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The map label for this gene is upp

Identifier: 15920473

GI number: 15920473

Start: 299694

End: 300344

Strand: Direct

Name: upp

Synonym: ST0281

Alternate gene names: 15920473

Gene position: 299694-300344 (Clockwise)

Preceding gene: 15920472

Following gene: 15920474

Centisome position: 11.12

GC content: 29.8

Gene sequence:

>651_bases
ATGCCTCTTTTTGTATTATCTAAACCAATTACATTACATTTTTTAACTCAGTTAAGATCTAAAAATACAGATCAGATTAC
TTTTAGGAAGACTTTAGTAAGATTAGGTAGAATTATAGGATATGAAATTCTTAATATGTTAGATTACAACATTATTGAAG
TAGAGACTCCTTTAGGTGTAAAAGCTAAAGGAGTCTATATCTATGACTTGGAAAATATCGTAATTATAAGTATTCTAAGA
GCAGCAACACCATTAGTTGAAGGACTTCTTAAAGCATTACCAACTGCTAGACTTGGTGTAATAGCTGCTAGTAGAAAGGA
GACACAGGTTAATTTAGGATATCCAAAGGAAATGGAAGTTGAAATATTCTATAATAAAATACCAGAAATAAACATAAAAG
ACAATGTAATAATAGCAGATCCCATGATAGCTACAGCGAGTACAATGCTCAAAGCGTTAAATATAATAAAAGACAAAAAG
CCTAAGAGAATTTTTATTGTATCTATAATAATATCCGAATATGGTCTGAAAAGAATATTAGAATCTTATCCCGATGTTAA
TATTATAACAGTATCTATAGATCCAGAATTAGATAATAGAGGATATATTTTGCCCGGATTAGGTGATGCAGGAGATAGAG
CATTTGGTTAA

Upstream 100 bases:

>100_bases
TTAACCAGAAATGTAAAGGGCCCAGTAAGATTAGGTGATATTTTAATACTTAGAGAAACAGAGAGAGAAGCAAGAAAATT
GACAACAAAGAGGTAAATAT

Downstream 100 bases:

>100_bases
ACATTTTTATCCTTAAATGCTTTCATCAATAAATATGGTTAAAATAGGACTAGAAGTACACGTTCATCTTACATCATTGA
AAACTAAATTATTCTGCTCC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MPLFVLSKPITLHFLTQLRSKNTDQITFRKTLVRLGRIIGYEILNMLDYNIIEVETPLGVKAKGVYIYDLENIVIISILR
AATPLVEGLLKALPTARLGVIAASRKETQVNLGYPKEMEVEIFYNKIPEINIKDNVIIADPMIATASTMLKALNIIKDKK
PKRIFIVSIIISEYGLKRILESYPDVNIITVSIDPELDNRGYILPGLGDAGDRAFG

Sequences:

>Translated_216_residues
MPLFVLSKPITLHFLTQLRSKNTDQITFRKTLVRLGRIIGYEILNMLDYNIIEVETPLGVKAKGVYIYDLENIVIISILR
AATPLVEGLLKALPTARLGVIAASRKETQVNLGYPKEMEVEIFYNKIPEINIKDNVIIADPMIATASTMLKALNIIKDKK
PKRIFIVSIIISEYGLKRILESYPDVNIITVSIDPELDNRGYILPGLGDAGDRAFG
>Mature_215_residues
PLFVLSKPITLHFLTQLRSKNTDQITFRKTLVRLGRIIGYEILNMLDYNIIEVETPLGVKAKGVYIYDLENIVIISILRA
ATPLVEGLLKALPTARLGVIAASRKETQVNLGYPKEMEVEIFYNKIPEINIKDNVIIADPMIATASTMLKALNIIKDKKP
KRIFIVSIIISEYGLKRILESYPDVNIITVSIDPELDNRGYILPGLGDAGDRAFG

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=212, Percent_Identity=28.7735849056604, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI57863312, Length=212, Percent_Identity=28.7735849056604, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI21450816, Length=183, Percent_Identity=26.775956284153, Blast_Score=71, Evalue=8e-13,
Organism=Escherichia coli, GI87082118, Length=223, Percent_Identity=27.8026905829596, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17539892, Length=217, Percent_Identity=26.2672811059908, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=217, Percent_Identity=26.2672811059908, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=206, Percent_Identity=32.5242718446602, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45550449, Length=209, Percent_Identity=32.0574162679426, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28573516, Length=209, Percent_Identity=32.0574162679426, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28573514, Length=209, Percent_Identity=32.0574162679426, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28573512, Length=209, Percent_Identity=32.0574162679426, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358379, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_SULTO (Q975Z7)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376142.1
- ProteinModelPortal:   Q975Z7
- SMR:   Q975Z7
- GeneID:   1458185
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0281
- NMPDR:   fig|273063.1.peg.310
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- ProtClustDB:   PRK00129
- BioCyc:   STOK273063:ST0281-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_A
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 24182; Mature: 24051

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: BINDING 80-80 BINDING 105-105 BINDING 203-203 BINDING 209-209

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFVLSKPITLHFLTQLRSKNTDQITFRKTLVRLGRIIGYEILNMLDYNIIEVETPLGV
CCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
KAKGVYIYDLENIVIISILRAATPLVEGLLKALPTARLGVIAASRKETQVNLGYPKEMEV
EECCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCCEEECCCCCCEEE
EIFYNKIPEINIKDNVIIADPMIATASTMLKALNIIKDKKPKRIFIVSIIISEYGLKRIL
EEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHH
ESYPDVNIITVSIDPELDNRGYILPGLGDAGDRAFG
HHCCCCEEEEEEECCCCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure 
PLFVLSKPITLHFLTQLRSKNTDQITFRKTLVRLGRIIGYEILNMLDYNIIEVETPLGV
CEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
KAKGVYIYDLENIVIISILRAATPLVEGLLKALPTARLGVIAASRKETQVNLGYPKEMEV
EECCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCCEEECCCCCCEEE
EIFYNKIPEINIKDNVIIADPMIATASTMLKALNIIKDKKPKRIFIVSIIISEYGLKRIL
EEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHH
ESYPDVNIITVSIDPELDNRGYILPGLGDAGDRAFG
HHCCCCEEEEEEECCCCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479