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The map label for this gene is glmU [H]

Identifier: 15897645

GI number: 15897645

Start: 632028

End: 633251

Strand: Reverse

Name: glmU [H]

Synonym: SSO0745

Alternate gene names: 15897645

Gene position: 633251-632028 (Counterclockwise)

Preceding gene: 15897646

Following gene: 15897643

Centisome position: 21.16

GC content: 35.38

Gene sequence:

>1224_bases
TTGAAAGCAGTAGTGTTAGCAGCGGGTAAAGGAGAGAGATTAGAACCAATAACCCATACAAGACCTAAACCTTTTGTTCC
TGTTCTTGAAACTCCCTTAATTTTAAGGCATATTCGGATATTAAAGAAATATATAAATAAGATTATAATTGTAATAAACT
CTAACCATAAGGATTATTTCAAAACTATTGAAGGAGTTAGTCTAGTTGAACAGACTGAAGGAAAAGGTACCGCTGCAGCT
TTACGAGCAGCCGAGAAATATCTTGAGGGAGATGAAGAATTTTTAGTAATTTACGGAGACCTTCTTTTTGAAGAAGATGC
ATTGGATAAAATAGTAAATACTGAGGGGGAGGCAATTCTAGCTAGAGAGTCTGAAGATCCTAGAAAATTTGGAGTTATAG
TGAAAGACTCAGAAAATAGATTAGTGAGAATAGTCGAAAAGCCTGAGAATCCTCCGTCAAATATAATTAACGCAGGTATC
TATAAGTTTACCTATGATATTTTCTCATATATTGATAAAATAAGTTTATCAAGTAGAGGTGAATTTGAGCTTACAGATGC
TGTAAATCTTATCGGAAATAAGGTTAAGGTAGTTACGTACAATGGAATATGGTTAGATATAGGAAGGCCTTGGGATTTAA
TAGAAGCTAATAAGGTACTTTTAGATAAGGAGAAGGATCGAAATCTAGGTGTAATCGAAGAAAATGTTAAAATCAAAGGT
AAAGTAGTTATTGAAGATGGGGTTATAATAAAATCTGGTACCTATATAGAGGGTCCCGTTTATATAGGTAAAAATTCTGT
TATCGGACCTAATGCGTATATAAGGCCATATAGTGTGATAGGAAGTAACGTTAAGGTTGGTGCGTTTAACGAGATAAAGG
AAAGCGTGATAATGGAAAACGCAAAGATTCCGCATTTAAGTTATGTCGGAGACAGTGTAATCTGTGAGGGTGTAAATTTT
GGAGCTGGAACTATAACCGCGAATTTGCGGTTTGATGAAGAGGAAGTTAAGGTTAATATAAAAAACGAAAGGGTAAGCAG
TGGTAGAAAGAAATTAGGTGCAATAGTAGGTGCCCATGTAAGAACTGGGATTAATGTATCAATATTGCCTGGGGTAAAGA
TTGGTGCATATGCTTGGATTTATCCAGGAGCTGTTGTTGATAGAGATGTTGAGAAAGGAGAGAAATATGTTCCATATTAC
CTAAGAAGGTCTAGCGGTACTTGA

Upstream 100 bases:

>100_bases
AACGAAATATTTGAAGCAGCAAAGAAGATATATCCACTAAGGAAGGCTGAGATAGAAAAAACTAAAGTGCTTAAAGTACC
AGAAAATTTAGGTAAACAAG

Downstream 100 bases:

>100_bases
AACAATCTTTATTACATCATTATTCTGTAGTTGATAATTCTCTCCCACTCTCATTTTTCTTTTCACATCAATAGCGTATA
AGAAACCTTTAGCTAGTTCC

Product: sugar phosphate nucleotydyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKAVVLAAGKGERLEPITHTRPKPFVPVLETPLILRHIRILKKYINKIIIVINSNHKDYFKTIEGVSLVEQTEGKGTAAA
LRAAEKYLEGDEEFLVIYGDLLFEEDALDKIVNTEGEAILARESEDPRKFGVIVKDSENRLVRIVEKPENPPSNIINAGI
YKFTYDIFSYIDKISLSSRGEFELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDKEKDRNLGVIEENVKIKG
KVVIEDGVIIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMENAKIPHLSYVGDSVICEGVNF
GAGTITANLRFDEEEVKVNIKNERVSSGRKKLGAIVGAHVRTGINVSILPGVKIGAYAWIYPGAVVDRDVEKGEKYVPYY
LRRSSGT

Sequences:

>Translated_407_residues
MKAVVLAAGKGERLEPITHTRPKPFVPVLETPLILRHIRILKKYINKIIIVINSNHKDYFKTIEGVSLVEQTEGKGTAAA
LRAAEKYLEGDEEFLVIYGDLLFEEDALDKIVNTEGEAILARESEDPRKFGVIVKDSENRLVRIVEKPENPPSNIINAGI
YKFTYDIFSYIDKISLSSRGEFELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDKEKDRNLGVIEENVKIKG
KVVIEDGVIIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMENAKIPHLSYVGDSVICEGVNF
GAGTITANLRFDEEEVKVNIKNERVSSGRKKLGAIVGAHVRTGINVSILPGVKIGAYAWIYPGAVVDRDVEKGEKYVPYY
LRRSSGT
>Mature_407_residues
MKAVVLAAGKGERLEPITHTRPKPFVPVLETPLILRHIRILKKYINKIIIVINSNHKDYFKTIEGVSLVEQTEGKGTAAA
LRAAEKYLEGDEEFLVIYGDLLFEEDALDKIVNTEGEAILARESEDPRKFGVIVKDSENRLVRIVEKPENPPSNIINAGI
YKFTYDIFSYIDKISLSSRGEFELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDKEKDRNLGVIEENVKIKG
KVVIEDGVIIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMENAKIPHLSYVGDSVICEGVNF
GAGTITANLRFDEEEVKVNIKNERVSSGRKKLGAIVGAHVRTGINVSILPGVKIGAYAWIYPGAVVDRDVEKGEKYVPYY
LRRSSGT

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=354, Percent_Identity=25.4237288135593, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI11761619, Length=329, Percent_Identity=25.531914893617, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1790224, Length=248, Percent_Identity=29.4354838709677, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1790168, Length=448, Percent_Identity=26.1160714285714, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788351, Length=247, Percent_Identity=27.1255060728745, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI133931050, Length=337, Percent_Identity=28.1899109792285, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17509979, Length=341, Percent_Identity=28.1524926686217, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17509981, Length=330, Percent_Identity=26.969696969697, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=330, Percent_Identity=27.8787878787879, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21355443, Length=329, Percent_Identity=26.4437689969605, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24644084, Length=329, Percent_Identity=26.4437689969605, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 45146; Mature: 45146

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVLAAGKGERLEPITHTRPKPFVPVLETPLILRHIRILKKYINKIIIVINSNHKDYF
CCEEEEECCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHCEEEEEEECCCHHHH
KTIEGVSLVEQTEGKGTAAALRAAEKYLEGDEEFLVIYGDLLFEEDALDKIVNTEGEAIL
HHHCCCHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEE
ARESEDPRKFGVIVKDSENRLVRIVEKPENPPSNIINAGIYKFTYDIFSYIDKISLSSRG
EECCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
EFELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDKEKDRNLGVIEENVKIKG
CEEEHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCCEEEEECCCCCCCCEEECCEEEEE
KVVIEDGVIIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMEN
EEEEECCEEEECCCEEECCEEECCCCEECCCCCCCCHHHCCCCEEECCHHHHHHHHHHCC
AKIPHLSYVGDSVICEGVNFGAGTITANLRFDEEEVKVNIKNERVSSGRKKLGAIVGAHV
CCCCEEEECCCCEEEECCCCCCEEEEEEEEECHHHEEEEECCCHHHHHHHHHHHHHHHHH
RTGINVSILPGVKIGAYAWIYPGAVVDRDVEKGEKYVPYYLRRSSGT
HCCCCEEEECCCEECEEEEECCCHHCCCHHHCCCCCCCEEEEECCCC
>Mature Secondary Structure
MKAVVLAAGKGERLEPITHTRPKPFVPVLETPLILRHIRILKKYINKIIIVINSNHKDYF
CCEEEEECCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHCEEEEEEECCCHHHH
KTIEGVSLVEQTEGKGTAAALRAAEKYLEGDEEFLVIYGDLLFEEDALDKIVNTEGEAIL
HHHCCCHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEE
ARESEDPRKFGVIVKDSENRLVRIVEKPENPPSNIINAGIYKFTYDIFSYIDKISLSSRG
EECCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
EFELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDKEKDRNLGVIEENVKIKG
CEEEHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCCEEEEECCCCCCCCEEECCEEEEE
KVVIEDGVIIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMEN
EEEEECCEEEECCCEEECCEEECCCCEECCCCCCCCHHHCCCCEEECCHHHHHHHHHHCC
AKIPHLSYVGDSVICEGVNFGAGTITANLRFDEEEVKVNIKNERVSSGRKKLGAIVGAHV
CCCCEEEECCCCEEEECCCCCCEEEEEEEEECHHHEEEEECCCHHHHHHHHHHHHHHHHH
RTGINVSILPGVKIGAYAWIYPGAVVDRDVEKGEKYVPYYLRRSSGT
HCCCCEEEECCCEECEEEEECCCHHCCCHHHCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]