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The map label for this gene is pyrD [H]

Identifier: 159041145

GI number: 159041145

Start: 597730

End: 598698

Strand: Reverse

Name: pyrD [H]

Synonym: Cmaq_0564

Alternate gene names: 159041145

Gene position: 598698-597730 (Counterclockwise)

Preceding gene: 159041146

Following gene: 159041144

Centisome position: 28.82

GC content: 41.9

Gene sequence:

>969_bases
ATGCAACCCAGTAAACTACTAGGCTACTTACCACCTGACTTAACCCACGATGTTACCCACCTCATACTCAGGACTTACCC
AGTTAAGGTGTTAATAGGTACTTTAACTAGGTTAACGGGTGCATTACCGTATAGGTTGAGGTTGCTTAACAGGGTTATTG
ATTCACCAATAGGTATTGGGGCAGGCATAGATAAGGATGGCTTACTAATCAGCCTTATGAGTAGGTTACCCATTGGATTC
CACATAGTGGGTTCCGTAACATTGAAGCCGAGGCGAGGCAACCCTAAGCCAAGGATGAGGAGGTACCCTGGGTTAGACGC
CATGGTTAATGCAATGGGATTACCCTCAAGGGGAGTGGACTTCCTTAAGGGTATTTTAAACAATGAATGCGTCAGGTGGC
CGAGGAGTAAACTACTTGGTGTTAGTGTGGCAGGCTTCAGTGAGACTGAGTTTAAACTACTACTGGACTCATTGACACCA
TACATGGATTGCGTGGATTTCATTGAAATTAACGTAAGCAGCCCAACCTACGGTGGATCATGGACAGAGCCTCATAGGCT
TAATGAATTACTTAATTCACTTAAGGGTTACGATAAACTAGTAATTAAACTACCCTTATTGAGTAGTATTAATGATGAGG
TTAAGCTCATTAAATTAATCATTAACCATAACCCATTTGGCCTAACCATAGCAAACACCCTCAGTATAAAGGCTGACTTA
CCCATGGGTTACGGAGGCTTAAGCGGTAAACCATTACTAGGAATCGTAATTAATCTAATTAAATTAACACGAAGAATAGG
CTACGGAGGCTTAATAATTGGCCTAGGTGGATTCATGAGGGGTATTGATATTATTAAAGGCATTAAAGCTGAAGCTGACT
TAATAGGTTTAGTGACAGGCTTCGCAATGGAGGGCCCATTAGTTGTGTATAGAATAATTAATGAATTAAGGCGACTCCAG
CCTGGATAG

Upstream 100 bases:

>100_bases
GATAGGCTTGAGGGAGGACTTGACGCAATTAGGAGAAGTGGGTATAGGGCTTGGTCACTATTAACGGTTAAGGATCTATT
TAACGCCATGGGAATCAGTA

Downstream 100 bases:

>100_bases
TAAAAAGGGAATTAAGGGCAATCCCCATCCTAAACACTGATGCGCATATTAATACGCATATTAATACATAAGTTACAACA
CTAAAGCAGTAACCTTAAAC

Product: dihydroorotate oxidase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MQPSKLLGYLPPDLTHDVTHLILRTYPVKVLIGTLTRLTGALPYRLRLLNRVIDSPIGIGAGIDKDGLLISLMSRLPIGF
HIVGSVTLKPRRGNPKPRMRRYPGLDAMVNAMGLPSRGVDFLKGILNNECVRWPRSKLLGVSVAGFSETEFKLLLDSLTP
YMDCVDFIEINVSSPTYGGSWTEPHRLNELLNSLKGYDKLVIKLPLLSSINDEVKLIKLIINHNPFGLTIANTLSIKADL
PMGYGGLSGKPLLGIVINLIKLTRRIGYGGLIIGLGGFMRGIDIIKGIKAEADLIGLVTGFAMEGPLVVYRIINELRRLQ
PG

Sequences:

>Translated_322_residues
MQPSKLLGYLPPDLTHDVTHLILRTYPVKVLIGTLTRLTGALPYRLRLLNRVIDSPIGIGAGIDKDGLLISLMSRLPIGF
HIVGSVTLKPRRGNPKPRMRRYPGLDAMVNAMGLPSRGVDFLKGILNNECVRWPRSKLLGVSVAGFSETEFKLLLDSLTP
YMDCVDFIEINVSSPTYGGSWTEPHRLNELLNSLKGYDKLVIKLPLLSSINDEVKLIKLIINHNPFGLTIANTLSIKADL
PMGYGGLSGKPLLGIVINLIKLTRRIGYGGLIIGLGGFMRGIDIIKGIKAEADLIGLVTGFAMEGPLVVYRIINELRRLQ
PG
>Mature_322_residues
MQPSKLLGYLPPDLTHDVTHLILRTYPVKVLIGTLTRLTGALPYRLRLLNRVIDSPIGIGAGIDKDGLLISLMSRLPIGF
HIVGSVTLKPRRGNPKPRMRRYPGLDAMVNAMGLPSRGVDFLKGILNNECVRWPRSKLLGVSVAGFSETEFKLLLDSLTP
YMDCVDFIEINVSSPTYGGSWTEPHRLNELLNSLKGYDKLVIKLPLLSSINDEVKLIKLIINHNPFGLTIANTLSIKADL
PMGYGGLSGKPLLGIVINLIKLTRRIGYGGLIIGLGGFMRGIDIIKGIKAEADLIGLVTGFAMEGPLVVYRIINELRRLQ
PG

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=299, Percent_Identity=30.1003344481605, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1787177, Length=342, Percent_Identity=26.9005847953216, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17509475, Length=304, Percent_Identity=28.6184210526316, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281361352, Length=298, Percent_Identity=29.8657718120805, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17137316, Length=298, Percent_Identity=29.8657718120805, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 35276; Mature: 35276

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSKLLGYLPPDLTHDVTHLILRTYPVKVLIGTLTRLTGALPYRLRLLNRVIDSPIGIG
CCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
AGIDKDGLLISLMSRLPIGFHIVGSVTLKPRRGNPKPRMRRYPGLDAMVNAMGLPSRGVD
CCCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHCCCCHHHHHHHCCCCCCCHH
FLKGILNNECVRWPRSKLLGVSVAGFSETEFKLLLDSLTPYMDCVDFIEINVSSPTYGGS
HHHHHHCCHHHHCCHHHHCEEEECCCCCHHHHHHHHHHCHHHHHHHHHEEEECCCCCCCC
WTEPHRLNELLNSLKGYDKLVIKLPLLSSINDEVKLIKLIINHNPFGLTIANTLSIKADL
CCCHHHHHHHHHHHCCCCEEEEEECCHHCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECC
PMGYGGLSGKPLLGIVINLIKLTRRIGYGGLIIGLGGFMRGIDIIKGIKAEADLIGLVTG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHH
FAMEGPLVVYRIINELRRLQPG
HHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQPSKLLGYLPPDLTHDVTHLILRTYPVKVLIGTLTRLTGALPYRLRLLNRVIDSPIGIG
CCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
AGIDKDGLLISLMSRLPIGFHIVGSVTLKPRRGNPKPRMRRYPGLDAMVNAMGLPSRGVD
CCCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHCCCCHHHHHHHCCCCCCCHH
FLKGILNNECVRWPRSKLLGVSVAGFSETEFKLLLDSLTPYMDCVDFIEINVSSPTYGGS
HHHHHHCCHHHHCCHHHHCEEEECCCCCHHHHHHHHHHCHHHHHHHHHEEEECCCCCCCC
WTEPHRLNELLNSLKGYDKLVIKLPLLSSINDEVKLIKLIINHNPFGLTIANTLSIKADL
CCCHHHHHHHHHHHCCCCEEEEEECCHHCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECC
PMGYGGLSGKPLLGIVINLIKLTRRIGYGGLIIGLGGFMRGIDIIKGIKAEADLIGLVTG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHH
FAMEGPLVVYRIINELRRLQPG
HHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA