Click here to switch to the map view.

The map label for this gene is moeA-2 [C]

Identifier: 15899122

GI number: 15899122

Start: 2158360

End: 2160012

Strand: Direct

Name: moeA-2 [C]

Synonym: SSO2365

Alternate gene names: 15899122

Gene position: 2158360-2160012 (Clockwise)

Preceding gene: 15899121

Following gene: 15899123

Centisome position: 72.13

GC content: 35.15

Gene sequence:

>1653_bases
TTGTTTTTTTATATGAGAGTATTTGTTAAGGATGAATTGTTATACTCAATAGAGGAAGCGATAAGAGTCTATTTATCATC
ACTAAATTTCATCCCTAAAACTGTAGAAGTAGAAGTAAAGGACTCTTTTGGATACGTGTCAGCAGAAGATCTGAACTCGC
CAATTGACTATCCTCCATTTTCAAGGTCTAACGTAGATGGTTATGCCTTAAAGTCCTCATGCACTCCCGGAGAACTGAAG
GTGATAGATAGAATAGAAATTGGTGAATTTAAAGAAGTTCACATAAATGAGTGCGTAGCTGTTGAAGTAGATACTGGAGC
AATCATCCCAATGGGTGCGGATGCCGTAATAAAAGTTGAAGATGTCAAAATAATAAGTGGTAATCTCATAAAAGTAGACA
AAAAAATGACTTTTGGCCAAAATATTGGGTGGATAGGAAGTGATATTCCTAAAAATTCAATTATATTGAGAAAAGGTGAA
GTGATTTCCCATGAGAAGATTGGCTTGTTAGCGTCATTAGGAATAAGTAAGGTAAAGGTATATGAAAAGTTAAAGGTATA
TCTAATTGCAACGGGAGATGAACTTGTTGAACCTGGTAACTCCTTGTCCCCAGGCAAAATTTATGAGTCTAATCTACATT
ACCTATATTCTAAGCTTAAACAAAATTATCAAATAGTTGGTCTTTCATTACTTAGAGATGATATAGAGAGCATTAAAAAT
GAGATAAAGAGAGCTATTTCGCTTGCTGATGTTTTGATACTAACCGGTGGCACTAGCGCTGGAGAAAAGGATTTCGTCCA
CAGAGCTATAAAAGAGTTAGGTAGTATAATAGTTCATGGTATAAAGATAAAGCCTGGAAAGCCGACCATTTTAGGAGTAG
TAGATAACAAGCCGGTAATTGGATTGCCTGGGAATATAGTATCTTCAGTTGTAGTTTTTGATACGGTTATCTCAGAAATT
CTGAGAAATCTCTATCCTTCCCGCAAAGAAATTGTTGAATTAGGCAAAATTAAAGCTAAGTTAGCACTGGGGACTAAGGC
TGATAAATATAGAAATACTCTAATTCCAGTCTATTTGTTTAAAAGTGTTGATAGTTCCTATTACGCACTTCCAGTAAAGT
TCGAGAGTTATATGATAGGTACTTTTTCCTTAACTGAGGGTTATATAATGCTTAATCCAAACGAAGAAATCGAAGAAGGT
AAGGAAGTTGAGGTTAACGTGAAGAAGTTTGATGATTCGATATCTATTATAGGAGAAGAGGATAAGAGGATTCTAAATTC
AGATACGAAAAATGTATTGCTGGGTTCCTTGCCTGCAAAAAAAGCTATAGAATACAAATTTGGAGATGTTGCAGTTATTA
GTTCGTTGTATTCTTCATCAGTAGATAATTATGATAGGGTTTTCTGTAGGCAAATTTTAGTTAATGGTGAGGGAGAGGAA
ATAGGTTATGACGATTGGATTGGGATGTCCAAAATCGTAAAGAACCCGGTAGTGAAGTTAAGATCTCCTTCCACAATTTA
CTCGTTATTAGGAAAGGCTAAGGTTTATGCTCCAGAAGGCTATATTATTGGTAAAAAGGTATTCGAGGAATGTCTATACA
TGATAGGAATTAGTGAAAGAGGCAAGAGGTATCTAAGCACGATAAAAGTATAA

Upstream 100 bases:

>100_bases
GAGGCAAATTTAGATATATCACAAGTACGTGACCCCGTAGTAATGGTATTAGACGAGTTAGAAAAGGCGTCACTCATAAC
TTTTTAATCCGTATAAGATA

Downstream 100 bases:

>100_bases
ATAATAATAGGCTTAATTTGGAGTAATGCTCTAAAGTATTAAATTAAAGATATAACTAGCTCTCTATCAAAGTTAGGTTA
TATGATCGATAGCTGTTACC

Product: putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MFFYMRVFVKDELLYSIEEAIRVYLSSLNFIPKTVEVEVKDSFGYVSAEDLNSPIDYPPFSRSNVDGYALKSSCTPGELK
VIDRIEIGEFKEVHINECVAVEVDTGAIIPMGADAVIKVEDVKIISGNLIKVDKKMTFGQNIGWIGSDIPKNSIILRKGE
VISHEKIGLLASLGISKVKVYEKLKVYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKQNYQIVGLSLLRDDIESIKN
EIKRAISLADVLILTGGTSAGEKDFVHRAIKELGSIIVHGIKIKPGKPTILGVVDNKPVIGLPGNIVSSVVVFDTVISEI
LRNLYPSRKEIVELGKIKAKLALGTKADKYRNTLIPVYLFKSVDSSYYALPVKFESYMIGTFSLTEGYIMLNPNEEIEEG
KEVEVNVKKFDDSISIIGEEDKRILNSDTKNVLLGSLPAKKAIEYKFGDVAVISSLYSSSVDNYDRVFCRQILVNGEGEE
IGYDDWIGMSKIVKNPVVKLRSPSTIYSLLGKAKVYAPEGYIIGKKVFEECLYMIGISERGKRYLSTIKV

Sequences:

>Translated_550_residues
MFFYMRVFVKDELLYSIEEAIRVYLSSLNFIPKTVEVEVKDSFGYVSAEDLNSPIDYPPFSRSNVDGYALKSSCTPGELK
VIDRIEIGEFKEVHINECVAVEVDTGAIIPMGADAVIKVEDVKIISGNLIKVDKKMTFGQNIGWIGSDIPKNSIILRKGE
VISHEKIGLLASLGISKVKVYEKLKVYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKQNYQIVGLSLLRDDIESIKN
EIKRAISLADVLILTGGTSAGEKDFVHRAIKELGSIIVHGIKIKPGKPTILGVVDNKPVIGLPGNIVSSVVVFDTVISEI
LRNLYPSRKEIVELGKIKAKLALGTKADKYRNTLIPVYLFKSVDSSYYALPVKFESYMIGTFSLTEGYIMLNPNEEIEEG
KEVEVNVKKFDDSISIIGEEDKRILNSDTKNVLLGSLPAKKAIEYKFGDVAVISSLYSSSVDNYDRVFCRQILVNGEGEE
IGYDDWIGMSKIVKNPVVKLRSPSTIYSLLGKAKVYAPEGYIIGKKVFEECLYMIGISERGKRYLSTIKV
>Mature_550_residues
MFFYMRVFVKDELLYSIEEAIRVYLSSLNFIPKTVEVEVKDSFGYVSAEDLNSPIDYPPFSRSNVDGYALKSSCTPGELK
VIDRIEIGEFKEVHINECVAVEVDTGAIIPMGADAVIKVEDVKIISGNLIKVDKKMTFGQNIGWIGSDIPKNSIILRKGE
VISHEKIGLLASLGISKVKVYEKLKVYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKQNYQIVGLSLLRDDIESIKN
EIKRAISLADVLILTGGTSAGEKDFVHRAIKELGSIIVHGIKIKPGKPTILGVVDNKPVIGLPGNIVSSVVVFDTVISEI
LRNLYPSRKEIVELGKIKAKLALGTKADKYRNTLIPVYLFKSVDSSYYALPVKFESYMIGTFSLTEGYIMLNPNEEIEEG
KEVEVNVKKFDDSISIIGEEDKRILNSDTKNVLLGSLPAKKAIEYKFGDVAVISSLYSSSVDNYDRVFCRQILVNGEGEE
IGYDDWIGMSKIVKNPVVKLRSPSTIYSLLGKAKVYAPEGYIIGKKVFEECLYMIGISERGKRYLSTIKV

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=416, Percent_Identity=30.2884615384615, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI10880983, Length=416, Percent_Identity=30.2884615384615, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1787049, Length=337, Percent_Identity=31.4540059347181, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI25147659, Length=331, Percent_Identity=30.8157099697885, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17562606, Length=327, Percent_Identity=26.9113149847095, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136978, Length=273, Percent_Identity=32.6007326007326, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24638841, Length=273, Percent_Identity=32.6007326007326, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 61098; Mature: 61098

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFYMRVFVKDELLYSIEEAIRVYLSSLNFIPKTVEVEVKDSFGYVSAEDLNSPIDYPPF
CEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEHHHCCCCCCCCCC
SRSNVDGYALKSSCTPGELKVIDRIEIGEFKEVHINECVAVEVDTGAIIPMGADAVIKVE
CCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEECCCEEEEEECCCEEEECCCCEEEEEE
DVKIISGNLIKVDKKMTFGQNIGWIGSDIPKNSIILRKGEVISHEKIGLLASLGISKVKV
EEEEECCCEEEEECCEECCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCHHHEE
YEKLKVYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKQNYQIVGLSLLRDDIESIKN
EEEEEEEEEECCHHHHCCCCCCCCCCEEHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHH
EIKRAISLADVLILTGGTSAGEKDFVHRAIKELGSIIVHGIKIKPGKPTILGVVDNKPVI
HHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCEE
GLPGNIVSSVVVFDTVISEILRNLYPSRKEIVELGKIKAKLALGTKADKYRNTLIPVYLF
ECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCHHHHCCEEEEEEE
KSVDSSYYALPVKFESYMIGTFSLTEGYIMLNPNEEIEEGKEVEVNVKKFDDSISIIGEE
ECCCCCEEEEEEEECCEEEEEEEEECCEEEECCCHHHHCCCEEEEEEEECCCCEEEECCC
DKRILNSDTKNVLLGSLPAKKAIEYKFGDVAVISSLYSSSVDNYDRVFCRQILVNGEGEE
HHHHHCCCCCCEEEECCCCCHHHEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
IGYDDWIGMSKIVKNPVVKLRSPSTIYSLLGKAKVYAPEGYIIGKKVFEECLYMIGISER
CCCHHHCCHHHHHCCCCEEECCCHHHHHHHCCCEEECCCCEEECHHHHHHHHHHHCCCHH
GKRYLSTIKV
HHHHHHHCCC
>Mature Secondary Structure
MFFYMRVFVKDELLYSIEEAIRVYLSSLNFIPKTVEVEVKDSFGYVSAEDLNSPIDYPPF
CEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEHHHCCCCCCCCCC
SRSNVDGYALKSSCTPGELKVIDRIEIGEFKEVHINECVAVEVDTGAIIPMGADAVIKVE
CCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEECCCEEEEEECCCEEEECCCCEEEEEE
DVKIISGNLIKVDKKMTFGQNIGWIGSDIPKNSIILRKGEVISHEKIGLLASLGISKVKV
EEEEECCCEEEEECCEECCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCHHHEE
YEKLKVYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKQNYQIVGLSLLRDDIESIKN
EEEEEEEEEECCHHHHCCCCCCCCCCEEHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHH
EIKRAISLADVLILTGGTSAGEKDFVHRAIKELGSIIVHGIKIKPGKPTILGVVDNKPVI
HHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCEE
GLPGNIVSSVVVFDTVISEILRNLYPSRKEIVELGKIKAKLALGTKADKYRNTLIPVYLF
ECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCHHHHCCEEEEEEE
KSVDSSYYALPVKFESYMIGTFSLTEGYIMLNPNEEIEEGKEVEVNVKKFDDSISIIGEE
ECCCCCEEEEEEEECCEEEEEEEEECCEEEECCCHHHHCCCEEEEEEEECCCCEEEECCC
DKRILNSDTKNVLLGSLPAKKAIEYKFGDVAVISSLYSSSVDNYDRVFCRQILVNGEGEE
HHHHHCCCCCCEEEECCCCCHHHEECCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
IGYDDWIGMSKIVKNPVVKLRSPSTIYSLLGKAKVYAPEGYIIGKKVFEECLYMIGISER
CCCHHHCCHHHHHCCCCEEECCCHHHHHHHCCCEEECCCCEEECHHHHHHHHHHHCCCHH
GKRYLSTIKV
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]