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The map label for this gene is metB [H]

Identifier: 15899124

GI number: 15899124

Start: 2161170

End: 2162300

Strand: Direct

Name: metB [H]

Synonym: SSO2368

Alternate gene names: 15899124

Gene position: 2161170-2162300 (Clockwise)

Preceding gene: 15899123

Following gene: 15899127

Centisome position: 72.23

GC content: 38.82

Gene sequence:

>1131_bases
TTGAAGGACGCGACTAGAGCAGTAAGGGAAGACATAGATGACTTAACTGGTGCTATAACTACTCCTATATATCAGACTTC
TGCCTATCATTATCCCGAGGGAGAAAAATATAGATATTCTAGGGAATCAAATCCTACTGTTCTAGAGCTAGCTAAGAAAA
TAGTAGAACTTGAGAACGCTGAGATGGGTATTGCGTTTTCTTCTGGGATGGGAGCTATCTCCACTACTGCCCTAGCACTG
CTAAAGCCTGGAAATAGTGTTTTGGTTCATCGTGACATGTTCGGGAGGTCCTATCGTTTCTTTACAGACTACCTTAAAAA
CTGGGGTGTTAATGTAGAGGCATCATATCCTGGGAACAATAATATTATAGAGAAAGCAAAGTCTAAGAGGTATGATGTAA
TATTTGTGGAGAATATCACAAATCCACTATTAAGGGTTATAGATGTCGCTGAATTATCCAAGGTAGCAAAGGAGCAAGGA
AGCATATTGATTGTAGATGCGACTTTTTCTACCCCAATAAATCAAAAGCCATTGGAGTTAGGAGCTGACATAGTAGTGCA
CAGTGCGTCGAAGTTTTTGGCTGGACATAATGACGTAATAGCGGGATTAGCTGCTGGTTACAGTAAGTACTTAAATGTTA
TAGATCAAATGAGAAGGACTTTAGGAACTTCTTTAGATCCTCATGCAGCATATCTAACTTTGAGGGGTATTAAGACTCTT
AAAATAAGGATGGATGTTATCAATAGGAATGCGGAGCAAATCGCTGAATTTTTAGAAGGACATCCTAAAGTCGTAAAAGT
ATATTATCCTGGTCTTAAGTCTCATGTGGATTACGATATAGCGAGAAAGGTTCTTAAAGGATTCGGAGGCGTTTTAAGTT
TTGAAGTAAATGGAGGTCAAGAAAGTGCGTTAAAAGTAATGAAATCACTTAAGTTGATAATCCCTGCACAAACGCTTGGT
GGGGTTAATTCTGTTATATCACATCCGGCCACTATGTCACATAGGACACTTAGTTTAGAAGAAAGAAAGATAGTTGGGAT
AACTGATAGCCTCCTCAGACTTTCCGTTGGAATAGAAGATGTAAATGACTTGATAGAGGATCTAGATAGGGCATTGAGCA
CTTTATACTAG

Upstream 100 bases:

>100_bases
ACCGATGAAAATAAAATTGTAGAAGAGGGAACTAAAACTTGTAATGAATTCAATGTTGAATGTAAAGTTATTAAAGCCAA
GATTGCTGGAGGTGTAGGGA

Downstream 100 bases:

>100_bases
ATTATTGTTCTTATTTCATGTCTTAATTCTTCCTCTAACATTTCTCTTATCTCTCTTCTGTGTACTCTGCTTAAATGTAA
ATAAAGTCCTTTTTTTGTGA

Product: hypothetical protein

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKDATRAVREDIDDLTGAITTPIYQTSAYHYPEGEKYRYSRESNPTVLELAKKIVELENAEMGIAFSSGMGAISTTALAL
LKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVEASYPGNNNIIEKAKSKRYDVIFVENITNPLLRVIDVAELSKVAKEQG
SILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYSKYLNVIDQMRRTLGTSLDPHAAYLTLRGIKTL
KIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYDIARKVLKGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLG
GVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALSTLY

Sequences:

>Translated_376_residues
MKDATRAVREDIDDLTGAITTPIYQTSAYHYPEGEKYRYSRESNPTVLELAKKIVELENAEMGIAFSSGMGAISTTALAL
LKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVEASYPGNNNIIEKAKSKRYDVIFVENITNPLLRVIDVAELSKVAKEQG
SILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYSKYLNVIDQMRRTLGTSLDPHAAYLTLRGIKTL
KIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYDIARKVLKGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLG
GVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALSTLY
>Mature_376_residues
MKDATRAVREDIDDLTGAITTPIYQTSAYHYPEGEKYRYSRESNPTVLELAKKIVELENAEMGIAFSSGMGAISTTALAL
LKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVEASYPGNNNIIEKAKSKRYDVIFVENITNPLLRVIDVAELSKVAKEQG
SILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYSKYLNVIDQMRRTLGTSLDPHAAYLTLRGIKTL
KIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYDIARKVLKGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLG
GVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALSTLY

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=362, Percent_Identity=34.2541436464088, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI299473759, Length=362, Percent_Identity=30.939226519337, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI25453487, Length=361, Percent_Identity=31.0249307479224, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1790375, Length=376, Percent_Identity=37.7659574468085, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1789383, Length=346, Percent_Identity=25.7225433526012, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71980708, Length=375, Percent_Identity=39.4666666666667, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17560056, Length=349, Percent_Identity=35.5300859598854, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17538055, Length=348, Percent_Identity=34.1954022988506, Blast_Score=203, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6319307, Length=388, Percent_Identity=38.1443298969072, Blast_Score=231, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6323333, Length=412, Percent_Identity=29.6116504854369, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6321254, Length=399, Percent_Identity=31.5789473684211, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321904, Length=349, Percent_Identity=28.6532951289398, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6321170, Length=317, Percent_Identity=26.813880126183, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI19922554, Length=363, Percent_Identity=34.7107438016529, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 41458; Mature: 41458

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDATRAVREDIDDLTGAITTPIYQTSAYHYPEGEKYRYSRESNPTVLELAKKIVELENA
CCHHHHHHHHHHHHHHHHHCCCEEECCCEECCCCCCEEECCCCCCHHHHHHHHHHHHCCC
EMGIAFSSGMGAISTTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVEASYPGNN
CEEEEECCCCCHHHHHHHHEECCCCCEEEEEHHCCCHHHHHHHHHHHCCCEEEEECCCCC
NIIEKAKSKRYDVIFVENITNPLLRVIDVAELSKVAKEQGSILIVDATFSTPINQKPLEL
CHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHH
GADIVVHSASKFLAGHNDVIAGLAAGYSKYLNVIDQMRRTLGTSLDPHAAYLTLRGIKTL
CCHHEEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEE
KIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYDIARKVLKGFGGVLSFEVNGGQ
EEEEHHHCCCHHHHHHHHCCCCEEEEEEECCCHHHCCHHHHHHHHHHCCCEEEEEECCCH
ESALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIED
HHHHHHHHHHHHEECHHHHCCHHHHHCCCCCCCCCEEECCCCEEECHHHHHHHHHCCHHH
VNDLIEDLDRALSTLY
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKDATRAVREDIDDLTGAITTPIYQTSAYHYPEGEKYRYSRESNPTVLELAKKIVELENA
CCHHHHHHHHHHHHHHHHHCCCEEECCCEECCCCCCEEECCCCCCHHHHHHHHHHHHCCC
EMGIAFSSGMGAISTTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVEASYPGNN
CEEEEECCCCCHHHHHHHHEECCCCCEEEEEHHCCCHHHHHHHHHHHCCCEEEEECCCCC
NIIEKAKSKRYDVIFVENITNPLLRVIDVAELSKVAKEQGSILIVDATFSTPINQKPLEL
CHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHH
GADIVVHSASKFLAGHNDVIAGLAAGYSKYLNVIDQMRRTLGTSLDPHAAYLTLRGIKTL
CCHHEEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEE
KIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYDIARKVLKGFGGVLSFEVNGGQ
EEEEHHHCCCHHHHHHHHCCCCEEEEEEECCCHHHCCHHHHHHHHHHCCCEEEEEECCCH
ESALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIED
HHHHHHHHHHHHEECHHHHCCHHHHHCCCCCCCCCEEECCCCEEECHHHHHHHHHCCHHH
VNDLIEDLDRALSTLY
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]