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The map label for this gene is sdhA [H]

Identifier: 15899114

GI number: 15899114

Start: 2150698

End: 2152398

Strand: Direct

Name: sdhA [H]

Synonym: SSO2356

Alternate gene names: 15899114

Gene position: 2150698-2152398 (Clockwise)

Preceding gene: 15899113

Following gene: 15899115

Centisome position: 71.88

GC content: 38.57

Gene sequence:

>1701_bases
ATGGAAAAGATCGAATACGACGCTGTTGTAATTGGAGGAGGACTAGCAGGATTAATGAGTGCACATGAGATAGCCTCTGC
TGGTTTTAAAGTTGCTGTTATTTCAAAGGTATTTCCCACGAGATCGCATTCTGCAGCAGCAGAAGGTGGAATAGCAGCCT
ATATTCCTGGGAATTCAGATCCAAATGATAACCCAGATTATATGACATACGATACAGTTAAAGGCGGAGATTATTTAGTT
GATCAAGATGCAGCGGAATTACTTTCCAACAAATCTGGAGAAATAGTAATGTTACTAGAAAGATGGGGTGCACTATTCAA
TAGGCAACCGGATGGCAGAGTTGCAGTCAGGTATTTTGGAGGACAGACCTATCCGAGAACTAGATTTGTTGGAGACAAAA
CTGGAATGGCACTGTTACATACACTTTTCGAAAGGACTTCTGGTTTAAATGTAGATTTTTACAACGAGTGGTTCTCTTTA
GACTTAGTTACTGATGATAAGAAGGTAGCTGGTATAGTGGCAATGCAAATGAAGACATTAACTCCATTCTTCTTTAAGAC
TAAGGCTGTCGTATTAGCGACTGGAGGAATGGGAATGTTATATAGACATACAACAAATAGCTACATCAATACTGGCGATG
GCTTTGGCATAGCATTAAGAGCTGGAGCTGCATTAAAAGATCCAGAATTTGTACAATTTCATCCAACAGCACTCTACCCA
TCAGACGTTTTAATTAGTGAGGCTGCTAGAGGTGAAGGAGCTATATTGAAAAATATAAAAGGAGAAAGATTTATGACGAG
ATATGCTCCTAAAAAGCTAGATCTAGCACCTAGGGATATAGTTTCAAGAGCAATAATTACTGAAATAAAAGAGGGAAGAG
GATTCCCTGGTGGGTATGTTGGTCTGGATTTGACTCATTTAGGTGAAGAATACATCAAAGAGAGATTAGCTTTAGCTGTG
GAAGCGGCAAAAAGCTTTGCAGGTGTTGATGCGTTTACTGAACCTATTCCAGTAAGACCTGCTCAACATTATTATATGGG
AGGAATAGACGTGGATATAGAGGGTAGGAACCCTGATATTGTGGGGCTATTCTCTGCAGGTGAAGCAGCTTGTGTATCAG
TACATGGTGCTAATAGATTAGGTTCTAATTCACTTCTGGATACTTTAGTATTCGGTCAAGTTACGGGTAGGGCTGTGGTT
CAATTTCTCAAGTCTAATTCAAGTAATCCCACATCAAATTATGAGAAAGAAGCTGAGAAAGTTGTTGATGATGCTTATAA
GTTAGTAAAAAGTGAGAGTGGCGTGCATTTTGGTCAAATACTAGAAAAACTAAGAGACACGATGTGGGATTATGTGGGAA
TATATAGAGATGAGGGTGGACTACTTAATGCGATGTCTGAGATAAACAAATTAAGAGGTATGATTAGCAATATGTATGTG
ACAGATAAGAGTAAAGTCTATAACACAGAATTCTTTAACGCCCTAGAATTGAGGAATATGTTAGATTTAGCATTCGTAAT
AGCTAAATCAGCTTTAGAAAGAAAAGAGTCAAGAGGAGCGCATTATAGAACGGATTATCCGGATAGGGATGATAATAATT
GGTTAAAACACACAATTGCGTATTTAAGGGGTAATACGGTTGAGGTTACATTCAAACCAGTTAAGATAACCAGATGGAAA
CCAGAACCTAGGGTGTATTAA

Upstream 100 bases:

>100_bases
GGAGTAATGTTAAGCCGAAATATGTAGTAAATACTTTATTAGACCTTTTGTGAAATTGTAGAAAGAATACTTAAAAACTA
TTACGCAAATATAAACATGT

Downstream 100 bases:

>100_bases
AATGACTCAGTCTCAAGAGGAAGAAGTTATATTAAAGGTAAAAAGATTTAACCCAGAAAAGGGATATTGGTGGGCGGAAT
ATAAGCTGAAGGTTGATAGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSDPNDNPDYMTYDTVKGGDYLV
DQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFGGQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSL
DLVTDDKKVAGIVAMQMKTLTPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYP
SDVLISEAARGEGAILKNIKGERFMTRYAPKKLDLAPRDIVSRAIITEIKEGRGFPGGYVGLDLTHLGEEYIKERLALAV
EAAKSFAGVDAFTEPIPVRPAQHYYMGGIDVDIEGRNPDIVGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRAVV
QFLKSNSSNPTSNYEKEAEKVVDDAYKLVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYV
TDKSKVYNTEFFNALELRNMLDLAFVIAKSALERKESRGAHYRTDYPDRDDNNWLKHTIAYLRGNTVEVTFKPVKITRWK
PEPRVY

Sequences:

>Translated_566_residues
MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSDPNDNPDYMTYDTVKGGDYLV
DQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFGGQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSL
DLVTDDKKVAGIVAMQMKTLTPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYP
SDVLISEAARGEGAILKNIKGERFMTRYAPKKLDLAPRDIVSRAIITEIKEGRGFPGGYVGLDLTHLGEEYIKERLALAV
EAAKSFAGVDAFTEPIPVRPAQHYYMGGIDVDIEGRNPDIVGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRAVV
QFLKSNSSNPTSNYEKEAEKVVDDAYKLVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYV
TDKSKVYNTEFFNALELRNMLDLAFVIAKSALERKESRGAHYRTDYPDRDDNNWLKHTIAYLRGNTVEVTFKPVKITRWK
PEPRVY
>Mature_566_residues
MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSDPNDNPDYMTYDTVKGGDYLV
DQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFGGQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSL
DLVTDDKKVAGIVAMQMKTLTPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYP
SDVLISEAARGEGAILKNIKGERFMTRYAPKKLDLAPRDIVSRAIITEIKEGRGFPGGYVGLDLTHLGEEYIKERLALAV
EAAKSFAGVDAFTEPIPVRPAQHYYMGGIDVDIEGRNPDIVGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRAVV
QFLKSNSSNPTSNYEKEAEKVVDDAYKLVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYV
TDKSKVYNTEFFNALELRNMLDLAFVIAKSALERKESRGAHYRTDYPDRDDNNWLKHTIAYLRGNTVEVTFKPVKITRWK
PEPRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=568, Percent_Identity=38.7323943661972, Blast_Score=384, Evalue=1e-106,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=41.156462585034, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1790597, Length=555, Percent_Identity=41.4414414414414, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1788928, Length=537, Percent_Identity=35.3817504655494, Blast_Score=263, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17505833, Length=591, Percent_Identity=40.2707275803723, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17550100, Length=589, Percent_Identity=38.8794567062818, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71986328, Length=478, Percent_Identity=28.2426778242678, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322416, Length=570, Percent_Identity=44.0350877192982, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322701, Length=570, Percent_Identity=43.6842105263158, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI17137288, Length=582, Percent_Identity=39.3470790378007, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24655642, Length=582, Percent_Identity=39.3470790378007, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24655647, Length=582, Percent_Identity=39.3470790378007, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24663005, Length=609, Percent_Identity=36.9458128078818, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 62533; Mature: 62533

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSD
CCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCCCCEEEEECCCCC
PNDNPDYMTYDTVKGGDYLVDQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFG
CCCCCCEEEEEEECCCCEEECCHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCEEEEEEC
GQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSLDLVTDDKKVAGIVAMQMKTL
CCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEECCEEEEEEEECCCHHHHHHHHHHHHC
TPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYP
CCHHHCCEEEEEEECCCCEEEEECCCCCEECCCCCEEEEECCCCCCCCCEEEECCCEECC
SDVLISEAARGEGAILKNIKGERFMTRYAPKKLDLAPRDIVSRAIITEIKEGRGFPGGYV
CHHHHHHHCCCCCHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEE
GLDLTHLGEEYIKERLALAVEAAKSFAGVDAFTEPIPVRPAQHYYMGGIDVDIEGRNPDI
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCEEECCEEEEECCCCCCE
VGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRAVVQFLKSNSSNPTSNYEKEAEK
EEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VVDDAYKLVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCEE
TDKSKVYNTEFFNALELRNMLDLAFVIAKSALERKESRGAHYRTDYPDRDDNNWLKHTIA
ECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
YLRGNTVEVTFKPVKITRWKPEPRVY
HHCCCEEEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSD
CCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCCCCEEEEECCCCC
PNDNPDYMTYDTVKGGDYLVDQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFG
CCCCCCEEEEEEECCCCEEECCHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCEEEEEEC
GQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSLDLVTDDKKVAGIVAMQMKTL
CCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEECCEEEEEEEECCCHHHHHHHHHHHHC
TPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYP
CCHHHCCEEEEEEECCCCEEEEECCCCCEECCCCCEEEEECCCCCCCCCEEEECCCEECC
SDVLISEAARGEGAILKNIKGERFMTRYAPKKLDLAPRDIVSRAIITEIKEGRGFPGGYV
CHHHHHHHCCCCCHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEE
GLDLTHLGEEYIKERLALAVEAAKSFAGVDAFTEPIPVRPAQHYYMGGIDVDIEGRNPDI
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCEEECCEEEEECCCCCCE
VGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRAVVQFLKSNSSNPTSNYEKEAEK
EEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VVDDAYKLVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCEE
TDKSKVYNTEFFNALELRNMLDLAFVIAKSALERKESRGAHYRTDYPDRDDNNWLKHTIA
ECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
YLRGNTVEVTFKPVKITRWKPEPRVY
HHCCCEEEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]