Click here to switch to the map view.

The map label for this gene is pyrE [H]

Identifier: 159041146

GI number: 159041146

Start: 598685

End: 599230

Strand: Reverse

Name: pyrE [H]

Synonym: Cmaq_0565

Alternate gene names: 159041146

Gene position: 599230-598685 (Counterclockwise)

Preceding gene: 159041147

Following gene: 159041145

Centisome position: 28.84

GC content: 43.77

Gene sequence:

>546_bases
ATGAGCATTGAGCTGGCTAGGTTATTGGTTAAGTACGGTGTGGTTAAGTTCGGTGACTTCACACTATCAAGTGGTGTTAA
GAGTAAGTACTACGTTGACATGAGGATGGCTATATCAATACCAGAGGTCTATAAGCCCATAATTGAGGAGTTAGCCTTAA
GGATTGGAGGCGGGATTGATTTAATTGCTGGGATTGAGAGTGGTAGCATACCCTGGGCATCAATGCTAGCCTATAGGTTA
AGTAAGGGTACATTATACGTTAGGAAGGCTGATAAGAGTCACGGCACCAGGAGGAGGATTGAGGGTTACTATAAGGGTGG
TGAAGGGGTACTTCTTATTGATGATGTAGTAACCACCGGTGGCACAATACTTGACTCAATAAGGGTTCTTGAGGAAAATG
GATTAAGGGTCATTGAGGTTGCTGTCATTGTTGATAGGCTTGAGGGAGGACTTGACGCAATTAGGAGAAGTGGGTATAGG
GCTTGGTCACTATTAACGGTTAAGGATCTATTTAACGCCATGGGAATCAGTAATGCAACCCAGTAA

Upstream 100 bases:

>100_bases
CAGGGTGCTTCACCTGGATCAACCCATTCTCCAATGCCAATACTGTGGAACATACTTAACGATTGATGATATTAATGCTC
AATTAACTGGTGAACGATGA

Downstream 100 bases:

>100_bases
ACTACTAGGCTACTTACCACCTGACTTAACCCACGATGTTACCCACCTCATACTCAGGACTTACCCAGTTAAGGTGTTAA
TAGGTACTTTAACTAGGTTA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MSIELARLLVKYGVVKFGDFTLSSGVKSKYYVDMRMAISIPEVYKPIIEELALRIGGGIDLIAGIESGSIPWASMLAYRL
SKGTLYVRKADKSHGTRRRIEGYYKGGEGVLLIDDVVTTGGTILDSIRVLEENGLRVIEVAVIVDRLEGGLDAIRRSGYR
AWSLLTVKDLFNAMGISNATQ

Sequences:

>Translated_181_residues
MSIELARLLVKYGVVKFGDFTLSSGVKSKYYVDMRMAISIPEVYKPIIEELALRIGGGIDLIAGIESGSIPWASMLAYRL
SKGTLYVRKADKSHGTRRRIEGYYKGGEGVLLIDDVVTTGGTILDSIRVLEENGLRVIEVAVIVDRLEGGLDAIRRSGYR
AWSLLTVKDLFNAMGISNATQ
>Mature_180_residues
SIELARLLVKYGVVKFGDFTLSSGVKSKYYVDMRMAISIPEVYKPIIEELALRIGGGIDLIAGIESGSIPWASMLAYRLS
KGTLYVRKADKSHGTRRRIEGYYKGGEGVLLIDDVVTTGGTILDSIRVLEENGLRVIEVAVIVDRLEGGLDAIRRSGYRA
WSLLTVKDLFNAMGISNATQ

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=160, Percent_Identity=33.75, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17554964, Length=171, Percent_Identity=37.4269005847953, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508631, Length=173, Percent_Identity=27.1676300578035, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17933654, Length=173, Percent_Identity=32.9479768786127, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 19860; Mature: 19729

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIELARLLVKYGVVKFGDFTLSSGVKSKYYVDMRMAISIPEVYKPIIEELALRIGGGID
CCHHHHHHHHHHCCHHCCCEECCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCEE
LIAGIESGSIPWASMLAYRLSKGTLYVRKADKSHGTRRRIEGYYKGGEGVLLIDDVVTTG
EEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHEEECCCCEEEEECHHHCC
GTILDSIRVLEENGLRVIEVAVIVDRLEGGLDAIRRSGYRAWSLLTVKDLFNAMGISNAT
HHHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCC
Q
C
>Mature Secondary Structure 
SIELARLLVKYGVVKFGDFTLSSGVKSKYYVDMRMAISIPEVYKPIIEELALRIGGGID
CHHHHHHHHHHCCHHCCCEECCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCEE
LIAGIESGSIPWASMLAYRLSKGTLYVRKADKSHGTRRRIEGYYKGGEGVLLIDDVVTTG
EEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHEEECCCCEEEEECHHHCC
GTILDSIRVLEENGLRVIEVAVIVDRLEGGLDAIRRSGYRAWSLLTVKDLFNAMGISNAT
HHHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA