAGGAGTTTTAGAAAGTGAATATGATCCAAGTATGAATTTAGATAAAGGGAAAGAAATTGTT
CTAAAAGCACTAAAAGCTGCAATAGAAAGAGATGTAACTTCAGGTGACGGAATAGATATATTAACGATAAAAAGAGATAA
TACATCAAGCGAAGATTTTATAAAGATTTTTTAA

Upstream 100 bases:

>100_bases
GTACAAAAGAGCAAGTGACTATTAAGGAAGAAAACCTTTTGGACTATCTTAAGCAAATAATTTAAGTTATCAAATAATCA
TTTTCATGGGTTATTAAAAC

Downstream 100 bases:

>100_bases
CACAAAAATAGACATGGTCCATCATCTTAAATAGACTATTACCTATTAATCCTTTTTCGCTATAGATTTTTACTATTAAT
CCAAATAGAGATATTTGATC

Product: proteasome subunit beta

Products: NA

Alternate protein names: 20S proteasome beta subunit 1; Proteasome core protein PsmB 1

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MEELPATALGIKLNDGIILAAERRLSYGGFVLSRSAKKVFKIGRFGIAGAGIMGDIQTLTRLMNVEIKYYEMYNNKPISV
KAAAKLLSVILYQYKWTPFISELLFGGVDDEGPKLFVLDPIGSLIEDNYAAVGSGARVAIGVLESEYDPSMNLDKGKEIV
LKALKAAIERDVTSGDGIDILTIKRDNTSSEDFIKIF

Sequences:

>Translated_197_residues
MEELPATALGIKLNDGIILAAERRLSYGGFVLSRSAKKVFKIGRFGIAGAGIMGDIQTLTRLMNVEIKYYEMYNNKPISV
KAAAKLLSVILYQYKWTPFISELLFGGVDDEGPKLFVLDPIGSLIEDNYAAVGSGARVAIGVLESEYDPSMNLDKGKEIV
LKALKAAIERDVTSGDGIDILTIKRDNTSSEDFIKIF
>Mature_197_residues
MEELPATALGIKLNDGIILAAERRLSYGGFVLSRSAKKVFKIGRFGIAGAGIMGDIQTLTRLMNVEIKYYEMYNNKPISV
KAAAKLLSVILYQYKWTPFISELLFGGVDDEGPKLFVLDPIGSLIEDNYAAVGSGARVAIGVLESEYDPSMNLDKGKEIV
LKALKAAIERDVTSGDGIDILTIKRDNTSSEDFIKIF

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4506201, Length=181, Percent_Identity=31.4917127071823, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI73747875, Length=181, Percent_Identity=30.939226519337, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI4758970, Length=181, Percent_Identity=30.939226519337, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4506193, Length=197, Percent_Identity=30.9644670050761, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4506191, Length=180, Percent_Identity=28.8888888888889, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4506203, Length=193, Percent_Identity=29.5336787564767, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI23110942, Length=191, Percent_Identity=29.3193717277487, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI22538465, Length=187, Percent_Identity=26.2032085561497, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI153791216, Length=179, Percent_Identity=29.0502793296089, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI195539356, Length=137, Percent_Identity=31.3868613138686, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI23110925, Length=179, Percent_Identity=24.0223463687151, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI222144262, Length=117, Percent_Identity=34.1880341880342, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508499, Length=169, Percent_Identity=32.5443786982249, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17508493, Length=191, Percent_Identity=28.2722513089005, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17541700, Length=190, Percent_Identity=27.3684210526316, Blast_Score=83, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17508495, Length=184, Percent_Identity=26.0869565217391, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17535357, Length=183, Percent_Identity=25.1366120218579, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554384, Length=177, Percent_Identity=24.8587570621469, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325360, Length=182, Percent_Identity=30.2197802197802, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324731, Length=179, Percent_Identity=28.4916201117318, Blast_Score=92, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321574, Length=197, Percent_Identity=27.9187817258883, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319430, Length=205, Percent_Identity=25.3658536585366, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320941, Length=175, Percent_Identity=25.1428571428571, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321692, Length=214, Percent_Identity=26.6355140186916, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355573, Length=195, Percent_Identity=32.8205128205128, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24652553, Length=195, Percent_Identity=32.8205128205128, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24639979, Length=176, Percent_Identity=31.8181818181818, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24664391, Length=178, Percent_Identity=29.7752808988764, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24654391, Length=195, Percent_Identity=27.6923076923077, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24654389, Length=195, Percent_Identity=27.6923076923077, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130281, Length=171, Percent_Identity=28.0701754385965, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28573221, Length=182, Percent_Identity=24.7252747252747, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17737605, Length=191, Percent_Identity=29.3193717277487, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24584895, Length=183, Percent_Identity=28.4153005464481, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21355629, Length=187, Percent_Identity=24.5989304812834, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653999, Length=181, Percent_Identity=24.8618784530387, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB1_SULTO (Q975U8)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376192.1
- HSSP:   P28061
- ProteinModelPortal:   Q975U8
- SMR:   Q975U8
- MEROPS:   T01.002
- GeneID:   1458238
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0324
- NMPDR:   fig|273063.1.peg.360
- HOGENOM:   HBG499923
- OMA:   EKRVSYG
- ProtClustDB:   CLSK883626
- BioCyc:   STOK273063:ST0324-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_02113_A
- InterPro:   IPR019983
- InterPro:   IPR000243
- InterPro:   IPR016050
- InterPro:   IPR001353
- PRINTS:   PR00141
- TIGRFAMs:   TIGR03634

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 21530; Mature: 21530

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 7-7

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELPATALGIKLNDGIILAAERRLSYGGFVLSRSAKKVFKIGRFGIAGAGIMGDIQTLT
CCCCCCEEEEEEECCCEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHH
RLMNVEIKYYEMYNNKPISVKAAAKLLSVILYQYKWTPFISELLFGGVDDEGPKLFVLDP
HHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECC
IGSLIEDNYAAVGSGARVAIGVLESEYDPSMNLDKGKEIVLKALKAAIERDVTSGDGIDI
CHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
LTIKRDNTSSEDFIKIF
EEEECCCCCCCCEEEEC
>Mature Secondary Structure
MEELPATALGIKLNDGIILAAERRLSYGGFVLSRSAKKVFKIGRFGIAGAGIMGDIQTLT
CCCCCCEEEEEEECCCEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHH
RLMNVEIKYYEMYNNKPISVKAAAKLLSVILYQYKWTPFISELLFGGVDDEGPKLFVLDP
HHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEEECC
IGSLIEDNYAAVGSGARVAIGVLESEYDPSMNLDKGKEIVLKALKAAIERDVTSGDGIDI
CHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
LTIKRDNTSSEDFIKIF
EEEECCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479