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The map label for this gene is thrB

Identifier: 15899123

GI number: 15899123

Start: 2160251

End: 2161186

Strand: Direct

Name: thrB

Synonym: SSO2367

Alternate gene names: 15899123

Gene position: 2160251-2161186 (Clockwise)

Preceding gene: 15899122

Following gene: 15899124

Centisome position: 72.19

GC content: 37.29

Gene sequence:

>936_bases
GTGGAGTGTAAAAGGGCTAGGGCGTATTCCAGTTCGGCTAATTTAGGTTCGGGCTTCGACATATTATCAATAGCACATAC
TGCGTTTTTTGACACTGTGGAAATATGTGTTGAGAATAAGAATTTAAATAACATTATAGTTGAAAGTAATTCAAAAATCC
CACTAGAACCAAATAAGAACTCTGCTACTTATCCAATAGTTAAGATTATGGAGGAAATAGGGATAAAGGCTAGCCTTAAA
GTTAGAGTAATAAAGGGTATTCCAGAGGGTTTAGGATTAGGGAGTAGTGGAGCATCGGCTGCTGCTGCTGTCATGGCGTT
CAATAATCTATTTAACCTAAACTTGTCTAAGGAGGATCTTGTCAGATATGCAATGTATGGAGAGATCGCCTCTTCTGGGT
CTCCTCATCCAGATAATGTCGCCGCTAGTGTTTTTGGCGGAGTTGTGTCTGTAGTTTCCGTTAGTCCGGTTAAAGTTGTT
GAAATACCTATAAATTACTCATTTGATATTTTGCTTTTCACCCCATTAAATGTGCATATTGAAGAGAAAACTAAGAAAGC
TAGGGAAATGGTACCTAAAACAGTTACACTTTCTGATTATATAAATAATTCGAGATATATATCGTCATTACTTCTTGGTT
TCATTAAAGGGGAGAGGGAGTTGATAAGATTAGGTTTAAACGATAAAATTGTAGAAAAGGCAAGACTTCCCTTATTCCCT
TACTATCCTAAAATTAAAGAGGTTGCGATAAAATATGACGCAATAGGCGCTTGCGTAAGTGGTGCAGGTCCTTCAATCCT
AGTTTTGACCGATAAGATGACCGATGAAAATAAAATTGTAGAAGAGGGAACTAAAACTTGTAATGAATTCAATGTTGAAT
GTAAAGTTATTAAAGCCAAGATTGCTGGAGGTGTAGGGATTGAAGGACGCGACTAG

Upstream 100 bases:

>100_bases
TATCCATTATTGCTATATCTCTCTTCGCTATTGGATAAGCGGATGTTATATGCCTCCACAAGATAATAAGAAATTTATAA
GTACTATTATTATTTAAGTT

Downstream 100 bases:

>100_bases
AGCAGTAAGGGAAGACATAGATGACTTAACTGGTGCTATAACTACTCCTATATATCAGACTTCTGCCTATCATTATCCCG
AGGGAGAAAAATATAGATAT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MECKRARAYSSSANLGSGFDILSIAHTAFFDTVEICVENKNLNNIIVESNSKIPLEPNKNSATYPIVKIMEEIGIKASLK
VRVIKGIPEGLGLGSSGASAAAAVMAFNNLFNLNLSKEDLVRYAMYGEIASSGSPHPDNVAASVFGGVVSVVSVSPVKVV
EIPINYSFDILLFTPLNVHIEEKTKKAREMVPKTVTLSDYINNSRYISSLLLGFIKGERELIRLGLNDKIVEKARLPLFP
YYPKIKEVAIKYDAIGACVSGAGPSILVLTDKMTDENKIVEEGTKTCNEFNVECKVIKAKIAGGVGIEGRD

Sequences:

>Translated_311_residues
MECKRARAYSSSANLGSGFDILSIAHTAFFDTVEICVENKNLNNIIVESNSKIPLEPNKNSATYPIVKIMEEIGIKASLK
VRVIKGIPEGLGLGSSGASAAAAVMAFNNLFNLNLSKEDLVRYAMYGEIASSGSPHPDNVAASVFGGVVSVVSVSPVKVV
EIPINYSFDILLFTPLNVHIEEKTKKAREMVPKTVTLSDYINNSRYISSLLLGFIKGERELIRLGLNDKIVEKARLPLFP
YYPKIKEVAIKYDAIGACVSGAGPSILVLTDKMTDENKIVEEGTKTCNEFNVECKVIKAKIAGGVGIEGRD
>Mature_311_residues
MECKRARAYSSSANLGSGFDILSIAHTAFFDTVEICVENKNLNNIIVESNSKIPLEPNKNSATYPIVKIMEEIGIKASLK
VRVIKGIPEGLGLGSSGASAAAAVMAFNNLFNLNLSKEDLVRYAMYGEIASSGSPHPDNVAASVFGGVVSVVSVSPVKVV
EIPINYSFDILLFTPLNVHIEEKTKKAREMVPKTVTLSDYINNSRYISSLLLGFIKGERELIRLGLNDKIVEKARLPLFP
YYPKIKEVAIKYDAIGACVSGAGPSILVLTDKMTDENKIVEEGTKTCNEFNVECKVIKAKIAGGVGIEGRD

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=282, Percent_Identity=28.7234042553192, Blast_Score=105, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321814, Length=335, Percent_Identity=26.2686567164179, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_SULSO (Q97W70)

Other databases:

- EMBL:   AE006641
- PIR:   G90407
- RefSeq:   NP_343728.1
- ProteinModelPortal:   Q97W70
- GeneID:   1453845
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO2367
- NMPDR:   fig|273057.1.peg.2151
- HOGENOM:   HBG646290
- OMA:   HYSACAK
- PhylomeDB:   Q97W70
- ProtClustDB:   PRK01212
- BioCyc:   SSOL273057:SSO2367-MONOMER
- BRENDA:   2.7.1.39
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 33649; Mature: 33649

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MECKRARAYSSSANLGSGFDILSIAHTAFFDTVEICVENKNLNNIIVESNSKIPLEPNKN
CCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCEEEEECCCCCCCCCCCC
SATYPIVKIMEEIGIKASLKVRVIKGIPEGLGLGSSGASAAAAVMAFNNLFNLNLSKEDL
CCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHEECCCCHHHH
VRYAMYGEIASSGSPHPDNVAASVFGGVVSVVSVSPVKVVEIPINYSFDILLFTPLNVHI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCEEEE
EEKTKKAREMVPKTVTLSDYINNSRYISSLLLGFIKGERELIRLGLNDKIVEKARLPLFP
HHHHHHHHHHCCCEEEHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCC
YYPKIKEVAIKYDAIGACVSGAGPSILVLTDKMTDENKIVEEGTKTCNEFNVECKVIKAK
CCCCHHHHEEEHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEE
IAGGVGIEGRD
ECCCCCCCCCC
>Mature Secondary Structure
MECKRARAYSSSANLGSGFDILSIAHTAFFDTVEICVENKNLNNIIVESNSKIPLEPNKN
CCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCEEEEECCCCCCCCCCCC
SATYPIVKIMEEIGIKASLKVRVIKGIPEGLGLGSSGASAAAAVMAFNNLFNLNLSKEDL
CCCHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHEECCCCHHHH
VRYAMYGEIASSGSPHPDNVAASVFGGVVSVVSVSPVKVVEIPINYSFDILLFTPLNVHI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCEEEE
EEKTKKAREMVPKTVTLSDYINNSRYISSLLLGFIKGERELIRLGLNDKIVEKARLPLFP
HHHHHHHHHHCCCEEEHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCC
YYPKIKEVAIKYDAIGACVSGAGPSILVLTDKMTDENKIVEEGTKTCNEFNVECKVIKAK
CCCCHHHHEEEHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEE
IAGGVGIEGRD
ECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726