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The map label for this gene is fadH [C]

Identifier: 15920268

GI number: 15920268

Start: 111755

End: 113395

Strand: Direct

Name: fadH [C]

Synonym: ST0090

Alternate gene names: 15920268

Gene position: 111755-113395 (Clockwise)

Preceding gene: 15920267

Following gene: 15920270

Centisome position: 4.15

GC content: 35.59

Gene sequence:

>1641_bases
ATGAGACTACTAGAGCCTTTTTACATAAGGGACGTTGAGTTAAAAAATAGGGTTGTAATGTCTCCTATGATCACTAATTT
AGGGGCACCAGAAGGCTATCCTACTGAAGAACATATAAGGTACTTTGTAAGAAGAGCTTCTGCTGGATTATTAATTACAG
AGTATACTTACGTAAATAAGGTCGATGCTAGGGGCTCTCCAAATCAGCTAGGTTTATATGATGATGAACTTATTCCAAAA
TTTGCAAGATTAACTGAAGCCGTTCATAATATGGACTCAAAAATTTTCGTTCAGCTTGTTCATGTTGGGAGGAAGACTAG
AAGGAGTTTAATATGGAACAATGATCCAATTGCTCCTTCTAATATACCTCTTTTAGATCCAGTTAGGGAGATGACAGAAG
ATGATATTAATAGGGTTATAATGGATTTTGTTAAGGCCTCAGAAAGAGCTGAAAAAAGCGGTTTCGACGGAATAGAATTA
CATGGTGCTCATGGGTATTTAATTGCTCAGTTTTTATCACCAGCCACAAACAAAAGAGAGGATAAATATAAGGATGGAGT
AATATTTCTAGAAGAATTACTGAAAGAGATAAGAAGAGTTGTAAGTATCCCAGTTGGAATGAGGATTTCCGTTACTGAAT
TCGATCCTCAAGGCTTAACACCAGAACTTGTAGCAAAAATAGTTAAGAGAGTAGAGAATTTATTGGATTACATTCATTTA
TCTGCTGGTAGAGACGGTCCATTAGGCGGCTCTTCTTCATTCTACTATAAAAGACCAAGTTATGTGGATGAGGCTAAAGT
AGTTAGAAAGGTAACTAATTTACCATTACTTCTGGTAGGTTCAGTATCAACTGTAGAAGATGCAGAAAAAGTCCTAGAGG
TTGCAGATGCCGTAGTTTTAGGTAGACAAATCTTGGCAGATCCTGATTGGGTAATAAAAGTTAAGAATAATTTACCAATA
AGACCATGCATCAGATGTAATCAATTATGTAGATTGTTATCAACTAGAGAAGTGAGATGTGATGTTAATCCAGAATTGGG
ATGGGAAATTCTTAACTTAGAGAAAGGTGAGGGTGAAGTTAGAATTGTTGGAGGAGGAGTAATGGGATTAGAGACTGCGA
GAGTTTTGGCTTTAAGAGGATTTGAGGTAAAAATATATGAGAAAAAGGATAAGATTGGTGGTCAGCTAAATGAGATTAGG
GATCCTTGGAAGAGAGAAGAATTTAGTAGATTGATAGACTACTACGAAAAAGAACTAAAGAGACTAGGAGTTAAAATATA
TTTATCTACGGAGGAAAGAAAGGCTGATATATTTGCATTACCAAAGGAGAGGCAACCAGAGTTTAAGGAGTATAAGGGAA
TGAGGATTTTGGTGAACTCAAATCTTTATGCTTATCAAGATTATGTATTTGAGTGGTTAAAGCACAATGAAGTTTACATT
ACAGAGAACGTGTTTAAGGGTTTAGACAGAAATAGGTCTTATCTACTTCAACAAAAGTACAAGGAGTTAGGAGTTAATAT
TGTTAAAGAAAATGTTAAGGCTGACATAGTTATTAATGATGTTAGAAGAAATCAACCTTCGATTGGGCAATCTATTGCTC
GTGGCTATTGGCTAGGTATGACTTTCAAACTGAAATACTAG

Upstream 100 bases:

>100_bases
TTTGTCAGCTTCTGTAACTATCGCACCAGATAAATCTCAGGAATACTGAGTTTCTCAAAAGTAAGTTAGATTTATTTATT
TTATTAACGTTTTTTAGCCC

Downstream 100 bases:

>100_bases
TCTCCTCTAACGGTTTTCTTGAGGTTTCTTTCGCTAACACTATGGATATTATATCGGCTAAAAGGGATAAACTACCAAAC
AACATAAGGACATTAGCAAA

Product: oxidoreductase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MRLLEPFYIRDVELKNRVVMSPMITNLGAPEGYPTEEHIRYFVRRASAGLLITEYTYVNKVDARGSPNQLGLYDDELIPK
FARLTEAVHNMDSKIFVQLVHVGRKTRRSLIWNNDPIAPSNIPLLDPVREMTEDDINRVIMDFVKASERAEKSGFDGIEL
HGAHGYLIAQFLSPATNKREDKYKDGVIFLEELLKEIRRVVSIPVGMRISVTEFDPQGLTPELVAKIVKRVENLLDYIHL
SAGRDGPLGGSSSFYYKRPSYVDEAKVVRKVTNLPLLLVGSVSTVEDAEKVLEVADAVVLGRQILADPDWVIKVKNNLPI
RPCIRCNQLCRLLSTREVRCDVNPELGWEILNLEKGEGEVRIVGGGVMGLETARVLALRGFEVKIYEKKDKIGGQLNEIR
DPWKREEFSRLIDYYEKELKRLGVKIYLSTEERKADIFALPKERQPEFKEYKGMRILVNSNLYAYQDYVFEWLKHNEVYI
TENVFKGLDRNRSYLLQQKYKELGVNIVKENVKADIVINDVRRNQPSIGQSIARGYWLGMTFKLKY

Sequences:

>Translated_546_residues
MRLLEPFYIRDVELKNRVVMSPMITNLGAPEGYPTEEHIRYFVRRASAGLLITEYTYVNKVDARGSPNQLGLYDDELIPK
FARLTEAVHNMDSKIFVQLVHVGRKTRRSLIWNNDPIAPSNIPLLDPVREMTEDDINRVIMDFVKASERAEKSGFDGIEL
HGAHGYLIAQFLSPATNKREDKYKDGVIFLEELLKEIRRVVSIPVGMRISVTEFDPQGLTPELVAKIVKRVENLLDYIHL
SAGRDGPLGGSSSFYYKRPSYVDEAKVVRKVTNLPLLLVGSVSTVEDAEKVLEVADAVVLGRQILADPDWVIKVKNNLPI
RPCIRCNQLCRLLSTREVRCDVNPELGWEILNLEKGEGEVRIVGGGVMGLETARVLALRGFEVKIYEKKDKIGGQLNEIR
DPWKREEFSRLIDYYEKELKRLGVKIYLSTEERKADIFALPKERQPEFKEYKGMRILVNSNLYAYQDYVFEWLKHNEVYI
TENVFKGLDRNRSYLLQQKYKELGVNIVKENVKADIVINDVRRNQPSIGQSIARGYWLGMTFKLKY
>Mature_546_residues
MRLLEPFYIRDVELKNRVVMSPMITNLGAPEGYPTEEHIRYFVRRASAGLLITEYTYVNKVDARGSPNQLGLYDDELIPK
FARLTEAVHNMDSKIFVQLVHVGRKTRRSLIWNNDPIAPSNIPLLDPVREMTEDDINRVIMDFVKASERAEKSGFDGIEL
HGAHGYLIAQFLSPATNKREDKYKDGVIFLEELLKEIRRVVSIPVGMRISVTEFDPQGLTPELVAKIVKRVENLLDYIHL
SAGRDGPLGGSSSFYYKRPSYVDEAKVVRKVTNLPLLLVGSVSTVEDAEKVLEVADAVVLGRQILADPDWVIKVKNNLPI
RPCIRCNQLCRLLSTREVRCDVNPELGWEILNLEKGEGEVRIVGGGVMGLETARVLALRGFEVKIYEKKDKIGGQLNEIR
DPWKREEFSRLIDYYEKELKRLGVKIYLSTEERKADIFALPKERQPEFKEYKGMRILVNSNLYAYQDYVFEWLKHNEVYI
TENVFKGLDRNRSYLLQQKYKELGVNIVKENVKADIVINDVRRNQPSIGQSIARGYWLGMTFKLKY

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=452, Percent_Identity=27.4336283185841, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1787939, Length=354, Percent_Identity=29.3785310734463, Blast_Score=125, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17565138, Length=320, Percent_Identity=29.0625, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17540738, Length=345, Percent_Identity=27.2463768115942, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17559802, Length=298, Percent_Identity=30.5369127516779, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17564188, Length=313, Percent_Identity=28.1150159744409, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI72001454, Length=344, Percent_Identity=30.2325581395349, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17559804, Length=314, Percent_Identity=28.0254777070064, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17566914, Length=270, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325086, Length=372, Percent_Identity=26.6129032258064, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321973, Length=369, Percent_Identity=24.390243902439, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 62786; Mature: 62786

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLEPFYIRDVELKNRVVMSPMITNLGAPEGYPTEEHIRYFVRRASAGLLITEYTYVNK
CCCCCCHHEECCCCCCEEEECHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEE
VDARGSPNQLGLYDDELIPKFARLTEAVHNMDSKIFVQLVHVGRKTRRSLIWNNDPIAPS
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NIPLLDPVREMTEDDINRVIMDFVKASERAEKSGFDGIELHGAHGYLIAQFLSPATNKRE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCC
DKYKDGVIFLEELLKEIRRVVSIPVGMRISVTEFDPQGLTPELVAKIVKRVENLLDYIHL
HHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
SAGRDGPLGGSSSFYYKRPSYVDEAKVVRKVTNLPLLLVGSVSTVEDAEKVLEVADAVVL
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHH
GRQILADPDWVIKVKNNLPIRPCIRCNQLCRLLSTREVRCDVNPELGWEILNLEKGEGEV
HHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCE
RIVGGGVMGLETARVLALRGFEVKIYEKKDKIGGQLNEIRDPWKREEFSRLIDYYEKELK
EEEECCEEHHHHHHHHEEECCEEEEEECCHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHH
RLGVKIYLSTEERKADIFALPKERQPEFKEYKGMRILVNSNLYAYQDYVFEWLKHNEVYI
HCCEEEEEECCCCCCCEEECCCCCCCCHHHHCCEEEEEECCCHHHHHHHHHHHHCCCEEE
TENVFKGLDRNRSYLLQQKYKELGVNIVKENVKADIVINDVRRNQPSIGQSIARGYWLGM
EHHHHHCCCCCHHHHHHHHHHHHCCHHHHCCCEEEEEEECCCCCCCHHHHHHHCCEEEEE
TFKLKY
EEEECC
>Mature Secondary Structure
MRLLEPFYIRDVELKNRVVMSPMITNLGAPEGYPTEEHIRYFVRRASAGLLITEYTYVNK
CCCCCCHHEECCCCCCEEEECHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEE
VDARGSPNQLGLYDDELIPKFARLTEAVHNMDSKIFVQLVHVGRKTRRSLIWNNDPIAPS
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NIPLLDPVREMTEDDINRVIMDFVKASERAEKSGFDGIELHGAHGYLIAQFLSPATNKRE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCC
DKYKDGVIFLEELLKEIRRVVSIPVGMRISVTEFDPQGLTPELVAKIVKRVENLLDYIHL
HHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
SAGRDGPLGGSSSFYYKRPSYVDEAKVVRKVTNLPLLLVGSVSTVEDAEKVLEVADAVVL
CCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHH
GRQILADPDWVIKVKNNLPIRPCIRCNQLCRLLSTREVRCDVNPELGWEILNLEKGEGEV
HHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCE
RIVGGGVMGLETARVLALRGFEVKIYEKKDKIGGQLNEIRDPWKREEFSRLIDYYEKELK
EEEECCEEHHHHHHHHEEECCEEEEEECCHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHH
RLGVKIYLSTEERKADIFALPKERQPEFKEYKGMRILVNSNLYAYQDYVFEWLKHNEVYI
HCCEEEEEECCCCCCCEEECCCCCCCCHHHHCCEEEEEECCCHHHHHHHHHHHHCCCEEE
TENVFKGLDRNRSYLLQQKYKELGVNIVKENVKADIVINDVRRNQPSIGQSIARGYWLGM
EHHHHHCCCCCHHHHHHHHHHHHCCHHHHCCCEEEEEEECCCCCCCHHHHHHHCCEEEEE
TFKLKY
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]