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The map label for this gene is hemL

Identifier: 15920397

GI number: 15920397

Start: 238102

End: 239016

Strand: Direct

Name: hemL

Synonym: ST0215

Alternate gene names: 15920397

Gene position: 238102-239016 (Clockwise)

Preceding gene: 15920396

Following gene: 15920398

Centisome position: 8.84

GC content: 32.24

Gene sequence:

>915_bases
ATGTTAGCAATACGCTTAGCTAGAGGATATACAAAAAGAGAAAAAATATTAAAATTTGACGGAAATTATCACGGAGCTCA
CGATTACGCTTTAATAAATGCTGGTAGTGCTGTATCAGAGTTCAATGTTATTATATCTTCAGGCATTCCAACTTCGATAA
TTAATACTGTAATAGTGTGTAAATATAATGACCTTGACTGCGTAGAAAAACACCTTAGAACTGAGGAAATAGCTGGAGTT
ATAGTTGAACCAGTAATGGGAAATATGGGAGTGATTTTACCAGAGCAAGACTTTCTTAATGGATTAAGAGAACTTACGAA
AACATATAATTCTGTACTTATATTCGATGAAGTAATAACTGGTTTTAGATTAGGACTTAGTGGCGCTCAGGGATATTTTA
AGGTAATCCCAGATTTAACTACTTTAGGAAAGATTATTGGTGGTGGCTTACCAATAGGTGCAGTTACTGGAAAAAAAGAA
ATTATGAGTAATCTTACCCCAGAAGGAAAAGTATTTAATGCTGGTACATTTAATGCTAATCCTCTTACAATGGCTGCAGG
AATAGCTACAATAGAAGTTCTAGAGACAACAAATGCATATGATATAGCTAATAAGGCTTCAAAAGAAATAGCAGAAGAAC
TAGATAATTCTTTATCTAAAAAGAATTTTAAATATACTATAAATAGAATACAAAGCATGTTCCAATTCTTTATAGGTATA
AGTAAAGTAACTAATGCTGATGATGCTAGGTTAGCTAATAAAGATCTCTATGTAAAGATTCATGAAAAACTGCTGAAACT
AGGCGTTTTCATTCCTCCTAGTCAATTTGAGACAATATTTACATCTAGTTCACACTCTGATGAGATAGTAAATCTTACTA
TTGAAGCAATTCATAAGGTGGTTAGCGAAATATGA

Upstream 100 bases:

>100_bases
AACCCCTAGTAAAAAGGAAATTGAATTAGCTGAAAAAATAAGATCTCATATACCATCTGCTGAAAAGATTAGATTTGTTA
ACAGTGGTACTGAAGCAACA

Downstream 100 bases:

>100_bases
GAATAAGAATAGCCGCTAGAGGTAGTAAACTAAGCAGAATTCAGGTAATGATGGTTGAAAACTATTTACATAAATTAGGT
ATAGAAACTGAATTTATAGA

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLAIRLARGYTKREKILKFDGNYHGAHDYALINAGSAVSEFNVIISSGIPTSIINTVIVCKYNDLDCVEKHLRTEEIAGV
IVEPVMGNMGVILPEQDFLNGLRELTKTYNSVLIFDEVITGFRLGLSGAQGYFKVIPDLTTLGKIIGGGLPIGAVTGKKE
IMSNLTPEGKVFNAGTFNANPLTMAAGIATIEVLETTNAYDIANKASKEIAEELDNSLSKKNFKYTINRIQSMFQFFIGI
SKVTNADDARLANKDLYVKIHEKLLKLGVFIPPSQFETIFTSSSHSDEIVNLTIEAIHKVVSEI

Sequences:

>Translated_304_residues
MLAIRLARGYTKREKILKFDGNYHGAHDYALINAGSAVSEFNVIISSGIPTSIINTVIVCKYNDLDCVEKHLRTEEIAGV
IVEPVMGNMGVILPEQDFLNGLRELTKTYNSVLIFDEVITGFRLGLSGAQGYFKVIPDLTTLGKIIGGGLPIGAVTGKKE
IMSNLTPEGKVFNAGTFNANPLTMAAGIATIEVLETTNAYDIANKASKEIAEELDNSLSKKNFKYTINRIQSMFQFFIGI
SKVTNADDARLANKDLYVKIHEKLLKLGVFIPPSQFETIFTSSSHSDEIVNLTIEAIHKVVSEI
>Mature_304_residues
MLAIRLARGYTKREKILKFDGNYHGAHDYALINAGSAVSEFNVIISSGIPTSIINTVIVCKYNDLDCVEKHLRTEEIAGV
IVEPVMGNMGVILPEQDFLNGLRELTKTYNSVLIFDEVITGFRLGLSGAQGYFKVIPDLTTLGKIIGGGLPIGAVTGKKE
IMSNLTPEGKVFNAGTFNANPLTMAAGIATIEVLETTNAYDIANKASKEIAEELDNSLSKKNFKYTINRIQSMFQFFIGI
SKVTNADDARLANKDLYVKIHEKLLKLGVFIPPSQFETIFTSSSHSDEIVNLTIEAIHKVVSEI

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=219, Percent_Identity=34.2465753424658, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI284507298, Length=219, Percent_Identity=34.2465753424658, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI13994255, Length=303, Percent_Identity=28.3828382838284, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI226442709, Length=268, Percent_Identity=27.6119402985075, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI37574042, Length=268, Percent_Identity=27.6119402985075, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI226442705, Length=268, Percent_Identity=27.6119402985075, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786349, Length=307, Percent_Identity=40.3908794788274, Blast_Score=246, Evalue=9e-67,
Organism=Escherichia coli, GI1789016, Length=223, Percent_Identity=30.9417040358744, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1788044, Length=281, Percent_Identity=29.5373665480427, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789759, Length=204, Percent_Identity=32.3529411764706, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI145693181, Length=126, Percent_Identity=40.4761904761905, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787560, Length=227, Percent_Identity=27.3127753303965, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25144271, Length=138, Percent_Identity=38.4057971014493, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144274, Length=138, Percent_Identity=38.4057971014493, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71992977, Length=286, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI32564660, Length=230, Percent_Identity=28.695652173913, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=236, Percent_Identity=27.9661016949153, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357415, Length=157, Percent_Identity=32.484076433121, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_SULTO (Q976H2)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376066.1
- ProteinModelPortal:   Q976H2
- SMR:   Q976H2
- GeneID:   1458105
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0215
- HOGENOM:   HBG725944
- BioCyc:   STOK273063:ST0215-MONOMER
- BRENDA:   5.4.3.8
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 33280; Mature: 33280

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAIRLARGYTKREKILKFDGNYHGAHDYALINAGSAVSEFNVIISSGIPTSIINTVIVC
CEEEEECCCCCHHHHHEEECCCCCCCCCEEEEECCCCHHHHHEEEECCCCHHHHCEEEEE
KYNDLDCVEKHLRTEEIAGVIVEPVMGNMGVILPEQDFLNGLRELTKTYNSVLIFDEVIT
ECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCEEHHHHHHH
GFRLGLSGAQGYFKVIPDLTTLGKIIGGGLPIGAVTGKKEIMSNLTPEGKVFNAGTFNAN
HHHHCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCC
PLTMAAGIATIEVLETTNAYDIANKASKEIAEELDNSLSKKNFKYTINRIQSMFQFFIGI
CHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
SKVTNADDARLANKDLYVKIHEKLLKLGVFIPPSQFETIFTSSSHSDEIVNLTIEAIHKV
HHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHH
VSEI
HHCC
>Mature Secondary Structure
MLAIRLARGYTKREKILKFDGNYHGAHDYALINAGSAVSEFNVIISSGIPTSIINTVIVC
CEEEEECCCCCHHHHHEEECCCCCCCCCEEEEECCCCHHHHHEEEECCCCHHHHCEEEEE
KYNDLDCVEKHLRTEEIAGVIVEPVMGNMGVILPEQDFLNGLRELTKTYNSVLIFDEVIT
ECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCEEHHHHHHH
GFRLGLSGAQGYFKVIPDLTTLGKIIGGGLPIGAVTGKKEIMSNLTPEGKVFNAGTFNAN
HHHHCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCC
PLTMAAGIATIEVLETTNAYDIANKASKEIAEELDNSLSKKNFKYTINRIQSMFQFFIGI
CHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
SKVTNADDARLANKDLYVKIHEKLLKLGVFIPPSQFETIFTSSSHSDEIVNLTIEAIHKV
HHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCHHHHHHHHHHHHH
VSEI
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479